DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trr and Nsd1

DIOPT Version :9

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:NP_032765.3 Gene:Nsd1 / 18193 MGIID:1276545 Length:2691 Species:Mus musculus


Alignment Length:2609 Identity:494/2609 - (18%)
Similarity:796/2609 - (30%) Gaps:876/2609 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   137 DKQSEYRISTPRNSQSN---PLLHRNTAFTSFTKKEGASSSASSSSSTASVISIEPSGSGQDHAE 198
            ||.|.:     .|.|||   ||  ........|...|.|.:|....|.:..|.:.       ..:
Mouse    27 DKDSPF-----GNGQSNFSEPL--NGCTMQLPTAASGTSQNAYGQDSPSCYIPLR-------RLQ 77

  Fly   199 NSGKSEDLDYVLMPASGADSSTSVGNSTGTGTPAGTPIGATTSTIILNANNGTAGVSGAGTTTIL 263
            :.....:::|:   :..||.|.|..:...:.:.|.:||..|:             :|..|.|.:.
Mouse    78 DLASMINVEYL---SGSADGSESFQDPAKSDSRAQSPIVCTS-------------LSPGGPTALA 126

  Fly   264 TQK------SGHTNYNIFNTTATG-SQTPTTTLLNRVNLHPKMKTQLMV----NAKKLSEVTQTT 317
            .::      |......:..||..| ......|.::..::..:|..:..|    :.:::.|.|||.
Mouse   127 MKQEPTCNNSPELQLRVTKTTKNGFLHFENFTGVDDADVDSEMDPEQPVTEDESIEEIFEETQTN 191

  Fly   318 AKVSIGNKTISVPLLKPLMSASGAATAGGA---TIVESKQLLQPGGQVTTVMSAAQQSGGQQVHP 379
            |..:...|           |.:|...|.|:   ::.||:.    |......:..|.|:..|:...
Mouse   192 ATCNYEPK-----------SENGVEVAMGSEQDSMPESRH----GAVERPFLPLAPQTEKQKNKQ 241

  Fly   380 HVHSHAHHNFTKLIKRGPKNSGTIVSFSGLQIKPANTKIVATKVVSKKMLQLQQHQQQIQQQQQL 444
            .......:..|.|:                   ||.|.:..|.|.             :::|...
Mouse   242 RSEVDGSNEKTALL-------------------PAPTSLGDTNVT-------------VEEQFNS 274

  Fly   445 QQLQVTSGGGLAP-PTGSIVTIT-TTNP--SQTYAMVQDSATVGPAAHSEDD---APAPRK---- 498
            ..|........:| |.|:::.|. |::|  ||.....|......|..:...|   |...|:    
Mouse   275 INLSFQDDPDSSPSPLGNMLEIPGTSSPSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWP 339

  Fly   499 --------ITAYSENLQKILNKSKSQ----ESTGGPEE-----------------FTNINSVVIK 534
                    |..:|:  .|:.|:...:    |:.|.|.|                 |..:  .|::
Mouse   340 CRICSDPLINTHSK--MKVANRRPYREYYVEAFGDPSEKAWVAGKAIVMFEGRHQFEEL--PVLR 400

  Fly   535 PLDKNTLNCPPSFNIFKQQQHSQAAQSQSISAVGSGAGTPVTFTMASGNASDLATTSTVSVSAG- 598
            ...|.           |::.:......:.:|...:..|....:.:..|:.:....:|:|.:.:. 
Mouse   401 KRGKQ-----------KEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNQKCVSSSVKLDSEE 454

  Fly   599 ----TICINSPMMGTRPIISIQNKNISLVLSKTTMAQQKPKMITTTTLSSQAALQMHHALIQDSS 659
                ..|.|.|                          ....::....|.|.|....|.|..::..
Mouse   455 DMPFEDCTNDP--------------------------DSEHLLLNGCLKSLAFDSEHSADEKEKP 493

  Fly   660 ADKAGSSANSGSATSGASMQLKLTTANTPTKLSVSLAPDVVKLEEVGSESKAKLLVKQEAVVKDS 724
            ..|        |....:|..:|.|          |:..|:|..|....|.:.|        :.|:
Mouse   494 CAK--------SRVRKSSDNIKRT----------SVKKDLVPFESRKEERRGK--------IPDN 532

