DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trr and Ash1l

DIOPT Version :9

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:NP_619620.3 Gene:Ash1l / 192195 MGIID:2183158 Length:2958 Species:Mus musculus


Alignment Length:2768 Identity:510/2768 - (18%)
Similarity:876/2768 - (31%) Gaps:886/2768 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 DPTRKKAKTELLLGTGTAAPSLPAKASSTA-PQQLLYQRSGQQAKAQVKAASEPQD--------- 102
            ||     :...:||.|:.:.....|:.||. |..|..:|     :|:::.|:|.:|         
Mouse     2 DP-----RNTAMLGLGSDSEGFSRKSPSTINPGTLASKR-----EAEIEGATEEEDPRKRNRERG 56

  Fly   103 --VETADGVWDARDQ-QIIVCNFGSGT---EMG--AIKAEDADKQSEYRISTPRNSQSNPLLHRN 159
              ....||..||:.| .:...||..|.   ::|  |.:.:...|..|..:..|  :....:.|..
Mouse    57 TEAGKEDGSTDAQQQFSVKETNFSEGNLKLKIGLQAKRTKKPPKNLENYVCRP--AIKTTIKHSR 119

  Fly   160 TAFTS----FTKKEGASSSASSS---SSTASVISIEPSGSGQDHAENSGKSEDLDYVLMPASG-- 215
            .|..|    ..|.|...|...||   .......:|:.......|..:.|:|..|...|.|...  
Mouse   120 KALKSGKMTDEKNEHCPSKWDSSKLFKKAGDATAIDCQAEESIHLHSQGESNPLSKKLSPVHSQM 184

  Fly   216 ADSSTSVGNSTGTGTP---------AGTPIGATTSTIILNANNGTAGVS-----GAGTTTILTQK 266
            ||..::..:..|:..|         .||.:....:.:|.......:..:     |.|||..|..|
Mouse   185 ADYISAAPSLVGSRDPDIKDRALLNGGTSVTEKLAQLIATCPPSKSSKAKPKKLGTGTTVGLVSK 249

  Fly   267 SGHTNYNIFNTTATGS-----------QTPTTTLLNRVNLHPKMKTQLMVNAKKLSEVTQTTAKV 320
                  ::......||           :...:|.:..|...|..|.  |.|| .:..:.:.:.| 
Mouse   250 ------DLIRKPGVGSIAGIIHKDLIKKPALSTAVGLVTKDPGKKP--MFNA-AVGLINKDSVK- 304

  Fly   321 SIGNKTISVPLLKPLMSASGAATAGGATIVESKQLLQPGGQVTTVMSAAQQSGGQQVHPHVHSHA 385
            .:|..|.:|.:.|.|....||.|..|....||.:.|..|    .|.....:..|:::       .
Mouse   305 KLGTGTTAVFINKDLGKKPGAITTVGLLSKESGKKLGIG----IVPGLVNKESGKKL-------G 358

  Fly   386 HHNFTKLIKR--GPKNSGTIVSFSGLQIKPANTKIVAT-------KVVSKKMLQLQQHQQQIQQQ 441
            ......|:.:  |.|.|.|:    ||..|....||||:       |.:.||:|.           
Mouse   359 LGTVVGLVNKELGKKLSSTV----GLVAKDVTKKIVASSAMGLVNKDIGKKLLN----------- 408

  Fly   442 QQLQQLQVTSGGGLAPPTGSIVTITTTN-------PSQTYAMVQDSATVGPAAHSEDDAPAPRKI 499
                          .|..|.:.:....|       |:|.......||.:  :.|...:.|...|.
Mouse   409 --------------CPMAGQLGSKDALNLKSEALLPTQEQLKASCSANI--SNHDSQELPESLKD 457

  Fly   500 TAYSENLQK-ILNKSKSQ--ESTGGPEEFTNINSVVIKPLDKNTLN---CPPSFNIFKQQQHSQA 558
            :|..:..:| ::..||..  |.....:|.||        |:|...|   |       .||.:..:
Mouse   458 SATGKAFEKSVMRHSKESMLEKFSVRKEITN--------LEKEMFNEGTC-------IQQDNFSS 507

  Fly   559 AQSQSISAVGSGAGTPVTFTMAS---GNASDLATT---------STVSVSAGTICINSPMMGTRP 611
            ::..:..........||..|...   |.|||.:|.         |.:..|:.|:.:| |:..:.|
Mouse   508 SERGAFETSKHEKQPPVYCTSPDFQIGGASDASTAKSPFSAVGESNLPSSSPTVSVN-PVTRSPP 571

  Fly   612 IISIQNKNISLVLSKTTMAQQKPKMITTTTLSSQAALQMH---------HAL------------- 654
            ..|.|.....|:|:.|  |:|..::..:...|...|...|         |:|             
Mouse   572 EASSQLVPNPLLLNST--AEQMEEISESIGKSQFTAESTHLNVGHRSLGHSLSIECKGIDKELNE 634

