DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trr and Setd2

DIOPT Version :9

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:XP_036010808.1 Gene:Setd2 / 235626 MGIID:1918177 Length:2551 Species:Mus musculus


Alignment Length:1866 Identity:332/1866 - (17%)
Similarity:590/1866 - (31%) Gaps:685/1866 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   894 SSQQVATASATALPVSAVAITT--PGVGGEAKLEQKSDQPAAIMQNQSQNQAPPPPPPPQQQQQQ 956
            |..|:|.::..|.|:..   ||  |.|..|:.:    |.|.:         :|||||||      
Mouse   168 SRPQLAASTTAASPLPP---TTQLPAVLAESMI----DSPPS---------SPPPPPPP------ 210

  Fly   957 QLHQPQQLQPSPHQVKQTVQIVSKETSFISGPVAAKTLVTEATSKPAELLPPPPYEMATAPISNV 1021
                ||...|||     ..||                      |:|..|..||...:.|:|...:
Mouse   211 ----PQASSPSP-----PAQI----------------------SEPVALPQPPATALMTSPPGPL 244

  Fly  1022 TISISTK-------QAAPKELQMKPKAVAMSLPMEQGD-ESLPEQAEPPLHSEQGATAAGVAPHS 1078
            ...::.:       ::.|:.|::..|...:|..:|:.. ::|.|||:..|..|..        |.
Mouse   245 PGDVAVRAQKESPVKSGPEVLEVDTKQDIVSNSLEEHTVQTLKEQADHLLQKEDS--------HI 301

  Fly  1079 G-------GPLVSAQWTNNHLEGGVATTKIPFKPGEPQKRKLPMHPQLDEKQI-----QQQAEIP 1131
            |       |..:|           :::.|...|....|.....:..:.||..:     |:..::.
Mouse   302 GKEEEVSDGSKIS-----------LSSKKASSKKKSSQFEGTFLGSESDEDSVRTSSSQRSHDLK 355

  Fly  1132 ISTSLPTTPTGQGTPDKVQLISAIATYVKKSGVPNEAQPIQNQSQGQ------------------ 1178
            .|||:          ||.:       ..|||..|::::.:...|:.:                  
Mouse   356 SSTSI----------DKER-------DFKKSSAPSKSEDLGKSSRSKTERDDRYCSYSKLERDTR 403

  Fly  1179 -VQMQAQMQATMQGHLSGQMSGQISGHAAGQIPAQMHLQVQHQLHMAVHPQQQQQQLHQNQP--Q 1240
             |..:.:.:...:...|...|.:.|           ...:.:......|....:::.|::.|  :
Mouse   404 YVSSRCRSERDRRRSRSRSRSDRAS-----------RTSLSYSRSERSHYYDSERRYHRSSPYRE 457

  Fly  1241 NATIPLPVTGQGAVPIPVPTMESKAGDQRKRRKREVQKPRRTNLNAGQAGGALKDLTGPLPAGAM 1305
            ......|.|...|      ...|.:.|:.|:     ..||||:.:      :.:||         
Mouse   458 RTRYSRPYTDNRA------RESSDSEDEYKK-----TYPRRTSAH------SYRDL--------- 496

  Fly  1306 VQLAGMPPGTQYIQGAASGTGHVITSTGQGVTLGGVGASTGASSSPMLKKRVRKFSKVE-EDHDA 1369
                                                  .|.:|.|...:....:.|.:| |....
Mouse   497 --------------------------------------RTSSSYSKFDRDCKTETSYLEMERRGK 523

  Fly  1370 FTEKLLTHIRQMQPLQVLE-----PHLNRNFHFLIGSNETSGGGSPASMSSAASAGSSSAGGGKL 1429
            :|.||....::....:.::     |:   ...|..||:.:....|.:...||.|  .|.:...|.
Mouse   524 YTSKLERESKRTSEHETIKRCCSPPN---ELGFRRGSSYSKHDNSTSRYKSALS--KSISKNDKF 583