  Fly   725 TGTPTSEERAEEIGTPEKRLNANATMTAINQVQNQSANQIQMATSTSTASNPSTPNPTVNATPMN 789
            .|......     |..:|                |::|::....::.|.|               
Mouse   533 LGLDFISG-----GVSDK----------------QASNELSRIANSLTGS--------------- 561

  Fly   790 NQRSAAEDNALLKQLLQNNS----------SSHSLNQISITSAHVGSASASAPLSARKVINVRAP 844
               |.|..:.|....:||.:          |...|::.::.|.|.|......|            
Mouse   562 ---STAPGSFLFSSSVQNTAKTDFETPDCDSLSGLSESALISKHSGEKKKLQP------------ 611

  Fly   845 SMGKVRSLEDQLARPVIPPVPTATQAAGSSSSSGSVATSTTTTTVASGGSSQQVATASATALPVS 909
              |:|.|.:.||.         ...|......|.||:.|||    :..|.|....|...:....|
Mouse   612 --GQVCSSKVQLC---------YVGAGDEEKRSNSVSVSTT----SDDGCSDLDPTEHNSGFQNS 661

  Fly   910 AVAITTPGVGGEAKLEQKSDQPAAIMQNQSQNQAPPPPPPPQQQQQQQLHQPQQLQPSPHQVKQT 974
            .:.||        ....|::...::.:|::|....|                           .|
Mouse   662 VLGIT--------DAFDKTENALSVHKNETQYSRYP---------------------------VT 691

  Fly   975 VQIVSKETSFISGPVAAKTLVTEATSKPAELLPPPPYEMATAPISNVTISISTKQAAPKELQMKP 1039
            .:|..|:.|.|:...|...:.:..|.:|           .||.:|.|.:| ..|.::|       
Mouse   692 NRIKEKQKSLITNSHADHLMGSTKTMEP-----------ETAELSQVNLS-DLKISSP------- 737

  Fly  1040 KAVAMSLPMEQGDESLPEQAEPPLHSEQGATAAGVAP---HSGGPLVSAQWTNNHLEGGVAT-TK 1100
                  :|..|           |.....|.|....||   .:..||.         :||:|. |.
Mouse   738 ------IPKPQ-----------PEFRNDGLTTKFSAPPGIRNENPLT---------KGGLANQTL 776

  Fly  1101 IPFKPGEPQKRKLPMHPQLDEKQIQQQAEI-----PISTSLPTTPTGQGTPDKVQLISAIATYVK 1160
            :|.|..:|:.|.:    :...|:....||.     .:|....::.| .|:|         ...:.
Mouse   777 LPLKCRQPKFRSI----KCKHKESPAVAETSATSEDLSLKCCSSDT-NGSP---------LANIS 827

  Fly  1161 KSGVPNEAQPIQNQSQGQVQMQAQMQATMQGH------------LSGQMSGQISGHAAGQIPAQM 1213
            ||| ..|...:.|....:.:..:.::..:..|            ||..:|.  ||.|....|. :
Mouse   828 KSG-KGEGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLSEDVSD--SGTAKASKPL-L 888

  Fly  1214 HLQVQHQLHMAVHPQ-------QQQQQLHQNQPQNATIPLPVTGQGAVPIPVPTMESKAGDQRKR 1271
            ......|.|:.:.|.       ...:.:|                          :||..:||..
Mouse   889 FSSASSQNHIPIEPDYKFSTLLMMLKDMH--------------------------DSKTKEQRLM 927

  Fly  1272 RKREV---QKPRRTNLNAGQAGGALKDLTGPLPAGAMVQLAGMPPGTQYIQGAASGTGHVITSTG 1333
            ..:.:   :.|.|.:.::|...|..|.|.          |....|.::....:...:.|.....|
Mouse   928 TAQNLASYRTPDRGDCSSGSPVGTSKVLV----------LGSSTPNSEKPGDSTQDSVHQSPGGG 982

  Fly  1334 QGVTLGGVGASTGASSSPMLKKRVRKFSKVEED----HDAFTEKLLTHIRQMQPLQVLEPHLN-- 1392
            .....|.:.:|..:.:|.  |:.:....|:..:    .:....|..:.:|:....|:::|.:|  
Mouse   983 DSALSGELSSSLSSLASD--KRELPACGKIRSNCIPRRNCGRAKPSSKLRETISAQMVKPSVNPK 1045