  Fly   655 ----------IQDSSADKAGSSANSG-SATSGASMQLKLTTANTP-TKLSVSLAPD--VVKLEEV 705
                      |..|...|...:::|| .|.:.:.:......:|.| .||....|||  ....|.:
Mouse   635 SKNTHLDIPRISSSLGKKPSLTSDSGIHAITPSVVNFTSLFSNKPFLKLGAVTAPDKHCQVAESL 699

  Fly   706 GSESKAKLLVKQ--------EAVVKDSTGTP--TSEERAEEIGTPEKRLNANATMTAINQVQNQS 760
            .|..::|.|.|:        :.|.:.:..:|  ...||:|        |..|.:           
Mouse   700 SSSFQSKPLKKRKGRKPRWTKVVARSTCRSPKGLDLERSE--------LFKNVS----------- 745

  Fly   761 ANQIQMATSTSTASNPSTPNPTVNATPMNNQRSAAEDNALLKQLLQNNSSSHSLNQISITSAHVG 825
                  .:|.|.:|.|:....|:.|       |:..|:..||:.|...|.|.:.:...:|.:...
Mouse   746 ------CSSLSNSSEPAKFMKTIGA-------SSFVDHDFLKRRLPKLSKSSAPSLALLTDSEKP 797

  Fly   826 S--------ASASAPLSARKVINVRAPSMGKVRSLE-DQLARPVIPPVPTATQAAGSSSSSGSVA 881
            |        .|:|..:::..:.::..|..|:.:|.| .||..|     |..|             
Mouse   798 SHKSFITHKLSSSMCVTSDLLSDIYKPKRGRPKSKEMPQLEGP-----PKRT------------- 844

  Fly   882 TSTTTTTVASGGSSQQVATASATALPVSAVAITTPGVGGEAKLEQKSDQPAAIMQNQ------SQ 940
                                  ..:|.|.|          ..|:.|.:|...|:|.:      .|
Mouse   845 ----------------------LKIPASKV----------FSLQSKEEQEPPILQPEIEIPSFKQ 877

  Fly   941 NQAPPPPPPPQQQQQQQLHQPQQLQPSPHQVKQTVQIVSKETSFISGPVAAKTLVTEATSKPAEL 1005
            :.:..|.|..:.:.::|:..|.:::|                                       
Mouse   878 SLSVSPFPKKRGRPKRQMRSPVKMKP--------------------------------------- 903

  Fly  1006 LPPPPYEMATAPISNVTISISTKQAAPKELQMKPKAVAMSLPMEQGDESLPEQAEPPLHSEQGAT 1070
                       |:.:|...::|:  :|.:|:.:.:....|....:.::.|  |....|......:
Mouse   904 -----------PVLSVAPFVATE--SPSKLESESENHRSSSDFFESEDQL--QDTDDLDDSHRQS 953

  Fly  1071 AAGVAPHSGGPLVSAQWTNNHLEGGVATTKIPFKPGEPQKRKLPMHPQLDEKQIQQQAEIPISTS 1135
            ...::.....|.......||   |.:..|.|         ||:.....|..|::..|.   :|:|
Mouse   954 VCSMSDLEMEPDKKISKRNN---GQLMKTII---------RKINKMKTLKRKKLLNQI---LSSS 1003

  Fly  1136 LPTTPTGQGTPDKVQ------LISAIATYVKKSGVPNEAQPIQNQSQGQVQMQAQM----QATMQ 1190
            :.::..|     |||      :.|..||:..|.|     |.|....:|.:.:..:.    :..:.
Mouse  1004 VESSNKG-----KVQSKLHNTVSSLAATFGSKLG-----QQINVSKKGTIYIGKRRGRKPKTVLN 1058

  Fly  1191 GHLSG---------QMSGQISGHAAGQIPAQMHLQVQHQLHMAVHPQQQQQQLHQNQPQNATIPL 1246
            |.|||         |.:.|.:|.|.|||...:                              :|.
Mouse  1059 GLLSGSPASLAVLEQTAQQAAGSALGQILPPL------------------------------LPS 1093

  Fly  1247 PVTGQGAVPIPVPTMESKAGDQRKRRKREVQKPRRTNLNAGQAGGALKDLTGPLPAGA-MVQLAG 1310
            |.:....:|.|:.:..|                       |.:||     ..|:.:.| .|:.:.
Mouse  1094 PASSSEILPSPICSQSS-----------------------GTSGG-----QSPVSSDAGFVEPSS 1130

