DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trr and kmt2d

DIOPT Version :9

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:XP_009295228.1 Gene:kmt2d / 100536523 ZFINID:ZDB-GENE-060223-2 Length:4967 Species:Danio rerio


Alignment Length:2679 Identity:687/2679 - (25%)
Similarity:1055/2679 - (39%) Gaps:749/2679 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 KAKPERVASVAAAAFNAVSLQKRSGDDTATPAEDPTRKKAKTELLLGTGTAAPS------LPAKA 73
            |||     .:|....|.|..|    |....|   |...:.:..||....|:||.      .||..
Zfish  2776 KAK-----MIALKGINRVLAQ----DPMGVP---PGMNRQQVSLLAQRLTSAPGNEDSQPPPAPG 2828

  Fly    74 SSTAPQQLLYQRSGQQAKAQVKAASEP------QDVETAD-GVWDARDQQIIVCNFGSGTEMGAI 131
            ||         :.|:.:. ||:....|      .|.|... ..|....||::....         
Zfish  2829 SS---------KEGEGSN-QVQTRPNPPQFGIINDAEQHQYEEWLVHTQQLLQMQL--------- 2874

  Fly   132 KAEDADKQSEYRISTPRNSQSNPLLHRNTAFTSFTKKEGASSSASSSSSTASVISIEPS------ 190
                  |..|.:|...|.|:......:.||      |:.....|.:.:....:::.|.|      
Zfish  2875 ------KFLEEQIGAHRKSRKALCAKQRTA------KKAGREFAEADAEKLKLVTEEQSKIQKQL 2927

  Fly   191 ------------------GSGQDHAENS-----GKSEDLDYVLMPASGADSSTSVGNSTGTGTPA 232
                              ...|.|.:.|     |.|....::|....|.......|.......|.
Zfish  2928 DQVRKQQKEHTNLIAEYRSKQQQHQQGSSMLAPGPSTPAPHMLSKMPGQMIGQPPGGMPQAAMPP 2992

  Fly   233 G---------TPIGATTSTIILNANNGTAGVSGAGTTTILTQKSGHTNYNIFNTTATGSQTPTTT 288
            |         .|.||...::.|          |||.   :....|      |.....|.|.|...
Zfish  2993 GGMPIRMPQMQPFGAAQPSLPL----------GAGP---VQPPPG------FFPQGPGPQAPDPR 3038

  Fly   289 LLN----RVNLHPKM---KTQLMVNAKKLSEVTQ--------------TTAKV---SIGNKTISV 329
            :|.    ::.:..||   :.|||:..:.:|...|              ..|:|   |:|...:..
Zfish  3039 VLQERQYKMQMVQKMQQQQQQLMMAQQPMSHQPQQPGIMNQQPGAMGSQPAQVLMGSLGQPNLQQ 3103

  Fly   330 PLLKPLMSASGAA-----------------TAGGATIVESKQLL--QPGGQVTTVMSAAQQSGGQ 375
            .|:....:..|..                 ...|..:.::..|:  ||.|.|          |.|
Zfish  3104 GLINSQQNQQGLVQTPPGMMGNQALGQTQHNVMGQQMTQTANLMAGQPQGMV----------GNQ 3158

  Fly   376 QV-----HPHVHSHAHHNFTKLIKRGPKNSGTIVSFSGLQIKPANTKIVATKVVSKKMLQLQQHQ 435
            |:     .|.|....|....:.:.|||..          |:.|....::|     ::||..||.|
Zfish  3159 QIVQQLQRPQVLMDQHGPVGQHVVRGPPT----------QLTPQQQSVMA-----QRMLMSQQQQ 3208

  Fly   436 ---QQIQQQQQLQQLQVTSGGGLAPPTGSIVTITTTNPSQTYAMVQDSATVGPAAHSEDDAPAPR 497
               :.:.|.||.|.||:....|.:.|..::                             :||:..
Zfish  3209 NAAKSLAQLQQQQILQLKQQAGPSEPQRAL-----------------------------EAPSSG 3244

