DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trr and set-9

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	NP_001379880.1	Gene:	set-9 / 177196	WormBaseID:	WBGene00017482	Length:	1623	Species:	Caenorhabditis elegans

Alignment Length:	1520	Identity:	281/1520 - (18%)
Similarity:	440/1520 - (28%)	Gaps:	598/1520 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  1048 MEQGDESLPEQAE----PPLHSEQGATAAGVAPHSGGPLVSA----QWTNNHLEGGVATTKIPFK 1104
            |..|:.:||...|    ||...:|        |....|:|.|    |..:...:...||.:.|
Worm     1 MADGEHTLPADEELFEQPPPQQQQ--------PEIAEPIVMAQEPIQGVSEDPQASEATHEAP-- 55

  Fly  1105 PGEPQKRKLPMHPQLDEKQIQQQAEIPISTSLPTTPTGQGTPDKVQLISAIATYVKKSGVPNEAQ 1169
                  ...|:..|::.::...:.:||....:|..|..|.           |.|    ..||...
Worm    56 ------DNYPVDHQMENQEFYHEPQIPEPQQIPQIPVFQP-----------AAY----NPPNYVA 99

  Fly  1170 PIQNQSQGQVQMQAQMQATMQGHLSGQMSGQISGHAAGQIPAQMHLQVQHQLHMAVHPQQQQQQL 1234
            |             |.:|...|.                 ||...          ..|..:|:||
Worm   100 P-------------QQRANNFGE-----------------PAAAD----------ARPLTEQEQL 124

  Fly  1235 HQNQPQNATI-------------------PLPVTGQGAVPIPVPTMESKAGDQRKRRKREVQKPR 1280
            ...:|...|:                   .||.:.....| |.|
Worm   125 AAERPTEDTVWIDSDDDTDVEEAILRANFWLPYSDHNYDP-PDP--------------------- 167

  Fly  1281 RTNLNAGQAGGALKDLTGPLPAGAMVQLAG-----------MP--------PGTQYIQGAASGTG 1326
                    |...:....||.|.     :||           ||        |||||.:...:|
Worm   168 --------ADRIILPTEGPFPC-----IAGLDEDCNIVKQWMPEDAVGPGSPGTQYRRNQQAG-- 217

  Fly  1327 HVITSTGQGVTLGGVGASTGASSSPMLKKRVRKFSKVEEDHDAFTEKLLTHIRQMQPLQVLEPHL 1391
                        ||:.:::.||....|..|                    |..|.:|:...:|
Worm   218 ------------GGLPSTSVASQQQQLPVR--------------------HNIQNRPMVAAQP-- 248

  Fly  1392 NRNFHFLIGSNETSGGGSPASMSSAASAGSSSAGGGKLKGGSRGWPLSRHLEGLEDCDGTVLGRY 1456
                 |.||.|:...||..:.|..              :|..|..|..|           |:..:
Worm   249 -----FSIGGNQVEYGGMDSRMQQ--------------RGVVRDGPQYR-----------VMNDF 283

  Fly  1457 GRVNLPGIPSLYDSERFGGSRGLVGGSARTRSPSPAESPGAEKMLPMSSIQNDFYD--------Q 1513
            |.    |:|          .|||:         .|..||.|..:......|...|.        |
Worm   284 GN----GLP----------MRGLL---------PPRNSPAANAINRAREQQQQMYHQAGARGSLQ 325

  Fly  1514 EFSTHMERNPRERLVRHIGAVKDCNLETVDLVESEGVAAWATLPRLTRYPGLILLNGNSRCHGRM 1578
            :.:.....:|.....:||          |:.|...|......:|...| ||:|   |.:..:.|.
Worm   326 QRAAPAPADPTPGSYQHI----------VNAVPGGGANPMRRVPPQAR-PGMI---GGAANNNRA 376

  Fly  1579 SP--VALPEDPLTMRFPVSPLL------------RSCGEELRKTQQMELGMGPLGNNNNNNYQQK 1629
            .|  |..|.|......||:|..            |...|:.::.|||                 .
Worm   377 RPTHVTRPMDTQEFEHPVAPAAAPPHRVVDVAPHRMTPEQRQELQQM-----------------N 424

  Fly  1630 NQNVILALPASASENIAGVLRDLANLLHLAPALTCKIIEDKIG--NKLEDQFMNQDDEKHVDFKR 1692
            .|......||:|::..|.|:                :|:.:.|  ::.....|.|:|......:|
Worm   425 RQRAAPQFPAAAAQRSAEVI----------------VIQQRPGASSRAPRPSMAQEDLLRSPTRR 473

  Fly  1693 PLSQVSHGHLRKILNGRRKLCRSCGNVVHATGLRVPRHSVPALEEQLPRLAQLMDMLP------- 1750
            ...:|...|...:|..||...:    |.......:|:.|     :|||  |||.:..|
Worm   474 LSERVPQEHQTPVLEPRRFQVK----VTDTYSTPIPKAS-----DQLP--AQLTEEDPPEESAAA 527

