Protein Alignment trr and G9a

DIOPT Version :10

• Sequence 1: NP_726773.2
• Gene: trr / 31149
• FlyBaseID: FBgn0023518
• Length: 2431
• Species: Drosophila melanogaster
• Sequence 2: NP_001259088.1
• Gene: G9a / 30971
• FlyBaseID: FBgn0040372
• Length: 1657
• Species: Drosophila melanogaster
• Alignment Length: 2130
• Identity: 381/2130 - (17%)
• Similarity: 605/2130 - (28%)
• Gaps: 889/2130 - (41%)

  Fly   665 SSANSGSATSGASMQLKLTTANTPTKLSVSLAPDVV---------------KLEEVGSESKAKLL 714
            |:.||..|||         ||...|.|:::||.|..               |..:...|.:.|..
  Fly    13 STFNSDCATS---------TAEGGTLLNLNLAEDKTLKWRNLANNQFASKEKKHKDKEEEERKEA 68

  Fly   715 VKQEAV---------VKDSTGTPTSEERA--------------EEIGTP---------------E 741
            ..||.:         |.|:......||.|              ||.|..               |
  Fly    69 RNQEEIEDIKALLADVVDAAAVKLEEEEAQNAEKVEPHTKCEIEEEGRKEMEYDQDVAKQDSEME 133

  Fly   742 KRLNANATMTAINQVQNQSANQIQMATSTSTASNPSTPNPTVNATPMNNQRSAAEDNALL--KQL 804
            |:.|..||...:....|:.|.  :.||..:|.|.....|.:......|.:.:..|:..:|  .|.
  Fly   134 KKQNGKATSITVKMESNERAE--KHATEIATTSTERWENESFKTEQQNKKAAEKEEEPILAATQK 196

  Fly   805 LQNNSSSHSLNQISITSAH-VGSASASAPLSARKVINVRAPSMGKVRSLEDQLARPVIPPVPTAT 868
            |:.|:...:..:|.:..|. :..:|||..|:|                              .||
  Fly   197 LEANAEPLTTTRIEVAVASPLVVSSASVKLAA------------------------------DAT 231

  Fly   869 QAAGSSSSSGSVATSTTTTTVASGGSSQQVATASATALPVSAVAITTPGVGGEAKLEQKSDQPAA 933
            ....:::|:|:...:.....|:.||:.:...|......|.|   :|...|..|.|...||:
  Fly   232 NQMRAATSAGAATLADKNVQVSPGGTRRSRRTPRPIDTPTS---VTDEHVQVENKKFGKSE---- 289

  Fly   934 IMQNQSQNQAPPPPPPPQQQQQQQLHQPQQLQPSPHQVKQTVQIVSKETSFISGPVAAKTLVTEA 998
                                        |....|.|..:.|   :...|:.:      :..:...
  Fly   290 ----------------------------QYTDCSSHLERFT---LDDNTAIV------RLQLKSE 317

  Fly   999 TSKPAELLPPPPYEMATAPISNVTISISTKQAAPKELQMKPKAVA----MSLPMEQGDESLPEQA 1059
            ..||:.....|....|.||          |:...:..:::|.|..    :.||.|   :||.|:
  Fly   318 PDKPSLTALSPEENSAPAP----------KRGRGRARKIRPDAEVETSEVILPCE---DSLGEK- 368

  Fly  1060 EPPLHSEQGATAAGVAPHSGGPLVSAQWTNNHLEGGVATTKIPFKPGEPQKRKLPMHPQLDEKQI 1124
                                                        |||  :|||||..| :|::|:
  Fly   369 --------------------------------------------KPG--RKRKLPDEP-IDQQQL 386

  Fly  1125 QQQAEIPISTSLPTTPTGQGTPDKVQLISAIATYVKKSGVPNEAQPIQNQSQGQVQMQAQMQATM 1189
            .                     |.|.             |..|.:.:.:...|.|:   :|:.::
  Fly   387 S---------------------DLVV-------------VKTEQEELGDAPLGDVK---RMRRSV 414

  Fly  1190 QGHLSGQMSGQISGHAAGQIPAQMHLQVQHQLHMAVHPQQQQQQLHQNQPQNATIPLPVTGQGAV 1254
            :  |..::      ||.|....::..:       |:|| |...:|...:..:..:||.|..:...
  Fly   415 R--LGNRL------HADGSPWEEVKTE-------ALHP-QPSAELSFAEVTSEILPLAVLDEKTP 463

  Fly  1255 PIPVPTMESKAGDQRKRRKREVQKPRRTNLNAGQAGGALKDLTGPLPAGAMVQLAGMPPGTQYIQ 1319
            |              |:|.|:.:.|                         .|:|.
  Fly   464 P--------------KKRGRKAKTP-------------------------CVKLE---------- 479

