DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trr and Set2

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	NP_572888.2	Gene:	Set2 / 32301	FlyBaseID:	FBgn0030486	Length:	2362	Species:	Drosophila melanogaster

Alignment Length:	2140	Identity:	394/2140 - (18%)
Similarity:	651/2140 - (30%)	Gaps:	778/2140 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   457 PPTGSIVTITTTNPSQTYAMVQDSATVGPAAHSEDDA-------PAPRKITAYSENLQKILNKSK 514
            ||..::..:..|.|....::....|...|.|..:.|:       .:.:||..:  :::.:|||::
  Fly    23 PPKVALSALGNTPPHINPSLKHADAEASPTAPEDQDSGQSECRRSSRKKIIKF--DVRDLLNKNR 85

  Fly   515 ------------SQESTGGPEEFTNINSVVIK----------------------PLDKNTLNCPP 545
                        |..|||..:..|...|..:.                      .:...:|..||
  Fly    86 KAHKIQIEARIDSNPSTGHSQSGTTAASTSMSTATASAASASSAATVSRLFSMFEMSHQSLPPPP 150

  Fly   546 ----SFNIFKQQQHSQ----AAQSQSISAVGSG------AGTPVTFTMASG-----NASDLATTS 591
                :..||.:.:.:|    |..:...||||..      ||.|.......|     ..:|.|...
  Fly   151 PPPTALEIFAKPRPTQSLIVAQVTSEPSAVGGAHPVQTMAGLPPVTPRKRGRPRKSQLADAAIIP 215

  Fly   592 TVSVSAGTICINSPMMGTRPIISIQNKNISLVLSKTT-MAQQKPKMITTTTLSSQAALQMHHALI 655
            ||.|.:   |.:|....|    |....|:|....:.. ...||||.....:|.   .|::...|
  Fly   216 TVIVPS---CSDSDTNST----STTTSNMSSDSGELPGFPIQKPKSKLRVSLK---RLKLGGRL- 269

  Fly   656 QDSSADKAGSSANSGSATSGASMQLKLTTANTPTKLSVSLAPD-----------VVKLEEVGSES 709
                     .|::||::.|.:|.:::      |..|....|.|           :|..|| .|:|
  Fly   270 ---------ESSDSGNSPSSSSPEVE------PPALQDENAMDERPKQEQNLSRMVDAEE-NSDS 318

  Fly   710 KAKLLVKQEAVVKDSTGTPTSEERAEEIGTPEKRLNANATMTAINQVQNQSANQIQMATSTSTAS 774
            .::::     .::..|.:|..||..|| |.|.             :|:.|....|.|    ..|.
  Fly   319 DSQII-----FIEIETESPKGEEEQEE-GRPV-------------EVEPQDLIDIDM----ELAK 360

  Fly   775 NPSTPNPTVNATPMNNQRSAAEDNALLKQLLQNNSSSHSLNQISITSAHVGSASASAPLSARKVI 839
            ...||:|             .||                |::|.:       ...|.|
  Fly   361 QEPTPDP-------------EED----------------LDEIMV-------EVLSGP------- 382

  Fly   840 NVRAPSM----GKVRSLEDQLARPVIPPVPTATQAAGSSSSSGSVATSTTTTTVASGGSSQQVAT 900
                ||:    .:....||...:...||   ..:.|..|.||   |...:..:....|||:|..|
  Fly   383 ----PSLWSADDEAEEEEDATVQRATPP---GKEPAADSCSS---APRRSRRSAPLSGSSRQGKT 437

  Fly   901 ASATALPVSAVA---ITTPGVGGEAKLEQKSDQPAAIMQ------NQSQNQAPPPPPPPQQQQQQ 956
            ...|...::|.:   |.      ||:..|..::...::.      ::|:..:...|.......::
  Fly   438 LEETFAEIAAESSKQIL------EAEESQDQEEQHILIDLIEDTLSESEVTSSVSPTIEHMVVEE 496

  Fly   957 QLHQPQQLQPSPHQVKQTVQ-IVSKETSFISGPVAAK--------TLVTEATSKPAELLPPPPYE 1012
            .:.:..||.....::..:.| .|.|:....|..:||.        .:.|:||.  .|::|.|  |
  Fly   497 VVVEENQLVDEADEILDSKQEFVIKKVFSESDNIAASLNKDIFEPKVETKATC--GEVVPRP--E 557

  Fly  1013 MATAPI------------SNVTISISTKQAAPKELQMKPKAVAMSLPMEQGDESLPEQAEPPLHS 1065
            |.|..:            |.|....:|:..|..:|.   ..|.:..|::  |||.|:|.|..|
  Fly   558 MVTEDVYITEGIAATLEKSAVVTKPTTEMIAETKLS---DEVVIEPPLK--DESDPKQTEVEL-- 615

