DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trr and Dido1

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	NP_780760.2	Gene:	Dido1 / 23856	MGIID:	1344352	Length:	2256	Species:	Mus musculus

Alignment Length:	1611	Identity:	303/1611 - (18%)
Similarity:	495/1611 - (30%)	Gaps:	560/1611 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SLGAAEKAKPERVASVAAAAFNAVSLQKRSGDDTATPAEDPTRK--KAKTELLLGTGTAAPSLPA 71
            ||....:.|||.:.|...:.:                .|.||:.  :::|:||         ..:
Mouse   747 SLAKLVRMKPEELVSKELSMW----------------TEKPTKSVIESRTKLL---------NES 786

  Fly    72 KASSTAPQQLLYQRSGQQAKAQVKAASEPQDVETADGVWDARDQQIIV----------------- 119
            |.::|.|:.:                   .|:|.:..|.|:.:||..|
Mouse   787 KKNTTKPETI-------------------PDMEDSPPVSDSEEQQESVRAAPEKSAAPLLDVFSS 832

  Fly   120 -----------------CNFGSGTEMGAIKAEDADKQSEYRIST------PRNSQSNPLLHRNTA 161
                             |...:| ::.:.:.|.|.|:.:...|:      ||:..|.|....|||
Mouse   833 MLKDTTSQHRAHLFDLNCKICTG-QVPSSEDEPAPKKQKLSASSKKEDFKPRHDSSPPNAVPNTA 896

  Fly   162 FTSF--TKKEGASS-SASSSSSTASVISIEPSGSGQDHAENSGKSEDLDYVLMPASGADSSTSVG 223
            ....  |..|.||. ...|:||........|...|..|.|.|.           ..|...|::.|
Mouse   897 DEGIADTLPENASEPDPESTSSLNQERKCFPESPGDSHPEPSS-----------LGGLSPSSASG 950

  Fly   224 NSTGTGTPAGTPIGATTSTIILNANNGTAGVSGAGTTT------ILTQKSGHTNYNIFNTTATGS 282
            .|           |..| |:.::..:....:||:.|.|      :...::..|..::.....|.:
Mouse   951 GS-----------GVVT-TVTMSGRDPRTALSGSCTVTASMAAHLDNSQASETKLDMIKPALTSA 1003

  Fly   283 QTPTTTLLNRVNLHPKMKTQLMVNAKKLSEVTQTTAKVSIGNKTISVPLLKPLMSASGAATAGGA 347
            ..|.:.|                 ||..|         |...:.:||| ..|.:|.|.:...|..
Mouse  1004 VVPKSIL-----------------AKPSS---------SPDPRYLSVP-PSPSISESRSPPEGDT 1041

  Fly   348 TIVES------KQLLQPGGQVTTVMSAAQQSG-----GQQVHPHVHSHAHHNFTKLIKRGPKNSG 401
            |:..|      |..:........|..|...||     .:.:...:|...        :..||
Mouse  1042 TLFLSRLNTIWKGFINMQSVAKFVTKAYPVSGCLDYLSEDLPDTIHIGG--------RIAPK--- 1095

  Fly   402 TIVSFSGLQIKPANTKIVATKVVSKKMLQLQQHQQQIQQQQQLQQLQVTSGGGLAPPTGSIVTIT 466
            |:..:.| ::|.:         |||::..::.|  ...:::::..:.:.|   .....|....:.
Mouse  1096 TVWDYVG-KLKSS---------VSKELCLIRFH--PATEEEEVAYISLYS---YFSSRGRFGVVA 1145

  Fly   467 TTNPSQTYAMVQDSATVGPAAHSEDDAPAPRKITAYS--------ENL-------QKILNKSKSQ 516
            ..|     ..|:|...:..:|..    |.|.|:..:.        .|:       ||:...|.:.
Mouse  1146 NNN-----RHVKDLYLIPLSAKD----PVPSKLLPFEGPGLESPRPNIILGLVICQKVKRPSSAG 1201