  Fly  1393 -------RNFHFLIGSNETSGGGSPASMSSAASAGSSSAGGGKLKGGSRGW--------PL---- 1438
                   |.|..|           ||...:|...|:..:  |.:.|.|||.        ||    
Mouse  1046 ALKTERKRKFSRL-----------PAVTLAANRLGNKES--GSVNGPSRGGAEDPGKEEPLQQMD 1097

  Fly  1439 -----------------------SRHLE---GLEDCDGTVLG--------------------RYG 1457
                                   .::||   ..|:..|..||                    |:.
Mouse  1098 LLRNEDTHFSDVHFDSKAKQSDPDKNLEKEPSFENRKGPELGSEMNTENDELHGVNQVVPKKRWQ 1162

  Fly  1458 RVN----LPG--IPSLYDSERFGGSRGLVGGSARTRSPSPAESPGAEKML-----PMSSIQNDFY 1511
            |:|    .||  .....:.|...|:.|::       .|:.|.....|..|     |.|..::...
Mouse  1163 RLNQRRPKPGKRANRFREKENSEGAFGVL-------LPADAVQKAREDYLEQRAPPTSKPEDSAA 1220

  Fly  1512 DQEFSTHMER-NPRERLVRHIGAVKDCNLETVDL--VESEGVAAWATLPRLTRYPGLILLNGNSR 1573
            |....:|.|. .||         :..|...:|.:  ||.|           |..|.|        
Mouse  1221 DPNHGSHSESVAPR---------LNVCEKSSVGMGDVEKE-----------TGIPSL-------- 1257

  Fly  1574 CHGRMSPVALPEDPLTMRFPVSPLLRSCGEELRK--------TQQMELGMGPLGNNNNNNYQQKN 1630
                |....|||          |.:||..:.|||        |::.:....|      ...|:|.
Mouse  1258 ----MPQTKLPE----------PAIRSEKKRLRKPSKWLLEYTEEYDQIFAP------KKKQKKV 1302

  Fly  1631 QNVILALPASASENIAGVLRDLANLLHLAPALTCKIIEDK--IGNKLEDQFMNQDDEKHVDF-KR 1692
            |..:        ..::....|.:.|....|:...|.:::.  |..|.|...:    |:...| :.
Mouse  1303 QEQV--------HKVSSRCEDESLLARCQPSAQNKQVDENSLISTKEEPPVL----EREAPFLEG 1355

  Fly  1693 PLSQVSHGHLRKILNGRRKLCRSCGNVVHATGLRVPR--HSVPALEEQLPRLA----QLM----- 1746
            ||:|...|                  |.||   .:|:  .|||...|..||.|    :|:     
Mouse  1356 PLAQSDLG------------------VTHA---ELPQLTLSVPVAPEASPRPALESEELLVKTPG 1399

  Fly  1747 ------------DMLPRKSVPPPFV-----YFCDRACFARFKWNGKDGQAEAASLLLQPAGGSAV 1794
                        .:|....:.|.|:     ....|.||...:......::.|.|.|.:.:||:  
Mouse  1400 NYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSRKCFEASRSGNGIVESRATSHLKEFSGGT-- 1462

  Fly  1795 KSSNGDSPGSFCASSTAPAEMVVKQ-EPEDEDEKTPSVPGNPT--NIPAQRKCIVKCFSADCFTT 1856
             :...|.|..........|.:..|: :.||..:.|||..|...  ...|..|.|::         
Mouse  1463 -TKIFDKPRKRKRQRLVTARVHYKKVKKEDLTKDTPSSEGELLIHRTAASPKEILE--------- 1517

  Fly  1857 DSAPSGLELDGTAGA--------GTGAGPVNNTVWETETSGLQLEDTRQCVFCNQRGDGQADGPS 1913
                .|:|.|....|        |.||....|.....|..|..|....||  |..          
Mouse  1518 ----EGVEHDPGMSASKKLQVERGGGAALKENVCQNCEKLGELLLCEAQC--CGA---------- 1566

  Fly  1914 RLLNFDVDKWVHLNCALWSNGVYETVSGALMNFQTALQAGLSQACSACHQPGATIK-CFKSRCNS 1977
                      .||.|.    |:.|...|..:  ......|: ..|..|.|.|..:| |....|..
Mouse  1567 ----------FHLECL----GLPEMPRGKFI--CNECHTGI-HTCFVCKQSGEDVKRCLLPLCGK 1614

