Protein Alignment trr and SETBP1

DIOPT Version :10

• Sequence 1: NP_726773.2
• Gene: trr / 31149
• FlyBaseID: FBgn0023518
• Length: 2431
• Species: Drosophila melanogaster
• Sequence 2: XP_024306917.1
• Gene: SETBP1 / 26040
• HGNCID: 15573
• Length: 1622
• Species: Homo sapiens
• Alignment Length: 1906
• Identity: 343/1906 - (17%)
• Similarity: 588/1906 - (30%)
• Gaps: 648/1906 - (33%)

  Fly   187 IEPS-----GSGQDHAENSGKS----------EDLDYVLMPASGADSSTSVGNSTGTGTPAGTPI 236
            :||.     |||:|...||...          |:.::.:..|:..:.|..:  ...|...|..|.
Human    55 MEPEEEDELGSGRDVDSNSNADSEKWVAGDGLEEQEFSIKEANFTEGSLKL--KIQTTKRAKKPP 117

  Fly   237 GATTSTI------ILNANNGTAGVSGAGTTTILTQKSGHTNYNIFNTTATGSQTPTTTLLNRVNL 295
            ....:.|      |....:|...||.||..:..|::...::......|.|.|..|:....:.|
Human   118 KNLENYICPPEIKITIKQSGDQKVSRAGKNSKATKEEERSHSKKKGVTVTYSDLPSCVWHSAV-- 180

  Fly   296 HPKMKTQLMVNAKKLSEVTQTTAKVSIGNKTISVPLLKPLMSASGAATAGGATIVESKQLLQPGG 360
                                           |:...|..|::||.
Human   181 -------------------------------IAEDCLGILLTASD-------------------- 194

  Fly   361 QVTTVMSAAQQSGGQ-QVH--PHVHSHAHHNFTKLIKRGPKNSGTIVSFSGLQIKPANTKIVATK 422
                 ::|:...|.| |.:  |..||..|:           ::|....|:|..:||
Human   195 -----LAASDLKGFQPQAYERPQKHSTLHY-----------DTGLPQDFTGDTLKP--------- 234

  Fly   423 VVSKKMLQLQQHQQQIQQQQQL------QQLQVTSGGGLAPPTG----SIVTITTTNPSQTYAMV 477
                      :|||:...|..:      ....||....::|.:|    |...|....|..::|..
Human   235 ----------KHQQKSSSQNHMDWSTNSDSGPVTQNCFISPESGRETASTSKIPALEPVASFAKA 289

  Fly   478 Q----------------------DSATVGPAAHSEDDAPAPRKITAYSENLQKILN------KSK 514
            |                      ......|::||   :|||...:|....||.:::      |..
Human   290 QGKKGSAGNTWSQLSNNNKDLLLGGVAPSPSSHS---SPAPPSSSAECNGLQPLVDQDGGGTKEP 351

  Fly   515 SQESTGGPEEFTNINSVVIKPLDKNTL----NCPPSFNIFKQQQHSQAAQS--------QSISAV 567
            .:..|.|.::.::...|:.:.:....|    |...:|:..:.::...:|.|        |::|:
Human   352 PEPPTVGSKKKSSKKDVISQTIPNPDLDWVKNAQKAFDNTEGKREGYSADSAQEASPARQNVSS- 415

  Fly   568 GSGAGTPVTFTMASGNASDLATTSTVSVSAGTICINSPMMGTRPIISIQNKNISLVLSKTTMAQQ 632
                        ||...:|   :|.|.:   ||.|.:|.:........:.::|..|:.|   ...
Human   416 ------------ASNPEND---SSHVRI---TIPIKAPSLDPTNHKRKKRQSIKAVVEK---IMP 459

  Fly   633 KPKMITTTTLSSQAALQMHHALIQDSSADK------------AGSSANSGSATSGASMQLKLTTA 685
            :..:.:..|:||:..    :.::.:|..:|            ...|.:.|..|.|.:.::.....
Human   460 EKALASGITMSSEVV----NRILSNSEGNKKDPRVPKLSKMIENESPSVGLETGGNAEKVIPGGV 520

