DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trr and Kmt2a

DIOPT Version :9

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:XP_038938273.1 Gene:Kmt2a / 315606 RGDID:1586165 Length:3986 Species:Rattus norvegicus


Alignment Length:2224 Identity:457/2224 - (20%)
Similarity:735/2224 - (33%) Gaps:713/2224 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   544 PPSFNIFKQQQHSQAAQS---QSISAV---------------------GSGAGTPVTFTMASGNA 584
            |||    ..:..|||:.|   ..||.|                     .:|:.||.|        
  Rat  2140 PPS----PDRPRSQASSSCYCHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTT-------- 2192

  Fly   585 SDLATTSTVSVSAGTICINSPMMGTRPIISIQNK-------NISLVLSKTTMAQQKPKMITTTTL 642
            .::.|.....:|:|...|.|....|..:..:::|       ....|.|::::: ..|.:.|.|..
  Rat  2193 HEIVTVGDPLLSSGLRSIGSRRHSTSSLSPLRSKLRIMSPVRSGSVYSRSSVS-SVPSLGTATDP 2256

  Fly   643 SSQAALQMHHALIQDSSADKAG---SSANSGSAT--SGASMQLKLTTANTPTKLSVSLAPDVVKL 702
            .|.|           .:.|:||   ||||.|.:|  |..|.:..:|..:..:.|..|.:..|.: 
  Rat  2257 ESSA-----------KATDRAGPLNSSANLGHSTPVSSGSQRTVVTGGSKTSHLDGSSSSGVKR- 2309

  Fly   703 EEVGSESKAKLLVKQEAVVKDSTGTPTSEERAEEIGTPEKRLNANATMTAIN-------QVQNQS 760
                 .|.:.|..|..::..:...||.|           |..:.:|..||.:       ||.|.:
  Rat  2310 -----SSASDLAPKGSSLKGEKNRTPGS-----------KSTDGSAHNTAYSGIPKLAPQVLNAA 2358

  Fly   761 ANQIQMATSTSTASNPSTPNPTVNATPMNNQRSAAEDNALLKQLLQNNSSSHSLNQISITSAHVG 825
            ..::.: :...|.:.|||       .|.      :::.....||       |...|.|....|:.
  Rat  2359 PGELNV-SKIGTFAEPST-------VPF------SKETVSYPQL-------HLRGQRSDRDQHMD 2402

  Fly   826 SASA--SAPLSARKVINVRAPSMGKVRSLEDQLARPVIPPVPTATQAAGSSS----SSGSVATST 884
            |..:  .:|....::..::.|.||.         ||.|     ..:..||||    ..|..::..
  Rat  2403 STQSVKPSPNEDGEIKTLKLPGMGH---------RPSI-----LHEHVGSSSRDRRQKGKKSSKE 2453

  Fly   885 TTTTVASGGS---SQQVATASATAL-PVSAVAITTPGVGGEAKLEQKSDQPAAIMQNQSQNQAPP 945
            |.....|..|   ..||.|.....| |..|..:.|||..|:.....       :..:::.::..|
  Rat  2454 TCKEKHSSKSFLEPGQVTTGEEGNLKPEFADEVLTPGFLGQRPCNN-------VSSDKTGDKILP 2511

  Fly   946 PPPPPQQQQQQ------QLHQPQQLQPSPHQVKQTVQIVSKETSFISGPVAAKTLVTEATSKPAE 1004
            ....|:.|..|      :|..|::.......:|...:..||.|...|||           ..||.
  Rat  2512 LSGVPKGQSTQVEGSSKELQAPRKCSVKVTPLKMESENQSKNTQKESGP-----------GSPAH 2565

  Fly  1005 LLPPPPYEMATAPISNVTISISTKQAAPKELQMKPKAVAMSLPMEQGDESLPEQAEPPLHSEQGA 1069
            :....|.|.|:|         |....|...:|..|...:...|.....::||||....:..:   
  Rat  2566 MESACPAEPASA---------SRSPGAGPGVQPSPNNTSSQDPQSNNYQNLPEQDRNLMIPD--- 2618

  Fly  1070 TAAGVAPHSGG------PLVSAQWTNNHLEG-----GVAT---TKIPFKPGEPQKR--------- 1111
               |..|...|      |..||:..:|...|     ||.:   ..|||......|:         
  Rat  2619 ---GPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQ 2680

  Fly  1112 -------------------------------KLPMHPQLDEKQIQQQAEIPISTSLPTTPTGQGT 1145
                                           :|..|....|   ::|.::|..:.|.....|..:
  Rat  2681 VDGADDLSTSDEDDLYYYNFTRTVISSGGDERLASHNLFRE---EEQCDLPKISQLDGVDDGTES 2742