  Fly   517 ESTGGPEEFTNINSVVIKPLDKNTLNCPPSFNIFKQQQHSQAAQSQSISAVGSGAGTPVTFTMAS 581
            |.....|:.|.:                       ||:..:.:....::|.......|..:::
Mouse  1202 ELDKTDEKRTRL-----------------------QQEELETSVYPKVTAALPSEKKPPKYSV-- 1241

  Fly   582 GNASDLATTSTVSVSAGTICINSPMMGTRPII----SIQNKNISLVLSKTTMAQQKPKMITT--- 639
             ::.|.|.|||....:..   ..|.:...|::    |::..:.|.|.:.||.|      |||
Mouse  1242 -HSIDTAATSTTPPGSPP---PPPPLPEPPVLKILSSLKPGSTSTVTAPTTAA------ITTTAS 1296

  Fly   640 --TTLSSQAALQMHHAL---------IQDSSADKAGS--SANSGSATSGASMQLKLTTANTPTKL 691
              |..:|:.|..:.|.|         .:.|..:..||  |.:..|...|..
Mouse  1297 PVTAATSKTASPLEHILQTLFGKKKSFEPSGKESVGSTLSPHQDSKAKGED-------------- 1347

  Fly   692 SVSLAP--DVVKLEEVGSESKAKLLVKQEAVVKDSTGTPTSE----------------------- 731
            ::|.||  |.: :::.|..||.|.|.::|.  .|....|..|
Mouse  1348 TMSAAPLLDPI-VQQFGQFSKDKALEEEEE--DDRPYDPEEEYNPDRAFHTLLAEPGRPHDVQSV 1409

  Fly   732 ----ERAEEIGTPEKRLNANATMTAINQVQNQSANQIQMATSTSTASNPSTPNPTVNATPMNNQR 792
                ||.|....||...........|:.:.|      :|....|....|:......::..:..|:
Mouse  1410 SETAEREEVAYDPEDETILEEAKVTIDDLPN------RMCMKVSATERPADFTTDASSASLVEQQ 1468

  Fly   793 SAAED--NALLKQLLQNNSSSHSLNQ----ISITSAH--VGSASASAPLSARKVINVRAPSMGKV 849
            ...|:  ..:.:|..|......:|.|    :.::.||  |..|..|.|..:         |:||.
Mouse  1469 KMLEELNKQIEEQKRQLEEQEEALRQQRAAVGVSMAHFSVSDALMSPPPKS---------SLGKT 1524

  Fly   850 R--SLEDQLARPVIPPVPT--------------ATQAAGSSSSSGSVATSTTTTTVASGGSSQQV 898
            .  |.|.|...|......|              |.:.|..::.:.|:..:.|.:|....|
Mouse  1525 ELFSQEQQAPDPSQGAPNTNHNLDSRQSRDPRQARRLAAENTENESLPRAPTGSTPGPQG----- 1584

  Fly   899 ATASATALPVSAVAITTPGVGGEAKLE-------------------QKSDQP---------AAIM 935
             |..|...|.....:..||:..|||..                   ||.:.|         .:.:
Mouse  1585 -TLPARETPAGTAVVQGPGLAAEAKESMAVPWAPGENAVLRPEHDIQKCEHPGNPVSLPLDTSHL 1648

  Fly   936 QNQSQNQAPPPPPPPQQQQQQQLHQPQQLQPSPHQV--KQTVQIVSKETSFISG---PVAAKTLV 995
            .......|.|.||            .:.|.|:|...  ..:..:..|..:|.||   |.:..|.:
Mouse  1649 PTAGDGAARPAPP------------RRVLLPTPPSTTFPPSFPLQPKAQNFSSGSREPFSGPTFM 1701

