DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trr and Setd1b

DIOPT Version :9

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:XP_006530300.1 Gene:Setd1b / 208043 MGIID:2652820 Length:1986 Species:Mus musculus


Alignment Length:2294 Identity:436/2294 - (19%)
Similarity:700/2294 - (30%) Gaps:767/2294 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   454 GLAPPTGSIVTITTTNPSQTYAMVQDSATVGPAAHSEDDAPAPRKITAYSENLQKILNKSKSQES 518
            |:|    .:|..|.....:....:..::.:|...|.|.|.....::..|     ::|...:....
Mouse   144 GIA----KVVFATVRGAKEAVQHLHSTSVMGNIIHVELDTKGETRMRFY-----ELLVTGRYTPQ 199

  Fly   519 TGGPEEFTNINSVVIKPLDKNTLNCPPSFNIFKQQQHSQAAQSQSISAVGSGAGTPVTFTMASGN 583
            |....|..     .|.|:...||....:....|....|....|.|.|...:..|||  |:..:..
Mouse   200 TLPVGELD-----AISPIVSETLQLSDALKRLKDGSLSAGCGSGSSSVTPNSGGTP--FSQDTAY 257

  Fly   584 ASDLATTSTVSVSAGTICINSPMMGTRPI-----ISIQNKNISLVLSK----TTMAQQKPKMITT 639
            :|....|.. |...||..  :|.:|| |.     .|.:....|.:.|:    |..|::.....|.
Mouse   258 SSCRLDTPN-SYGQGTPI--TPRLGT-PFSQDSSYSSRQPTPSYLFSQDPTATFKARRHESKFTD 318

  Fly   640 TTLSSQAALQMHHALIQDSSADKAGSS------ANSGSATSGASMQLKLTTANTPTKLSVSLA-- 696
            ..........:|::.:..::|...|||      ..|......|..|...|.|:||.....:.|  
Mouse   319 AYNRRHEHHYVHNSAVAGATAPFRGSSDLSFGTVGSSGTPFKAQSQDATTFAHTPPPAQTATASG 383

  Fly   697 -------------PDVVKLEE------VGSESKAKL--------LVKQEAVVKDSTGTPTSEERA 734
                         |.....||      .||....:.        |...|...|:..|||.     
Mouse   384 FKSAFSPYQTPAPPFPPPPEEPTATAAFGSRDSGEFRRAPAPPPLPPAEPPAKEKPGTPP----- 443

  Fly   735 EEIGTPEKRLNANATMTAINQVQNQSANQIQMATSTSTASNPSTPNPTVNATPMNNQRSAAEDNA 799
               |.|....|:           .:...:.....|.....:|.|  ||:.::|...::.....::
Mouse   444 ---GPPPPDSNS-----------MELGGRPTFGWSPEPCDSPGT--PTLESSPAGPEKPHDSLDS 492

  Fly   800 LLKQLLQNNSS-------SHSLNQISITSAHVGSASAS-APLS---ARKVINVRAPSMGKVR--- 850
            .::.||:...:       ..|..:|.:..:.:.|:|:. :|||   .......|.||....|   
Mouse   493 RIEMLLKEQRTKLPFLREQDSDTEIQMEGSPISSSSSQLSPLSHFGTNSQPGFRGPSPPSSRPSS 557

  Fly   851 -SLEDQLARPV----------------IPPVPTATQAAGSSSSSGSV----ATSTTTTT------ 888
             .|||....|:                .||.|......|....:..|    |...|.|:      
Mouse   558 TGLEDISPTPLPDSDEDEDLGLGLGPRPPPEPGPPDPMGLLGQTAEVDLDLAGDRTPTSERMDEG 622

  Fly   889 VASGGSSQQVATASATALPVSAV-----AITTPGVGGEAKLEQKSDQPAAIMQNQSQNQAPP--- 945
            ..|.|...:::.....:.|:::.     .:.|||.|..|       .|..:..|.   ..||   
Mouse   623 QQSSGEDMEISDDEMPSAPITSADCPKPMVVTPGAGAVA-------APNVLAPNL---PLPPPPG 677

  Fly   946 ----PPPPPQQQQQQQLHQPQQLQPSPHQVKQTVQIVSKETSFISGPVAAKTLVTEATSKPAELL 1006
                |||||....|.....|..|.|.|.........|:.....:..|...         .|..:|
Mouse   678 FPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPPGV---------PPPPIL 733

  Fly  1007 PP-PPYEMATAPISNVTIS-ISTKQ--AAPKELQMKPKAVAMSLPMEQGDESLPEQAEPPLHSEQ 1067
            || ||:.....|:..|.:| :...|  ..|...||:.:.::.   :..|..:.|   .||.    
Mouse   734 PPLPPFPPGLFPVMQVDMSHVLGGQWGGMPMSFQMQTQMLSR---LMTGQGACP---YPPF---- 788

