DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trr and LOC101883274

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	XP_021331411.1	Gene:	LOC101883274 / 101883274	-ID:	-	Length:	766	Species:	Danio rerio

Alignment Length:	894	Identity:	166/894 - (18%)
Similarity:	268/894 - (29%)	Gaps:	287/894 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1655 LLHLAPALTCKIIEDKIGNKLEDQFMNQDDEKHV-----DFKRPLSQVSH-------GHLRKILN 1707
            :..|.|  .||.....:...|....|....|..:     :.|:.||:..|       |.:..||:
Zfish     1 MFFLCP--VCKKAPHSLPGHLRKVCMRNSTEAEIQAVVKEAKKELSEFCHKGRFWEFGKICDILD 63

  Fly  1708 GRRKLCRSCGNVVHATGLRVPRHSVPALEEQLPRLAQLMDMLPRKSVPPPFVYFCDRACFARFKW 1772
            ....|.|.... :.:.||.:  :::|::   ||..|:    ....|||
Zfish    64 STNPLARMIAE-MQSKGLVI--NNLPSV---LPEPAR----STTSSVP----------------- 101

  Fly  1773 NGKDGQAEAASLLLQPAGGSAVKSSNGD---SPGSFCASSTAPAEMVVKQEPEDEDEKTPSVPGN 1834
               ....|.|...|:|...|....|:|:   |.|....:|:...|||.|..........|.:.|
Zfish   102 ---QSSGEGAESSLEPPNESLSDESSGEYYQSTGGPMWTSSVRVEMVKKGLYNKHSIDHPLLAG- 162

  Fly  1835 PTNIPAQRKCIVKCFSADCFTTDSAPSGLELDGTAGAGTGAGPVNN-TVWETETSGLQ-LEDTRQ 1897
                          |:...:                  |..|..|: .|.||.:..|. ::.|..
Zfish   163 --------------FNKYLY------------------TDLGYKNSKQVVETVSRFLHYMDPTEP 195

  Fly  1898 CVFCNQRGDGQADGPSRLLNFDVDKWV----------------------HLNCALWSNGVYETVS 1940
            .:...:|.:...:..:.|.:..:.||.                      |.|.||:.:  .|:..
Zfish   196 NLMFVRRVEKVREYFNILSDTKLSKWTVFNYSKSLKRFMKYIITSTDIRHNNPALFQD--CESFM 258

  Fly  1941 GALMNFQTALQAGLSQACSACHQPGATIKCFKSRCNSLYHLP--CAIREECVFYKNKSVHCSVHG 2003
            .||.    .:|:|:|:..|.    ..|.|..:..|.... ||  |....|..|...::|.|.:.|
Zfish   259 DALY----GIQSGMSKEVSM----EVTAKKSEFGCGKEV-LPKDCLAVLEAAFKDFQAVICKMQG 314

  Fly  2004 HAHAGITMGAGAGATTGAGLGGSVADNE-------LSSLVVHRRVFVDRDENRQVATVMHYSELS 2061
                           .||..|..:..||       |.::::.:.|     :...:.|.|...:..
Zfish   315 ---------------PGAITGDCLTKNERLLVLYYLEAVIMLKLV-----QRPGIVTHMTVEDWE 359

  Fly  2062 NLLRVGNMTFLNVGQLLPHQLEAFHTPHYIYPIGYKVSRYYWCVRRPNRRCRYICSIAEAGCKPE 2126
            ...|:.|...:.|.:   |::...|.....:.:       |:...||
Zfish   360 GRSRIENGVCVAVKE---HKVPLSHEQELWFDL-------YFNEVRP------------------ 396

  Fly  2127 FRIQVQDAGDKEPEREFRGSSPSAVWQQILQPITRLRKVHKWLQLFPQHISGEDLFGLTEPAIVR 2191
            ..:|....||......|..||..   :.|..|...|:::|....| |....| |.....|.|...
Zfish   397 VMLQENRTGDDVAVDSFFVSSSG---RSIYNPSNDLKRLHDKYSL-PSVTCG-DAQRAFEAAAQN 456

  Fly  2192 ILESLPGIETLTDYRFKYGRNPLLEFPLAINPSGAARTEPKQRQLLVWRKPHTQRTAGSCSTQRM 2256
            :.|....:....:|..:...:|.|  .|::....|.:|            |.....|..|.|:..
Zfish   457 LSEVERNVAAERNYMRRTSSDPFL--ALSVLDQLAGKT------------PQRSSRASCCETRVD 507

  Fly  2257 ANSAAIAGEVACPYS---------------------------------------------KQFVH 2276
            ..:|....|..||.:                                             :|...
Zfish   508 EQTAYKTLEQFCPVTLEGPPPKRSRRTELCGSEHERHCYDRWRSEQLKLREQHALEHFTGQQPSE 572

  Fly  2277 SKSSQYKKMKQEWRNNV-----------YLARSKI--------------------------QGLG 2304
            ||.|::.. ||.|.:||           .:||..:                          :|.|
Zfish   573 SKISRWMD-KQGWTSNVPQAAVVLKQWKPVARLDLVIDSSFVKKMILSQRWKGLTVRPVPDKGDG 636

  Fly  2305 LYAARDIEKHTMIIEYIGEVIRTE-------VSEIREKQ---YESKNRGIYMFRLDEDRVVDATL 2359
            ::..|..:...::.||.||::..|       .|.||...   |.:|..........|:......:
Zfish   637 VFTKRPFQIGEVVCEYHGELVSHEDGMAIASTSSIRAGHLFFYRNKQHEAMCIDAHEESCQCHPM 701

  Fly  2360 SGGLARYINHSCNPNCVTEIVEV--DRDVRIIIFAKRKIYRGEELSYDY 2406
            .....|.|.||.....:...:.|  |||: |:..|.:.|...|||.|||
Zfish   702 KFNYGRLIRHSSKRANIRPRLYVLNDRDI-ILFIATKDISSDEELLYDY 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		ePHD2_KMT2C_like	1898..2002	CDD:277136	25/127 (20%)
		FYRN	2068..2118	CDD:283589	7/49 (14%)
		FYRC	2126..2215	CDD:197781	19/88 (22%)
		SET	<2266..2431	CDD:225491	44/235 (19%)
		SET	2291..2413	CDD:214614	35/165 (21%)
		PostSET	2415..2431	CDD:214703
LOC101883274	XP_021331411.1	SET	625..751	CDD:214614	31/126 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593792
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840