DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trr and Setbp1

DIOPT Version :9

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:NP_444329.2 Gene:Setbp1 / 240427 MGIID:1933199 Length:1582 Species:Mus musculus


Alignment Length:1957 Identity:352/1957 - (17%)
Similarity:611/1957 - (31%) Gaps:694/1957 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 RKKAKTELLLGTGTAAPSLPAKASSTAPQQLLYQRSGQQAKAQVKAASEPQDVETADGVWDARDQ 115
            ::.:::|.|.|:.:.:|..|.             .||:..|. :....|..:.|..|.:...|| 
Mouse    12 QRGSESEFLQGSSSRSPPAPG-------------CSGEPLKG-ISVGGERMEPEEEDELGSGRD- 61

  Fly   116 QIIVCNFGSGTEM-----GAIKAEDADKQSEY-------RISTPRNSQSNPLLHRN--------- 159
              :.||..:.:|.     |..:.|.:.|::.:       :|.|.:.::..|....|         
Mouse    62 --VDCNSNADSEKWVAGDGLEEQEFSIKEANFTEGSLKLKIQTTKRAKKPPKNLENYICPPEIKI 124

  Fly   160 ------------TAFTSFTKKEGASSSASSSSSTASVISIEPSGSG----QDHA-ENSGKSEDLD 207
                        |...|...||...:.:.....||.    :|:.|.    |..| |...|...|.
Mouse   125 TIKQSGDQKVSRTGKNSKATKEDERNHSKKKLLTAG----DPTASDLKAFQTQAYERPQKHSTLQ 185

  Fly   208 YVLMPASGADSSTSVGNSTGTGTPAGTPIGATTSTIILNANNGTAGVSGAGTTTILTQKSGHTNY 272
            |        |...|.|.::.|..|......::.|.:..::|:                .||....
Mouse   186 Y--------DPGHSQGFTSDTLKPKHQQKSSSQSHMEWSSNS----------------DSGPATQ 226

  Fly   273 NIFNTTATGSQTPTTTLLNRVNLHPKMKTQLMVNAKKLSEVTQTTAKVSIGNKTISVPLLKPLMS 337
            |.|.:...|..|.:|:                                       .||.|:|:.|
Mouse   227 NCFISPEAGRDTASTS---------------------------------------KVPALEPVAS 252

  Fly   338 ASGAATAGGATIVESKQLLQPGGQVTTVMSAAQQSGGQQVHPHVHSHAHHNFTKLIKRGPKNSGT 402
            .:.|.:..|:|          ||..:.:.|:::......|.|...||          ..|....:
Mouse   253 FAKAQSKKGST----------GGAWSQLSSSSKDLLLGSVVPSPSSH----------NSPATPSS 297

  Fly   403 IVSFSGLQIKPANTKIVATKVVSKKMLQLQQHQQQIQQQQQLQQLQVTSGGGL----APPTGSIV 463
            ....:|                                   ||.|....||..    .||     
Mouse   298 SAECNG-----------------------------------LQPLGDQDGGSTKDLPEPP----- 322

  Fly   464 TITTTNPSQTYAMV------QDSATVGPAAHSEDDAPAPRKITAYS-ENLQKILNKSKSQESTGG 521
            |:::...|....|:      .|...|..|..:.:.....|:  ||| ::.|:.....:|..|...
Mouse   323 TLSSKKKSSKKDMISQTLPNSDLDWVKSAQKAFETTEGKRE--AYSADSAQEASPARQSISSVSN 385

  Fly   522 PEEFTNINSVVIKPLDKNTLNCPPSFNIFKQQQHSQAAQSQSI--SAVGSGAGTPVTFTMASGNA 584
            ||   |.:|.|...:...|.:..||.:..|::|..:|...:.:  .|:.||              
Mouse   386 PE---NDSSHVRITIPIKTPSLDPSNHKRKKRQSIKAVVEKIVPEKALASG-------------- 433

  Fly   585 SDLATTSTVSVSAGTICINSPMMGTRPIISIQNKNISLVLSKTTMAQQKP------KMITTTTLS 643
                                        ||:.::.::.:||.:..:::.|      |||...|.|
Mouse   434 ----------------------------ISMSSEVVNRILSNSEGSKKDPRVPKLGKMIENETPS 470