  Fly  1978 LYHLPCAIREECVFYKNKSVHCSVHGHAHAGITMGAGAGATTGAGLG------------------ 2024
            .||..|..:......:||...|.:    |..||..|...|...|..|                  
Mouse  1615 FYHEECVQKYPPTVTQNKGFRCPL----HICITCHAANPANVSASKGRLMRCVRCPVAYHANDFC 1675

  Fly  2025 ---GS--VADNELSSLVVHRRVFVDR-----DENRQVATVMHYSELSNLL------RVGNMTFLN 2073
               ||  :|.|.    ::....|..|     .|:..|:.....||..:||      ...:...||
Mouse  1676 LAAGSKILASNS----IICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLN 1736

  Fly  2074 V----GQLLPHQLEAFHTPHYIYPIGYKVSRYYWCVRRPNRRCRYICSIAEAGCKPEFRIQVQDA 2134
            :    |....:..:|...|||...:..||.||.|.   |...|.                     
Mouse  1737 IDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWW---PAEICH--------------------- 1777

  Fly  2135 GDKEPEREFRGSSPSAVWQQILQPITRLRKVHKWLQLFPQHISGEDLFGLTEPAIVRILESLPGI 2199
                         |.||      | :.:.|:...:..||....|.:.:..|..|.|     .|.:
Mouse  1778 -------------PRAV------P-SNIDKMRHDVGEFPVLFFGSNDYLWTHQARV-----FPYM 1817

  Fly  2200 ETLTDYRFKYGRNPLLEFPLAINPSGA----ARTEPKQRQLLVWRK------PH----TQRTAG- 2249
            |.....:.|.|:.....:..|:..:.|    .:.:.:.|||...||      |:    ..|..| 
Mouse  1818 EGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGR 1882

  Fly  2250 ------------SCSTQRM-ANSAAIAGE------------VACPYSKQFVHSKSSQYKKMKQEW 2289
                        .|:.:.. .|...|..|            ..||..   |..::..:.|.:.. 
Mouse  1883 VQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAG---VRCQNQCFSKRQYP- 1943

  Fly  2290 RNNVYLARSKIQGLGLYAARDIEKHTMIIEYIGEVIRTEV--SEIREKQYESKNRGIYMFRLDED 2352
              :|.:.|:..:|.||....||:|...:.||:||:|..|.  :.||..| |......||..||:|
Mouse  1944 --DVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQ-EHDITNFYMLTLDKD 2005

  Fly  2353 RVVDATLSGGLARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGEELSYDYKFDIEDESHKI 2417
            |::||...|..||::||.|.|||.|:...|:.|.|:.:||...|..|.||:::|..:..... |.
Mouse  2006 RIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNG-KT 2069

  Fly  2418 PCACGAPNC 2426
            .|.||||||
Mouse  2070 VCKCGAPNC 2078

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513 25/146 (17%)
ePHD2_KMT2C_like 1898..2002 CDD:277136 22/104 (21%)
FYRN 2068..2118 CDD:283589 14/53 (26%)
FYRC 2126..2215 CDD:197781 15/88 (17%)
SET <2266..2431 CDD:225491 58/163 (36%)
SET 2291..2413 CDD:214614 46/123 (37%)
PostSET 2415..2431 CDD:214703 8/12 (67%)
Nsd1NP_032765.3 MSH6_like 320..430 CDD:99898 17/124 (14%)
TNG2 <1453..1587 CDD:227367 37/177 (21%)
PHD1_NSD1_2 1546..1587 CDD:277118 12/68 (18%)
PHD2_NSD1 1593..1639 CDD:277120 13/49 (27%)
PHD3_NSD1 1640..1693 CDD:277123 10/56 (18%)
PHD4_NSD1 1710..1749 CDD:277126 7/38 (18%)
WHSC1_related 1755..1849 CDD:99899 27/142 (19%)
AWS 1902..1940 CDD:375420 6/40 (15%)
SET_NSD1 1942..2083 CDD:380987 54/142 (38%)
PHD5_NSD1 2121..2163 CDD:277129
C5HCH 2162..2211 CDD:375464
PHA03307 2255..>2576 CDD:223039
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167848346
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.870

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