  Fly  1320 GAASGTGHVITSTGQGVTLGGVGASTGASSSPML------KKRVRKFSKVEEDHDAFTEKLLTHI 1378
                      :.|..|:........|.:|....|      |:|::...|:.|:.:...|....||
  Fly   480 ----------SETSCGLPFANGNKKTNSSGGCELQLPKRSKRRIKPTPKILENDELRCEFETKHI 534

  Fly  1379 RQMQPLQVLEPHLNRNFHFLIGSNETSGGGSPASMSSAASAGSSSAGGGKLKGGSRGWP------ 1437
            .:|...:        :...:.|..||...|...|.||.:...|..:.|...:||. |.|
  Fly   535 ERMTQWE--------SAAAVDGDFETPTTGGNGSNSSTSRQKSDKSDGSNFEGGP-GHPAGTSAI 590

  Fly  1438 ----LSRHLEGLEDCDGTVLGRYGRVNLPGIPSLYDSERFGGSRGLVGGSARTRSPSPAE----- 1493
                .|:....:|:....:|   .:..||..|   |.|:|...   :..|....:.||.|
  Fly   591 KKRLFSKSQRDIENYGAAML---AKSKLPPCP---DVEQFLND---IKASRINANRSPEERKLNK 646

  Fly  1494 ------SPGAEKMLPMSSIQNDFYDQ-----EFSTHMERNPRERLVRHIGAVKDCNLETVDLVES 1547
                  :...||.|....:|.:..|:     ..:|..|..|..|:  .:|. ....|...:.|..
  Fly   647 KQQRKLAKQKEKHLKHLGLQKNHRDEPSDNDSSNTDNEFFPTTRV--QVGK-PSVTLRVRNSVTK 708

  Fly  1548 EGVAAWATL----------PRLTRYPGLILLNGNSRCHGRMSPVALPEDPLTMRFPVSPLLRSCG 1602
            | :...|||          .:|||..|       :|..|.::..|....|::.  |.:..|.|..
  Fly   709 E-LPTTATLKSRRNPVVQAAKLTRRIG-------ARAAGEVTEAARASVPIST--PDAEQLHSLD 763

  Fly  1603 EELRK--TQQMELGMGPLGNNNNNNYQQKNQNVILALPASASENIAGVLRDLANLLHLAPALTCK 1665
            ..::.  |...:|.|.|         .....:..:.|....|:..|....|        .:..|.
  Fly   764 TSIQADVTPIRDLDMRP---------STSRVSKFICLCQKPSQYYARNAPD--------SSYCCA 811

  Fly  1666 I--IED-KIG--NKLEDQFMNQDDEKHVDFKRPLSQVSH-----GHLRKILNGRRKLCRSCGNVV 1720
            |  |:| |||  |:|..:..|        ..||..:||:     .|.:::.:  ...|..||
  Fly   812 IDHIDDQKIGCCNELSSEVHN--------LLRPSQRVSYMILCDEHKKRLQS--HNCCAGCG--- 863

  Fly  1721 HATGLRVPRHSVPALEEQLPRLAQLMDMLPRKSVPPPFVYFCDRACFARFKWNGKDGQAEAASLL 1785
                                                   .||.:..|...|          ....
  Fly   864 ---------------------------------------IFCTQGKFVLCK----------QQHF 879

  Fly  1786 LQPAGGSAVKSSNGDSPGSFCASSTAPAEMVVKQEPEDEDEKTPSVPGNPTNIPAQRKCIVKCFS 1850
            ..|           |....|..|::...|:   .:.||:..|..|        |.   .::||
  Fly   880 FHP-----------DCAQRFILSTSYEKEL---GDEEDQGVKFSS--------PV---LVLKC-- 917

  Fly  1851 ADCFTTDSAPSGLELDGTAGAGTGAGPVNNTVWETETSGLQLEDTRQC----VFCNQRGDGQADG 1911
            ..|        ||:                |...|.|.      |.:|    ||.  |.......
  Fly   918 PHC--------GLD----------------TPERTSTV------TMKCQSLPVFL--RTQKYKIK 950

  Fly  1912 PSRLLNFDVDKWVHLNCALWSNGVYETVSGALMNFQTALQAGLSQACSACHQPGATIKCFKSRCN 1976
            |:||                      |.|..|..|.|...|         :.||||.
  Fly   951 PARL----------------------TTSSHLTQFGTVENA---------NTPGATA-------- 976

  Fly  1977 SLYHLPCAIREECVFYKNKSVHCSVHGHAHAGITMGAGA-------GATTG-AGLGGSVADNELS 2033
                            :||       |.....:|:.|.:       ||..| ||...|.:.:.|:
  Fly   977 ----------------RNK-------GGLSTAVTLSAASSPASKTNGAQRGRAGTSNSNSRHALN 1018