  Fly   644 SQAALQMHHALIQDSSADKAGSSANSGSATSGASMQLK---LTTANTPTKLSVSLAPDVVKLEEV 705
            .        .|....:|:|.        ...|||.|.|   :.|:.|.|:.:.|     .||.|:
Mouse   471 V--------GLETGGNAEKI--------VPGGASKQRKPPMVMTSPTRTEHAPS-----GKLSEI 514

  Fly   706 GSESKAKLLVKQEAVVKDSTGTPTSEERAEEIGTPEKRLNANATMTAINQVQNQSANQIQMATST 770
               ...|...|:..    |...|.:..|...:.|.||.:           |:..||..|      
Mouse   515 ---QHPKFAAKRRC----SKAKPPAMLREAVLATAEKLM-----------VEPPSAYPI------ 555

  Fly   771 STASNP---STPNPTVNATPMNNQRSAAEDNALLKQLLQNNSSSHSLNQISITSAHVG-SASASA 831
             |.|:|   :|.:.|| .||:..:|...:...||                ::.:.|.| |.|..:
Mouse   556 -TPSSPLYTNTDSLTV-ITPVKKKRGRPKKQPLL----------------TVETIHEGTSTSPVS 602

  Fly   832 PLS-------ARKVINVRAPSMGKVRSL---EDQLARPVIPPVPTATQAAGSSSSSGSVATSTTT 886
            |:|       .||    |..::.|:..|   ||:         |.:............|....|.
Mouse   603 PISREFPGTKKRK----RRRNLAKLAQLVPGEDK---------PMSEMKFHKKVGKLGVLDKKTI 654

  Fly   887 TTVASGGS-------SQQVATASATALPVSAVAITTPGVGG-EAKLEQKSD--QPAAIMQNQSQN 941
            .|:....:       :|.::.:|:.||...|...|:||... |:||.::.:  :...|...:.:.
Mouse   655 KTINKMKTLKRKNILNQILSCSSSVALKAKAPPETSPGAASIESKLGKQINVSKRGTIYIGKKRG 719

  Fly   942 QAPPPP-PPPQQQQQQQLHQPQQL--QPSPHQVKQTVQIVSKETSFISGPVAAKTLVTEATSKPA 1003
            :.|... |||.::.:..:..|:.:  ||....|..:.|     :...|.|.|...|.|:......
Mouse   720 RKPRTELPPPSEEPKTAIKHPRPVSSQPDVPAVPSSFQ-----SPVASSPAAMHPLSTQLGGSNG 779

  Fly  1004 ELLPPPP----YEMATAPISNVTISISTKQAAPKELQ---------MKPKAVAMSLP---MEQGD 1052
            .|.|...    .|:.|.|      ::....|.|.:.|         :.|..:..:.|   .|.| 
Mouse   780 NLSPASTETNFSELKTMP------NLQPISALPTKTQKGIHGGTWKLSPPRLMANSPSHLCEIG- 837

  Fly  1053 ESLPEQAEPPL---HSEQGATAAGVAPHSGGPLVSAQWTNNHLEGGVATTKIPFKPGEPQKRKLP 1114
             ||.|....|:   |||:..           |..|...|:|:     :|:....|..|.::|.  
Mouse   838 -SLKEITLSPVSESHSEETI-----------PSDSGIGTDNN-----STSDQAEKSSESRRRY-- 883

  Fly  1115 MHPQLDEKQIQQQAEIPISTSLPTTPTGQGTPDKVQLISAIATY--VKKSGVPNEAQPIQNQSQG 1177
               ..|...:.....||..||   |....|...|..::.....:  :||.....:.:.:||:.  
Mouse   884 ---SFDFCSLDNPEAIPSDTS---TKNRHGHRQKHLIVDTFLAHESLKKPKHKRKRKSLQNRD-- 940

  Fly  1178 QVQMQAQMQATMQGHLSGQMSGQISGHAAGQIPAQMHLQVQHQLHMAVHPQQQQQQLHQNQPQNA 1242
            .:|..|:::..                    |......::.|:.:...|..........|..|. 
Mouse   941 DLQFLAELEEL--------------------ITKFQVFRISHRGYTFYHENPYPSIFRINFDQY- 984

  Fly  1243 TIPLPVTGQGAVPIPVPTME-------SKAGDQRKRRKREVQKPRRTNLNAGQAGGALKDLTGPL 1300
                         .|||.::       .:..|.:.::||  .:|.:||....:. ..|:..:.|:
Mouse   985 -------------YPVPYIQYDPLLYLRRTSDLKSKKKR--GRPAKTNDTMTKV-PFLQGFSYPI 1033

