DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trr and Kmt2c

DIOPT Version :9

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:XP_006535745.1 Gene:Kmt2c / 231051 MGIID:2444959 Length:4976 Species:Mus musculus


Alignment Length:2681 Identity:705/2681 - (26%)
Similarity:1047/2681 - (39%) Gaps:787/2681 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 EKAKPERVASV-------AAAAFNAVSLQK--RSGDDT----------ATPAEDPTRKKAKTELL 59
            :|..|:|.:||       |.:.::...:|.  ::.||:          |..|:.....:.||.||
Mouse  2820 DKDLPQRKSSVSSEIKTEALSPYSKEEIQSEIKNHDDSRGDADTACSQAASAQTNHSDRGKTALL 2884

  Fly    60 LGTGTAAPSLPAKASSTAPQQLLYQRSGQQAKAQVKAASEPQDVETADGVWDARDQQIIVCNF-G 123
                            |..|.:|.:|..|:....|.:|.:......|..|.::       |:. |
Mouse  2885 ----------------TTDQDMLEKRCNQENAGPVVSAIQGSTPLPARDVMNS-------CDITG 2926

  Fly   124 SGTEMGAIKAEDADKQSEYRI--STPRNSQSNPLLHRNTAFTSFTKKEGAS--------SSASSS 178
            |...:.::.:.:....|:.|.  |:|.:...:|..|            |:|        .|....
Mouse  2927 STPVLSSLLSNEKCDDSDIRPSGSSPPSLPISPSTH------------GSSLPPTLIVPPSPLLD 2979

  Fly   179 SSTASVISIEPSGSGQDHAENSGKSEDLDYVLMPASGADSSTSVGNSTGTGTPAGTPIGATTSTI 243
            ::..|.:::.|.   .:||.:.|...:..::       ...:||.::.|||.|       |..|:
Mouse  2980 NTVNSNVTVVPR---INHAFSQGVPVNPGFI-------QGQSSVNHNLGTGKP-------TNQTV 3027

  Fly   244 ILNANNGTAGVSGAGTTTILTQKSGHTNYNIFNTTATGSQTPTTTLLNRVNLHPKMKTQLMVNAK 308
            .|...:.|              .||.....|..|.|..::.....|..:     .:..|.:::.:
Mouse  3028 PLTNQSST--------------MSGPQQLMIPQTLAQQNRERPLLLEEQ-----PLLLQDLLDQE 3073

  Fly   309 KLSEVTQTTAKVSIGNKTISVP---------LLKPLMSASGAATAGGATIVESKQLLQPGGQVTT 364
            :..:..|...:..|..:  |.|         :..|:|.|...|..|...::....|    |....
Mouse  3074 RQEQQQQRQMQAMIRQR--SEPFFPNIDFDAITDPIMKAKMVALKGINKVMAQNSL----GMPPM 3132

  Fly   365 VMSAAQQSGGQQVHPHVHSHAHHNFTKLIKRGPKNSGTIVSFSGLQIKPANTKIVATKVVSKKML 429
            |||.....|     |.|....:::...|:.:.....|:|..    ||...|........|:..  
Mouse  3133 VMSRFPFMG-----PSVAGTQNNDGQTLVPQAVAQDGSITH----QISRPNPPNFGPGFVNDS-- 3186

  Fly   430 QLQQHQQQIQQQQQLQQLQVTSGGGLAPPTGSIVTITTTNPSQTYAMVQDSATVGPAAHSEDDAP 494
            |.:|:::.:|:.|||.|:|...   |....|:     .....:..:..|.:|........|:||.
Mouse  3187 QRKQYEEWLQETQQLLQMQQKY---LEEQIGA-----HRKSKKALSAKQRTAKKAGREFPEEDAE 3243