  Fly  2034 SL------------VVHR--------RV-----------FVDRDENRQVATVM--HYSELSNLLR 2065
            |:            ||.|        ||           .|..|:..:||.::  .::.|:.:..
  Fly  1019 SINFAQLIPESVMNVVLRGHVVSASGRVTAEFTPRDMYYAVQNDDLERVAEILAADFNVLTPIRE 1083

  Fly  2066 VGNMTFLNVGQLLPHQ----------LEAFHTPHYIYPIGYKVSRYYWCVRRPNRRCRYICSIAE 2120
            ..|.|.|:   |:.|.          .:...:|.::..:.|::.....|... |.:|..:....:
  Fly  1084 YLNGTCLH---LVAHSGTLQMAYLLLCKGASSPDFVNIVDYELRTALMCAVM-NEKCDMLNLFLQ 1144

  Fly  2121 AGCKPEFRIQVQDAGDKEPEREFRGSSPSAVWQQI-----LQPITRLRKVHKWLQLFPQHISGED 2180
            .|.         |...|.|:    |.:...:..|:     .|.|....:..:.:..|...|..:|
  Fly  1145 CGA---------DVAIKGPD----GKTSLHIAAQLGNLEATQLIVDSYRTSRNITSFLSFIDAQD 1196

  Fly  2181 LFGLT---------EPAIVRILESLP--------------------------------------- 2197
            ..|.|         ...||| |.|||
  Fly  1197 EGGWTAMVWAAELGHTDIVR-LASLPQAVFLKLINIFLFISFLLNQDADPNICDNDNNTVLHWST 1260

  Fly  2198 ----GIETLT---------DYRFKYGRNPL--------LEFPLAINPSGA--------------- 2226
                |::|:|         :.:...|..||        ....:|:..:||
  Fly  1261 LHNDGLDTITVLLQSGADCNVQNVEGDTPLHIACRHSVTRMCIALIANGADLMIKNKAEQLPFDC 1325

  Fly  2227 --------ARTEPKQRQLLVWRKPHTQRTAGSCS----------TQRMANSAAI------AGEVA 2267
                    .||.....|:..:| |...||...|:          .|.:.|..|:      |..:.
  Fly  1326 IPNEESECGRTVGFNMQMRSFR-PLGLRTFVVCADASNGREARPIQVVRNELAMSENEDEADSLM 1389

  Fly  2268 CP---YSKQ-FVHSKSSQYKKMKQEWR--------------------NNVYLARSKI-------- 2300
            .|   |..| .:...|.|..:...:.|                    .|.|.|.|::
  Fly  1390 WPDFRYVTQCIIQQNSVQIDRRVSQMRICSCLDSCSSDRCQCNGASSQNWYTAESRLNADFNYED 1454

  Fly  2301 ----------------------------------------QGLGLYAARDIEKHTMIIEYIGEVI 2325
                                                    :|.|:.|..::.|.|.:..|.||::
  Fly  1455 PAVIFECNDVCGCNQLSCKNRVVQNGTRTPLQIVECEDQAKGWGVRALANVPKGTFVGSYTGEIL 1519

  Fly  2326 -------RTEVSEIREKQYESKNRGIYMFRLDEDRVVDATLSGGLARYINHSCNPNCV-TEIVEV 2382
                   ||:.|              |.|.||....:||...|.:.|:.||||.||.: ..:...
  Fly  1520 TAMEADRRTDDS--------------YYFDLDNGHCIDANYYGNVTRFFNHSCEPNVLPVRVFYE 1570

  Fly  2383 DRDVR---IIIFAKRKIYRGEELSYDY--KFDIEDESHKIPCACGAPNCR 2427
            .:|.|   |..|:.|.|..|||:.:||  ||...:....:.|.|....|:
  Fly  1571 HQDYRFPKIAFFSCRDIDAGEEICFDYGEKFWRVEHRSCVGCRCLTTTCK 1620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		PRK13914	<623..>851	CDD:237555	51/241 (21%)
		ePHD2_KMT2C_like	1898..2002	CDD:277136	19/107 (18%)
		FYRN	2067..2118	CDD:461787	10/60 (17%)
		FYRC	2126..2215	CDD:197781	25/162 (15%)
		SET_KMT2C_2D	2278..2430	CDD:380948	48/231 (21%)
G9a	NP_001259088.1	PTZ00121	<68..>188	CDD:173412	24/121 (20%)
		EHMT_ZBD	786..933	CDD:411018	44/273 (16%)
		ANKYR	1063..1322	CDD:440430	42/276 (15%)
		ANK repeat	1088..1120	CDD:293786	5/34 (15%)
		ANK repeat	1124..1153	CDD:293786	5/38 (13%)
		ANK repeat	1155..1196	CDD:293786	6/44 (14%)
		ANK repeat	1199..1249	CDD:293786	9/50 (18%)
		ANK repeat	1251..1283	CDD:293786	3/31 (10%)
		ANK repeat	1285..1316	CDD:293786	6/30 (20%)
		SET_EHMT	1391..1622	CDD:380941	51/244 (21%)