DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trr and Ezh1

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	NP_031996.1	Gene:	Ezh1 / 14055	MGIID:	1097695	Length:	750	Species:	Mus musculus

Alignment Length:	937	Identity:	181/937 - (19%)
Similarity:	286/937 - (30%)	Gaps:	341/937 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1534 VKDCNLETVDLVESEGVAAWATLPRLTRYPG-----LILLNGNSRCHGRMSPVALPEDPLTMRFP 1593
            :|.|.:|::                   :||     :::.:.|:..   :.|:.....||...|.
Mouse    83 LKKCTIESI-------------------FPGFDSQDMLMRSLNTVA---LVPIMYSWSPLQQNFM 125

  Fly  1594 VSPLLRSC-----GEELRKTQQM---ELGMGPLGNNNNNNYQQKNQNVILALPASASENIAGVLR 1650
            |......|     |:|:::..:.   ||         .|||..|.......:|.|       ||.
Mouse   126 VEDETVLCNIPYMGDEVKEEDETFIEEL---------INNYDGKVHGEEEMIPGS-------VLI 174

  Fly  1651 DLANLLHLAPALTCKIIEDKIGNKLEDQFMNQDDEKHVDFKRPLSQVSHGHLRKILNGRRKLCRS 1715
            ..|..|.|..||      ::..::.||...:..|.|..|.|..| .|:....|..:.|.:|..:.
Mouse   175 SDAVFLELVDAL------NQYSDEEEDGHNDPSDGKQDDSKEDL-PVTRKRKRHAIEGNKKSSKK 232

  Fly  1716 ---CGNVVHATGLRVPRHSVPALEEQLPRLAQLMDMLPRKSVPPP-------------------- 1757
               ...:..|.....|.:.||  ::...|..:|.:|....::||.
Mouse   233 QFPNDMIFSAIASMFPENGVP--DDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLH 295

  Fly  1758 --FVYFCDRACFARFKWNGKDGQAEAASLLLQP--AGGSAVKSSNGDSPGSFCASSTAPAEMVVK 1818
              ...|| |.|   ||::          ..|.|  |..:..|..|.:                :|
Mouse   296 SFHTLFC-RRC---FKYD----------CFLHPFHATPNVYKRKNKE----------------IK 330

  Fly  1819 QEPED---------EDEKTPSVPGNP-TNIPAQRKCIVKCFSADCFTTDSAPSGLELDGTAGAGT 1873
            .|||.         |..|..::..|| :....:|:......||.|....::......:|.:...|
Mouse   331 IEPEPCGTDCFLLLEGAKEYAMLHNPRSKCSGRRRRRHPVVSASCSNASASAMAETKEGDSDRDT 395

  Fly  1874 GAGPVNNTVWETETSGLQLEDTRQCVFCNQRGDGQADGPSRLLNFDVDKWVHLNCALWSNGVYET 1938
            |    |:  |.:.:|    |...:|    |....|...|:.
Mouse   396 G----ND--WASSSS----EANSRC----QTPTKQKASPAP------------------------ 422

  Fly  1939 VSGALMNFQTALQAGLSQAC--SACHQP----GATIKCFKSRCNSLYHLPCAIREECVFYKNKSV 1997
                            :|.|  .|..:|    ||....|:     ::|        ..::.|
Mouse   423 ----------------AQLCVVEAPSEPVEWTGAEESLFR-----VFH--------GTYFNN--- 455

  Fly  1998 HCSVHGHAHAGITMGAGAGATTGAGLGGSVADNELSSLVVHRRVFVDRDENRQVATVMHYSELSN 2062
            .||:                   |.|.|:....::....|..                     |.
Mouse   456 FCSI-------------------ARLLGTKTCKQVFQFAVKE---------------------SL 480

  Fly  2063 LLRVGNMTFLNVGQ--LLPHQLEAFHTPHYIYPIGYKVSRYYWCVRRPNRRCRYICSIAEAGCKP 2125
            :|::.....:|..|  ...|:|.|.|                         ||.|....:.....
Mouse   481 ILKLPTDELMNPAQKKKRKHRLWAAH-------------------------CRKIQLKKDNNSTQ 520

  Fly  2126 EFRIQVQDAGDKEPEREFRGSSPSAVWQQILQPITRLRKVHKWLQLFPQHISGEDLFGLTEPAIV 2190
            .:..|..|    .|:|....:.|..:.|...:         |:.|..|.
Mouse   521 VYNYQPCD----HPDRPCDSTCPCIMTQNFCE---------KFCQCSPD---------------- 556

  Fly  2191 RILESLPGIETLTDYRFKYGRNPLLEFPLAINPSGAARTEPKQRQLLVWRKPHTQRTAGSCSTQR 2255
             .....||....|....|       :.|..:    |.|.......|......|......||..
Mouse   557 -CQNRFPGCRCKTQCNTK-------QCPCYL----AVRECDPDLCLTCGASEHWDCKVVSCKN-- 607

  Fly  2256 MANSAAIAGEVACPYSKQFVHSKSSQYKKMKQEWRNNVYLARSKIQGLGLYAARDIEKHTMIIEY 2320
                        |               .:::..:.::.||.|.:.|.|.:....::|:..|.||
Mouse   608 ------------C---------------SIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEY 645

  Fly  2321 IGEVIRTEVSEIREKQYESKNRGIYMFRLDEDRVVDATLSGGLARYINHSCNPNCVTEIVEVDRD 2385
            .||:|..:.::.|.|.|: |....::|.|:.|.|||||..|...|:.|||.||||..::|.|:.|
Mouse   646 CGELISQDEADRRGKVYD-KYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGD 709

  Fly  2386 VRIIIFAKRKIYRGEELSYDYKFDIED 2412
            .||.|||||.|..||||.:||::...|
Mouse   710 HRIGIFAKRAIQAGEELFFDYRYSQAD 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		ePHD2_KMT2C_like	1898..2002	CDD:277136	15/109 (14%)
		FYRN	2068..2118	CDD:283589	9/51 (18%)
		FYRC	2126..2215	CDD:197781	13/88 (15%)
		SET	<2266..2431	CDD:225491	52/147 (35%)
		SET	2291..2413	CDD:214614	51/122 (42%)
		PostSET	2415..2431	CDD:214703
Ezh1	NP_031996.1	EZH2_WD-Binding	42..70	CDD:288468
		SANT	436..477	CDD:238096	10/75 (13%)
		SANT	436..477	CDD:197842	10/75 (13%)
		SET	<466..730	CDD:225491	81/380 (21%)
		SET	616..737	CDD:214614	51/122 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848404
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840