DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trr and SETD2

DIOPT Version :9

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:XP_011531934.1 Gene:SETD2 / 29072 HGNCID:18420 Length:2572 Species:Homo sapiens


Alignment Length:2025 Identity:375/2025 - (18%)
Similarity:636/2025 - (31%) Gaps:715/2025 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   738 GTPEKRLNANATMTAINQVQNQSANQIQMA-------------TSTSTASNPSTPNPTVNATPMN 789
            |....|.....|.|.:| ::.|...::..:             |:........||||.  |.|  
Human    56 GVASSRFLPKGTKTKVN-LEEQGRQKVSFSFSLTKKTLQNRFLTALGNEKQSDTPNPP--AVP-- 115

  Fly   790 NQRSAAEDNALLKQLLQNNSSSHSLNQISITSAHVGSASASAPLSARKVINVRAPSMGKV---RS 851
                           ||.:|:.....:|..|   :.:|..|:|..:|       ..:||:   :.
Human   116 ---------------LQVDSTPKMKMEIGDT---LSTAEESSPPKSR-------VELGKIHFKKH 155

  Fly   852 LEDQLARPVIPPVPTATQAAGSSSSSGSVATSTTTTTVASGGSSQQVATASATALPVSAVAITTP 916
            |....:||::                      .|||.|||       ....|..||......|| 
Human   156 LLHVTSRPLL----------------------ATTTAVAS-------PPTHAAPLPAVIAESTT- 190

  Fly   917 GVGGEAKLEQKSDQPAAIMQNQSQNQAPPPPPPPQQQQQQQLHQPQQLQPSPHQVKQTVQIVSKE 981
                       .|.|.:         :|||||||.|                             
Human   191 -----------VDSPPS---------SPPPPPPPAQ----------------------------- 206

  Fly   982 TSFISGPVAAKTLVTEATSKPAELLPPPPYEMATAPISNVTISISTKQAAPKELQMKPKAVAMSL 1046
                     |.||     |.||.:         |.|::.....|:...|||           :.|
Human   207 ---------ATTL-----SSPAPV---------TEPVALPHTPITVLMAAP-----------VPL 237

  Fly  1047 PMEQGDESLPEQAEPPLHSEQGATAAGVAPHSGGPLVSAQWTNNHLEGGVATTKIPFKPGEPQKR 1111
            |::....||   .|||:.         :.|.|..........:|.||..|  |:|..:..:...:
Human   238 PVDVAVRSL---KEPPII---------IVPESLEADTKQDTISNSLEEHV--TQILNEQADISSK 288

  Fly  1112 KLPMHPQLDEKQIQQQAEIPIST--SLPTTPTG---------------QGTPDKVQLISAIATY- 1158
            |...|...||       |||.|:  ||....||               :...|.|:..|:..:: 
Human   289 KEDSHIGKDE-------EIPDSSKISLSCKKTGSKKKSSQSEGIFLGSESDEDSVRTSSSQRSHD 346

  Fly  1159 ------------VKKSGVPNEAQPIQNQSQGQV----------QMQAQMQATMQGHLSGQMSGQI 1201
                        .|||..|.:::.:...|:.:.          :::...:.......|.:...:.
Human   347 LKFSASIEKERDFKKSSAPLKSEDLGKPSRSKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRS 411

  Fly  1202 SGHAAGQIPAQMHLQVQHQLHMAVHPQQQQQQLHQNQP--QNATIPLPVTGQGAVPIPVPTMESK 1264
            ..|:..:..::.:|........  |.....::.|::.|  :......|.|...|         .:
Human   412 RSHSRSERGSRTNLSYSRSERS--HYYDSDRRYHRSSPYRERTRYSRPYTDNRA---------RE 465

  Fly  1265 AGDQRKRRKREVQKPRRTNLNA------------------------------GQAGGALKDLTGP 1299
            :.|..:..|:...  |||:.::                              |:....|:..:..
Human   466 SSDSEEEYKKTYS--RRTSSHSSSYRDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLERESKR 528

  Fly  1300 LPAGAMVQLAGMPP-------GTQYIQGAASGTGHVIT--------------------------- 1330
            ......::....||       |:.|.:..:|.:.:..|                           
Human   529 TSENEAIKRCCSPPNELGFRRGSSYSKHDSSASRYKSTLSKPIPKSDKFKNSFCCTELNEEIKQS 593

