DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trr and set-16

DIOPT Version :9

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:NP_499819.3 Gene:set-16 / 176802 WormBaseID:WBGene00011729 Length:2475 Species:Caenorhabditis elegans


Alignment Length:2566 Identity:578/2566 - (22%)
Similarity:911/2566 - (35%) Gaps:770/2566 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   337 SASGAATAGGATIVESKQLLQPGGQVTT----------VMSAAQQSGGQQVHPHVHSHAHHNFTK 391
            |..|....|||     |:....||...|          ..||.|.........|:|.....:.|:
 Worm   209 STRGRGRGGGA-----KKKPGRGGSTGTRRQTNPGPSGFFSATQLQAMSGDFSHLHQPQQTSSTR 268

  Fly   392 LIKRGPKNSGTIVSFSGLQIKPANTKIVATKVVSKKMLQLQQHQQQIQQQQQLQQLQVTSGGGLA 456
             .|||.:.:||.|     ..:|.       |...:...:.:.....|.|..||||:|..:.|  |
 Worm   269 -GKRGKRGNGTSV-----PRQPG-------KGPGRGRGRGRGSAAAIAQLAQLQQVQYGAQG--A 318

  Fly   457 P---------PTGSIVTITTTNPSQTYAMVQDSA-TVGPAAHSEDDAPAPRKITAYSE------- 504
            |         ||...|. .|..||.||..|..:| ...||..:....|.|..:.::.:       
 Worm   319 PMFNGAPQLHPTQPTVA-PTLPPSVTYQNVAPTAPPAPPALQTPLPDPLPSIVPSFQQAPQAVAI 382

  Fly   505 -NLQKILNKSKSQESTGG--PEEFTNINSVVIKPLDKNTL------------------------N 542
             .:.:::.:.:|...:||  .:|...|.:.::..::...|                        |
 Worm   383 REVDELMLEDESSRQSGGSRSDEPEYIRTAIVCRVNDEFLQKACMCLVCGSIGKGPEGSMVACSN 447

  Fly   543 CPPSFNIFKQQQHSQAAQSQSISAVG-----------SGAGTPVTFTMASGNASDLATTSTVSVS 596
            |..:::.:....|.:.    :.:.||           .|.||       .|:.::|.......||
 Worm   448 CAQTYHTYCVTLHDKL----NSAVVGRGWRCLDCTVCEGCGT-------GGDEANLLLCDECDVS 501

  Fly   597 AGTICINSPMMGTRPIISIQNKNISLVLSKTTMAQQKP--------------KMITTTTLSSQ-- 645
            ....|: .|::...|                    |.|              |..:...|:||  
 Worm   502 YHIYCM-KPLLDKIP--------------------QGPWRCQWCSRCRRCNHKAASGNDLTSQGL 545

  Fly   646 ----AAL----------QMHHALIQDSSADKAGSSANSGSAT----SGASMQLKLTTANTPTKLS 692
                |:|          |::..||:.|...|....|..|..|    ..|::.....:|..|.::.
 Worm   546 CFPCASLRKCPRCERNYQLNEKLIRCSQCSKWQHGACEGLYTDEQLEQAAIDRMRCSACRPKRVQ 610

  Fly   693 VSLAPDV--VKLEEVGSESKAKLLVK------------QEAV---------------VKDS---- 724
            .|...||  |..:.|..:..|..::|            .|:|               ::||    
 Worm   611 PSGFSDVDTVWCDYVALDKDAHEILKSKYTPSALKNHMMESVGYRESFDHYDDDYNPLEDSSDQV 675

  Fly   725 TGTPTSEERAEEIGTPEKRLNANATMTAINQV------QNQSANQIQMATSTSTASNPSTPNPTV 783
            |..|...:|....|.|..|       ..:|::      .....::||..|..:.|:..|:.:...
 Worm   676 TPLPIPGQRGRGRGNPSGR-------RGMNRIGIGGFYAKLPRHRIQALTEEAAAAAASSEDSKQ 733

  Fly   784 NATPMNNQRSAAED-------------NALLKQLL----------------QNNSSSHSLNQISI 819
            ...|..::||..||             .|:..::|                ...:.|....::.:
 Worm   734 AKRPRKSRRSQLEDAYPPQIQEAFFGIKAVEGKVLVDTPVDEPFLAEFNGWYKRTRSTKAFELCM 798

  Fly   820 TSAHVGSASASAPLSARKVIN-VRAPSMG---------------KVRSLEDQLARPVIPPVPTAT 868
            |:    |......:...:.:: |..|:|.               .|....|:|...:: ..|..|
 Worm   799 TA----SEMLRTDIDENEFLDCVGLPNMETDALDDFDFNLLEDFDVDEENDELENSLL-GAPGNT 858