  Fly   495 APRKITAYSENLQKILNKSKSQESTGGPEEFTNINSVVIKPLDKNTLNCPPSFNIFKQQQHSQAA 559
            ..:.:|.....:||.|.:.:.|:                    |........:.|.:|||..|.|
Mouse  3244 QLKHVTEQQSMVQKQLEQIRKQQ--------------------KEHAELIEDYRIKQQQQQQQCA 3288

  Fly   560 QSQSISAVGSGAGTPVTFTMASGNASDLATTSTVSVSAGTICINSPMMGTRPIISIQNKNISLVL 624
            .:..|...|.....|    :..|     ||:.|:|..      |.||:..:    :|::..:.|:
Mouse  3289 LAPPILMPGVQPQPP----LVPG-----ATSLTMSQP------NFPMVPQQ----LQHQQHTAVI 3334

  Fly   625 SKTTMAQQKPKMITTTTLSSQAALQMHHALIQDSSADKAGSSANSGSATSGASMQLKLTTANTPT 689
            |..|...:.|.:....:.|:.|.|.::...||...|                  ||.|.|. ||.
Mouse  3335 SGHTSPARMPSLPGWQSNSASAHLPLNPPRIQPPIA------------------QLSLKTC-TPA 3380

  Fly   690 KLSVSLA------PDVVKLEEVGSESKAKLLVKQEAVVKDSTGTPTSE-----ERAEEIGTPEKR 743
            ..:||.|      |..|:.::                     ..|.||     ||.|.:...::|
Mouse  3381 PGTVSSANPQNGPPPRVEFDD---------------------NNPFSESFQERERKERLREQQER 3424

  Fly   744 LNANATMTAINQVQNQSANQIQMATSTSTASNPSTPNPTVNATPMNNQRSAAEDNALLKQLLQ-- 806
                ..:..:.:|..|.|.|.:|...........    ..|.||::.......|...  ..||  
Mouse  3425 ----QRVQLMQEVDRQRALQQRMEMEQHCLMGAE----LANRTPVSQMPFYGSDRPC--DFLQPP 3479

  Fly   807 ---NNSSSHSLNQIS--ITSAHVGSASASAPLSARKVINVRAPSMGKVRSLEDQLARPVIPP--V 864
               ..|..|. .||.  :...:|...|.::|           |:...:::.|.   |.|.||  |
Mouse  3480 RPLQQSPQHQ-QQIGPVLQQQNVQQGSVNSP-----------PNQTFMQTNEQ---RQVGPPSFV 3529

  Fly   865 PTATQAAGSSSSSGSVATSTTTTTVASGGSSQQVATASATALPVSAVAITTPGVGGEAKLEQKSD 929
            |.:..|:|.|.:..||........    |||.|.:.......|:      .||....|.......
Mouse  3530 PDSPSASGGSPNFHSVKPGHGNLP----GSSFQQSPLRPPFTPI------LPGTSPVANSNVPCG 3584

  Fly   930 QPAAIMQNQSQNQAPPPPPPPQQQQQQQLHQPQQLQPSPHQVKQTVQIVSKETSFISGPVAAKTL 994
            |..|:.|.|:.:.:        .|...||:  ..:.|.....|:..:...|:....||..     
Mouse  3585 QDPAVTQGQNYSGS--------SQSLIQLY--SDIIPEEKGKKKRTRKKKKDDDAESGKA----- 3634

  Fly   995 VTEATSKPAELLPPPPYEMATAPISNVTISISTKQAAPKELQMKPKAVAMSLPMEQGDESLPEQA 1059
                        |..|:....||:   |..:|...:.|          |:|.|.|...:...|..
Mouse  3635 ------------PSTPHSDCAAPL---TPGLSETTSTP----------AVSSPSELPQQRQQEPV 3674

  Fly  1060 EP-PLHSEQGATAAGVAPHSGGPLVSAQWTNNHLEGGVATTKIPFKPGEP---QKRKLPMHPQLD 1120
            || |:.:               |.|||                    |:|   .:.||| :.:..
Mouse  3675 EPVPVPT---------------PNVSA--------------------GQPCIESENKLP-NSEFI 3703

