DRSC/TRiP Functional Genomics Resources

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Protein Alignment trr and SETD1B

DIOPT Version :9

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:NP_001340274.1 Gene:SETD1B / 23067 HGNCID:29187 Length:1966 Species:Homo sapiens


Alignment Length:2263 Identity:436/2263 - (19%)
Similarity:701/2263 - (30%) Gaps:779/2263 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   436 QQIQQQQQLQQLQVTSGGGLAPPTGSIVTITTTNPSQTYAMVQDSATVG-----PAAHSEDDAPA 495
            :.:|....|::|:   .|||:...||..:..|.|...| ...||:|...     |.::.:.....
Human   216 ETLQLSDALKRLK---DGGLSAGCGSGSSSVTPNSGGT-PFSQDTAYSSCRLDTPNSYGQGTPLT 276

  Fly   496 PRKITAYSENLQKILNKSKSQESTGGPEEFTNINSVVIKPLDKNTLNCPPSFNIFKQQQHSQAAQ 560
            ||..|.:|::     :...|::.|  |....:.:..|.....::......::|  ::.:|.....
Human   277 PRLGTPFSQD-----SSYSSRQPT--PSYLFSQDPAVTFKARRHESKFTDAYN--RRHEHHYVHN 332

  Fly   561 SQSISAVGSGAGTPVTFTMASGNASDLATTSTVSVSAGTICINSPMMGTRPIISIQNKNISLVLS 625
            |.:::|| :||      |.|...:|||    ......||...:.|....:|            ..
Human   333 SPAVTAV-AGA------TAAFRGSSDL----PFGAVGGTGGSSGPPFKAQP------------QD 374

  Fly   626 KTTMAQQKPKMITTTTLSSQAALQMHHALI-------QDSSADKAGSSANSGSATSGASMQLKLT 683
            ..|.|...|....|.....::|...:...:       ::.:|..|..:.:||        :.:..
Human   375 SATFAHTPPPAQATPAPGFKSAFSPYQTPVAHFPPPPEEPTATAAFGARDSG--------EFRRA 431

  Fly   684 TANTPTKLSVSLAPDVVKLEEVGSESKAKLLVKQEAVVKDSTGTPTSEERAEEIGTPEKRLNANA 748
            .|..|                         |...|.:.|:..|||.        |.|....|:  
Human   432 PAPPP-------------------------LPPAEPLAKEKPGTPP--------GPPPPDTNS-- 461

  Fly   749 TMTAINQVQNQSANQIQMATSTSTASNPSTPNPTVNATPMNNQRSAAEDNALLKQLLQNNSSS-- 811
                     .:...:.....|.....:|.|  ||:.::|...::.....::.::.||:...:.  
Human   462 ---------MELGGRPTFGWSPEPCDSPGT--PTLESSPAGPEKPHDSLDSRIEMLLKEQRTKLL 515

  Fly   812 -----HSLNQISITSAHVGSASAS----APLSARKVINVRAPSMGKVR----SLEDQLARPV--- 860
                 .|..::.:..:.:.|:|:.    ||.........|.|:....|    .|||....|:   
Human   516 FLREPDSDTELQMEGSPISSSSSQLSPLAPFGTNSQPGFRGPTPPSSRPSSTGLEDISPTPLPDS 580

  Fly   861 -------------IPPVPTATQAAGSSSSSGSVATS-----TTTTT-----VASGGSSQQVATAS 902
                         .||.|.....||..|.:..||..     |.|:.     ..|.|...:::...
Human   581 DEDEELDLGLGPRPPPEPGPPDPAGLLSQTAEVALDLVGDRTPTSEKMDEGQQSSGEDMEISDDE 645

  Fly   903 ATALPVSAV-----AITTPGVGGEAKLEQKSDQPAAIMQNQSQNQAPP-----PPPPPQQQQQQQ 957
            ..:.|:::.     .:.|||....|        ..:::........||     |||||....|..
Human   646 MPSAPITSADCPKPMVVTPGAAAVA--------APSVLAPTLPLPPPPGFPPLPPPPPPPPPQPG 702

  Fly   958 LHQPQQLQPSPHQVKQTVQIVSKETSFISGPVAAKTLVTEATSKPAELLPPPPYEMATAPISNVT 1022
            ...|..|.|.|                                      ||||            
Human   703 FPMPPPLPPPP--------------------------------------PPPP------------ 717

  Fly  1023 ISISTKQAAPKELQMKPKAVAMSLPMEQGDESLPEQAEPPLHSEQGATAAGVAPHSGGPLVSAQW 1087
                            |...|:::|            .|||.:..|.....:.|    ||.    
Human   718 ----------------PAHPAVTVP------------PPPLPAPPGVPPPPILP----PLP---- 746

  Fly  1088 TNNHLEGGVATTKIPFKPGEPQKRKLPMHP--QLDEKQI--QQQAEIPISTSLPT-----TPTGQ 1143
                          ||.||        :.|  |:|...:  .|...:|:|..:.|     ..|||
Human   747 --------------PFPPG--------LFPVMQVDMSHVLGGQWGGMPMSFQMQTQVLSRLMTGQ 789