  Fly   869 Q-----AAGSSSSSG--SVATSTTTTTVASGGSSQQVATASATALPVSAVAITTPGV-------G 919
            :     |.|...|.|  |.......:|.::|||............|.: .|...|||       |
 Worm   859 EMKEDAAEGIEGSYGPTSFNLDQRPSTSSAGGSLGSQDPFHPGMNPAN-FAQHAPGVRNAIARSG 922

  Fly   920 GEAKLEQK--------SDQP--------AAIMQNQSQNQAPPPPPPPQQQQQQQLHQPQQLQ--- 965
            .:....::        .|:|        |.:..|:.....       :||....:.:.:|:|   
 Worm   923 SQTDNSERYQFSARWEEDEPNGLQATTAAVLYSNEKHGYL-------RQQFPNWVDRVKQIQKLW 980

  Fly   966 -PSPHQVKQTVQIVSKETSFISG--PVAAKTLVTEATSKPAELLPPPP---YEMATAPISNVTIS 1024
             ...|:|:......:::....||  |...:|.|....|      ||||   :::...|.||:..|
 Worm   981 RTLNHEVRLDYVNRARDNRTRSGNRPRPRRTNVQSTDS------PPPPQMGFKVPANPSSNMMGS 1039

  Fly  1025 ISTKQAAPKELQMKPKAVAMS--LPM----------------EQGDESLPEQAEPPLHSEQGATA 1071
                    .|..|:||.|.::  |||                |:.:.||.||.......::...|
 Worm  1040 --------SEQSMQPKQVFITHHLPMDVYQVYQDLKRVKFDRERLNGSLEEQLNKARKQKKNLAA 1096

  Fly  1072 AGVAPHSGGPLVSAQWTNNHLEGGVATTKIPFKPGEPQKRKLPMHPQLDEKQIQQQAEIPISTSL 1136
                  ....:|..|            |..|...|.          .:|..:..||....::..:
 Worm  1097 ------KKRQMVKTQ------------TAAPDYDGR----------NIDLNESDQQTLATLTEQI 1133

  Fly  1137 PTTPTGQGTPDKVQL--------ISAIATYVKKSGV-PNE------------------------- 1167
            ..|..      :::|        .|.::.:|.|.|: .||                         
 Worm  1134 KVTQA------EIELHRRDLKKHESNLSDFVMKHGILRNEHEVKREDVQLSAIRDQQYAAHADEM 1192

  Fly  1168 -AQPIQNQSQGQVQ------MQAQMQATM----QGHLSGQMSGQISGHAAGQIPAQMHLQVQHQL 1221
             ||..|||..|||.      .||.:...|    |.|....|..|:.|...||.  .|..|...|.
 Worm  1193 LAQQAQNQGLGQVHPPVLVAPQAAISLPMLNQQQQHHQRMMQMQMRGGPPGQF--MMRAQPPQQP 1255

  Fly  1222 HMAVHPQQQQQQLHQNQPQNATIPLPVTG---QGAVPIPV-----PTMESKAGDQRKRRKREV-- 1276
            .:.:|..:..:::...|.:||.   ||.|   ...:..|:     ..:|:...|.....:||.  
 Worm  1256 QINMHNHEIAKRMLMQQFRNAH---PVMGGIRHDEITDPIMRDVYDCLEAIVFDVHTVAEREAMQ 1317

  Fly  1277 ---QKP-------RRTNLNAGQAGGALKDLTGPLPAGAMVQLAG-----MPPGTQYIQGAASGTG 1326
               |:|       |....:.|..||....:.|..|     ||.|     .||..|..|.....  
 Worm  1318 AAGQQPPPPHIMQRMMQQHPGGPGGPRLIMPGQFP-----QLQGRRIPQQPPPVQLPQVDVDP-- 1375

  Fly  1327 HVITSTGQGVTLGGVGASTGASSSPMLKKRVRKFSKVEEDHDAFTEKLLTHIRQMQ--PLQVLEP 1389
               ..|......||......|||.|           ...::||:.|::....|...  |.:..||
 Worm  1376 ---PKTAAKRKKGGGNPKKNASSYP-----------AAGEYDAWIEQMRMRFRLCPDIPKKQKEP 1426

  Fly  1390 HLNRNFHFLIGSNETSGGGSPASMSSAASAGS--SSAGGGKLKGGSRGWPLSRHLEGLED-CDGT 1451
            .|||.     |....|.|.:..::.:......  ...|..::|.|:|       |.|.|: .:.:
 Worm  1427 RLNRP-----GCEFVSHGLTDMAVRATKKRTPLVGEFGAMRVKRGTR-------LFGNEERGEKS 1479

