Protein Alignment trr and NSD

DIOPT Version :10

• Sequence 1: NP_726773.2
• Gene: trr / 31149
• FlyBaseID: FBgn0023518
• Length: 2431
• Species: Drosophila melanogaster
• Sequence 2: XP_316738.6
• Gene: NSD / 1277307
• VectorBaseID: AGAMI1_000310
• Length: 1323
• Species: Anopheles gambiae
• Alignment Length: 1558
• Identity: 285/1558 - (18%)
• Similarity: 487/1558 - (31%)
• Gaps: 573/1558 - (36%)

  Fly  1096 VATTKIPFKPGEPQKRKLPMHPQLDEKQIQQQAEIPISTSLPTTPTGQGTPD-KVQ---LISAIA 1156
            |.|.::..:....:|..:..|..: :|..:..|.....|.|..|.:|..:.: |.|   |.:|.|
Mosquito    10 VVTPEMKLQGNATRKAVIQRHKSM-KKNTKDTASDRSFTRLVLTSSGNNSKETKAQENLLETAAA 73

  Fly  1157 TYVKKSGV-PNEAQP-IQNQSQGQVQMQAQMQATMQG---HLSGQ---MSGQISGHAAGQ----- 1208
            |..:...: |...|. :::|.......:...|..|.|   :.||:   .|.||..|...:
Mosquito    74 TNFETDLLSPTTTQKRVKSQESTPQSQKIAKQEPMSGSEMNESGKENAFSDQIRNHPTDENSNTV 138

  Fly  1209 --IPAQMHLQVQHQLHMAVHPQQQQQQL-----------HQNQPQNAT-IPLPVTGQ-GAVPIPV 1258
              :|.:..|:   ||..::.|:..:..:           ||.|..|:. :|:.:... |:.|...
Mosquito   139 VRVPGRYLLK---QLSSSLSPKMTEINIDTDRRVSRYGRHQKQKDNSDYVPVDLMKYVGSTPSKF 200

  Fly  1259 PTMESKAGDQRKRRKREVQKPRRTN-LNAGQAGGALKDLTGPLPAGAMVQLAGMPPGTQYIQGAA 1322
            .| :|:..|.....|....||..:: |..|....:|.....|||               .|.|:
Mosquito   201 KT-KSETDDPNSVNKTLETKPHSSDELRTGSNDISLSLTVVPLP---------------LIDGS- 248

  Fly  1323 SGTGHVITSTGQGVTLGGVGASTGASSSPMLKKRVRKFSKVEEDHDAFTEKLLTHIRQMQPLQVL 1387
                                          :.||..             ||.|..:.:::.:.:.
Mosquito   249 ------------------------------IMKRPE-------------EKQLLSMEEIKIVGME 270

  Fly  1388 EPH-----------LNRNFHFLIGSNETSGGGSPASMSSAASAGS-------------------- 1421
            ||:           :|........|:..||.||...::....||:
Mosquito   271 EPYYTDKGSDNNCFMNNLLERKTSSDADSGKGSSVDLAIIYRAGNLYWAAQTRKSIHWPCIVHVD 335

  Fly  1422 ------SSAGGGKL---------KGGSRGWPLSRH----LEGLED-CDGTVLGRYGRVNLPGIPS 1466
                  :...|.|.         ..|.|.| :..|    .||::: |.......||::    :.|
Mosquito   336 PETDQITRLYGDKFLEVHVSYFGDRGRRAW-IKEHSILPFEGVDEYCTNAKNMEYGKL----LKS 395

  Fly  1467 LYDSERFGGSRGLVGGSARTRSPSPAESPGAEKMLPMS-SIQNDFYDQEFSTHMERNPRERLVRH 1530
            ...|||:..:..:                 ||:.:.:: |.:...:|.|....:.|:   :::||
Mosquito   396 ALKSERWKNACSI-----------------AERYMTLALSERIASFDHEVKLELARH---KVMRH 440

  Fly  1531 ----IGAVKDCNLETVDLV----ESEGVAAW-----ATLPRLTRY---PGLILLNGNSRCHGRMS 1579
                .|.:|:...:.:..:    .||.:..|     ::.|....|   ||:.....|
Mosquito   441 RMAIEGRIKNGASQKMPALLPSDNSEVLEHWNKRDRSSSPESPEYELLPGVFPTKNN-------- 497

  Fly  1580 PVALPEDPLTMRFPVSPLLRSCGEELRKTQQMELGMGPLGNNNNNNYQQKNQNVILALPASASE- 1643
            |:        .:...||.:::|        .:.....||....::...::|.      |.||::
Mosquito   498 PI--------KKIKFSPSMQNC--------ILNDNRSPLDRPLHSMDSEENP------PGSATKA 540

  Fly  1644 -----NIAGVLRDLANLLHLAPALTCKIIEDKIGNKLEDQFMNQDD----------EKHVDFKRP 1693
                 ...|| .||.||                 |..|     .||          :.|..:
Mosquito   541 NGPKATTLGV-SDLENL-----------------NSTE-----YDDILTFIRYYMFDGHTSY--- 579

  Fly  1694 LSQVSHG---HLRKILNGRRKLCRSCGNVVHATGLRVPRHSVPALEEQLPRLAQLMDMLPRKSVP 1755
              :|..|   ::|.|.|                   :.:||....|..:.|  |.|..| |||
Mosquito   580 --EVEKGLQLYVRGICN-------------------LKKHSNRGTERTVGR--QRMHAL-RKS-- 618

