Protein Alignment trr and Ezh1

DIOPT Version :10

• Sequence 1: NP_726773.2
• Gene: trr / 31149
• FlyBaseID: FBgn0023518
• Length: 2431
• Species: Drosophila melanogaster
• Sequence 2: NP_001100521.1
• Gene: Ezh1 / 303547
• RGDID: 1305028
• Length: 747
• Species: Rattus norvegicus
• Alignment Length: 949
• Identity: 177/949 - (18%)
• Similarity: 281/949 - (29%)
• Gaps: 365/949 - (38%)

  Fly  1534 VKDCNLETVDLVESEGVAAWATLPRLTRYPG-----LILLNGNSRCHGRMSPVALPEDPLTMRFP 1593
            :|.|.:|::                   :||     :::.:.|:..   :.|:.....||...|.
  Rat    80 LKKCTIESI-------------------FPGFDSQDMLMRSLNTVA---LVPIMYSWSPLQQNFM 122

  Fly  1594 VSPLLRSC-----GEELRKTQQM---ELGMGPLGNNNNNNYQQKNQNVILALPASASENIAGVLR 1650
            |......|     |:|:::..:.   ||         .|||..|.......:|.|       ||.
  Rat   123 VEDETVLCNIPYMGDEVKEEDETFIEEL---------INNYDGKVHGEEEMIPGS-------VLI 171

  Fly  1651 DLANLLHLAPALTCKIIEDKIGNKLEDQFMNQDDEKHVDFKRPLSQVSHGHLRKILNGRRKLCRS 1715
            ..|..|.|..||      ::..::.|:...:..|.|..|.|..| .|:....|..:.|.:|..:.
  Rat   172 SDAVFLELVDAL------NQYSDEEEEGHNDTSDGKQDDSKEDL-PVTRKRKRHAIEGNKKSSKK 229

  Fly  1716 ---CGNVVHATGLRVPRHSVPALEEQLPRLAQLMDMLPRKSVPPP-------------------- 1757
               ...:..|.....|.:.||  ::...|..:|.:|....::||.
  Rat   230 QFPNDMIFSAIASMFPENGVP--DDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLH 292

  Fly  1758 --FVYFCDRACFARFKWNGKDGQAEAASLLLQP--AGGSAVKSSNGDSPGSFCASSTAPAEMVVK 1818
              ...|| |.|   ||::          ..|.|  |..:..|..|.:                :|
  Rat   293 SFHTLFC-RRC---FKYD----------CFLHPFHATPNVYKRKNRE----------------IK 327

  Fly  1819 QEPED---------EDEKTPSVPGNP-TNIPAQRKCIVKCFSADCFTTDSAPSGLELDGTAGAGT 1873
            .|||.         |..|..::..|| :....:|:......||.|..|.::......:|.:...|
  Rat   328 IEPEPCGADCFLWLEGAKEYAMLHNPRSKCSGRRRRRHPVVSASCSNTSASAMAETKEGDSDRDT 392

  Fly  1874 GAGPVNNTVWETETSGLQLEDTRQCVFCNQRGDGQA-------DGPSRLLNFDVDKWVHLNCALW 1931
            |    |:  |.:.:|    |...:|....::....|       :.||..:     :|.....:|:
  Rat   393 G----ND--WASSSS----EANSRCQTPTKQKASPAPPQLCVVEAPSEPV-----EWTGAEESLF 442

  Fly  1932 S--NGVYETVSGALMNFQTALQAGLSQACSACHQPGATIKCFKSRCNSLYHLPCAIREECVF--- 1991
            .  :|.|      ..||           ||.....|.      ..|..::..  |::|..:.
  Rat   443 RVFHGTY------FNNF-----------CSIARLLGT------KTCKQVFQF--AVKESLILKLP 482

  Fly  1992 --------YKNKSVHCSVHGHAHAGITMGAGAGATTGAGLGGSVADNELSSLVVHRRVFVDRDEN 2048
                    .|.|..|.....|.                                 |::.:.:|.|
  Rat   483 TDELMNPSQKKKRKHRLWAAHC---------------------------------RKIQLKKDNN 514

  Fly  2049 RQVATVMHYSELSNLLRVGNMTFLNVGQLLPHQLEAFHTPHYIYPIGYKVSRYYWCVRRPNRRCR 2113
                                                          ..:|..|..| ..|:|.|.
  Rat   515 ----------------------------------------------STQVYNYQPC-DHPDRPCD 532

  Fly  2114 YICSIAEAGCKPEFRIQVQDAGDKEPEREFRGSSPSAVWQQILQPITRLRKVHKWLQLFPQHISG 2178
            ..|                               |..:.|...:         |:.|..|.
  Rat   533 STC-------------------------------PCIMTQNFCE---------KFCQCSPD---- 553

  Fly  2179 EDLFGLTEPAIVRILESLPGIETLTDYRFKYGRNPLLEFPLAINPSGAARTEPKQRQLLVWRKPH 2243
                         .....||....|....|       :.|..:    |.|.......|......|
  Rat   554 -------------CQNRFPGCRCKTQCNTK-------QCPCYL----AVRECDPDLCLTCGASEH 594

  Fly  2244 TQRTAGSCSTQRMANSAAIAGEVACPYSKQFVHSKSSQYKKMKQEWRNNVYLARSKIQGLGLYAA 2308
            ......||..              |               .:::..:.::.||.|.:.|.|.:..
  Rat   595 WDCKVVSCKN--------------C---------------SIQRGLKKHLLLAPSDVAGWGTFIK 630

  Fly  2309 RDIEKHTMIIEYIGEVIRTEVSEIREKQYESKNRGIYMFRLDEDRVVDATLSGGLARYINHSCNP 2373
            ..::|:..|.||.||:|..:.::.|.|.|: |....::|.|:.|.|||||..|...|:.|||.||
  Rat   631 ESVQKNEFISEYCGELISQDEADRRGKVYD-KYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNP 694

  Fly  2374 NCVTEIVEVDRDVRIIIFAKRKIYRGEELSYDYKFDIED 2412
            ||..::|.|:.|.||.|||||.|..||||.:||::...|
  Rat   695 NCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQAD 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		PRK13914	<623..>851	CDD:237555
		ePHD2_KMT2C_like	1898..2002	CDD:277136	19/123 (15%)
		FYRN	2067..2118	CDD:461787	7/50 (14%)
		FYRC	2126..2215	CDD:197781	9/88 (10%)
		SET_KMT2C_2D	2278..2430	CDD:380948	51/135 (38%)
Ezh1	NP_001100521.1	EZH2_WD-Binding	39..68	CDD:463308
		PRC2_HTH_1	159..262	CDD:436286	25/118 (21%)
		SANT	433..474	CDD:238096	11/65 (17%)
		preSET_CXC	560..591	CDD:408079	7/41 (17%)
		SET_EZH1	608..743	CDD:380994	51/127 (40%)