Protein Alignment trr and EHMT2

DIOPT Version :10

• Sequence 1: NP_726773.2
• Gene: trr / 31149
• FlyBaseID: FBgn0023518
• Length: 2431
• Species: Drosophila melanogaster
• Sequence 2: XP_006715037.2
• Gene: EHMT2 / 10919
• HGNCID: 14129
• Length: 1395
• Species: Homo sapiens
• Alignment Length: 1613
• Identity: 325/1613 - (20%)
• Similarity: 514/1613 - (31%)
• Gaps: 520/1613 - (32%)

  Fly   990 AAKTLVTEATSKPAELLPPPPYEMATAPISNVTISISTKQAAPKELQMKPKAVAMSLPMEQGDES 1054
            ||:........:.|| .||||..:.:||                |::..|:...:.....:|
Human    94 AARAAGRRGRGRGAE-APPPPPPLLSAP----------------EMRGLPRGRGLMRARGRG--- 138

  Fly  1055 LPEQAEPPLHSEQGATAAGVAPHSGG---------PLVSAQWTNNHLEGGVATTKIPFKPGEPQK 1110
               :|.||  ..:|....|  ||.|.         |...|.|| ..|..|:.:..:|..|.:.:
Human   139 ---RAAPP--GSRGRGRGG--PHRGRGRPRSLLSLPRAQASWT-PQLSTGLTSPPVPCLPSQGE- 194

  Fly  1111 RKLPMHPQLDEKQIQQQAEIPISTSLPTTPTGQ-----GTPDKVQLI--SAIATYVKKSGVPNEA 1168
            ....|...|.||:.:...| .:..||..||..:     .|||.::..  |:.|:.....|.....
Human   195 APAEMGALLLEKETRGATE-RVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGAD 258

  Fly  1169 QPIQNQSQGQVQMQAQMQATMQGHLSGQMSGQ--ISGHAAGQIPAQMHLQVQHQLHMAVHPQQQQ 1231
            .|:     |...:.......::|  .|.:.|.  :.|||....|:
Human   259 TPV-----GATPLIGDESENLEG--DGDLRGGRILLGHATKSFPS-------------------- 296

  Fly  1232 QQLHQNQPQNATIP----LPVTGQGAVPIPVPTMESKAGDQRKRRKREVQKPRRTNLNAGQAGGA 1292
                 :..:..:.|    :.:||.|..|   |:::|.|
Human   297 -----SPSKGGSCPSRAKMSMTGAGKSP---PSVQSLA--------------------------- 326

  Fly  1293 LKDLTGPLPAGAMVQLAGMPPGTQYIQGAASGTGHVITSTGQGVTLGGVGASTGASSSPMLKKRV 1357
                         ::|..||..    ||||:.......:|            |.....|.:.:..
Human   327 -------------MRLLSMPGA----QGAAAAGSEPPPAT------------TSPEGQPKVHRAR 362

  Fly  1358 RKFSKVEEDHDAFTEKLLTHIRQMQPLQVLEPHLNRNFHFL--IGSN------ETSGGGSPASMS 1414
            :..||.........||        :|.::....::.:.|.|  :.|:      ..||||....:.
Human   363 KTMSKPGNGQPPVPEK--------RPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEELG 419

  Fly  1415 SAASAGSSSAGGGKLKGGSRGWPLSRHLEGLEDCDGTVLGRYGRVNLPGIPSLYDSERFGGSRGL 1479
            ||..:|..:.        ::|.|.|  ||..|...|.....|           |||
Human   420 SARRSGEVTL--------TKGDPGS--LEEWETVVGDDFSLY-----------YDS--------- 454

  Fly  1480 VGGSARTRSPSPAESPGAEKMLPMSSIQNDFYDQEFSTHMERNPRERLVRHIGAVKDCNLETVDL 1544
            .....|..|.|.:|.....:.|.....:.:..::|.....|....|.           :.|:.:.
Human   455 YSVDERVDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEE-----------DEESGNQ 508

  Fly  1545 VESEGVAAWATLPRLTRYPGLILLNGNSRCHGRMSPVALPEDPLTMRFPVSPLLRSCGEELRKTQ 1609
            .:..|.:......:..|               :.||...|......|.|..      .:|.|
Human   509 SDRSGSSGRRKAKKKWR---------------KDSPWVKPSRKRRKREPPR------AKEPR--- 549

  Fly  1610 QMELGMGPLGNNNNNNYQQKNQNVILALPA--SASENIAGVLRDLANL-----LHLAPALTCKI- 1666
                |:..:|::..:.|.:.... .|.||:  :.|.|.|||..|.::|     ....|..:|::
Human   550 ----GVNGVGSSGPSEYMEVPLG-SLELPSEGTLSPNHAGVSNDTSSLETERGFEELPLCSCRME 609

  Fly  1667 ------IEDKIGNK------------------LEDQFMNQDDEKHVDFKRPLSQVS-----HGHL 1702
                  |.::.|:|                  |:.:.|           ||.|:|:     ..|.
Human   610 APKIDRISERAGHKCMATESVDGELSGCNAAILKRETM-----------RPSSRVALMVLCETHR 663

  Fly  1703 RKILNGRRKLCRSCGNVVHATGLRVPRHSVPALEEQLPR--LAQLMDMLPRKSVPPPFVYFCDRA 1765
            .:::  :...|..||....| |..:..|....:..:..:  ::||..|:           ||...
Human   664 ARMV--KHHCCPGCGYFCTA-GTFLECHPDFRVAHRFHKACVSQLNGMV-----------FCPHC 714