  Fly  1331 ---------STGQGVTL----------GGVGASTGASSSPMLKKRVRKFSKVEEDHDAFTEKLLT 1376
                     |.|..:.:          |....|...:.||.|||.        ::...|..:.:|
Human   594 HSFSLQTPCSKGSELRMINKNPEREKAGSPAPSNRLNDSPTLKKL--------DELPIFKSEFIT 650

  Fly  1377 H-----IRQMQPLQVLEPHLNRNFHFLIGSNETSGGGSPASMSSAAS-----------AGSSSAG 1425
            |     |:::..|..::....|:|..:    |.:..|||.:.|..|:           ....|..
Human   651 HDSHDSIKELDSLSKVKNDQLRSFCPI----ELNINGSPGAESDLATFCTSKTDAVLMTSDDSVT 711

  Fly  1426 GGKLKG-------GSRGWP-LSRHLEGLEDCDGTVLGRYGRVNLPGIPSLYDSERFGGSRGLVGG 1482
            |.:|..       .|.|:. :||..|  :|.|.|.:             |:..           .
Human   712 GSELSPLVKACMLSSNGFQNISRCKE--KDLDDTCM-------------LHKK-----------S 750

  Fly  1483 SARTRSPSPAESPGAEKMLPMSSIQNDFYDQEFSTHMERNPRERLVRHIGAVKDCNLETVDLV-- 1545
            .:..|...|..||..:|::.|..:..|     :|..:.:.|.:.      .|..|..:..|:.  
Human   751 ESPFRETEPLVSPHQDKLMSMPVMTVD-----YSKTVVKEPVDT------RVSCCKTKDSDIYCT 804

  Fly  1546 -----------ESEGVAAWATLPRLTRYPGLILLNGNS--RCHGRMSPVALPEDPLT--MRFPVS 1595
                       |:|.:.           |.::.::.||  ..|....||......||  .:|   
Human   805 LNDSNPSLCNSEAENIE-----------PSVMKISSNSFMNVHLESKPVICDSRNLTDHSKF--- 855

  Fly  1596 PLLRSCGEELRKTQQMELGMGPLGNNNNNNYQQKNQNVILALPASASENI-AGVLRDLANLL--- 1656
                :| ||.:::      :|...:.:.|::....|.:..:..||:.::: .|:..|...||   
Human   856 ----AC-EEYKQS------IGSTSSASVNHFDDLYQPIGSSGIASSLQSLPPGIKVDSLTLLKCG 909

  Fly  1657 -HLAPALTCKIIEDK---------------IGNKLEDQ---FMNQDDEKHVDFKRPLSQVSHGHL 1702
             :.:|.|...:...|               :|:.|.|.   |.::::.::........|.:....
Human   910 ENTSPVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGKGFASRENRRNNGLSGKCLQEAQEEG 974

  Fly  1703 RKIL---NGRRKLC---RSCGNVVHATGLRVPRHSVPALEEQLPRLAQLMDMLPRKSVPPPFVYF 1761
            ..||   .||.::.   |..|..||.:.           :.::...:..:::....|....:...
Human   975 NSILPERRGRPEISLDERGEGGHVHTSD-----------DSEVVFSSCDLNLTMEDSDGVTYALK 1028

  Fly  1762 CDRACFARFKWNGKDGQA-EAASLLLQPAGGSAVKSSNGDSPGSFCASSTAPAEMVVKQEPEDED 1825
            ||           ..|.| |..|.:.:...||: :|||.:|                  :.||.|
Human  1029 CD-----------SSGHAPEIVSTVHEDYSGSS-ESSNDES------------------DSEDTD 1063

  Fly  1826 EKTPSVPGN--------PTNIPAQRKCIVKCFS---------ADCFTTDSAPSGLEL-----DGT 1868
            ....|:|.|        |.|.....:....|.|         :|.:..:...|...|     :..
Human  1064 SDDSSIPRNRLQSVVVVPKNSTLPMEETSPCSSRSSQSYRHYSDHWEDERLESRRHLYEEKFESI 1128

  Fly  1869 AG------------AGTGAGPVNNTVWETETSGLQLEDTRQCVFCNQRGDGQADGPSRLLNFDV- 1920
            |.            .||...|   .:..|::|..|:::.     ..:....|:||.....:.|| 
Human  1129 ASKACPQTDKFFLHKGTEKNP---EISFTQSSRKQIDNR-----LPELSHPQSDGVDSTSHTDVK 1185