  Fly  1121 EKQIQQQAEIPISTSLPTTPTGQGTPDKVQLISAIATYVKKSGVPNEAQPIQNQSQGQVQMQAQM 1185
            ::...||..:......|:..    ||:|.:.|.     ::|:    |.||.|..::.:.:...::
Mouse  3704 KETSNQQTHVNAEADKPSVE----TPNKTEEIK-----LEKA----ETQPSQEDTKVEEKTGNKI 3755

  Fly  1186 QATMQGHLSGQMSGQISGHAAGQIPAQMHLQVQHQLHMAVHPQQQQQQLHQNQPQNATIPLPVTG 1250
            :..:.|.:|   |.|...|                                              
Mouse  3756 KDIVAGPVS---SIQCPSH---------------------------------------------- 3771

  Fly  1251 QGAVPIPVPTMESKAGDQ--------RKRRKREVQKPRRTNLNAGQAGGALKDLTGPLPAGAMVQ 1307
                |:..||.:...|::        :|......|||..| |::.::  :.||       |.:::
Mouse  3772 ----PVGTPTTKGDTGNELLKHLLKNKKASSLLTQKPEGT-LSSDES--STKD-------GKLIE 3822

  Fly  1308 LAGMPPGTQ----YIQGAASGTGHVITSTGQGVTLGGVGAS------------TGASSSPMLKKR 1356
            ......|.|    .:||...|....:..|.        |||            ||..::|..|||
Mouse  3823 KQSPAEGLQTLGAQMQGGFGGGNSQLPKTD--------GASENKKQRSKRTQRTGEKAAPRSKKR 3879

  Fly  1357 VRKFSKVEEDHDAF--TEKLLTHIR-QMQPLQVLEPHLNRNF-HFLIGSNETSGGGSPASMSSAA 1417
                .|.||:..|.  :....||:: |:..|.::||.:..|| |||                   
Mouse  3880 ----KKDEEEKQAMYSSSDSFTHLKQQLSLLPLMEPIIGVNFAHFL------------------- 3921

  Fly  1418 SAGSSSAGGGKLKGGSR--GWPLSRHLEGLEDCDGTVLGRYGRVNLPGIP--------------- 1465
                 ..|.|:...|:|  |...|..|||:.|....::.:...::.|..|               
Mouse  3922 -----PYGSGQFNSGTRLLGTFGSAALEGVSDYYSQLIYKQNNLSNPPTPPASLPPTPPPMACQK 3981

  Fly  1466 ---SLYDSERFGGSRGLVGGS--ARTRSPSPAESPGAEKMLPMSSIQNDFYDQEFS--------- 1516
               ....:|...|..|::...  ||...|.|.:.|    ..|    |:|...:..:         
Mouse  3982 MANGFATTEELAGKAGVLVSHEVARALGPKPFQLP----FRP----QDDLLARAIAQGPKTVDVP 4038

  Fly  1517 ----THMERNPRE-RLVRHIG-------AVKDCNLETVDLVESEGVAAWATLPRLTRYPGLILLN 1569
                |....|..| |:..|.|       .|...:.|:|..||            :.:||.|.|:.
Mouse  4039 ASLPTPPHNNHEELRIQDHYGDRDTPDSFVPSSSPESVVGVE------------VNKYPDLSLVK 4091

  Fly  1570 GNSRCHGRMSPVALPEDPLTMRFPVSPLLRSC----GEELRKTQQMELG----MGPLGNNNNNNY 1626
                          .|.|..:..|:.|:|.|.    .|..|...:.|.|    ..|.|::.|.. 
Mouse  4092 --------------EEPPEPVPSPIIPILPSISGKNSESRRNDIKTEPGTLFFTSPFGSSPNGP- 4141