  Fly  1068 GATAAGVAPHSGGPLVSAQWTNNHLEGGVATTKIPFK-----PGEPQKRKLPMHPQLDEKQIQQQ 1127
              .||..|..|.|    .|:.|      :...:.||.     ||..|  ..|..|:.|       
Mouse   789 --MAAAAAAASAG----LQFVN------LPPYRSPFSLSNSGPGRGQ--HWPPLPKFD------- 832

  Fly  1128 AEIPISTSLPTTPTG----QGTPDKVQLISAIATYVKKSGVPNEAQPIQNQSQGQVQMQAQMQAT 1188
                  .|:|  |.|    |..|.|..:...:...:|                       :::|.
Mouse   833 ------PSVP--PPGYIPRQEDPHKATVDGVLLVVLK-----------------------ELKAI 866

  Fly  1189 MQGHLSGQMSGQISGHAAGQIPAQMHLQVQHQLHMAVHPQQQQQQLHQNQPQNAT---------- 1243
            |:..|:.:|...::..|..    :...:.:.....::.|.:..:...:::|:...          
Mouse   867 MKRDLNRKMVEVVAFRAFD----EWWDKKERMAKASLTPVKSGEHKDEDRPKPKDRIASCLLESW 927

  Fly  1244 ----------IPLPVTGQGAVPIP-------VPTMESKAGDQRKRR--------KREVQKPRRTN 1283
                      :.|.:..:||:.:|       .|...:.:|||::.|        ..|.::.|..:
Mouse   928 GKGEGLGYEGLGLGIGLRGAIRLPSFKVKRKEPPDTASSGDQKRLRPSTSVDEEDEESERERDRD 992

  Fly  1284 LNAGQAGGALKDLTGPLPAGAMV-QLAGMPPGTQYIQGAASGTGHVITSTGQGVTLGGVGASTGA 1347
            :     ..|..:||...|....| :..|.|  .:...|........::::.........|:||.:
Mouse   993 I-----ADAPCELTKRDPKSVGVRRRPGRP--LELDSGGEEDEKESLSASSSSSASSSSGSSTTS 1050

  Fly  1348 SSSPMLKKRVRKFSKVEEDHDAFTEKLLTHIRQMQPLQVLEPHLNRNFHFLIGSNETSGGGSPAS 1412
            .||....|........||:.:...|:                           :.|....|..:.
Mouse  1051 PSSSASDKEEEDRESTEEEEEEEEEE---------------------------AEEEEEEGPRSR 1088

  Fly  1413 MSSAASAGSS---------SAGGGKLKG--GSRGWPLSRHLE------GLEDCDGTVLGRYGRVN 1460
            :||.:|:.||         :...|::..  ..:|.|||...|      ..|:.:.....:     
Mouse  1089 ISSPSSSSSSDKDDEDDNEADSDGQIDSDIDDQGAPLSEASEKDNGDSEEEETESITTSK----- 1148

  Fly  1461 LPGIPSLYDSERFGGSRGLVGGSARTRSPSPAES-----PG------------------------ 1496
            .|...|...||..|.|.......:.:.|.|..:.     ||                        
Mouse  1149 APAESSSSSSESSGSSEFESSSESESSSSSSEDEEEMTVPGVEEEEEEEEEEEKETAMAAATVVA 1213

  Fly  1497 -AEKMLPMSSIQNDFYDQEFSTHMERNPRERLVRHIGAVKDCNLETVDLVESEGVAAWATLPRLT 1560
             ||:.:|.:..| ||  ::....:...||..:...:|..::.::|..|.|..      ...|.|.
Mouse  1214 MAEESMPPAGGQ-DF--EQDRAEVPLGPRGPMRESLGTEEEVDIEAEDEVPE------MQAPELE 1269

  Fly  1561 RYPGLILLNGNSRCHGRMSPVALPEDP---------LTMRFPVSPLLRSCGEELRKTQQMELGMG 1616
            ..|   |..|..:..|...|   ||:|         |:...|.           |:|::.:|...
Mouse  1270 EPP---LPMGARKLEGSPEP---PEEPGPNTQGDMLLSPELPA-----------RETEEAQLPSP 1317

  Fly  1617 PLGNNNNNNYQQKNQNVILALPASASENIAGVLRDLANLLHLAPALTCKIIEDKIGNKLEDQFMN 1681
            |.....::...:.....:|:||                   |.|.|                   
Mouse  1318 PEHGPESDLDMEPEPPPMLSLP-------------------LQPPL------------------- 1344

  Fly  1682 QDDEKHVDFKRPLSQVSHGHLRKILNGRRKLCRSCGNVVHATGLRVPRHSVPALEEQLPRLAQLM 1746
                       |..::                           ||.|.   |..|.:.|.     
Mouse  1345 -----------PPPRL---------------------------LRPPS---PPPEPETPE----- 1363

  Fly  1747 DMLPRKSV---PPPFVYFCDRACFARFKWNGKDGQAEAASLLLQPAGGSAVKSSNGDSPGSFCAS 1808
              .|:..|   |||                 :|.......|.     ||..||.         ::
Mouse  1364 --PPKPPVPLEPPP-----------------EDHPPRTPGLC-----GSLAKSQ---------ST 1395

