DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trr and mes-4

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	NP_506333.1	Gene:	mes-4 / 179824	WormBaseID:	WBGene00003222	Length:	898	Species:	Caenorhabditis elegans

Alignment Length:	771	Identity:	157/771 - (20%)
Similarity:	257/771 - (33%)	Gaps:	233/771 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1797 SNGDSPGSFCASSTAPAEMVVKQE----------------------------PEDEDEKTPSVPG 1833
            |:|||....|    ||.:.:|::|                            .||:.|:.|.:..
Worm     4 SSGDSSKENC----APQDGIVEKEGPNKPFKKKNVKQRNATPQGAGSETSSNAEDKQEEAPILTN 64

  Fly  1834 NPTNIPAQRKCIVKCFSADC--FTTDSAPSGLELDGTAGAGTGAGPVNNTVWETETSGLQLEDT- 1895
            .|.:|.:.:....|.|.::.  |.....|. ..............|.  |..|.:..|..|.|.
Worm    65 APKDIISMQIQETKAFLSEYEEFVDTDYPK-TTFTHVPRKFLSVSPF--TPIEADAEGEFLPDAD 126

  Fly  1896 RQCVFCNQRGD---------------GQADGPSRLLN----FDVDKWVHLNCAL-WSNGVYETVS 1940
            .:||.|::..|               |:.|...|||.    |......|.:|.: :::|.:....
Worm   127 SKCVICHEEKDKTGKSDLITCHGYINGEMDDGKRLLGNIPMFPCRSKFHASCMINYNSGGFHFQY 191

  Fly  1941 GALMNFQTALQAGLSQACSAC----HQPGATI----KCFKSRCNSLYHLPCAIREECVFYKNKSV 1997
            .|.:..|..|...| ..|::|    |:..|.:    :|  :.|...:||               .
Worm   192 AARLECQARLLCPL-HCCNSCNLDHHKQSAYVGDIAEC--ALCLRAFHL---------------T 238

  Fly  1998 HCSVHGHAHAGITMGAGAGATTGAGLGGSVADNELSSLVVHRR-----VFVDRDENRQVA-TVMH 2056
            .|...|          |........:||.|...|:.....|..     .|.::.:.|:.| ||:.
Worm   239 SCYPSG----------GRDLNVSITIGGKVEKFEMIICPAHYLPGADVQFYNKHKKRKNAVTVVP 293

  Fly  2057 YSELSNLLRVGNMTFLNVGQLLPHQLEAFHTPHYIYPIGYKVSRYYWCVRRPNRR---CRYICSI 2118
            .::::....:                              |......|.:..|.:   |:..|..
Worm   294 KADVTMKSHI------------------------------KACCVIGCEKSSNSKTIMCKTCCRS 328

  Fly  2119 AEAGCK----------PEFRIQVQDAGDKEPERE--FRGSSPSAVWQQILQP------------- 2158
            ..:||:          |:.:.:....||..|:..  ....:.::.|..:...
Worm   329 FHSGCREVETLNGKPIPDDQCESCVCGDPIPQNTLILAKWTDNSFWLALTLDWYKYPTGNRGNIN 393

  Fly  2159 ITRL-RKVHKWLQLFPQHISGEDLFGLTEP--AIVRILESLPGIETLTDYRFKYGRNPLL----- 2215
            ..|| ..|.:|  |.||....|     .:|  :||.:.:    |..||...|...:|..|
Worm   394 FERLGYTVVQW--LIPQENDKE-----KQPLMSIVPVSD----IARLTKNYFSLAKNSTLRNLWE 447

  Fly  2216 -------EFPLAINP------SGAART------EPKQRQLLVWRKPHTQRTAGSCSTQRMANSAA 2261
                   :..|...|      .|..||      |||..:.      |...........|....:.
Worm   448 EKYEEQADTALKRCPYVCKTVFGRLRTSVYYKCEPKLEEY------HNNEVCNCEGADRCTKLSC 506

  Fly  2262 --IAGEVACPYS---KQFVHSKSSQYKKMKQEWRNNVYLARSKIQGLGLYAARDIEKHTMIIEYI 2321
              :|.:..||.|   |...|::......:.::    :.||.:..:|.|::|...|||...|.||:
Worm   507 QYLADDYECPPSCSKKGVCHNRQVSMGIVSEK----IKLAATLCKGYGVFAKGQIEKDEYICEYV 567

  Fly  2322 GEVIRTEVSEIR------EKQYESKNRGIYMFRLDEDRVVDATLSGGLARYINHSCNPNCVTEIV 2380
            ||:|.....:.|      .:.:::.:   ||..|.:...|||...|.::|||||||:||..:.:.
Worm   568 GEIIDKAEKKRRLDSVSISRDFQANH---YMMELHKGLTVDAARYGNISRYINHSCDPNAASFVT 629

  Fly  2381 EVD---------RDVRIIIFAKRKIYRGEELSYDYKFDIEDESHKIP-CACGAPNC 2426
            :|.         .|.|..|.|.|.|..|:|:::.|..:.|:   .:| |.|||.||
Worm   630 KVFVKKTKEGSLYDTRSYIRAIRTIDDGDEITFSYNMNNEE---NLPDCECGAENC 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		ePHD2_KMT2C_like	1898..2002	CDD:277136	26/131 (20%)
		FYRN	2068..2118	CDD:283589	5/52 (10%)
		FYRC	2126..2215	CDD:197781	20/106 (19%)
		SET	<2266..2431	CDD:225491	54/180 (30%)
		SET	2291..2413	CDD:214614	42/136 (31%)
		PostSET	2415..2431	CDD:214703	7/13 (54%)
mes-4	NP_506333.1	PHD_SF	207..269	CDD:304600	15/88 (17%)
mes-4	NP_506333.1	SET	537..671	CDD:214614	42/143 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102575
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840