  Fly  1066 EQGATAAGVAPHSGGPLVSAQWTNNHLEGGVATTKIPFKPGEPQKRKLPMHPQLDEKQIQQQAEI 1130
                      |.| .|.|:...:...|...|.||..|..|.|....:....|.|        .|.
  Fly   616 ----------PES-KPAVNIPKSERILSAEVETTSSPLVPPECCTLESVSGPVL--------LET 661

  Fly  1131 PISTSLPTTPTGQGTPDKVQLISAIATYVKKSGVPNEAQPIQNQSQGQVQMQAQMQATMQGHLSG 1195
            .:||...:....:.||.|.:.       .|:...|  |.|.:..|..    ..:....::.:.|.
  Fly   662 SLSTEEKSNENVETTPLKTEA-------AKEDSPP--AAPEEEASNS----SEEPNFLLEDYESN 713

  Fly  1196 QMSGQISGHAAGQIPAQMHLQVQHQLHMAVHPQQQQQQLHQNQPQNATIPLPVTGQGAVPIPVPT 1260
            |.                  ||.....|..:.|:.|:|                      .|:|.
  Fly   714 QE------------------QVAEDEMMKCNNQKGQKQ----------------------TPLPE 738

  Fly  1261 M---ESKAGDQRKRRKREVQKPRRTN-------LNAGQ-AGGALKDLTGPLPAGAM---VQLAGM 1311
            |   |....:...::::.::.|.|::       :.||: ....:|...|.:|...|   ...|.:
  Fly   739 MKEPEKPVAETVSKKEKAMENPARSSPAIVDKKVRAGEMEKKVVKSTKGTVPEKKMDSKKSCAAV 803

  Fly  1312 PPGTQYIQGAASGTGHVITSTGQGVTLGGVGASTGASSSPMLKKRVRKFSKVEEDHDAFTEKLLT 1376
            .|..|...|.::....:...|.:..:...:.     ||||      ....|..:|...::.:|.|
  Fly   804 TPAKQKESGKSAKEAILKKETEKEKSSAKLD-----SSSP------NTLDKKGKDTAQWSPQLQT 857

  Fly  1377 HIR-QMQPLQVLEPHLNRNFHFLIGSNETSGGGSPASMSSAASAG-SSSAGGGKLKGGSRGWPLS 1439
            ..: ..:|.|...|.        :.|..||...:|.....||..| |.::....||...:.
  Fly   858 LPKSSTKPPQESAPS--------VISKTTSNQPAPKEEQHAAKKGLSDNSPPSVLKAKEKA---- 910

  Fly  1440 RHLEGLEDCDGTV-----------LGRYGRVNLPGIPSLYDSERFGGSRGLVGGSARTRSPSPAE 1493
              :.|..:||...           |....:..|..:|:            .|....:...|:...
  Fly   911 --VSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPT------------KVEAPPKVEPPTAVP 961

  Fly  1494 SPGAEKML--PMSSIQNDFYDQEFSTHMERNPRERLVRHIGAVKDCNLETVDLVESEGVAAWATL 1556
            .||.:|.|  ..|..:|..|  |.|.::|||               :..:.|..::...|
  Fly   962 VPGQKKSLSGKTSLRRNTVY--EDSPNLERN---------------SSPSSDSAQANTSA----- 1004

  Fly  1557 PRLTRYPGLILLNGNSRCHGRMSPVALPEDPLTMRFPVSP---LLRSCGEELRKTQQMELGMGPL 1618
                               |::.|..:.:       .::|   .:....::||
  Fly  1005 -------------------GKLKPSKVKK-------KINPRRSTICEAAKDLR------------ 1031

  Fly  1619 GNNNNNNYQQKNQNVILALPASASENIAGVLRDLANLLHLAPALTCKIIEDKIGNKLEDQFMNQD 1683
               ::::.....:.|..:.|.|.|                                      :..
  Fly  1032 ---SSSSSSTPTREVAASSPVSTS--------------------------------------SDS 1055

  Fly  1684 DEKHVDFKRPLSQVSHGHLRKILNGRRKLCRSCGNVVHATGLRVPRHSVPALEEQLPRLAQLMDM 1748
            ..|....||..|.:..|  .|:...|..:|..          |.|..::|     :|...:...|
  Fly  1056 SSKRNGSKRTTSDLDGG--SKLDQRRYTICED----------RQPETAIP-----VPLTKRRFSM 1103