  Fly  1809 STAPA----EMVVKQEPEDEDEKTPSVPGNPTNIPAQRKCIV---------KCFSADCFT-TDSA 1859
            .|.||    |..:..........:|.|||:|.:.|:....:.         :.||   || |...
Mouse  1396 ETVPATPGGEPPLSGSSSGLSLSSPQVPGSPFSYPSPSPGLSSGGLPRTPGRDFS---FTPTFPE 1457

  Fly  1860 PSGLELDGTAGAGTG-----AGPVNNTVWETETSGLQL--------------------------- 1892
            |||..|.......||     .||:.:.|. .|| ||.|                           
Mouse  1458 PSGPLLLPVCPLPTGRRDERTGPLASPVL-LET-GLPLPLPLPLPLPLALPVPVLRAQPRPPPQL 1520

  Fly  1893 -----EDTRQCVFCNQRGDGQ-ADGPSRLLNFDVDKWVHLNCALWSNGVYETVSGALMNFQTALQ 1951
                 .....|....:|..|: ...|..:|:.|             ..:.....|..:.....|.
Mouse  1521 PPLLPATLAPCPTPIKRKPGRPRRSPPSMLSLD-------------GPLVRPPPGPALGRDLLLL 1572

  Fly  1952 AGLSQACSACHQPGATIKCFKSRCNSLYHLPCAIREECVFYKNKSVHC----------------S 2000
            .|         ||.|.|  |.|.     |.|.|:..:   ::|..:..                .
Mouse  1573 PG---------QPPAPI--FPSA-----HDPRAVTLD---FRNTGIPAPPPPLPPQPPPPPPPPP 1618

  Fly  2001 VHGHAHAGITMGAGAGATTGAGLGGSVADNELSSLVVHRRVFVDRDENRQVATVMHYSELSNLLR 2065
            |.                                                 :|.:.:.||.|   
Mouse  1619 VE-------------------------------------------------STKLPFKELDN--- 1631

  Fly  2066 VGNMTFLNVGQLLPHQLEAFHTPHYIYPIGYK---VSRYY---WCVRRPNRRCRYICSIAEAGCK 2124
                                ..|....|.|.:   |:..|   ..||.|.||            .
Mouse  1632 --------------------QWPSEAIPPGPRRDEVTEEYVDLAKVRGPWRR------------P 1664

  Fly  2125 PEFRIQVQDAGDKEPEREFRGSSPSAVWQQILQPITRLRKVHKWLQLFPQHISGEDLFGLTEPAI 2189
            |:.|.:...|....||     .||.   |.:.:|.:...::.....::...|..||:..|. ...
Mouse  1665 PKKRHEDLVAPSASPE-----PSPP---QPLFRPRSEFEEMTILYDIWNGGIDEEDIRFLC-VTY 1720

  Fly  2190 VRILESLPGIETLTDYRFKYGRNPLLEFPLA---------------------------------I 2221
            .|:|:...|::.|.|..:.|  :|......|                                 :
Mouse  1721 ERLLQQDNGMDWLNDTLWVY--HPSTSLSSAKKKKREDGIREHVTGCARSEGFYTIDKKDKLRYL 1783

  Fly  2222 NPSGAARTEP---KQRQLLVWRKPHTQRTAGSCSTQRMANSAAIAGEVACPYSKQFVHSKSSQYK 2283
            |.|.|:..||   .|:.:.:..:||....|||   :|.:....:............:.....:::
Mouse  1784 NSSRASTDEPPMDTQQGMSIPAQPHASTRAGS---ERRSEQRRLLSSFTGSCDSDLLKFNQLKFR 1845

  Fly  2284 KMKQEWRNNVYLARSKIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQYESKNRG-IYMF 2347
            |.|.::      .:|.|...||:|...|....|:|||:|:.||..::::|||:||.:..| .|||
Mouse  1846 KKKLKF------CKSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMF 1904

  Fly  2348 RLDEDRVVDATLSGGLARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGEELSYDYKFDIED 2412
            |:|.|.::|||..|..||:|||||||||..:::.|:...:|:|::|:.|...||::|||||.|||
Mouse  1905 RVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSKQHINVNEEITYDYKFPIED 1969

  Fly  2413 ESHKIPCACGAPNCRKWMN 2431
            .  ||||.||:.|||..:|
Mouse  1970 V--KIPCLCGSENCRGTLN 1986

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513
ePHD2_KMT2C_like 1898..2002 CDD:277136 19/120 (16%)
FYRN 2068..2118 CDD:283589 10/55 (18%)
FYRC 2126..2215 CDD:197781 19/88 (22%)
SET <2266..2431 CDD:225491 66/165 (40%)
SET 2291..2413 CDD:214614 54/122 (44%)
PostSET 2415..2431 CDD:214703 9/15 (60%)
Setd1bXP_006530300.1 RRM_Set1B 100..192 CDD:240993 9/56 (16%)
N-SET 1698..1841 CDD:371711 24/148 (16%)
SET_SETD1 1835..1982 CDD:380946 64/154 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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