  Fly   686 NTPTKLSVSLAPDVV-------KLEEVG------------SESKAKLLVKQEAVVKDSTGTPTSE 731
            :.|.|..:.:.|...       ||.|:.            |:.|...::: |||:..|.......
Human   521 SKPRKPPMVMTPPTCTDHSPSRKLPEIQHPKFAAKRRWTCSKPKPSTMLR-EAVMATSDKLMLEP 584

  Fly   732 ERAEEIGTPEKRLNANA-TMTAINQVQNQ----------SANQIQMATSTSTASNPSTPNPTVNA 785
            ..|..| ||...|..|. ::|.|..|:.:          :...|...||||..|      |....
Human   585 PSAYPI-TPSSPLYTNTDSLTVITPVKKKRGRPKKQPLLTVETIHEGTSTSPVS------PISRE 642

  Fly   786 TPMNNQRSAAEDNALLKQLLQNNSSSHSLNQISITSAHVGSASASAPLSARKVINVRAPS-MGKV 849
            .|...:|....:.|.|.||:.......|..:.......:|........:..|:..::..: :.::
Human   643 FPGTKKRKRRRNLAKLAQLVPGEDKPMSEMKFHKKVGKLGVLDKKTIKTINKMKTLKRKNILNQI 707

  Fly   850 RSLEDQLARPVIPPVPTATQAAGSSSSSGSVATSTTTTTVASGGSSQQVATASATALPVSAVAIT 914
            .|....:|.....|..|:..||...|..|.....:...|:..|...
Human   708 LSCSSSVALKAKAPPETSPGAAAIESKLGKQINVSKRGTIYIGKKR------------------- 753

  Fly   915 TPGVGGEAKLEQKSDQP-AAIMQNQSQNQAPPPPPPPQQQQQQQLHQPQQLQPSPHQV---KQTV 975
              |....|:|...|::| .||...:..:..|..|..|...|......|..:.|...|:   ...:
Human   754 --GRKPRAELPPPSEEPKTAIKHPRPVSSQPDVPAVPSNFQSLVASSPAAMHPLSTQLGGSNGNL 816

  Fly   976 QIVSKETSFISGPVAAKTLVTEATSKPAELLP--------------PPPYEMATAPISNVTISIS 1026
            ...|.||:|       ..|.|....:|...||              .||..||.:|      |..
Human   817 SPASTETNF-------SELKTMPNLQPISALPTKTQKGIHSGTWKLSPPRLMANSP------SHL 868

  Fly  1027 TKQAAPKELQMKPKAVAMSLPMEQGDESLPEQAEPPLHSEQGATAAGVAPHSGGPLVSAQWTNNH 1091
            .:..:.||:.:.|.:.:.|      :|::|..             :|:.            |:|:
Human   869 CEIGSLKEITLSPVSESHS------EETIPSD-------------SGIG------------TDNN 902

  Fly  1092 LEGGVATTKIPFKPGEPQKRKLPMHPQLDEKQIQQQAEIPISTSLPTTPTGQGTPDKVQLISAIA 1156
                 :|:....|..|.::|.     ..|...:.....||..||   |....|...|..::....
Human   903 -----STSDQAEKSSESRRRY-----SFDFCSLDNPEAIPSDTS---TKNRHGHRQKHLIVDNFL 954

  Fly  1157 TY--VKKSGVPNEAQPIQNQSQGQVQMQAQMQATMQGHLSGQMSGQISGHAAGQIPAQMHLQVQH 1219
            .:  :||.....:.:.:||:.  .:|..|.::                           .|..:.
Human   955 AHESLKKPKHKRKRKSLQNRD--DLQFLADLE---------------------------ELITKF 990

  Fly  1220 QLHMAVHPQQQQQQLHQNQPQNATIPLP----VTGQGAVPIPVPTME-----SKAGDQRKRRKRE 1275
            |:....|  :.....|:|       |.|    :......|:|....:     .:..|.:.::||
Human   991 QVFRISH--RSYTFYHEN-------PYPSIFRINFDHYYPVPYIQYDPLLYLRRTSDLKSKKKR- 1045

  Fly  1276 VQKPRRTNLNAGQAGGALKDLTGPLPAGAMVQLAGMP---------------PGTQYIQ---GAA 1322
             .:|.:||....:. ..|:..:.|:|:|:.....|||               |...|:.   |||
Human  1046 -GRPAKTNDTMTKV-PFLQGFSYPIPSGSYYAPYGMPYTSMPMMNLGYYGQYPAPLYLSHTLGAA 1108