  Fly  1144 GTPDKVQLISAIATYVKKSGVPNEAQPIQNQSQGQVQMQAQMQATMQGHLSGQMSGQISGHAAGQ 1208
            |.......::|.|                      ....|.:|........|..|...||...||
Human   790 GACPYPPFMAAAA----------------------AAASAGLQFVNLPPYRGPFSLSNSGPGRGQ 832

  Fly  1209 IPAQMHLQVQHQLHMAVHPQQQQQQLHQNQPQNATIPLPVTGQGAVPIPVPTMES---------- 1263
                 |.....:...:|.|.....:  |..|..||:      .|.:.:.:..:::          
Human   833 -----HWPPLPKFDPSVPPPGYMPR--QEDPHKATV------DGVLLVVLKELKAIMKRDLNRKM 884

  Fly  1264 ------KAGDQRKRRKREVQKPRRTNLNAGQAGGALKDLTGPLPAGAMVQLAGMPPGTQYIQGAA 1322
                  :|.|:...:|..:.|...|.:.:|:.    ||...|.|...:...              
Human   885 VEVVAFRAFDEWWDKKERMAKASLTPVKSGEH----KDEDRPKPKDRIASC-------------- 931

  Fly  1323 SGTGHVITSTGQGVTLG------GVGASTGASSSPMLK---------------KRVRKFSKV-EE 1365
                 ::.|.|:|..||      |:|. .||...|..|               ||:|..:.| ||
Human   932 -----LLESWGKGEGLGYEGLGLGIGL-RGAIRLPSFKVKRKEPPDTTSSGDQKRLRPSTSVDEE 990

  Fly  1366 DHDAFTEK------------------LLTHIRQMQPLQVLEPHLNRNFHFLIGSNETSGGGSPAS 1412
            |.::..|:                  :....|..:||                  |...||....
Human   991 DEESERERDRDMADTPCELAKRDPKGVGVRRRPARPL------------------ELDSGGEEDE 1037

  Fly  1413 MSSAASAGSSSAGGGKLKGGSRGWPLSRHLEGLEDCDGTVLGRYGRVNLPGIPSLYDSERFGGSR 1477
            ..|.:::.||||...  .|.|...|.|...:..|:.:.|.......          :.|.....|
Human  1038 KESLSASSSSSASSS--SGSSTTSPSSSASDKEEEQESTEEEEEAE----------EEEEEEVPR 1090

  Fly  1478 GLVGGSARTRSPSPAESPGAEKMLPMSSIQNDFYDQEFSTHMERNPRERLVRHIGAVKDCNLETV 1542
            ..:..|: |.|.|..:....:.. .....:||..|...|...|::..:          ....|||
Human  1091 SQLSSSS-TSSTSDKDDDDDDSD-DRDESENDDEDTALSEASEKDEGD----------SDEEETV 1143

  Fly  1543 DLVESEGVAAWATLPRLTRYPGLILLNGNSRCHGRMSPVALP-----EDPLTMRFPVSPLLRSCG 1602
            .:|.|:..|..::             ..:.......|..:.|     |:.:..|           
Human  1144 SIVTSKAEATSSS-------------ESSESSEFESSSESSPSSSEDEEEVVAR----------- 1184

  Fly  1603 EELRKTQQMEL-------GMGPLGNNNNNNYQQKNQNVILALPASASENIAGVLRDLANLLHLAP 1660
            ||..:.::.|:       ..||      .:::|..:...||..|.|.::: |:..::       .
Human  1185 EEEEEEEEEEMVAEESMASAGP------EDFEQDGEEAALAPGAPAVDSL-GMEEEV-------D 1235

  Fly  1661 ALTCKIIEDKIGNKLEDQFMNQDDEKHVDFKRP-----LSQ-----VSHGHLRKILNGRRKLCRS 1715
            ..|..:..::..:.|::..:....|:..|.:.|     |||     :|.....|.:..|..|...
Human  1236 IETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPLSPE 1300

  Fly  1716 CGNVVHATGLRVPRHSVPALEEQLPRLAQL-------MDMLPRKSVPPPFVYFCDRACFARFKWN 1773
                      |.|.|.: .:|.:.|.:..|       ....||...|||               .
Human  1301 ----------RAPEHDL-EVEPEPPMMLPLPLQPPLPPPRPPRPPSPPP---------------E 1339

  Fly  1774 GKDGQAEAASLLLQPAG-----------GSAVKSSNGDSPGSFCASSTAPAEMVVKQEPEDEDE- 1826
            .:...|...|:..:|..           ||..||.         ::.|.||      .|..|.. 
Human  1340 PETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKSQ---------STETVPA------TPGGEPPL 1389

  Fly  1827 ---------KTPSVPGNPTNIPAQRKCIV---------KCFSADCFT-TDSAPSGLELDGTAGAG 1872
                     .:|.|||:|.:.||....:.         :.||   || |.|.|||..|.......
Human  1390 SGGSSGLSLSSPQVPGSPFSYPAPSPSLSSGGLPRTPGRDFS---FTPTFSEPSGPLLLPVCPLP 1451