  Fly  1311 MPPGTQYIQGAASGTGHVITSTGQGV-TLGGVGASTGASSSPMLKKRVRKFSKVEEDHDAFTEKL 1374
            :|    |:        ||.:..|..: ||....||.|       ::|:...:.:.......:|  
Mouse  1131 VP----YL--------HVHSRQGSMIQTLAMKKASKG-------RRRLSPPTLLPNSPSHLSE-- 1174

  Fly  1375 LTHIRQMQPLQVLEPHLNRNFHFLIGSNETSGGGSPASMSSAASAGSSSAGGGKLKGGSRGWPLS 1439
            ||.:::..|..|.|.|          |:||    .|:.........|:|....|..|..:.....
Mouse  1175 LTSLKEATPSPVSESH----------SDET----IPSDSGIGTDNNSTSDRAEKFCGQKKRRHSF 1225

  Fly  1440 RHLEGLEDCDGTVLGRYGRVNLPGIPSLYDSERFGGSRGLVGGSARTRSPSPAESPGAEKMLPMS 1504
            .|:..:.....|||.           ||.:..:.         ..:.||                
Mouse  1226 EHISLIPPETSTVLN-----------SLKEKHKH---------KCKRRS---------------- 1254

  Fly  1505 SIQNDF--YDQEFSTHMERNPRERLVRHIGAVKDCNLETVDLV-ESEGVAAWATLPRLTR----- 1561
               :|:  ||:     |:|..|:|..::   .:..|.:..|.: |.|.:.:..:..|:|.     
Mouse  1255 ---HDYLSYDK-----MKRQKRKRKKKY---PQLRNRQDPDFIAELEELISRLSEIRITHRSHHF 1308

  Fly  1562 -----YPGLILLNGNSRCHGRMSPVALPEDPL----------------TMRFPVS--PLLRSCGE 1603
                 .|.:..:|.||    ..:..:.|.|||                .||..::  |.:.|...
Mouse  1309 IPRDLLPTIFRINFNS----FYTHPSFPLDPLHYIRKPDLKKKRGRPPKMREAMAEMPFMHSLSF 1369

  Fly  1604 ELRKT----------QQMELGMGPLGNNNNNNY--------------------QQKNQNVILALP 1638
            .|..|          ....|...|:|......|                    ...:...:|..|
Mouse  1370 PLSSTGFYPSYGMPYSPSPLTAAPIGLGYYGRYPPTLYPPPPSPSFTTPLPPPSYMHAGHLLLNP 1434

  Fly  1639 ASASENIAGVLRDLANL-LHLAPALTCKII-----EDKIGNKLEDQFMNQDDEKHVDFKRPLSQV 1697
            ....:....:||..|.| ....|.|:....     |...|..:|.:..::  .||.:.:....||
Mouse  1435 TKYHKKKHKLLRQEAFLTTSRTPLLSMSTYPSVPPEMAYGWMVEHKHRHR--HKHREHRSEQPQV 1497

  Fly  1698 S--HGHLRKILNGRRKL------------------CR-SCGNVVHATGL---------RVPRHSV 1732
            |  .|..|.:|...::.                  |. ||.::..:..|         |.|..|.
Mouse  1498 SMDSGSSRSVLESLKRYRFGKDTVGDRYKHKEKHRCHMSCPHLSPSKNLINREEQWVSREPSESS 1562

  Fly  1733 P-ALEEQLPRLAQLMDMLPRKSVPPPFVYFCDRACFARFKWNGKDGQA-EAASLLLQPAGGSAVK 1795
            . ||..|.|......:..|..|:             ..|..|.:...: |..:|.....|...|.
Mouse  1563 SLALGLQTPLQIDCSESSPSLSL-------------GGFTPNSEPASSDEHMNLFTSAIGSCRVS 1614

  Fly  1796 SSNG-------DSPGSFCASSTAPAEMVVKQEPEDEDEKT-PSVPG--NPTNIPAQRKCIVKCFS 1850
            :.|.       ||||.|....|| .....::||....|:. .|:.|  :.::.|:||    ...|
Mouse  1615 NPNSSCRKKLTDSPGLFPVQDTA-LNRPHRKEPLPSSERAIQSLAGSQSASDKPSQR----SSES 1674

  Fly  1851 ADCFTTDSAPSGLELDGTAGAGTGAGPVNNTVWETETSGLQLEDTRQCVFCNQRGDGQADGPSRL 1915
            .:|..|....|......|         ||.....:......::|:...:.            .|:
Mouse  1675 TNCSPTRKRSSSESTSST---------VNGVPSRSPRLVASMDDSVDSLL------------QRI 1718

  Fly  1916 LNFDVDKWVHLNCALWSNGVYETVSGALMNFQTALQAGLSQACSACHQPGATIKCFKSRC----N 1976
            ::.|..:.:..|    .:....|||                 ......||.:..  |.|.    :
Mouse  1719 VHHDEQESMEKN----GDASITTVS-----------------APPSSSPGHSYS--KERALGKSD 1760

