DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trr and Phf20l1

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	XP_006520979.1	Gene:	Phf20l1 / 239510	MGIID:	2444412	Length:	1018	Species:	Mus musculus

Alignment Length:	949	Identity:	180/949 - (18%)
Similarity:	291/949 - (30%)	Gaps:	329/949 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   861 IPPVPTATQAAGS--------SSSSGSVATSTTTTTVASGGSSQQVATASAT--ALPVSAVAITT 915
            |.|..:..|:.||        ::::.:....|.|...||..|:::.......  .||......:|
Mouse   160 IDPAGSCNQSMGSEDWIALVKAAAAAAAKNKTGTKPRASANSNKEKERDGGKWFKLPSKKAETST 224

  Fly   916 PGVGGEAKLEQKSDQPAAIMQNQSQNQAPPPPPPPQQQQQQQLH---QPQQLQPSPHQVKQTVQI 977
            ..|  .|::|:|.:.|.:                  .:....||   .|:.:.|.|.......:.
Mouse   225 CIV--TAEIEKKEELPTS------------------SETFVGLHIDTVPKIVFPQPESTLTNKRK 269

  Fly   978 VSKETSF---------ISGPVAAKTLVTEATSKPAELLPPPPYEMATAPISNVTISISTKQAAPK 1033
            .::..||         |:|.:|:|.:..:...:..:.       .||||:....||       ||
Mouse   270 NNQGNSFQAKRARLNKITGLLASKAVGVDGAERKEDC-------SATAPVLEQAIS-------PK 320

  Fly  1034 -ELQMKPKAVAMSLPMEQGDESLPEQAEPPLHS---EQGATAAGVAPHSGGPLVSAQWTNNHLEG 1094
             :.|.|.:||..|....|         :|.|.|   ..|...:....|..|          ...|
Mouse   321 PQSQKKNEAVISSSANTQ---------KPALLSSTLSSGKARSKKCKHESG----------ESSG 366

  Fly  1095 GVATTKIPFKPGEPQKRKLPMHPQLDEKQIQQQAEIPISTSLPTTPTGQGTPDKVQLISAIATYV 1159
            .:.|.|.|..|...|.:.|                                    .|:|.:::.:
Mouse   367 CIKTPKSPLAPELIQAKDL------------------------------------TLVSQLSSVI 395

  Fly  1160 KKSGVPNEAQPIQNQSQGQVQMQAQMQATMQ------GHLSGQMSGQISGHAAGQIPAQMHLQVQ 1218
            .|:..|....|.:.....:.:.::|..||:.      ..||.. |....|.|
Mouse   396 NKTSSPQPVNPPRPCKHSERRRRSQRLATLPMPDDSLEKLSSS-SSATDGKA------------- 446

  Fly  1219 HQLHMAVHPQQQQQQLHQNQPQNATIPLPVTGQGAVPI-------------PVPTMESKAGDQRK 1270
                .::..|.|||......|..|.:||...|. .:|:             |.|   |..|.:..
Mouse   447 ----FSISSQNQQQSSVPEVPAIAYVPLQKLGP-CLPLDLSCGSEVTGSRTPHP---SYHGGECP 503

  Fly  1271 RRKREVQKPRRTNLNAGQAGGALKDLTGPLPAGAMVQLAGMPPGTQYIQGAASGTGHVITSTGQG 1335
            |.::|     .|.|.|......:.|                      ::|||:.||  |:.|.:.
Mouse   504 REEKE-----ETPLFANPTSKVVSD----------------------VKGAAAATG--ISKTEKK 539

  Fly  1336 VTLGGVGASTGASSSPMLKKRVRKFSKVEEDHDAFTEKLLTHIRQMQPLQVLEPHLNRNFHFLIG 1400
            |.|   ...|..:.....:|...|..|.::||....:|.....::.........:.:.:..||
Mouse   540 VKL---EEKTSTAFGKRKEKDKEKKEKRDKDHYKPKQKKKKKKKKKSKQHDYSDYEDSSLDFL-- 599

  Fly  1401 SNETSGGGSPASMSSAASAGSSSAGGGKLKGGSRGWPLSRHLEGLEDCDGTVLGRYGR----VNL 1461
                ....||.:.||    |||.|            |.|...|      .|...:|.|    |:|
Mouse   600 ----ERCSSPLTRSS----GSSLA------------PRSTFTE------KTTTYQYPRAILSVDL 638

  Fly  1462 PGIPSLYDSERFGGSRGLVGGSARTRSPSPAESPGAEKMLPMSSIQNDFYDQEF-STHMERNPRE 1525
            .| .:|.|.|....|                   ..|.:|    :..|.|:|:| ||:.|.:..|
Mouse   639 SG-ENLSDVEFLDDS-------------------STESLL----LSGDEYNQDFDSTNFEESQDE 679

  Fly  1526 -----RLVRHIGAVKDCNLETVD--LVESEGVAAWATLPRLTRYPGLILLNGNSRCHGRMSPVAL 1583
                 .:||.|     |.|:..:  :::.|....|.                :|.|.|.:.. ::
Mouse   680 DDALNEIVRCI-----CELDEENGFMIQCEECLCWQ----------------HSVCMGLLED-SI 722

  Fly  1584 PE--------DPLTMRFPVSPLLRSCGEELRKTQQMELGMGPLGNNNNNNYQQKNQNVILALPAS 1640
            ||        ||...|:  |...|...|.|...:...|..      ...||...|...|:
Mouse   723 PEQYICYICRDPPGQRW--SAKYRYDKEWLNNGRMYGLSF------LKENYSHLNAKKIV----- 774

  Fly  1641 ASENIAGVLRDLANLLHLAPALTCKIIEDK---------IGNKLEDQFMNQDDEKHVDFKRPLSQ 1696
            ::.::...:..:..:|| ...|...|:::|         ...|.:||     |:...:.:|.::.
Mouse   775 STHHLLADVYGVTEVLH-GLQLKIGILKNKHHPDLHLWAYSGKRKDQ-----DQAVAEAERKITP 833

  Fly  1697 VSHGHLRKILNGRRKLCRSCGNVVHATGLRVPRHSVPAL 1735
            ....      |...|.|             |..|..|||
Mouse   834 QDRA------NSEGKEC-------------VQNHKEPAL 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		ePHD2_KMT2C_like	1898..2002	CDD:277136
		FYRN	2068..2118	CDD:283589
		FYRC	2126..2215	CDD:197781
		SET	<2266..2431	CDD:225491
		SET	2291..2413	CDD:214614
		PostSET	2415..2431	CDD:214703
Phf20l1	XP_006520979.1	MBT	3..68	CDD:388438
		TUDOR	90..135	CDD:119391
		PTZ00449	<320..511	CDD:185628	49/272 (18%)
		PHD20L1_u1	323..388	CDD:374703	19/119 (16%)
		PHD_PHF20L1	688..733	CDD:277103	11/66 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030