  Fly  1627 QQKNQNVILALPASASENIAGVLRDLANLLHLAPALTCKIIEDKIGNKLEDQFMNQDDEKHVDFK 1691
            :....:|.:.|..:|:|||:.|:...::|||:           :|.|..|  ..|..|..     
Mouse  4142 RSGLISVAITLHPTAAENISSVVAAFSDLLHV-----------RIPNSYE--VSNAPDVP----- 4188

  Fly  1692 RPLSQVSHGHLRKILNGRRKLCRSCGNVVHATGLRVPRHSVPALEEQLPRLAQLMDMLPRKSVP- 1755
             |:..||...:...|..|:.|.           ||.|    |......||||... .|.:.:|| 
Mouse  4189 -PMGLVSSHRVNPSLEYRQHLL-----------LRGP----PPGSANPPRLATSY-RLKQPNVPF 4236

  Fly  1756 PPFVYFCDRACFARFKWNG----KD---GQAEAASLLLQPAG---------GSAVKSSNGD---- 1800
            ||             ..||    ||   |.||.||  |:|..         ||.|:.|..|    
Mouse  4237 PP-------------TSNGLSGYKDSSHGPAEGAS--LRPQWCCHCKVVILGSGVRKSCKDLTFV 4286

  Fly  1801 SPGS------------FCA-------SSTAPAEMVVKQEPEDEDEKTPSVPGNPTNIPAQRKCIV 1846
            :.||            ||:       ||.|.|      :..|..|..||:|.:|...|:      
Mouse  4287 NKGSRENTKRMEKDIVFCSNNCFILYSSAAQA------KNSDNKESLPSLPQSPMKEPS------ 4339

  Fly  1847 KCF---SADCFTTD------------------------------------------------SAP 1860
            |.|   |.:..|.|                                                :.|
Mouse  4340 KAFHQYSNNISTLDVHCLPQFQEKVSPPASPPISFPPAFEAAKVESKPDELKVTVKLKPRLRTVP 4404

  Fly  1861 SGLE------------------LDGTAGAGTGAGPVNNTVWE-TETSGLQL------EDTRQCVF 1900
            .|||                  :......||...|..:.:.| .:..|..|      :|.|:|.|
Mouse  4405 VGLEDCRPLNKKWRGMKWKKWSIHIVIPKGTFKPPCEDEIDEFLKKLGTCLKPDPVPKDCRKCCF 4469

  Fly  1901 CNQRGDGQADGPSRLLNFDVDKWVHLNCALWSNGVYETVSGALMNFQTALQAGLSQACSACHQPG 1965
            |::.|||..|||:||||.|:|.||||||||||..||||.:|||:|.:.||:.||...|..||:.|
Mouse  4470 CHEEGDGLTDGPARLLNLDLDLWVHLNCALWSTEVYETQAGALINVELALRRGLQMKCVFCHKTG 4534

  Fly  1966 ATIKCFKSRCNSLYHLPCAIREECVFYKNKSVHCSVHGHAHAGITMGAGAGATTGAGLGGSVADN 2030
            ||..|.:.||.::||..||.:.:|:|:|:|::.|.:|...                    .:.:.
Mouse  4535 ATSGCHRFRCTNIYHFTCATKAQCMFFKDKTMLCPMHKPK--------------------GIHEQ 4579

  Fly  2031 ELSSLVVHRRVFVDRDENRQVATVMHYSELSNLLRVGNMTFLNVGQLLPHQLEAFHTPHYIYPIG 2095
            :||...|.|||:|.|||.||:|:::...|..:..|||::.|..:|||||.|::|||:|..::|:|
Mouse  4580 QLSYFAVFRRVYVQRDEVRQIASIVQRGERDHTFRVGSLIFHTIGQLLPQQMQAFHSPKALFPVG 4644

  Fly  2096 YKVSRYYWCVRRPNRRCRYICSIAEAGCKPEFRIQVQDAGDKEPEREFRGSSPSAVWQQILQPIT 2160
            |:.||.||..|..||||||:|||.|...:|.|.|::.:.|.:  :.....|||..||.:||:|:.
Mouse  4645 YEASRLYWSTRYANRRCRYLCSIEEKDGRPVFVIRIVEQGHE--DLVLSDSSPKDVWDKILEPVA 4707