  Fly  1146 PDKVQLISAIAT---------------------------YVKKSGVPNEAQP-IQN-------QS 1175
            ...|...|..::                           :|.||.|.::.:| :.|       ::
  Rat  2743 DTSVTATSRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVIKSAVGHKNEPKLDNCHSVSRVKA 2807

  Fly  1176 QGQVQMQAQ---MQATMQGHLS------------------------GQMSGQI------------ 1201
            |||..::||   ::::.:.|.|                        ....|.|            
  Rat  2808 QGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKN 2872

  Fly  1202 --SGHAAGQIPAQ-----------MHLQVQHQLHMAVHPQQQQQQLHQNQPQNATIPLPVTGQGA 1253
              |..|.|:.|..           :.|....:..|.:. :...|||...:|.::::...::.:..
  Rat  2873 TPSMQALGESPESSSSELLTLGEGLGLDSNREKDMGLF-EVFSQQLPATEPVDSSVSSSISAEEQ 2936

  Fly  1254 VPIPV-------------PTMESK-------AGDQRKRRKREVQKPRRTNLNAGQAGGA-LKDLT 1297
            ..:|:             ||:.|:       ..|..::|....:|    ::.:.:...| |....
  Rat  2937 FELPLELPSDLSVLTTRSPTVPSQNSSRLAVISDSGEKRVTITEK----SVTSTEGDPALLSPGV 2997

  Fly  1298 GPLPAGAMVQLAGMPPGTQYIQGAASGTGHV----ITSTGQGVTLGGVGAS---TGASSSPMLKK 1355
            .|.|.|.|..       ..:||      ||:    |:|...|....|.|.:   |..||:|.|:.
  Rat  2998 DPAPEGHMTP-------DHFIQ------GHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQV 3049

  Fly  1356 RV--------RKFSKVEEDHDA------------------FTEKLLTHIRQMQPLQVLEPHLNRN 1394
            .|        :|:.....|...                  .||||:...:.||||.||:...|  
  Rat  3050 PVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPN-- 3112

  Fly  1395 FHFLIGSNETSGGGSPAS-----MSSAASAGSSSAGGGKLKGG---------------SRG---W 1436
                 |..:.....||.|     |.:..|.......|..|..|               |:|   .
  Rat  3113 -----GVTQKIQLTSPVSSTPNVMETNTSVLGPMGSGLTLTTGLNPSLPPSQSLFPPASKGLLSM 3172

  Fly  1437 PLSRHLEGLEDC-------------DGTVLGRYGRVNLPGIPSLYDSERFGGSRGLVGGSARTRS 1488
            |..:||......             .|.::|    |..|..|.|..||          .:.||..
  Rat  3173 PHHQHLHSFPAAAQSSFPPNISSPPSGLLIG----VQPPPDPQLLGSE----------ANQRTDL 3223

  Fly  1489 PSPAESPGAE-KMLPMSSIQNDFYDQEFSTHMERNPRERLVRHIGAVKDCNLETVDLVESEGVAA 1552
            .:...:|.:. |..|:|.:           |..:|  ::|.   .:....|:...|:|.:..:..
  Rat  3224 TTTVTTPSSGLKKRPISRL-----------HTRKN--KKLA---PSSAPSNIAPSDVVSNMTLIN 3272

  Fly  1553 WATLPRLTRYPGLILLNG-NSRCHGRMSPVALPEDPLTMRFPVSPLL--RSCGEELRKTQQMELG 1614
            : |..:|:.:|.|:.|.. |...|..:..:........|.|..:|||  :|.|            
  Rat  3273 F-TPSQLSNHPSLLDLGSLNPSSHRTVPNIIKRSKSGIMYFEQAPLLPPQSVG------------ 3324

  Fly  1615 MGPLGNNNNNNYQQKNQNVILALPASASENIAGVLRDLANLLHLAPALTCKIIEDKIGNKLEDQF 1679
             |.......::...::.:.:.:.|.||..:.:.||    |::.:....|                
  Rat  3325 -GTTATGAGSSTISQDTSHLTSGPVSALASGSSVL----NVVSMQTTTT---------------- 3368

  Fly  1680 MNQDDEKHVDFKRPLSQVS-HGHLRKILNGRRKLCRSCGNVVHATGLRVPRHSVPALEEQLPRLA 1743
                         |.|..| .||: .:.|.|.......|::.|.  |....|....:::|...|.
  Rat  3369 -------------PTSSTSVPGHV-TLANQRLLGTPDIGSISHL--LIKASHQSLGIQDQPVALP 3417

  Fly  1744 QLMDMLPRKSVPPPFVYFCDRACFARFKWNGKDGQAEAASLLLQPAGGSAVKSSNGDSPGSFCAS 1808
            |...|.|:.                        |.::..|.....|..|.....:..:.|...||
  Rat  3418 QSSGMFPQL------------------------GTSQTPSAAAMTAASSICVLPSSQTAGMTAAS 3458