  Fly  1301 PAGAMVQLAGMP---------------PGTQYIQ---GAAS-------------GTGHVITS--- 1331
            |:|:.....|||               |...|:.   ||||             .:.||..|   
Mouse  1034 PSGSYYAPYGMPYTSMPMMNLGYYGQYPAPLYLSHTLGAASPFMRPTVPPPQFHASSHVKISGAT 1098

  Fly  1332 ---TGQGVTLGG-----------------VGASTGASSSPMLKKRVRKFSKVEEDHDAFTEKLLT 1376
               ...||.|.|                 ||.:| .|||.:.|::.:...|.:||.         
Mouse  1099 KHKAKHGVHLQGTVGMGLGDIQPSLNPPKVGGAT-LSSSRLHKRKHKHKRKHKEDR--------- 1153

  Fly  1377 HIRQMQPLQVLEPHLNRNFHFLIGSNETSGGGSPASMSSAASAGSSSAGGGKLKGGSRGWPL--- 1438
                                 ::|:::...|    ..:..|:..||.....:|.|..:..||   
Mouse  1154 ---------------------ILGTHDNLSG----LFAGKATGFSSHLLSERLSGSDKELPLVSE 1193

  Fly  1439 -SRHLEGLEDCDGTVLGRYGRVNLP----GIPSLYDSERFGGSRGL-------VGGSARTRSPSP 1491
             |:|.|..:...|....:..:.|..    ...||.|::.:..::..       |...|:..|.|.
Mouse  1194 KSKHKERQKHQHGEASHKVSKNNFEVDTLSTLSLSDAQHWTQAKDKGDLSSEPVESCAKRYSGSG 1258

  Fly  1492 AESPGAEKMLPMSSI--QNDFYDQEFSTHMERNPRERLVRHIGAVKDCNLETVDLVESEGVAAWA 1554
            .:|..:|.:...|.:  .:|.:|.:..     ..:.|.....|..::.:::...:...|..:..:
Mouse  1259 GDSTRSEGLDVFSEMNPSSDKWDSDMG-----GSKRRSFEGFGTYREKDIQAFKMNRKERGSYES 1318

  Fly  1555 TLPRLTRYPGLILLN-------GNSRCHGRMSPVALPEDPL---TMRFPVSPLLRSCGEELRKTQ 1609
            ::.     ||:...:       .:|:..|.:|.:...:.|.   ::..|.:|:|.          
Mouse  1319 SMS-----PGMPSPHLKVDQTAAHSKSEGSISAMMARKKPTAVDSVAIPSAPVLS---------- 1368

  Fly  1610 QMELGMGPLGNNNNNNYQQKNQNVILALPASASENIAGVLR-------------DLANLLHLAPA 1661
                                    :||..|:.|:..:..|:             ::..:.|....
Mouse  1369 ------------------------LLAASAATSDAASSSLKKRFKRREIEAIQCEVRKMCHYTKL 1409

  Fly  1662 LTCKIIEDKIGNKLEDQFMNQDDEKHVDFKRPLSQVSHGHLRKILNGRR--KLCRSCGNVVHATG 1724
            |:.|                    |::|           |:.|||..:|  :..::..|.|....
Mouse  1410 LSTK--------------------KNLD-----------HVNKILKAKRLQRQSKTGNNFVKKRR 1443

  Fly  1725 LRVPRHSVPALEE----QLPRLAQLMDMLPRKSVPPPFVYFCDRACFARFKWNGKDGQAEAAS-L 1784
            .| ||......:|    |:|.|.:.:| ||                       .|.||..:.| |
Mouse  1444 GR-PRKQPSQFDEDSRDQMPVLEKCID-LP-----------------------SKRGQKPSLSPL 1483

  Fly  1785 LLQPAGG 1791
            .|:||.|
Mouse  1484 ALEPASG 1490

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513 22/140 (16%)
ePHD2_KMT2C_like 1898..2002 CDD:277136
FYRN 2068..2118 CDD:283589
FYRC 2126..2215 CDD:197781
SET <2266..2431 CDD:225491
SET 2291..2413 CDD:214614
PostSET 2415..2431 CDD:214703
Setbp1NP_444329.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..76 16/80 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 124..246 29/188 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 278..416 35/192 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 446..513 21/87 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 595..617 7/25 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 709..787 17/82 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 845..880 11/50 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1128..1155 10/57 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1182..1215 7/32 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1236..1265 5/28 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1429..1461 6/32 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1470..1489 9/41 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1507..1582
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167848402
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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