  Fly  1452 VLGR-------------YGRVNLPGIPSLYD------------------SERFGGSRGLVGGSAR 1485
            ::.:             :...|.| :|::.|                  .:.....||..|....
 Worm  1480 IMFQDLNLYQVEPQIRLFALYNNP-LPTMEDDVFRDEEDQIIDKPTSALQKLLNKKRGASGAMDH 1543

  Fly  1486 TRS-----------PSPA-----ESPGAEKMLPMSSIQNDF-YDQEFSTHMERNPRERL---VRH 1530
            .||           |:|.     |:..||:.:.:..:.|.. ..:|.|...:::...||   :|.
 Worm  1544 IRSRARYMEETNIPPAPERGMFYENVEAEEEVTVELVFNTCDITEESSVDEKKDVCGRLHEQIRD 1608

  Fly  1531 IGAVKDCNLETVDLVESEGVAAWATLPRLTRYPGLILLNGNSRCHGRMSPVALPEDPLTMRFPVS 1595
            :.|:||             ..||                            ::.:.|     |.|
 Worm  1609 LLAIKD-------------EVAW----------------------------SMEDTP-----PES 1627

  Fly  1596 PLLRSCGEELRKTQQMELGMGPLGNNNNNNYQQKNQNVILALPASASENIAGVLRDL-ANLLHLA 1659
            |:.||        .:.|..:|.:...::.:          ..|:.|:|.  .:.|:: .....:|
 Worm  1628 PVSRS--------PEPEATVGAVQQTSSTS----------RAPSEATER--EIKREVEEEAAPVA 1672

  Fly  1660 PALTCKIIEDKIGNKLEDQFMNQDDEKHVDFKRPLSQVSHGHLRKILNGRRKL-CRSCGNVVHAT 1723
            |.:..:|:|..         .:|:..:..:.::.|.  ||.....:.....|| ....|:||...
 Worm  1673 PEIKREIVEPS---------QSQNSSQCKNCQKALE--SHSSTSIVTVKAEKLNLAPTGSVVTTR 1726

  Fly  1724 GLRVP--------RHSVPALEEQLPRLAQLMDMLPRKSVPPPFVYFCDRACF------ARFKWNG 1774
            ...||        ....|:.|:....||.                ||.:.|:      .|.....
 Worm  1727 AAPVPPGVPGAPGAPIAPSEEKTKEELAS----------------FCSKKCYYELASATRAPLTE 1775

  Fly  1775 KDGQA-------EAASLLLQPAGGSAVKS-SNGDSPGSFCASSTAPAEMVVKQEPEDEDEKTPSV 1831
            ::..|       |..:.|.|....:.||: |.|..|.   ...|:|.:.....   ||..:.   
 Worm  1776 EEVAAAEQHVSEEVYNKLKQVLTENIVKAVSQGKKPD---PQLTSPRDTRCMM---DEGRRE--- 1831

  Fly  1832 PGNPTNIPAQRKCIVKCFSADCFTTDSAPSGLELDGTAGAGTGAGPVNNTVWETETSGLQLE--- 1893
              |.|.:|.          |.......||........|.|.........::|::..:..|..   
 Worm  1832 --NVTIVPV----------ASLIGAVEAPKEAPSQRAAEAAEDWKAYTKSIWDSFVNIQQQHAHH 1884

  Fly  1894 ---------------DTRQCVFCNQRGDGQADGPSRLLNFDVDKWVHLNCALWSNGVYETVSGAL 1943
                           |.|.||||...|||:.....||::.....|||:||||||..|:|..:|.|
 Worm  1885 ILSPKIGVPHPPYHLDKRICVFCGGIGDGETTRCGRLISLTEFYWVHVNCALWSAEVFENQTGGL 1949

  Fly  1944 MNFQTALQAGLSQACSACHQPGATIKCFKSRCNSLYHLPCAIREECVFYKNKSVHCSVHGHAHAG 2008
            .|...|:......||..|.:|||::||.|..|...||:.||::....|.|:::..|..|......
 Worm  1950 TNVDRAVLRAAQTACDHCKRPGASVKCHKMNCGVNYHVLCAMQNNGFFIKDRTFICKQHEKVSNQ 2014

  Fly  2009 ITMGAGAGATTGAGLGGSVADNELSSLVVHRRVFVDRDENRQVATVMHYSELSNL-LRVGNMTFL 2072
            ..:|                  .|.:|   ||::|.||||..:..:...::...| :|:|..||.
 Worm  2015 AIVG------------------RLDAL---RRIYVKRDENTMLTRLFELTDGPTLCMRLGAFTFY 2058

