DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trr and SPCC645.13

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	NP_001342882.1	Gene:	SPCC645.13 / 2538700	PomBaseID:	SPCC645.13	Length:	721	Species:	Schizosaccharomyces pombe

Alignment Length:	768	Identity:	145/768 - (18%)
Similarity:	264/768 - (34%)	Gaps:	228/768 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 SSSASSSSSTASVISIEPSGSGQDHAENSGKSEDLDYVLMPASGAD--------SSTSVGNSTGT 228
            |.:......||.::: ...|:.:::.||:..|.|....:...|||:        ::::||.:|.:
pombe    79 SPNKDEEHQTADLLA-SNEGNEKNNEENNVVSSDSKEAITKESGAELESSEPASTNSNVGMTTRS 142

  Fly   229 GTPA-GTPIGATTSTIILNANNGTAGVSGAGTTTILTQKSGHTNYNIFNTTATGSQTPTTTLLNR 292
            |..: .||||:||.....:..:........|||...|::|    .|...|:...:...|......
pombe   143 GRQSPRTPIGSTTPKSSHSPPSTRKRRGSVGTTATHTKRS----KNAPKTSPKDASNETADQEKE 203

  Fly   293 VNLHPKMKTQLMVNAKKLSEVTQTTAKVSIGNKTISVPLLKPLMSASGAATAGGATIVESKQLLQ 357
            ::||           ..:.|: |...:.|:....:|| ..|.:..|......|...:..:...||
pombe   204 LSLH-----------TSIDEI-QNPVRKSVAKAWVSV-FEKIIEKAKLEGVQGLEDLNSTSLALQ 255

  Fly   358 PGGQVTTVMSAAQQSGGQQVHPHVHSHAHHN----------FTKLIKRGP-------KNS---GT 402
            ....:..|:|....          ||...:|          |..:..:.|       ||.   ..
pombe   256 LEHIMFMVLSYTTD----------HSLTPNNKYREKFRALRFNLVDDKNPAFRARVLKNEISFND 310

  Fly   403 IVSFSGLQIKPANTKIVATKV--VSKKMLQLQQH----------QQQIQQQQQLQQLQVTSGGGL 455
            :|:.|..::...:.|.:|.::  .|.:...::||          :.::.||.:|         |:
pombe   311 LVNLSSEEMANPDLKNLAEEIRQQSTENTVIKQHLIAPRDRLLDEDKLTQQDEL---------GI 366

  Fly   456 A---------PPTGSIVTITTTNPSQTYAMVQDSATVGPAAH---SEDDAPAPRKITAYSENLQK 508
            |         ||...:..|:......|.    ||.:.....|   ||||          :.|..|
pombe   367 AENDDAMFPKPPGELVAPISIAEEEPTI----DSKSPTLPEHNPLSEDD----------TSNGDK 417

  Fly   509 ILNKSKSQESTGGPEEFTNINSVVIKPLDKNTLNCPPSFNIFKQQQHSQAAQSQSISAVGSGAGT 573
            ...:..|...|   :...|:.|:|       .::.|...:|.:::   ..|::.|.|:..|
pombe   418 AAKRKGSFNDT---KPIVNVPSIV-------EIDDPTILDIVEEE---PLARNDSFSSPYS---- 465

  Fly   574 PVTFTMASGNASDLATTS----------TVSVSAGTI------CINSPMMGTRPIISIQNKNISL 622
                     .|.|:|..|          |..|...|:      .:|  :.|     .:...::..
pombe   466 ---------PAEDMAEESEFFGMKEKIWTGKVKMATVSEFHANALN--LFG-----DVSASHLFE 514

  Fly   623 VLSKTTMAQQKPKMITTTTLSSQAALQMHHALIQDSSADKAGSSANSGSATSGASMQLKLTTANT 687
            :||.|.:.:.:        :|..:.||..|||                              ..|
pombe   515 ILSATALIEGR--------ISVSSVLQYFHAL------------------------------RKT 541

  Fly   688 PTK--LSVSLAP--------DV-----VKLEEVGSESKAKLLVKQEAVVKDSTGTPTSE--ERAE 735
            |:|  ::|...|        |:     ||....|........||...::...:|....|  :...
pombe   542 PSKEIIAVLFVPTEQNSQGFDILYDYFVKRNRYGVLHSKSNSVKDAYIIPMPSGNSVPELLDLLP 606

  Fly   736 EIGTPEKRLNANATMTAINQVQNQSANQ---IQMATSTSTASN--PSTPNPTVNATPMNNQRS-- 793
            ::..|:.| |....|...  |.|:|:::   ::.||..:|::|  ||| ..:.:.||.|...|
pombe   607 KVDLPKDR-NFQYFMGLF--VLNKSSSRHESVERATPITTSTNGIPST-YQSASGTPTNPVHSYP 667

  Fly   794 ---------AAEDNALLKQLLQNNSSSHSLNQISITSAHVGSASASAPLSARK 837
                     ...|..|:|.:::||....:...::|....:.:|.::|...|.|
pombe   668 SLESIINALTPSDMLLIKDVVENNPQIRANPSLAINPQFMQNAISAAQKKASK 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513	30/144 (21%)
		ePHD2_KMT2C_like	1898..2002	CDD:277136
		FYRN	2068..2118	CDD:283589
		FYRC	2126..2215	CDD:197781
		SET	<2266..2431	CDD:225491
		SET	2291..2413	CDD:214614
		PostSET	2415..2431	CDD:214703
SPCC645.13	NP_001342882.1	PHD_SF	22..66	CDD:328929
		TFS2M	215..330	CDD:128786	21/125 (17%)
		SPOC	474..624	CDD:311609	32/197 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030