  Fly  1977 SLYHLPCAIREEC----VFYKNKSVHCSVHGHAHAGITMGAGAGATTGAGLGGSVADNELSSLVV 2037
            ||. :|....:.|    :..:..:..||.| |....:.               .....:...:..
Mouse  1761 SLL-VPAVPNDSCSNIPLLSEKSASRCSPH-HIKRSVV---------------EAMQRQARKMCN 1808

  Fly  2038 HRRVFVDRDENRQVATVMHYSELSNLLRVGNMTFLNVGQLLPHQ--------LEAFHTPHYIYP- 2093
            :.::...:.....|..::...:|....|.|| .|:......|.:        ::||....::.| 
Mouse  1809 YDKILATKKNLDHVNKILKAKKLQRQARTGN-NFVKRRPGRPRKCPLQAVVSMQAFQAAQFVSPE 1872

  Fly  2094 --IGYKVSRYYWCVRRPNRRCRYICSIAEA---------GCKPEFRIQVQDAGDKE---PEREFR 2144
              .|..:|.:.    .|:.....|.::.::         |.|.:..:..:....|:   ||.|.:
Mouse  1873 LNEGEDMSLHL----SPDTVTDVIEAVVQSVNLTSEHKKGVKRKNWLLEEQTRKKQKTVPEEEEQ 1933

  Fly  2145 GSSPSAVW------------------QQILQPITRL-----------RKVHKWLQLFPQHISGED 2180
            .::.|.:.                  :..|||:..|           :|.::...|:      .|
Mouse  1934 ENNKSFIETPVEIPSPLETPAEPSEPENTLQPVLALIPREKKAPRPPKKKYQRAGLY------SD 1992

  Fly  2181 LFGLTEP--AIVRI----LESLPGIETLTDYRFKYGRNPLLEFPLAINPSGAARTEPKQRQL--- 2236
            ::...:|  .::::    ||..||       ..:||.     ||..|:.....|.:....||   
Mouse  1993 VYKTIDPKSRLIQLKKEKLEYTPG-------EHEYGL-----FPAPIHVGKYLRQKRIDFQLPYD 2045

  Fly  2237 LVWRKPHTQ--------------------------RTAGSCSTQRMANSA--------------A 2261
            ::|:..|.|                          ..|.:|:.::..:..              |
Mouse  2046 ILWQWKHNQLYKKPDVPLYKKIRSNVYVDVKPLSGYEATTCNCKKPDDDTRKGCGDDCLNRMIFA 2110

  Fly  2262 IAGEVACPYSKQFVHSKSSQYKKMKQEWRNNVYLARSKIQGLGLYAARDIEKHTMIIEYIGEVIR 2326
            ......||..:|..:.:..::     ||...:...|::.:|.|:.....::....||||:|||:.
Mouse  2111 ECSPNTCPCGEQCCNQRIQRH-----EWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVS 2170

  Fly  2327 TEVSEIREKQYES--KNRGIYMFRLDEDRVVDATLSGGLARYINHSCNPNCVTEIVEVDRDVRII 2389
            .:  |.|.:..|.  .:...|...||...|:|:...|..||:|||||:|||..:...|:...||.
Mouse  2171 EQ--EFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIG 2233

  Fly  2390 IFAKRKIYRGEELSYDYKFDIEDESHKIPCACGAPNCR 2427
            ::|.:.:..|.||:|||.|...:...:..|.||...||
Mouse  2234 LYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCR 2271

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513 29/162 (18%)
ePHD2_KMT2C_like 1898..2002 CDD:277136 16/111 (14%)
FYRN 2068..2118 CDD:283589 10/60 (17%)
FYRC 2126..2215 CDD:197781 19/126 (15%)
SET <2266..2431 CDD:225491 50/164 (30%)
SET 2291..2413 CDD:214614 40/123 (33%)
PostSET 2415..2431 CDD:214703 5/13 (38%)
Ash1lNP_619620.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..78 20/85 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..137 5/20 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 505..580 16/75 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 823..843 8/24 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 877..963 15/139 (11%)
motB <1061..1187 CDD:183756 36/204 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1094..1126 9/59 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1149..1219 19/92 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1243..1279 9/71 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1579..1599 4/32 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1613..1704 24/104 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1722..1754 8/54 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1921..1941 5/19 (26%)
Catalytic domain. /evidence=ECO:0000250 2059..2278 53/220 (24%)
AWS 2082..2133 CDD:197795 6/55 (11%)
SET_ASH1L 2136..2276 CDD:380951 45/138 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2278..2334
Bromo_ASH1 2432..2537 CDD:99955
PHD_ASH1L 2575..2617 CDD:277023
BAH_polybromo 2654..2788 CDD:240068
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2814..2846
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2861..2909
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.940

Return to query results.
Submit another query.