  Fly  1749 LPRKSVPPPFVYFCDRACFARFKWNGKDGQAEAASLLLQPAGGSAVKSSNGDSPGSFCASSTAPA 1813
            .|:.|..|........|...|.:..||:..:...||               ||..|  ||..||.
  Fly  1104 HPKASANPLHDTLLQTAGKKRGRKEGKESLSRQNSL---------------DSSSS--ASQGAPK 1151

  Fly  1814 EMVVKQEPEDEDEKTPSVPGNPTNIPAQRKCIVKCFSADCFTTDSAPSGLELDGTAGAGTGAGPV 1878
            :..:|.                          .:..||....|:|:.|           |.:|.
  Fly  1152 KKALKS--------------------------AEILSAALLETESSES-----------TSSGS- 1178

  Fly  1879 NNTVWETETS------------GLQLED-----TRQCVFCNQRGDGQADGPSRLLNFDVDKWVHL 1926
            ..:.|:.:||            ...:||     .|..|..:||.:|| |...|..:.:.|::...
  Fly  1179 KMSRWDVQTSPELEAANPFGDIAKFIEDGVNLLKRDKVDEDQRKEGQ-DEVKREADPEEDEFAQR 1242

  Fly  1927 NCALWSNGVYETVSGALMNFQTALQAGLSQACSACHQPGATIKCFKSRCNSLYHLPCAIREECVF 1991
            ...:.:.....|.|....|.:.:  |..:.........|..     .|.:.:...|
  Fly  1243 VANMETPATTPTPSPTQSNPEDS--ASTTTVLKELETGGGV-----RRSHRIKQKP--------- 1291

  Fly  1992 YKNKSVHCSVHGHAHAGITMGAGAGATTGAGLGGSVADNELSSLVVHRRVFVDRDENRQVATVMH 2056
                                 .|..|:.|.|: .|||...:|           .||  |:|
  Fly  1292 ---------------------QGPRASQGRGV-ASVALAPIS-----------MDE--QLA---- 1317

  Fly  2057 YSELSNLLRVGNMTF-----LNVGQLLPHQLEAFHTPHYIYPIGYKVSRYYWCVRRPNRRCRYIC 2116
              ||:|:..: |..|     ||..|||.                   ..:|.|.|:.::.
  Fly  1318 --ELANIEAI-NEQFLRSEGLNTFQLLK-------------------ENFYRCARQVSQE----- 1355

  Fly  2117 SIAEAGCKPEFRIQVQDAGDKEPEREFRGSSPSAVWQQILQPITRLRKVHKWLQLFPQHISGEDL 2181
                   ..|.:......||:|.:
  Fly  1356 -------NAEMQCDCFLTGDEEAQ----------------------------------------- 1372

  Fly  2182 FGLTEPAIVRILESLPGIETLTDYRFKYGRNPLLEFPLAINPSGAARTEPKQRQLLVWRKPHTQR 2246
                                                                        .|...
  Fly  1373 ------------------------------------------------------------GHLSC 1377

  Fly  2247 TAGSCSTQRMANSAAIAGEVACPYSKQFVHSKSSQYKKMKQEWRNNVYLARSKIQGLGLYAARDI 2311
            .||..:...|.....:....|...:|:|         :..|.|...|:  |::.:|.|:.|...|
  Fly  1378 GAGCINRMLMIECGPLCSNGARCTNKRF---------QQHQCWPCRVF--RTEKKGCGITAELLI 1431

  Fly  2312 EKHTMIIEYIGEVIRTEVSEIREKQY-ESKNRGIYMFRLDEDRVVDATLSGGLARYINHSCNPNC 2375
            .....|:||:||||.:|..|.|:..| :.:||..|...|..:.|:|||..|.::|||||||:||.
  Fly  1432 PPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNA 1496

  Fly  2376 VTEIVEVDRDVRIIIFAKRKIYRGEELSYDYKF-----DIEDESHKIPCACGAPNCRKWM 2430
            .|:...|:.::||..|:.:.|..|||:::||::     |.:      .|.|.|.|||.|:
  Fly  1497 ETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQ------RCYCEAANCRGWI 1550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		ePHD2_KMT2C_like	1898..2002	CDD:277136	15/103 (15%)
		FYRN	2068..2118	CDD:283589	10/54 (19%)
		FYRC	2126..2215	CDD:197781	4/88 (5%)
		SET	<2266..2431	CDD:225491	59/171 (35%)
		SET	2291..2413	CDD:214614	47/127 (37%)
		PostSET	2415..2431	CDD:214703	7/16 (44%)
Set2	NP_572888.2	AWS	1358..1410	CDD:197795	11/161 (7%)
		SET	1414..1533	CDD:214614	46/120 (38%)
		PostSET	1535..1551	CDD:214703	8/22 (36%)
		WW	2014..2043	CDD:278809
		SRI	2270..2348	CDD:285448
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467619
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.870