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Protein Alignment trr and Nsd2

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	NP_001074571.2	Gene:	Nsd2 / 107823	MGIID:	1276574	Length:	1366	Species:	Mus musculus

Alignment Length:	1226	Identity:	231/1226 - (18%)
Similarity:	375/1226 - (30%)	Gaps:	468/1226 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  1468 YDSERFGGSRGLVGGSARTRSPSPAESPGAEKMLPMSSIQNDFYDQEFSTHMERNPRERLVRH-I 1531
            |||..   .:|||..:..::..||     |:|.:|:.        :|...:..|: |:.|::: :
Mouse   175 YDSLL---EQGLVEAALVSKISSP-----ADKKIPVK--------KESCPNTGRD-RDLLLKYNV 222

  Fly  1532 GAVKDCNLETVDLVESE--GVAAWATL----PRL---TRYPG----------------------- 1564
            |          |||.|:  |...|..:    |.|   |:..|
Mouse   223 G----------DLVWSKVSGYPWWPCMVSADPLLHNHTKLKGQKKSARQYHVQFFGDAPERAWIF 277

  Fly  1565 ---LILLNGNSR----CHGRMSPVALPEDPLTMRFPVSPLLRSCGEELRKTQQMELGMGPLGNNN 1622
               |:...|..:    |...........:.:.:..|:|..||:         |.|:|
Mouse   278 EKSLVAFEGEEQFEKLCQESAKQAPTKAEKIKLLKPISGRLRA---------QWEMG-------- 325

  Fly  1623 NNNYQQKNQNVILALPASASENIAG-----VLRDLANLLHLAP--ALTCKIIEDKIGNKLEDQFM 1680
                       |:....:||.:|..     ....:.:.|||.|  |....|:.:.:|..::....
Mouse   326 -----------IVQAEEAASMSIEERKAKFTFLYVGDQLHLNPQVAKEAGIVTEPLGEMVDSSGA 379

  Fly  1681 NQDDEKHVDFKRPLSQVSHGHLRK--ILNGRRKLCRSCGNVVHATGLRVPRHSVPALEEQLPRLA 1743
            :::           :.|..|.:|:  |...||:              |..|.|....:|..|.
Mouse   380 SEE-----------AAVDPGSVREEDIPTKRRR--------------RTKRSSSAENQEGDPG-- 417

  Fly  1744 QLMDMLPRKSVPPPFVYFCDRACFARFKWNGKDGQAEAASLLLQPAG-----GSAVKSSNGDSPG 1803
                  ..||.||                  |..:||....:..|||     |||.:|..|||..
Mouse   418 ------TDKSTPP------------------KMAEAEPKRGVGSPAGRKKSTGSAPRSRKGDSAA 458

  Fly  1804 SFCASSTAPAEMVVKQEPEDEDEKTPSVPGNPTNI------------------------------ 1838
            .|........:.||.:.|:...|:...:.|:..::
Mouse   459 QFLVFCQKHRDEVVAEHPDASGEEIEELLGSQWSMLNEKQKARYNTKFSLMISAQSEEDSGNGNG 523

  Fly  1839 -----------PA----------------------QRKCI------------------------V 1846
                       ||                      ||:.|                        .
Mouse   524 KKRSHTKRADDPAEDVDVEDAPRKRLRADKHSLRKQRETITDKTARTSSYKAIEAASSLKSQAAT 588

  Fly  1847 KCFSADC------------------FTTDSAPSGL----ELDGTAGAGTGAGPVNNTVWETETS- 1888
            |..|..|                  |...|:||..    |:..:.|......|..:.. ||:|.
Mouse   589 KNLSDACKPLKKRNRASATASSALGFNKSSSPSASLTEHEVSDSPGDEPSESPYESAD-ETQTEA 652

  Fly  1889 ---------GLQLEDTRQCVFCNQRG-----DGQADGPSRLLNFDVDKWVHLNCALWSNGVYETV 1939
                     |:..:....|..|.:.|     :|...|.           .||.|.    |:....
Mouse   653 SVSSKKSERGMAAKKEYVCQLCEKTGSLLLCEGPCCGA-----------FHLACL----GLSRRP 702

  Fly  1940 SGALMNFQTALQAGLSQACSACHQPGATIK-CFKSRCNSLYHLPCAIREECVFYKNKSVHCSVHG 2003
            .|.....:.|  :|: .:|..|.:....:| |..::|...||..|..:.....::::...|.:|.
Mouse   703 EGRFTCTECA--SGI-HSCFVCKESKMEVKRCVVNQCGKFYHEACVKKYPLTVFESRGFRCPLHS 764

  Fly  2004 ----HA-----------------------HAG-ITMGAGAGATTGAGL----------------- 2023
                ||                       |.| ..:.||........:
Mouse   765 CMSCHASNPSNPRPSKGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTARKGKRHHTH 829

  Fly  2024 -----------GGSVADNELSSLVVHRRVF-VDRDENR------QVATVMHYSELSNLLRVGNMT 2070
                       |||:...|......|.... ::..:..      :....:|:.::. .:::||..
Mouse   830 VNVSWCFVCSKGGSLLCCEACPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDII-WVKLGNYR 893

  Fly  2071 FL------------NVGQLLPHQLEAFHTPHYIYPIGYKVSR-YYWC-------VRRPNRRCRYI 2115
            :.            |: |.:.|::..|       |:.:..|: |||.       ....:|..||
Mouse   894 WWPAEVCHPKNVPPNI-QKMKHEIGEF-------PVFFFGSKDYYWTHQARVFPYMEGDRGSRY- 949

  Fly  2116 CSIAEAGCKPEFRIQVQDA----GDKEPEREFRGSSPSAVWQQILQPITRLRKVHKWLQLFPQHI 2176
              ....|....|:..:|:|    .:.:.:||.|.:..|.            ||...:     :||
Mouse   950 --QGVRGIGRVFKNALQEAEARFNEVKLQREARETQESE------------RKPPPY-----KHI 995

  Fly  2177 SGEDLFGLTEPAIVRILESLPGIETLTDYRFKYGRNPLLEFPLAINPSGAARTEPKQRQLLVWRK 2241
            .....:|..:.....|.| :|          |....|..|     ||.| :.:|...|.|:....
Mouse   996 KVNKPYGKVQIYTADISE-IP----------KCNCKPTDE-----NPCG-SDSECLNRMLMFECH 1043

  Fly  2242 PHTQRTAGSCSTQRMANSAAIAGEVACPYSKQFVHSKSSQYKKMKQEWRNNVYLARSKIQGLGLY 2306
            |........|..|             |...:|:..:|                :.::..:|.||.
Mouse  1044 PQVCPAGEYCQNQ-------------CFTKRQYPETK----------------IIKTDGKGWGLV 1079

  Fly  2307 AARDIEKHTMIIEYIGEVIRTEVSEIREK-QYESKNRGIYMFRLDEDRVVDATLSGGLARYINHS 2370
            |.|||.|...:.||:||:|..|....|.| .:|:.....||..:|:||::||...|..:|::|||
Mouse  1080 AKRDIRKGEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHS 1144

  Fly  2371 CNPNCVTEIVEVDRDVRIIIFAKRKIYRGEELSYDYKFDIEDESHKIPCACGAPNC 2426
            |.|||.|....|:.|.|:.:||...|..|.||:::|..|... :.|..|.|||.||
Mouse  1145 CQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLG-NEKTVCRCGASNC 1199

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.