  Fly   996 TEATSKPAELLPPPPYEMAT----APISNVTISISTKQAAPKELQMKPKAVAMSLPM--EQG--- 1051
            ::.||..:.....|....:.    :|::::..|        :|.|.:|.....|.|.  ::|
Mouse  1702 SQETSLGSSQYEDPRGAQSAGKNDSPVADMEDS--------REPQPRPGESTTSFPQPGQRGGGP 1758

  Fly  1052 DESLPEQAEP----------------------PLHSEQGATAAGVAPHSGGP------------- 1081
            ....|.|.||                      |.:||:     .:.|:|.||
Mouse  1759 QPQFPGQREPAPRTFGMSGHHGPSFPGPRGPVPPYSEE-----NLVPNSDGPRGPPPARFGAQKP 1818

  Fly  1082 ----LVSAQ------WTNNHL--------EGGVATTKIPFKPGEPQKRKLPMHPQLDEKQIQQQA 1128
                |.|.|      ..|..|        .||.        |.:.:.||.| |   .||:..|..
Mouse  1819 PIPSLFSGQHGPPPYGDNRGLSPSYLGGPRGGA--------PAQFEDRKDP-H---GEKREFQDT 1871

  Fly  1129 EIPISTSLPTTPTGQGTPDKVQLISAIATYVKKSGVPNEAQPIQNQSQG------QVQMQAQMQA 1187
            .....|..|....|   ||:.|.:...|.:  :.|  .:.:|:..|.:|      ..|..|| :.
Mouse  1872 PYNEMTGAPAQCEG---PDQAQFMGNRAPF--QFG--GQRRPLLTQMKGPRGGPPPSQFGAQ-RG 1928

  Fly  1188 TMQGHLSGQMS--------------GQISGHAAGQIPAQMHLQVQHQLHMAVHPQQQQQQLHQNQ 1238
            ...||..|...              ||..| |.||.|..|      .....:.|||.::|...:.
Mouse  1929 PPPGHFVGPRGPHPSQFENSRGTHPGQFEG-ARGQAPGFM------PGPRGIQPQQFEEQRVNSP 1986

  Fly  1239 P----QNATIPLPVTG-QGAVPIPVPTMESKAGDQRKRRKREVQKPRRTNLNAGQAGGALKDLTG 1298
            |    |.|:.|||..| :|..|.|               ::..|.|.|.:.. |.:...:|.
Mouse  1987 PRFAGQRASAPLPYGGPRGPAPFP---------------EKNEQPPSRFHFQ-GPSSQPVKP--- 2032

  Fly  1299 PLPAGAMVQLAGMP------------PGTQYIQGAASGTGHVITSTGQGVT 1337
              |...:::|...|            |.|.....|..|.||  .:.||..|
Mouse  2033 --PPRPLLELPSHPPQHRKDRWDEAGPATALPSSAGPGQGH--EADGQWAT 2079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513	23/141 (16%)
		ePHD2_KMT2C_like	1898..2002	CDD:277136
		FYRN	2068..2118	CDD:283589
		FYRC	2126..2215	CDD:197781
		SET	<2266..2431	CDD:225491
		SET	2291..2413	CDD:214614
		PostSET	2415..2431	CDD:214703
Dido1	NP_780760.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..256
		TNG2	<157..299	CDD:227367
		Nuclear localization signal. /evidence=ECO:0000255	162..170
		Nuclear localization signal. /evidence=ECO:0000255	182..190
		PHD_DIDO1_like	263..316	CDD:277109
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..535
		PHA03247	<483..663	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	598..624
		PRK14954	<600..>665	CDD:184918
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	641..668
		TFS2M	669..770	CDD:128786	6/38 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	778..822		13/71 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	856..970		30/136 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1011..1039		10/37 (27%)
		SPOC	1045..1190	CDD:369497	26/179 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1197..1218		6/43 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1245..1288		10/45 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1320..1347		6/26 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1362..1421		12/60 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1509..1609		24/114 (21%)
		PHA03247	<1571..2083	CDD:223021	120/590 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1630..2256		109/525 (21%)
		SF-CC1	2142..>2180	CDD:273721
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030