Protein Alignment trr and Setdb2

DIOPT Version :10

• Sequence 1: NP_726773.2
• Gene: trr / 31149
• FlyBaseID: FBgn0023518
• Length: 2431
• Species: Drosophila melanogaster
• Sequence 2: NP_001307649.1
• Gene: Setdb2 / 239122
• MGIID: 2685139
• Length: 697
• Species: Mus musculus
• Alignment Length: 884
• Identity: 165/884 - (18%)
• Similarity: 281/884 - (31%)
• Gaps: 312/884 - (35%)

  Fly  1667 IEDKIGNKLEDQFMNQDDEKHVDFKRPLSQ-VSHGHLRKILNGRRKLCRSCGNVVHATGL--RVP 1728
            :|:|.|:........|||.| ||.....:| |.|...:||.:|    ..:.|:.|.|..|  ...
Mouse     1 MEEKNGDAKTFWMELQDDGK-VDLMFEKTQNVLHSLKQKIKDG----SATNGDYVQAMNLVNEAT 60

  Fly  1729 RHSVPALEEQLPRLAQLMDMLPRKSVPPPFVYFCDRACFARFKWNGKDGQAEAASLLLQPAGGSA 1793
            ..:...||:....:.|........:||..   .||.:|                     |.|.:.
Mouse    61 LSNTQTLEKDHTPVTQSEQENKSSAVPSA---SCDNSC---------------------PKGCTI 101

  Fly  1794 VKSSNGDSPGS--FCASSTAPAEMVVKQEPEDED-----------EKTP-SVPG-NPTNIPAQRK 1843
                  .|||.  |.........:|.|:.|....           .:|| |:.| ||..:|
Mouse   102 ------PSPGKKVFLPVKNKADNLVKKEAPLHISFHRHICSRTCLMETPLSLKGENPLQLP---- 156

  Fly  1844 CIVKC-FSADCFTTDSAPSGLELDGTAGAG---TGAGPVNNTVWETETSGLQLED---------T 1895
              ::| |......|:|..|.|.::.....|   .....|.:.:.|||.:.|..::         |
Mouse   157 --IRCHFQRRHAKTNSHSSALHVNYKTPCGRNLRNMEEVFHYLLETECNFLFTDNFSFNTYVQLT 219

  Fly  1896 R---------------------QCVFCNQRGDGQADGPSRLLNFDVDKWVHLNCALWSNGVYETV 1939
            |                     ...|||:           :.|..:.::.:.| .:|.. :|.
Mouse   220 RNHPKQNEVVSDVDISNGVESVSIPFCNE-----------IDNSKLPRFKYRN-TVWPR-IYH-- 269

  Fly  1940 SGALMNFQTALQAGLSQACSACHQPGATIK---CFKSRCNSLYHLPCAIREECVFYKNKSVHCSV 2001
                :||...    .|.:|. |.:....||   |.:....:....|.:...||..||.|.:...:
Mouse   270 ----LNFSNM----FSDSCD-CSEGCIDIKKCACLQLTAKNAKACPLSSDGECAGYKYKRLQRLI 325

  Fly  2002 HGHAHAGITMGAGAGATTG-------AGLGGSVADNELSSLVVHRRVFVDRDENR---------- 2049
                            .||       ......:..|.:....|..|:.|.:.|.:
Mouse   326 ----------------PTGIYECNLLCKCNKQMCQNRVIQHGVRVRLQVFKSEKKGWGVRCLDDI 374

  Fly  2050 -QVATVMHYSELSNLLRVGNMTFLNVGQLLPHQLEAFHTPHYIYPIGYKVSRYYWCVRRPNRRCR 2113
             :...|..||  ..|||.......|:|:   :..|..|.      :....|:        .|:..
Mouse   375 DKGTFVCIYS--GRLLRRATPEKTNIGE---NGREQQHI------VKNSFSK--------KRKLE 420

  Fly  2114 YICSIAEAGCKPEFRIQVQDAGDKEPEREFRGSSPSAVWQQILQPITRLRKVHKWLQLFPQHISG 2178
            .:||..:|.|                      .||.|                   :..|..:||
Mouse   421 VVCSDCDAHC----------------------DSPKA-------------------EDCPPKLSG 444

  Fly  2179 EDLFGLTEPAIVRILESLPGIETLTDYRFKYGRNPLLEFPLAINPSGAARTEPKQRQLLVWRKPH 2243
            :    |.|||:                              .:|....:||:...    |.|:..
Mouse   445 D----LKEPAV------------------------------EMNHRNISRTQHHS----VIRRTK 471

  Fly  2244 TQRTAGSCSTQRM----ANSAAIAGEVACPYSKQFVHSKSSQYKKMKQEWRNN-------VYLAR 2297
            ::.|....|.:.|    ::|||...:.....:::.|:|::   ::..::..:|       ..|..
Mouse   472 SKTTVFHYSEKNMGFVCSDSAAPEDKNGFKPAQEHVNSEA---RRAHEDLSSNPAGDSEDTQLTE 533

  Fly  2298 SKIQGLGLYAARDIE------KHTMIIEYIGEVIRTEVSEIRE----KQYE-------------- 2338
            |.:  :.:.|:|:..      ||..|::      |.:..::.|    |..|
Mouse   534 SDV--IDITASREDSAPAYRCKHATIVD------RKDTKQVLEVPGKKSQEEEPAASQSQQALCD 590

  Fly  2339 -------SKNRGIYMFRLDEDR--VVDATLSGGLARYINHSCNPNCVTEIVEV---DRDVRII-I 2390
                   :|.....:.:|.::.  ::||:..|.:.|::||||.||...:.|.|   ||:..:: .
Mouse   591 EELPSERTKIPSASLMQLSKESLFLLDASKEGNVGRFLNHSCCPNLWVQNVFVETHDRNFPLVAF 655

  Fly  2391 FAKRKIYRGEELSYDYKFDI-EDESHKIPCACGAPNCRK 2428
            |..|.:....||::||.::. ...:.:|.|.||...|||
Mouse   656 FTNRYVKARTELTWDYGYEAGATPAKEILCQCGFNKCRK 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		PRK13914	<623..>851	CDD:237555
		ePHD2_KMT2C_like	1898..2002	CDD:277136	21/106 (20%)
		FYRN	2067..2118	CDD:461787	7/50 (14%)
		FYRC	2126..2215	CDD:197781	10/88 (11%)
		SET_KMT2C_2D	2278..2430	CDD:380948	41/196 (21%)
Setdb2	NP_001307649.1	HMT_MBD	152..212	CDD:238689	14/65 (22%)
		SET	210..696	CDD:394802	110/634 (17%)
		SET	365..>435	CDD:459965	18/110 (16%)