  Fly  1323 S-------------GTGHVITSTG-----------QGVTLGGVG-----------ASTGASSSPM 1352
            |             ...||..|..           ||....|:|           .|...||..:
Human  1109 SPFMRPTVPPPQFHTNSHVKMSGAAKHKAKHGVHLQGPVSMGLGDMQPSLNPPKVGSASLSSGRL 1173

  Fly  1353 LKKRVRKFSKVEED-----HD----------------AFTEKLLTHIRQMQPLQVLEPHLNRNFH 1396
            .|::.:...|.:||     ||                ..:|:|.:..:::..:.....|..:..|
Human  1174 HKRKHKHKHKHKEDRILGTHDNLSGLFAGKATGFSSHILSERLSSADKELPLVSEKNKHKEKQKH 1238

  Fly  1397 FLIGSNETSGGGSPAS--------MSSAASAGSSSAGGGKLKGGSRGWPLSRHLEGLEDCDGTVL 1453
                  :.|..|..||        :|:.:.:.:......|.||.....|       ::.|
Human  1239 ------QHSEAGHKASKNNFEVDTLSTLSLSDAQHWTQAKEKGDLSSEP-------VDSC----- 1285

  Fly  1454 GRYGRVNLPGIPSLYDSERFGGSRGLVGGSARTRSPSPAESPGAEKMLPMSSI--QNDFYDQEFS 1516
                            ::|:.||.| .|||.|           :|.:...|.:  .||.:|.:.|
Human  1286 ----------------TKRYSGSGG-DGGSTR-----------SENLDVFSEMNPSNDKWDSDVS 1322

  Fly  1517 THMERNPRERLVRHIGAVKDCNLETVDLVESEGVAAWATLPRLTRYPGLILLNGNSRCHGRMSPV 1581
                 ..:.|.....|..::.:::...:...|                      .|.....|||
Human  1323 -----GSKRRSYEGFGTYREKDIQAFKMNRKE----------------------RSSYDSSMSP- 1359

  Fly  1582 ALPEDPLTMRFPVSPLLRSCGEELRKTQQMELGMGPLGNNNNNNYQQKNQNVILAL-----PASA 1641
            .:|          ||.|        |..|..:             ..||:..:..:     ||:.
Human  1360 GMP----------SPHL--------KVDQTAV-------------HSKNEGSVPTMMTRKKPAAV 1393

  Fly  1642 -SENI--AGVLRDLANLLHLAPALTCKIIEDKIGNKLEDQFMNQDDE-------KHVDFKRPLSQ 1696
             |..|  |.||..||     |.|.|    .|.:|:.|:.:|..::.|       |..::.:.||.
Human  1394 DSVTIPPAPVLSLLA-----ASAAT----SDAVGSSLKKRFKRREIEAIQCEVRKMCNYTKILST 1449

  Fly  1697 VSH-GHLRKILNGRR--KLCRSCGNVVHATGLRVPRHSVPALEE----QLPRLAQLMDMLPRKSV 1754
            ..: .|:.|||..:|  :..::..|.|.....| ||......:|    |:|.|.:.:| ||
Human  1450 KKNLDHVNKILKAKRLQRQSKTGNNFVKKRRGR-PRKQPTQFDEDSRDQMPVLEKCID-LP---- 1508

  Fly  1755 PPPFVYFCDRACFARFKWNGKDGQAEAAS-LLLQPAGGSAVKSSNGDSPGSFCASSTAPAEMVVK 1818
                               .|.||..:.| |:|:||.          |..:..|:..|...|..:
Human  1509 -------------------SKRGQKPSLSPLVLEPAA----------SQDTIMATIEAVIHMARE 1544

  Fly  1819 QEPEDEDEKTPSVPGNPTNIP 1839
            ..|.......|..|..|..:|
Human  1545 APPLPPPPPPPLPPPPPPPLP 1565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513	27/153 (18%)
		PRK13914	<623..>851	CDD:237555	48/270 (18%)
		ePHD2_KMT2C_like	1898..2002	CDD:277136
		FYRN	2067..2118	CDD:461787
		FYRC	2126..2215	CDD:197781
		SET_KMT2C_2D	2278..2430	CDD:380948
SETBP1	XP_024306917.1	None