  Fly  2073 NVGQLLPHQLEAFHTPHYIYPIGYKVSRYYWCVRRPNRRCRYICSIAEAGCKPEFRIQVQDAGDK 2137
            .:|.:.|.||:.|||..||:|..|:::|.:|..:....|..:.|.|.:...:|.|.::..:    
 Worm  2059 KIGSITPKQLKRFHTKDYIFPNNYRITRLFWSPKSHRERMMFECIIEDRNNQPIFVVKSLE---- 2119

  Fly  2138 EPEREFRGSSPSAVWQQILQPITRLRKVHKW--LQLFPQHISGEDLFGLTEPAIVRILESLPGIE 2200
            :|...::..|.|..||.|.:.:.:||:..:.  |:.|...|.||.||||.|.||.:|.|||||.:
 Worm  2120 DPTICYKAVSASKAWQPIYEKVHQLREQQQGDSLKFFGSQICGETLFGLNENAITKITESLPGFD 2184

  Fly  2201 TLTDYRFKYGRNPLLEFPLAINPSGAARTEPKQRQL--LVWRKP-------HTQRTAGSCSTQR- 2255
            |:..|:.::..:|:||.|||.|..|.||.||:.|.:  ....||       |...:|...|:|. 
 Worm  2185 TIFTYQHRHQNSPVLELPLAENLMGCARAEPRNRTIGQHFRTKPQPMGGTHHHIGSASGLSSQAT 2249

  Fly  2256 -MANSAAIAGE---------------------VACPYSK-------------------------Q 2273
             :|:|::.|.|                     |...|::                         |
 Worm  2250 IIASSSSSANESLQSRQAATSVTSANSGRTRGVRSYYTEEAAARARAFGIPPEMASLSLRMETTQ 2314

  Fly  2274 FVHSKSSQYKKMKQEWRNNVYLARSKIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQYE 2338
            ...:..|.|:||::||::.||||||:|.||||||..||.....||||.||:||:||.|:||.:|.
 Worm  2315 NAQTAFSAYQKMRREWKDRVYLARSRIAGLGLYAKVDISMGDFIIEYKGEIIRSEVCEVREIRYV 2379

  Fly  2339 SKNRGIYMFRLDEDRVVDATLSGGLARYINHSCNPNCVTEIVEVD---RDVRIIIFAKRKIYRGE 2400
            ::|||:||||:||:.|:|||::||.||||||||:|||.|:|::..   |:.:|||.|.|.|...|
 Worm  2380 AQNRGVYMFRIDEEWVIDATMAGGPARYINHSCDPNCSTQILDAGSGAREKKIIITANRPISANE 2444

  Fly  2401 ELSYDYKFDIEDESHKIPCACGAPNCRKWMN 2431
            ||:|||:|::|..:.||||.||||||.||||
 Worm  2445 ELTYDYQFELEGTTDKIPCLCGAPNCVKWMN 2475

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513
ePHD2_KMT2C_like 1898..2002 CDD:277136 41/103 (40%)
FYRN 2068..2118 CDD:283589 17/49 (35%)
FYRC 2126..2215 CDD:197781 30/90 (33%)
SET <2266..2431 CDD:225491 93/192 (48%)
SET 2291..2413 CDD:214614 72/124 (58%)
PostSET 2415..2431 CDD:214703 12/15 (80%)
set-16NP_499819.3 PHD_SF 42..84 CDD:276966
PHD4_KMT2C_like 427..477 CDD:276987 5/53 (9%)
PHD5_KMT2C_like 479..524 CDD:276988 12/72 (17%)
PHD6_KMT2C_like 554..604 CDD:276989 9/49 (18%)
DUF1351 1060..>1163 CDD:284492 19/136 (14%)
ePHD2_KMT2C_like 1904..2008 CDD:277136 41/103 (40%)
FYRN 2055..2104 CDD:283589 17/48 (35%)
FYRC 2112..2199 CDD:197781 30/90 (33%)
SET 2333..2457 CDD:214614 72/123 (59%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160159079
Domainoid 1 1.000 129 1.000 Domainoid score I3267
eggNOG 1 0.900 - - E2759_KOG4443
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002860
OrthoInspector 1 1.000 - - oto17290
orthoMCL 1 0.900 - - OOG6_102575
Panther 1 1.100 - - LDO PTHR45888
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 1 1.000 - - X2220
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1312.730

Return to query results.
Submit another query.