  Fly  1873 TG-----AGPVNNTVWETETSGLQLEDTRQCVFCNQRGDGQADGPSRLLNFDVDKWVHLNCALWS 1932
            ||     :||:.:.|. .|| ||.|                   |..|.       :.|..||  
Human  1452 TGRRDERSGPLASPVL-LET-GLPL-------------------PLPLP-------LPLPLAL-- 1486

  Fly  1933 NGVYETVSGALMNFQTALQAGLSQACSACHQPGATIKCFKSRCNSLYHLPCAIREECVFYKNKSV 1997
                ..|..|.....|.|...|....::|..|      .|.:.......|.::            
Human  1487 ----PAVLRAQARAPTPLPPLLPAPLASCPPP------MKRKPGRPRRSPPSM------------ 1529

  Fly  1998 HCSVHGHAHAGITMGAGAGATTGAGLGGSVADNELSSLVVHRR--VFVDRDENRQVATVMHYSEL 2060
             .|:.|..         .....||.||     .||..|....:  ||....:.|.|         
Human  1530 -LSLDGPL---------VRPPAGAALG-----RELLLLPGQPQTPVFPSTHDPRTV--------- 1570

  Fly  2061 SNLLRVGNMTFLNVG-----QLLPHQLEAFHTPHYIYP--IGYK--------------------- 2097
                   .:.|.|.|     ..||.|......|..:.|  :.:|                     
Human  1571 -------TLDFRNAGIPAPPPPLPPQPPPPPPPPPVEPTKLPFKELDNQWPSEAIPPGPRGRDEV 1628

  Fly  2098 --------VSRYYWCVRRPNRRCRYICSIAEAGCKPEFRIQVQDAGDKEPEREFRGSSPSAVWQQ 2154
                    .||..|  |||.:: |:...:..|| .||.                   ||.   |.
Human  1629 TEEYMELAKSRGPW--RRPPKK-RHEDLVPPAG-SPEL-------------------SPP---QP 1667

  Fly  2155 ILQPITRLRKVHKWLQLFPQHISGEDLFGLTEPAIVRILESLPGIETLTDYRFKYGRNPLLEFPL 2219
            :.:|.:...::.....::...|..||:..|. ....|:|:...|::.|.|..:.|  :|......
Human  1668 LFRPRSEFEEMTILYDIWNGGIDEEDIRFLC-VTYERLLQQDNGMDWLNDTLWVY--HPSTSLSS 1729

  Fly  2220 A---------------------------------INPSGAARTEP--KQRQLLVWRKPHTQRTAG 2249
            |                                 :|.|.|:..||  ..:.:.:..:||....||
Human  1730 AKKKKRDDGIREHVTGCARSEGFYTIDKKDKLRYLNSSRASTDEPPADTQGMSIPAQPHASTRAG 1794

  Fly  2250 SCSTQRMANSAAIAGEVACPYSKQFVHSKSSQYKKMKQEWRNNVYLARSKIQGLGLYAARDIEKH 2314
            |   :|.:....:............:.....:::|.|.::      .:|.|...||:|...|...
Human  1795 S---ERRSEQRRLLSSFTGSCDSDLLKFNQLKFRKKKLKF------CKSHIHDWGLFAMEPIAAD 1850

  Fly  2315 TMIIEYIGEVIRTEVSEIREKQYESKNRG-IYMFRLDEDRVVDATLSGGLARYINHSCNPNCVTE 2378
            .|:|||:|:.||..::::|||:||.:..| .||||:|.|.::|||..|..||:|||||||||..:
Human  1851 EMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAK 1915

  Fly  2379 IVEVDRDVRIIIFAKRKIYRGEELSYDYKFDIEDESHKIPCACGAPNCRKWMN 2431
            ::.|:...:|:|::|:.|...||::|||||.|||.  ||||.||:.|||..:|
Human  1916 VITVESQKKIVIYSKQHINVNEEITYDYKFPIEDV--KIPCLCGSENCRGTLN 1966

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513
ePHD2_KMT2C_like 1898..2002 CDD:277136 15/103 (15%)
FYRN 2068..2118 CDD:283589 16/85 (19%)
FYRC 2126..2215 CDD:197781 16/88 (18%)
SET <2266..2431 CDD:225491 66/165 (40%)
SET 2291..2413 CDD:214614 54/122 (44%)
PostSET 2415..2431 CDD:214703 9/15 (60%)
SETD1BNP_001340274.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
RRM_Set1B 101..193 CDD:240993
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 235..302 16/74 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 357..660 57/368 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 675..719 16/109 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 963..1462 113/622 (18%)
Trypan_PARP <1237..1308 CDD:330686 15/81 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1501..1541 7/67 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1555..1606 12/66 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1636..1668 14/57 (25%)
N-SET 1679..1821 CDD:314603 23/147 (16%)
WDR5 interaction motif (WIN). /evidence=ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:22665483 1745..1750 0/4 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1767..1800 10/35 (29%)
SET 1834..1949 CDD:214614 53/114 (46%)
PostSET 1950..1966 CDD:214703 9/17 (53%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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