  Fly  2161 RLRKVHKWLQLFPQHISGEDLFGLTEPAIVRILESLPGIETLTDYRFKYGRNPLLEFPLAINPSG 2225
            .:||..:.|||||.::.||||||||..|:.||.|||||:|...:|.|:||||||:|.|||:||:|
Mouse  4708 CVRKKSEMLQLFPAYLKGEDLFGLTVSAVARIAESLPGVEACENYTFRYGRNPLMELPLAVNPTG 4772

  Fly  2226 AARTEPK-----QRQLLVWRKPHTQRTAGSCSTQRMANSAAIAGEVACPYSKQFVHSKSSQYKKM 2285
            .||:|||     :|.:|   :||   |..|.||.:...| .:.||:..||||||||||||||::|
Mouse  4773 CARSEPKMSAHVKRFVL---RPH---TLNSTSTSKSFQS-TVTGELNAPYSKQFVHSKSSQYRRM 4830

  Fly  2286 KQEWRNNVYLARSKIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQYESKNRGIYMFRLD 2350
            |.||::|||||||:|||||||||||||||||:|||||.:||.||:..:||.|||:|||:||||:|
Mouse  4831 KTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGVYMFRMD 4895

  Fly  2351 EDRVVDATLSGGLARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGEELSYDYKFDIEDESH 2415
            .|.|:||||:||.||||||||.||||.|:|..:|..:|||.:.|:|.:||||.||||||.||:.|
Mouse  4896 NDHVIDATLTGGPARYINHSCAPNCVAEVVTFERGHKIIISSNRRIQKGEELCYDYKFDFEDDQH 4960

  Fly  2416 KIPCACGAPNCRKWMN 2431
            ||||.|||.|||||||
Mouse  4961 KIPCHCGAVNCRKWMN 4976

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513 22/135 (16%)
ePHD2_KMT2C_like 1898..2002 CDD:277136 55/103 (53%)
FYRN 2068..2118 CDD:283589 26/49 (53%)
FYRC 2126..2215 CDD:197781 42/88 (48%)
SET <2266..2431 CDD:225491 117/164 (71%)
SET 2291..2413 CDD:214614 85/121 (70%)
PostSET 2415..2431 CDD:214703 13/15 (87%)
Kmt2cXP_006535745.1 PHD2_KMT2C 390..435 CDD:277069
PHD3_KMT2C 466..517 CDD:276986
PHD4_KMT2C 947..1003 CDD:277071
PHD5_KMT2C_like 1004..1050 CDD:276988
RanBP2-type Zn finger 1079..1101 CDD:275375
PHD6_KMT2C 1081..1131 CDD:277073
HMG-box 1661..1712 CDD:381793
Tma16 1699..>1782 CDD:371407
PHA03247 <1880..2370 CDD:223021
PHA03247 <2146..2753 CDD:223021
PKK 3189..3275 CDD:372134 20/113 (18%)
Atrophin-1 3288..>3590 CDD:367360 82/395 (21%)
ePHD2_KMT2C 4467..4571 CDD:277167 55/103 (53%)
FYRN 4616..4667 CDD:368685 27/50 (54%)
FYRC 4673..4757 CDD:368686 38/85 (45%)
SET_KMT2C_2D 4823..4975 CDD:380948 107/151 (71%)
ePHD1_KMT2C 247..330 CDD:277166
PHD1_KMT2C_like 343..388 CDD:276984
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167848403
Domainoid 1 1.000 156 1.000 Domainoid score I4182
eggNOG 1 0.900 - - E2759_KOG4443
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002860
OrthoInspector 1 1.000 - - otm42831
orthoMCL 1 0.900 - - OOG6_102575
Panther 1 1.100 - - O PTHR45888
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 1 1.000 - - X2220
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1211.730

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