  Fly  1766 CFARFKWNGKDGQAEAASLLLQPAGGSAVKSSNGDSPGSFCASSTAPAEMVVKQE-PEDEDEKTP 1829
                    |:|. :||..:.: |.|       :|.:|.   |.:.|||...:.|: |...|...|
Human   715 --------GEDA-SEAQEVTI-PRG-------DGVTPP---AGTAAPAPPPLSQDVPGRADTSQP 759

  Fly  1830 SV----PGNPTNIPAQRKCIVKCFSADCFTTDSAPSGLELDG---TAGAGTGAGPVNN------T 1881
            |.    .|.|...|...       .||  |.||:...|.|..   .:..|...||...      .
Human   760 SARMRGHGEPRRPPCDP-------LAD--TIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALV 815

  Fly  1882 VWETETSGLQLEDTRQCVFCNQRGDGQADGPSRLLNFDVDKWVHLNCALWSNGVYETVSGALMNF 1946
            :.|:|.........||.....::|:.|......|.|.|                        .||
Human   816 IQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLD------------------------PNF 856

  Fly  1947 QT-----------ALQAGLSQACSACHQPGATIKCF-KSRCNSLY------HLPCA----IREEC 1989
            |:           |.|.|..:.|....|.||.|... |.:...|.      ||..|    .|..|
Human   857 QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGC 921

  Fly  1990 VFYKNKSVHCSVHGHAHAG------ITMGAGAGATTGAGLGGSV--------------------- 2027
            |:.|.:.....:|..|..|      :.:..|.........||..
Human   922 VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG 986

  Fly  2028 ADNELSSLVVHRRVFVDRDENRQVATVMHYSELSNLLRVGNMTFLNVGQLLPHQLEAFH--TPHY 2090
            ||..|:..|..|.|   .:||    ..:|::..:....:..: .||....| |.:. :|  ||.:
Human   987 ADVTLTDNVSERLV---EEEN----ICLHWASFTGSAAIAEV-LLNARCDL-HAVN-YHGDTPLH 1041

  Fly  2091 IYPIGYKVSR--YYWCVRRPNRRCRYICSIAEAGCKPEFRIQVQD-AGDKEPEREFRGSSPSAVW 2152
            |      .:|  |:.||          ......|..||.|.:..| |.|..|||       |.||
Human  1042 I------AARESYHDCV----------LLFLSRGANPELRNKEGDTAWDLTPER-------SDVW 1083

  Fly  2153 QQILQPITRLRKVHKWLQLFPQHISGEDLFGLTEPAIVRILESLPGIETLTDYRFKYGRNPLLEF 2217
             ..||...:||.......:..:.|...|:....|...:..:..:.|.....||::
Human  1084 -FALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKY---------- 1137

  Fly  2218 PLAINPSGAARTEPKQRQLLVWRKPHTQR--TAGSCSTQRMANSAAIAGE--VACPYSKQFVHSK 2278
               |:.:....|....|.:     .|.|.  ....||     :|..:.|:  :.|.|.|.  ...
Human  1138 ---ISENCETSTMNIDRNI-----THLQHCTCVDDCS-----SSNCLCGQLSIRCWYDKD--GRL 1187

  Fly  2279 SSQYKKMKQE-----------WRN------------NVYLARSKIQGLGLYAARDIEKHTMIIEY 2320
            ..::.|::..           |||            .:.|.|:...|.|:.|.:.|.:.|.|.||
Human  1188 LQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEY 1252

  Fly  2321 IGEVIRTEVSEIREKQYESKNRGIYMFRLD----EDRVVDATLSGGLARYINHSCNPNCV-TEIV 2380
            :||:|....:::||..       .|:|.||    |...:||...|.::|:|||.|:||.: ..:.
Human  1253 VGELISDAEADVREDD-------SYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVF 1310

  Fly  2381 EVDRDV---RIIIFAKRKIYRGEELSYDYK---FDIEDESHKIPCACGAPNCR 2427
            .:.:|:   ||..|:.|.|..||||.:||.   :||  :|....|.||:..|:
Human  1311 MLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDI--KSKYFTCQCGSEKCK 1361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		PRK13914	<623..>851	CDD:237555
		ePHD2_KMT2C_like	1898..2002	CDD:277136	25/125 (20%)
		FYRN	2067..2118	CDD:461787	12/54 (22%)
		FYRC	2126..2215	CDD:197781	21/89 (24%)
		SET_KMT2C_2D	2278..2430	CDD:380948	53/184 (29%)
EHMT2	XP_006715037.2	PHA03247	<126..382	CDD:223021	65/367 (18%)
		2A1904	<396..504	CDD:273344	27/148 (18%)
		EHMT_ZBD	598..727	CDD:411018	27/163 (17%)
		ANKYR	806..1072	CDD:440430	61/315 (19%)
		ANK repeat	864..893	CDD:293786	8/28 (29%)
		ANK repeat	928..960	CDD:293786	4/31 (13%)
		ANK repeat	962..993	CDD:293786	5/30 (17%)
		ANK repeat	1002..1033	CDD:293786	7/36 (19%)
		ANK repeat	1035..1066	CDD:293786	11/46 (24%)
		SET_EHMT2	1133..1371	CDD:380931	67/263 (25%)