  Fly  1921 -DKWVHLNCALWSNGVYETVSGALMNFQTALQAGLS--------------QACSACHQP----GA 1966
             |...|.|..       |||...:.:.|   |..|.              |..:..::|    |.
Human  1186 SDPLGHPNSE-------ETVKAKIPSRQ---QEELPIYSSDFEDVPNKSWQQTTFQNRPDSRLGK 1240

  Fly  1967 TIKCFKSRC-----------NSLYHLPCAIREE---CVFYKNKSVHCSVHGHAHA------GIT- 2010
            |...|.|.|           ..|.:|.....:|   ..:.:..|.:.:..||.:.      |.| 
Human  1241 TELSFSSSCEIPHVDGLHSSEELRNLGWDFSQEKPSTTYQQPDSSYGACGGHKYQQNAEQYGGTR 1305

  Fly  2011 ---MGAG-----AGATTGAGL-----GGSVADNELSSLVVHRRVFVDRDENRQVATVMHYSELSN 2062
               .|.|     :|...|.|:     .|.|.|    ||...|    :.:||.......|:|:.|:
Human  1306 DYWQGNGYWDPRSGRPPGTGVVYDRTQGQVPD----SLTDDR----EEEENWDQQDGSHFSDQSD 1362

  Fly  2063 LLRVGNMTFLNVGQLLPHQLEAFHTPHYIYPIGYKVSRYYWCVRRPNRRCRYICSIAEAGCKPEF 2127
            ..            ||..|.:             |.|     |:.|......|........|.:|
Human  1363 KF------------LLSLQKD-------------KGS-----VQAPEISSNSIKDTLAVNEKKDF 1397

  Fly  2128 --RIQVQDAGDKEP----EREFRGSSPSAVWQQILQPITRLR-KVHKWLQLFPQHISGEDLFGLT 2185
              .::..|..|:.|    .:|....|.|   ...||...::| :|.:.....|   .|..|.|  
Human  1398 SKNLEKNDIKDRGPLKKRRQEIESDSES---DGELQDRKKVRVEVEQGETSVP---PGSALVG-- 1454

  Fly  2186 EPAIVRILESLPGIETLTDYR--------FKYGRNP----LLEFPLAINPSGAARTEPKQRQLLV 2238
             |:.|           :.|:|        .|.|:.|    |:|       .....||.|:     
Human  1455 -PSCV-----------MDDFRDPQRWKECAKQGKMPCYFDLIE-------ENVYLTERKK----- 1495

  Fly  2239 WRKPHTQRTAGSCSTQRMANSAAIAGEVAC-----------PYSKQFVHSKSSQYKKMKQEWRNN 2292
             .|.|.......|....::......||:||           ..|.:..:......::.:::...:
Human  1496 -NKSHRDIKRMQCECTPLSKDERAQGEIACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHAD 1559

  Fly  2293 VYLARSKIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQY-ESKNRGIYMFRLDEDRVVD 2356
            |.:..::.:|.||.||:|:..:|.::||.|||:..:..:.|.|:| .:||...|...|..|.::|
Human  1560 VEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIID 1624

  Fly  2357 ATLSGGLARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGEELSYDYKFD-IEDESHKIPCA 2420
            ||..|..:|::||||.|||.|:...|:..:|:..|..:.:..|.||::||:|. ...|:.|  |.
Human  1625 ATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQK--CF 1687

  Fly  2421 CGAPNCRKWM 2430
            ||:.|||.::
Human  1688 CGSANCRGYL 1697

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513
ePHD2_KMT2C_like 1898..2002 CDD:277136 25/137 (18%)
FYRN 2068..2118 CDD:283589 8/49 (16%)
FYRC 2126..2215 CDD:197781 22/107 (21%)
SET <2266..2431 CDD:225491 54/178 (30%)
SET 2291..2413 CDD:214614 43/123 (35%)
PostSET 2415..2431 CDD:214703 7/16 (44%)
SETD2XP_011531934.1 AWS 1503..1557 CDD:197795 6/53 (11%)
SET 1558..1681 CDD:214614 43/122 (35%)
PostSET 1682..1698 CDD:214703 8/18 (44%)
Asp-B-Hydro_N <1948..2131 CDD:191249
WW 2399..2428 CDD:278809
SRI 2477..2556 CDD:285448
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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