  Fly  1751 --RKSVP------PPFVYFC-----------DRACFARFKWNGKDGQAEAASLLLQPAGGSAVKS 1796
              .:.||      ||.|...           ..|.|||.. ..|:....:.|:|.|.|....|
Worm   528 AAPEDVPDAAPEDPPKVILKPTPPHRMTQEEKNAHFARLT-TDKEKPTSSTSILPQDAAPPHV-- 589

  Fly  1797 SNGDSPGSFCASSTAPAEMVVKQEPEDED--------EKTPSVPGNPTNIPAQRKCIVKC----- 1848
                        ...|..:|::...:||.        |..|..|    :.|..::.|.|.
Worm   590 ------------PPPPPPLVLRPHHQDETLAMVQSVFESKPRQP----DTPKDKETISKIADLLR 638

  Fly  1849 FSADCFTTDSAPSGLELDGTAGAGTGAGPVNNTVWETETSGLQLEDTRQCVFCNQRGDGQADGPS 1913
            ||||.||..|..|......|. :|:.|          .....|:...:| ...:|....|...|
Worm   639 FSADEFTGQSGSSAAARQRTV-SGSAA----------RAQTYQMHHQQQ-QHHHQMPMDQRKRP- 690

  Fly  1914 RLLNFDVDKWVHLNCALWSNGVYETVSGALMNFQTALQAGLSQACSACHQPGATIKCFKSRCNSL 1978
                              |:|.|:.:.||:     .||          .||......|: ..:|:
Worm   691 ------------------SSGRYDALMGAM-----PLQ----------QQPPPPPSQFQ-HTDSI 721

  Fly  1979 YHLPCAIREECVFYKNKSVHCSVHGHAHA------GITMGAGAGATTGAGLGGSVADNELSSLVV 2037
            .|.|.. |.:...:.:.:|.....|.|..      .:.|.|..||      ....:|:|...:
Worm   722 AHRPRG-RPKGTRHPSVAVQPQRSGGARTLPPRAQTVAMSARNGA------NAKNSDSESEGI-- 777

  Fly  2038 HRRVFVDRDENRQVATVMHYSELSNLLRVGNMTFLNVGQLLPH------QLEAFHTPHYIYPIGY 2096
                    ||..:.:..|.               .:.|  :.|      :.|...|..::..:|.
Worm   778 --------DEAAEESWTMR---------------CHCG--MDHGDGDTIECEGCKTWQHMACMGL 817

  Fly  2097 KVSRYYWCVRRPNRRCRYICSIAEAGCKPEFRIQVQDA-GDKEPER-----------EFRGSSPS 2149
            .:.         :...:|.|.:    |.|. |:.|..| ..:|.||           :.|.|.|.
Worm   818 TLK---------SNTSKYKCEM----CLPR-RLPVSKAEAAREQERILNRLRAAARKQKRKSEPV 868

  Fly  2150 AVWQQILQPITRLRKVHKWLQLFPQHISGEDLFGLTEPAIVRILESLPGIETLTDYRFKYGRNPL 2214
            ...|:..||.|..:.....||               :||..|:.:       |.||
Worm   869 EQKQKSSQPSTSRKSAPMALQ---------------QPAEPRVAQ-------LNDY--------- 902

  Fly  2215 LEFPLAINPSGAARTEPKQRQLLVWRKPHTQRTAGSCSTQRMANSAAIAGEVACPYSKQFVHSKS 2279
                            .||...|::   ..::|||:                      ..:.::|
Worm   903 ----------------SKQASALLF---GMEQTAGA----------------------DTLLAES 926

  Fly  2280 SQYKKMKQEWRNNVYLARSKIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQYESKNRGI 2344
            ..:||.::.:......|        |.....::...:|:|..|.|..:  ||:  |:.......|
Worm   927 RLHKKARRMFVEEAVEA--------LVTTDLVQIRQVILEVNGHVSMS--SEV--KRQPGGGNCI 979

  Fly  2345 YMF------RLDEDR-------VVDATLSGGLARYINHSCNPNCVTE-IVEVDRDVRIIIFAKRK 2395
            :|:      ...||.       .:|....|...::...||.||||.: ::..:..:.|:|.|.:.
Worm   980 FMYDGLMKGTAGEDMGDGQELVCIDTKRKGNDTKFTRRSCVPNCVLKHVLGSNATLGIMIVATKD 1044

  Fly  2396 IYRGEELSYDYKFDIEDESHKIPCA 2420
            |.|..|::..:..|..:...::.||
Worm  1045 ITRNTEVTLPFDADWRESEVELECA 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		ePHD2_KMT2C_like	1898..2002	CDD:277136	18/103 (17%)
		FYRN	2068..2118	CDD:283589	7/55 (13%)
		FYRC	2126..2215	CDD:197781	21/100 (21%)
		SET	<2266..2431	CDD:225491	33/169 (20%)
		SET	2291..2413	CDD:214614	28/135 (21%)
		PostSET	2415..2431	CDD:214703	2/6 (33%)
set-9	NP_001379880.1	PRK03427	<9..>132	CDD:235124	35/193 (18%)
		Med15	196..>373	CDD:312941	55/279 (20%)
		PHD_Bye1p_SIZ1_like	788..831	CDD:277045	7/72 (10%)
		SET_SETD5-like	927..1059	CDD:380927	29/143 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030