  Fly  1430 KGGSRGWPLSR-----HLEGLE-DCD-GTVLGRYGRVNLPGIPSLYDSERFGGSRGLVGGSARTR 1487
            |.......|:.     |...|: .|. |:.|....::          |||           .:|.
Mouse   584 KNSFCCTELNEENKQSHSFSLQTPCSKGSELRTINKI----------SER-----------EKTG 627

  Fly  1488 SPSPA----ESPGAEKMLPMSSIQNDFYDQEFSTHMERNPRERLVRHIGAVKDCNLETVDLVESE 1548
            ||:|:    :||..:|:     .::.....||..|..|...:.|  .:..||:..|.....:|  
Mouse   628 SPTPSNQLNDSPTFKKL-----DESPVLKPEFIGHDGRESIKEL--ELSKVKNDQLRNFCSIE-- 683

  Fly  1549 GVAAWATLPRLTRYPGLILLNGNSR--------CHGRMSPVALPEDPLTMRFPVSPLLRSCGEEL 1605
                             :.:||:..        |..:...:::..|.......||||:::|    
Mouse   684 -----------------LNVNGSPETEADVATFCTSKTDAISMTSDDSVTGSEVSPLIKAC---- 727

  Fly  1606 RKTQQMELGMGPLG----NNNNNNYQQKN----------------QNVILALPASASENIAGVLR 1650
               .....|...:|    .::::..:|.|                .:.:::||....:....:::
Mouse   728 ---MLSSNGFQNVGRCRERDSDDTCRQHNTSKSPFREMEPLLSPHHDKLMSLPVKTIDYPKTLIK 789

  Fly  1651 DLANLLHLAPALTCKIIEDKIGNKLEDQFMNQDDEKHVDFKRPLSQV--SHGHLRKILNGRRKLC 1713
            :..:..|..    ||       .|..|.:.:.::....:...|.:..  ||..:...|..:..:|
Mouse   790 EPVDKRHSC----CK-------TKDSDIYCSPNENPEAENAEPSAMTISSHSFVNVHLESKTVIC 843

  Fly  1714 RSCGNVVHATGLRVP--RHSVPALEEQLPRLAQLMDMLPRKSVPPPFVYFCDRACFARFKWNGKD 1776
            .:          |.|  |||....:|.            ::|:                      
Mouse   844 DN----------REPTDRHSENTCDEY------------KQSI---------------------- 864

  Fly  1777 GQAEAASL-----LLQPAGGSAVKSSNGDSPGSFCASSTAPAEMVVK------------------ 1818
            |...:||.     |.:|.|.|.:.|......|..|..:|:|....|:                  
Mouse   865 GSTSSASHNHFDGLYEPIGSSGISSLQSPPSGIRCEENTSPTLDAVESKKGIDFLKYARKETDVG 929

  Fly  1819 -------------------------QEPEDEDEK-------TPSVP------GNPTNIPAQRKCI 1845
                                     ||.::|...       .|.:|      |: |:|....:.:
Mouse   930 SALPDSGKGFSWENRHNNVLSGQSLQEAQEEGNSILHERRGRPEIPLDEEQRGH-THISDDSEVV 993

  Fly  1846 ------------------VKCFSA-----------DCFTTDSAPSGLELDG----TAGAGTGAGP 1877
                              :||.|:           :.::..||.|..|.|.    :..:......
Mouse   994 FPYDLNLTMEDSDGITYTLKCDSSGNAPEIVSTVHEDYSGSSASSSDESDSEDTESDDSSIPRNR 1058

  Fly  1878 VNNTVWETETSGLQLEDTRQCVFCNQRGDGQADGPSRLLNFDVDKWVHLNCALWSNGV------- 1935
            :.:.|...:.|.|.:|:|..|          :...|:......|:        |.:|:       
Mouse  1059 LQSVVVVPKNSTLPMEETSPC----------SSRSSQSYKHYSDR--------WEDGLETRRHAY 1105

  Fly  1936 ---YETVSGALMNFQTALQAGLSQACSACHQPGATIKCFKSRCNSLYHLP--CAIREECVFYKNK 1995
               ||: .|.....:..|..|..::..:|:..      |..:.::  |||  ...:.:.|...::
Mouse  1106 EEEYES-KGCSQTEKYFLHKGTERSAESCYSQ------FGRKADN--HLPDIAHAQSDGVDSTSQ 1161

