DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trr and set1

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	NP_587812.1	Gene:	set1 / 2538762	PomBaseID:	SPCC306.04c	Length:	920	Species:	Schizosaccharomyces pombe

Alignment Length:	1008	Identity:	226/1008 - (22%)
Similarity:	362/1008 - (35%)	Gaps:	332/1008 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1582 ALPEDPLTMRF--PVSPLLRSCGEELR-------KTQQMELGMGPLGNNNNN----NYQQKNQNV 1633
            :|..:|.|..|  .:|||:.|  |:||       :...::|.:.|....:..    ::.:::...
pombe    87 SLGPEPPTQVFVSNISPLVTS--EQLRYHFKSFGEVFDLDLKLNPYTGTSLGLCCISFDKRSSIS 149

  Fly  1634 ILALPASASENIAGVLR----DLANLLHLAPALTCKIIEDKIGNKLEDQFMNQDDEKHVDFKRPL 1694
            :.|..|..:...|..||    .|:.:|....:| |:....|..|.:|.||..:..:|. .|:|.
pombe   150 VAAHSAKIAVQQANGLRFSGKPLSVVLDRDGSL-CEEAFKKALNAVEKQFQEETLQKQ-RFERE- 211

  Fly  1695 SQVSHGHLRKILN---------GRRKLCRSCGNVVHATGLRVPRHS--VPALEEQLPRLAQLMD- 1747
            .:.|...|...:|         .:.....|.|::.|:....|.:.|  :.:.|..:|:  .:.|
pombe   212 DESSRQKLSAAMNEDIPPWRQPSKNSQTLSNGDLQHSKVQNVDQKSGFLTSSETDVPK--NINDY 274

  Fly  1748 ---MLPRKSVPPPFVYFCD-RACFARFKWN----GKDGQAEAASLLLQPAGGSAVKSSNGDSPGS 1804
               ::..:.|||..||:.| :..|.:|.:.    .|||               ...:.|.....|
pombe   275 IYLLIDDRFVPPDRVYYTDIKHHFRKFLYEKIYMNKDG---------------FYITFNNYREAS 324

  Fly  1805 FCASSTAPAEMVVKQEPEDEDEKTPSVPGNPTNIPAQRKCIVKCFSADCFTTDSAPSGLELDGTA 1869
            .|..:.               ::|           ..:.|.:|....|      .||..:.||..
pombe   325 NCYRAL---------------DRT-----------YVQNCRIKLKFHD------IPSRTKEDGKK 357

  Fly  1870 GAGTGAGPVNNTVWE-----TETSGLQLEDTRQCVFCNQRGDGQADGPSRLLNFDVDKWVHLNCA 1929
            .|      |...|..     .|.:.:.|.|....:.        .|..|:::...:.|::|   :
pombe   358 SA------VRRVVLPPEEAYAEATSVVLRDLEAALL--------RDVKSKIIGPAIFKYLH---S 405

  Fly  1930 LWSNGVYETVSGALMNFQTALQAGLSQACSACHQPGATIKCFKSRCNSLYHLPCAIREECVFYKN 1994
            :....|.|.:...|:...|::             |...:| .:|....|..||        .:|
pombe   406 MPKPSVKEELQENLLVSSTSV-------------PDVPLK-IESTVGKLPSLP--------KFK- 447

  Fly  1995 KSVHCSVHGHAHAGITMGAGAGATTGAGLGGSVADNELSSLVVHRRVFVDRDENRQVATVMHY-- 2057
            |.|..|         .|...||:.|             .|.:..||      ..|..|..:||
pombe   448 KRVDSS---------KMNLSAGSKT-------------KSKLQRRR------RRRHEARPLHYQL 484

  Fly  2058 ------------SELSNLL----------RVGNMTFLNVGQLLP------HQLEAFHTPHYIYPI 2094
                        |:...||          ::|::..:...:..|      .:.:.||.    :..
pombe   485 NQMYNSSASEAESDQELLLSSGDERVERGKIGSIKSVKSDEATPVFSDTSDENDKFHR----FRT 545

  Fly  2095 GYKVSRYYWCVRRPNRRCRYICSIAEAGCKPEFRIQVQDAGDKEPEREFRGSSP--------SAV 2151
            ..|:|:                       |...:::|......|.|.:....||        ||:
pombe   546 KSKISK-----------------------KKYEKMEVDYTSSSETESDASILSPSAAIPKSGSAI 587

  Fly  2152 WQQILQPITRLRKV----HKW------------LQLFPQHISGEDLFGLTEPAIVRILESLPGIE 2200
            ..:::.|...:.:|    .||            ....|.:...:|           :|..|.|::
pombe   588 KDELISPKKEIDEVLALAPKWRINEFDETGSVYYGALPYNYPEDD-----------VLLDLDGLQ 641

  Fly  2201 TLT----DYRF---------------------------------KYGRNPLLEFP---LAINPSG 2225
            .|.    ||.:                                 |||...:|..|   ...|.||
pombe   642 YLVKNDEDYSYLQEALKDEPLMDINDPNFWAYERKSCKFKNGDVKYGDTAILPEPKGYFRSNTSG 706

  Fly  2226 AARTE-------PKQRQLLVWRKPHTQRTAGSCSTQRM------ANSAAIAGEVACPYSKQFVHS 2277
            :|::|       .::...|..|...|..|. |.||.|:      .|:..:|..|
pombe   707 SAKSEGYYIIPTTEKSLYLPLRNRSTIDTI-SHSTSRITSRMNRVNNRRLAAGV----------- 759

  Fly  2278 KSSQYKKMKQEWRNNVYLAR--------SKIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIRE 2334
            :.||........|.|...||        |:|..|||:|..:|:|:.|:||||||:||..|::.||
pombe   760 EKSQLPAEADLLRFNALKARKKQLHFGPSRIHTLGLFAMENIDKNDMVIEYIGEIIRQRVADNRE 824

  Fly  2335 KQYESKNRG-IYMFRLDEDRVVDATLSGGLARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYR 2398
            |.|..:..| .|:||:|||.:||||..|.:||:|||||.|||:..|:.|:...:|:|:|.|.|..
pombe   825 KNYVREGIGDSYLFRIDEDVIVDATKKGNIARFINHSCAPNCIARIIRVEGKRKIVIYADRDIMH 889

  Fly  2399 GEELSYDYKFDIEDESHKIPCACGAPNCRKWMN 2431
            ||||:|||||  .:|:.||||.||||.||.::|
pombe   890 GEELTYDYKF--PEEADKIPCLCGAPTCRGYLN 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		ePHD2_KMT2C_like	1898..2002	CDD:277136	18/103 (17%)
		FYRN	2068..2118	CDD:283589	5/55 (9%)
		FYRC	2126..2215	CDD:197781	22/149 (15%)
		SET	<2266..2431	CDD:225491	78/173 (45%)
		SET	2291..2413	CDD:214614	63/130 (48%)
		PostSET	2415..2431	CDD:214703	10/15 (67%)
set1	NP_587812.1	RRM	<90..>226	CDD:223796	32/140 (23%)
		RRM_spSet1p_like	96..180	CDD:240749	17/85 (20%)
		SET_assoc	279..342	CDD:288600	16/103 (16%)
		SET	457..920	CDD:225491	137/533 (26%)
		N-SET	641..771	CDD:288597	26/141 (18%)
		SET	783..899	CDD:214614	58/115 (50%)
		PostSET	904..920	CDD:214703	10/15 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940