  Fly  1809 STAPAEMVVKQEPEDE-------------DEKTPSVPG-NPTNIPAQRKCIVKCFSADCFT-TDS 1858
            ....||...|.:..::             |....|.|| .|:|                || |..
  Rat  3459 PPREAEEQYKLQRVNQLLAGKTGTLSLQRDRDPDSAPGTQPSN----------------FTQTAE 3507

  Fly  1859 APSGLELDGTAGAGTGAGPVNNTVWETETSGLQLEDTRQCVFCNQRGDGQADGPS------RLLN 1917
            ||:|:.|:......:.....:.:...:.:||            .|.|.....||:      :.:.
  Rat  3508 APNGVRLEQNKTLPSAKQASSTSPGSSPSSG------------QQSGSSSVPGPTKPKPKVKRIQ 3560

  Fly  1918 FDVDKWVHLNCALWSNGVYETVSGALMNFQTALQAGL-SQACSACHQPGATIKCFKSRCNSLYHL 1981
            ..:||         .:|....||    :.:|:.:|.: .:..:...||            |:...
  Rat  3561 LPLDK---------GSGKKHKVS----HLRTSSEAHIPHREANPAPQP------------SVKRT 3600

  Fly  1982 PCAIREECVFYKNKSVHCSVHGHAHAGITM------GAGAGATTGAGLGGSVADNELSSLVVHRR 2040
            |.|.||:               ...||:..      |..||..|.           |..:...:.
  Rat  3601 PRADREQ---------------QEAAGVEQPSQKECGQPAGPATA-----------LPEIQATQN 3639

  Fly  2041 VFVDRDENRQVATVMHYSELSNLLRVGNMTFLNVGQLLPHQLEAFHTPHYIYPIGYKVSRYYWCV 2105
            . .:..||.:...|                        ..:..:|.:|..:           |..
  Rat  3640 P-ANEQENAEPKAV------------------------EEEESSFSSPLML-----------WLQ 3668

  Fly  2106 RRPNRRCRYICSIAEAGCKPE----FRIQVQDAGDKEPEREFRGSSPSAVWQQILQPITRLRKVH 2166
            :...|:    .||.|.  ||:    |.|...|.      .:....|....|:.:...:...|...
  Rat  3669 QEQKRK----ESITER--KPKKGLVFEISSDDG------FQICAESIEDAWKSLTDKVQEARSNA 3721

  Fly  2167 KWLQLFPQHISGEDLFGLTEPAIVRILESLPGIETLTDYRFKYGRNPLLEFPLAINPSGAARTEP 2231
            :..||....::|..:.|:...|:|.::|.|.|.:...:|:|::.:......| .:||.|:||.|.
  Rat  3722 RLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEP-PLNPHGSARAEV 3785

  Fly  2232 KQRQLLV---------WRKPHTQRTAGSCSTQRMANSAAIAGEVACPYSKQFVHSKSSQYKKMKQ 2287
            ..|:...         .|:|...........:....||..|..:..|...:|.|.|.:..:.:  
  Rat  3786 HLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAV-- 3848

  Fly  2288 EWRNNVYLARSKIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQYESKNRGIYMFRLDED 2352
                .||  ||.|.|.||:..|:|:...|:|||.|.|||:..::.|||.|:||..|.||||:|:.
  Rat  3849 ----GVY--RSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDS 3907

  Fly  2353 RVVDATLSGGLARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGEELSYDYKFDIEDESHKI 2417
            .|||||:.|..||:|||||.|||.:.::.:|....|:|||.|||||||||:|||||.|||.|:|:
  Rat  3908 EVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKL 3972

  Fly  2418 PCACGAPNCRKWMN 2431
            ||.|||..|||::|
  Rat  3973 PCNCGAKKCRKFLN 3986

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513
ePHD2_KMT2C_like 1898..2002 CDD:277136 18/110 (16%)
FYRN 2068..2118 CDD:283589 4/49 (8%)
FYRC 2126..2215 CDD:197781 17/92 (18%)
SET <2266..2431 CDD:225491 82/164 (50%)
SET 2291..2413 CDD:214614 67/121 (55%)
PostSET 2415..2431 CDD:214703 9/15 (60%)
Kmt2aXP_038938273.1 zf-CXXC 1145..1192 CDD:366873
PHD1_KMT2A 1451..1497 CDD:277063
PHD2_KMT2A 1499..1548 CDD:277065
PHD3_KMT2A 1586..1645 CDD:277067
Bromo_ALL-1 1668..1798 CDD:99925
ePHD_KMT2A 1892..2004 CDD:277163
FYRN 2045..2092 CDD:399155
FYRC 3686..3769 CDD:197781 17/88 (19%)
SET_KMT2A_2B 3833..3986 CDD:380947 81/160 (51%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166351990
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D738155at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.850

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