  Fly  1996 SVHCSVH-GHAHAGITMGAGAGATTGAGLGGSVADNELSSLVVHRR---VFVDR-DENRQVATVM 2055
            :...|.| ||.:...|:    .|.|.......|..::...|....|   :|.:| |.:|...|.:
Mouse  1162 TDSRSDHLGHLNPEDTL----RAKTSRPQELPVYSDDFEDLPNKSRQQMIFSNRPDSSRLGKTEL 1222

  Fly  2056 HYSELSNLLRVGNM----TFLNVG-----QLLP----------------HQLEAFHTPHYIYPIG 2095
            .:|...::.|:..:    ...|:|     |..|                |:.:. .|.||.....
Mouse  1223 SFSSSCDISRMDGLHSSEELRNLGWDFSQQERPTTTYQQPDSSYGTCGTHKYQQ-STEHYGGTHN 1286

  Fly  2096 YKVSRYYWCVRRPNRRCRYICSIAEAGCKP-------EFRIQVQDA--GDKEPEREF------RG 2145
            |.....||..|             .||..|       ..:.||.|:  .|:|.|..:      ..
Mouse  1287 YWQGNGYWDPR-------------SAGRPPGTGLAYDRIQGQVPDSLTDDREEEEHWDQRSGSHF 1338

  Fly  2146 SSPSAVW---------------------------------------------------QQI---- 2155
            ||||..:                                                   |::    
Mouse  1339 SSPSNKFFFHQKDKGSVQAPEISSNSIKDALVMNERKDFSKNFEKNDIKERGPPKKRRQELESDS 1403

  Fly  2156 -----LQPITRLR-KVHKWLQLFPQHISGEDLFGLTEPAIVRILESLPGIETLTDYR-------- 2206
                 ||...::| ::.:.....|||   .:|.|   |:.           .:.|:|        
Mouse  1404 ESDGELQARKKVRVEMEQGESSVPQH---SELMG---PSC-----------AMDDFRDPQRWKEF 1451

  Fly  2207 FKYGRNP----LLEFPLAINPSGAARTEPKQRQLLVWRKPHTQRTAGSCSTQRMANSAAIAGEVA 2267
            .|.|:.|    |:|       .....||.|:      .|.|.......|....::......||||
Mouse  1452 AKLGKMPCYFDLIE-------ENVYLTERKK------NKSHRDIKRMQCECTPLSKDERAQGEVA 1503

  Fly  2268 C-----------PYSKQFVHSKSSQYKKMKQEWRNNVYLARSKIQGLGLYAARDIEKHTMIIEYI 2321
            |           ..|.:..:......::.:::...:|.:..::.:|.||.||:|:..:|.::||.
Mouse  1504 CGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYC 1568

  Fly  2322 GEVIRTEVSEIREKQY-ESKNRGIYMFRLDEDRVVDATLSGGLARYINHSCNPNCVTEIVEVDRD 2385
            |||:..:..:.|.|:| .:||...|...|..|.::|||..|..:|::||||.|||.|:...|:..
Mouse  1569 GEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQ 1633

  Fly  2386 VRIIIFAKRKIYRGEELSYDYKFD-IEDESHKIPCACGAPNCRKWM 2430
            :|:..|..:.:..|.||::||:|. ...|:.|  |.||:.|||.::
Mouse  1634 LRVGFFTTKLVPSGSELTFDYQFQRYGKEAQK--CFCGSANCRGYL 1677

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513
ePHD2_KMT2C_like 1898..2002 CDD:277136 17/115 (15%)
FYRN 2068..2118 CDD:283589 12/74 (16%)
FYRC 2126..2215 CDD:197781 25/169 (15%)
SET <2266..2431 CDD:225491 55/178 (31%)
SET 2291..2413 CDD:214614 43/123 (35%)
PostSET 2415..2431 CDD:214703 7/16 (44%)
Setd2XP_036010808.1 AWS 1483..1537 CDD:197795 7/53 (13%)
SET_SETD2 1537..1678 CDD:380949 51/143 (36%)
WW 2378..2407 CDD:395320
SRI 2454..2542 CDD:400510
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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