  Fly  1756 PPFVYFCDRACFARFKWNGKDGQAEAASLLLQPAGGSAVKSSNGDSPGSFCASSTAPAEMVVKQE 1820
                          ::..|.:..||.::.|                       .|..|..|:|:|
Mosquito   619 --------------YEILGIEPSAEVSTSL-----------------------KTRNAHPVIKKE 646

  Fly  1821 PEDEDEKTPSVPGNPTNIPAQRKCIVKCFSAD-CFTTDSAPSGLELDGTAGAGTGAGPVNNTVWE 1884
            |:..:||.                   .|..| .|.....|.|.
Mosquito   647 PKTLEEKF-------------------IFELDKNFLMKGVPKGF--------------------- 671

  Fly  1885 TETSGLQLEDTRQCVFCNQRGDGQADGPSRLLNFDVDK----WVHLNCALWSNGVYETVSGALMN 1945
                        .|..||:        |:     :|.|    .:||:....:|...|.|....:.
Mosquito   672 ------------VCYICNR--------PN-----NVTKCSKCTLHLHLVCLANDPEEVVKMQELV 711

  Fly  1946 FQTAL-------QAGLSQACSACHQ--PGAT----IKCFKSRCNSLYHLPC-----AIRE----- 1987
            .|..|       .:.:.:.|..|:.  |..:    .:|...:|...||:.|     .:|:
Mosquito   712 DQKKLCCEKCSTTSIVEKTCFICNDEIPEKSNEQIYRCVVGKCTQAYHISCLQLFPQVRQVSAST 776

  Fly  1988 ---------ECV---------FYKNKSVHC-----SVHGHAHAGITMGAGAGATTG--------- 2020
                     .||         ..|....||     |.|...:. |..|:....||.
Mosquito   777 IICPYHTCHTCVASEPRSTASMVKTTLAHCLKCPTSYHPSGNC-IPAGSVLLTTTQLICPKHTLE 840

  Fly  2021 -----------AGLGGSVADNELSSLVVH----------RRVFVDRDENRQVATVMHYSELSNLL 2064
                       .|.||::...|...|..|          .:.|.:..|:.::..   |:|:. :.
Mosquito   841 QIPLNVNWCFICGKGGNLICCETCPLACHPVCLQFTPPDEKYFCEGCESGRLPL---YNEIV-IA 901

  Fly  2065 RVGNMTF-----LNVGQLLPHQLEAFHTPHYIYPIGYKVSRYYWCVRRPNRRCRYICSIAEAGCK 2124
            ::|:..:     |...::..:.|:..|.|..|....:......|.    ||:..|:.
Mosquito   902 KMGSFRWWPALTLPPSEIPQNMLQLRHKPSDICVKFFNTHDMSWL----NRKRMYLY-------- 954

  Fly  2125 PEFRIQVQDAGDKEPEREFRGS-SPSAVWQQILQPITRLRKVHKWLQLFPQHISGEDLFGLTEPA 2188
                       .:|......|| |.|::.::....:|...|:.|.||....         |...|
Mosquito   955 -----------QREDSESLDGSQSGSSMDKRYRSAMTEASKIFKILQTRKM---------LGPSA 999

  Fly  2189 IVRILESLPGIETLTDYRFKYGRNPLLEFPLAIN------PSGAARTEPK------------QRQ 2235
            .:...:::|..:.:...|:    .|.|: |.::|      .....|.:|.            .|.
Mosquito  1000 SLSYSKAVPVYKKIKTNRY----IPPLK-PPSVNRQLDGVEDSVCRCQPSDDDPCGPTSACLNRA 1059

  Fly  2236 LLVWRKPHTQRTAGSCSTQRMANSAAIAGEVACPYSKQFVHSKSSQYKKMKQEWRNNVYLARSKI 2300
            :::.....|.....|||.||.......|.||      :|...|
Mosquito  1060 IMMECSSKTCPAKESCSNQRFTKRIYPALEV------RFFSDK---------------------- 1096

  Fly  2301 QGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQYE-SKNRGIYMFRLDEDRVVDATLSGGLA 2364
             |.||.|..|::....:|||:||||.:|..:.|....: :|....|...::.|..:||...|.::
Mosquito  1097 -GFGLVALEDLKSGQFVIEYVGEVINSEEFDRRVMMMQAAKETNYYFLTVEPDLTIDAGPKGNVS 1160

  Fly  2365 RYINHSCNPNCVTEIVEVDRDVRII-IFAKRKIYRGEELSYDYKFDIEDESHKIPCACGAPNC 2426
            |:|||||.|||.|:...:. :.|:| :||.:.|..||||:::|..:....:.:: |.|||..|
Mosquito  1161 RFINHSCEPNCETQKWTIG-ETRVIGLFAIKDINAGEELTFNYNLESLGNNKRV-CLCGAGKC 1221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		PRK13914	<623..>851	CDD:237555
		ePHD2_KMT2C_like	1898..2002	CDD:277136	28/153 (18%)
		FYRN	2067..2118	CDD:461787	10/55 (18%)
		FYRC	2126..2215	CDD:197781	15/89 (17%)
		SET_KMT2C_2D	2278..2430	CDD:380948	46/151 (30%)
NSD	XP_316738.6	None