  Fly   498 KITAYSENLQKILNKSKSQESTGGPEEFTNINSVVIKPLDKNTLNCPPSFNIFKQQQHSQAAQSQ 562
            .....:||||:.:...::....||          ::.|      ..||       ||        
Zfish  3245 GNQGVAENLQQGVQDHQNPNKDGG----------LLSP------KTPP-------QQ-------- 3278

  Fly   563 SISAVGSGAGTPVTFTMASGNASDLATTSTVSVSAGTICINSPMMGTRPIISIQNKNISLVLSKT 627
                    .|.|....|..|::.:....           :..|                      
Zfish  3279 --------GGPPTPLQMQQGSSGEQQCV-----------VGQP---------------------- 3302

  Fly   628 TMAQQKPKMITTTTLSSQAALQMHHALIQDSSADKAGSSANSGSATSGASMQLKLTTANTPTKLS 692
                                 |..||.:......:..::.|.|.|.....:.      |......
Zfish  3303 ---------------------QQQHAFLGQQQTAQPQTNQNIGVAEQHGFVD------NQQAGPH 3340

  Fly   693 VSLAPDVVKLEEVGSESKAKLLVKQEAVVKDSTGTPTSEERAEEIGTPEKR----LNANATMTAI 753
            :.:.|...:: ::|.:::.|:.:|||    |......::::|.:|...:.:    .|:..||..|
Zfish  3341 LKVQPPQPQM-QIGLQTQTKIQIKQE----DQQMCFMAQQQAGQIAAQQPQGVAVQNSGQTMGNI 3400

  Fly   754 NQVQNQSANQIQM----ATSTSTASNPSTPNPTVNATPMNNQRSAAEDNALLKQLLQNNSSSHSL 814
            ...|.|:....||    |........|..|...:. |.:|.|...|: |..|:.|    :.|..|
Zfish  3401 TNQQQQALLTQQMGIPRAQQMMMTQRPGAPAGQIR-TSINIQAFIAQ-NPQLRHL----TPSQQL 3459

  Fly   815 NQISITSAHVGSASASAPLSARKVINVRAPSMGKVRS--LEDQLARPVIPPVPTATQ-----AAG 872
            .||.       :..|...|...:::.::..:.|::|.  |:.....|.||.:.|..|     .||
Zfish  3460 QQIQ-------AMLAQRQLQQGQMLRLQGQAQGQMRPQVLQGPSVGPRIPVIETQQQQHRFGLAG 3517

  Fly   873 SSSSSGSVATSTTTTTVASGGSSQQVATASATALPVSAVAITTPGVGGEAKLEQKSDQP------ 931
            .                 .|.|:||                 .|||     :.|:|...      
Zfish  3518 K-----------------HGSSTQQ-----------------QPGV-----IRQQSGMAPQFHQG 3543

  Fly   932 -AAIMQNQSQNQAPPPPPPPQQQ---QQQQLHQPQQLQ---PSP--HQVKQTVQIVSKETSFISG 987
             ...||..||...|......|||   ||||:||.|.::   |.|  .||:.|.      ...::.
Zfish  3544 VIGAMQQPSQGPLPQYINSAQQQQMIQQQQVHQHQMMRGQVPRPIMGQVRNTA------PGHLAR 3602

  Fly   988 PVAAKTLVTEATSKPAELLPPPPYEMATAPISNVTISISTKQAAP--KELQMKPK-AVAMSLPME 1049
            |::.:.|:.:.:  |.            :|:||....:...|..|  :.||.:.. ..|:|    
Zfish  3603 PMSPRQLLGQGS--PG------------SPLSNQQRLVRMSQTPPGTQHLQQQTHGTTALS---- 3649

  Fly  1050 QGDESLPEQAEPPLHSEQGATAAGVAPHSGGPLVSAQWTNNHLEGGVATTKIPFKPGEPQKRKLP 1114
                  |.||.|   |..|:.|....|.:|.|.:     |....|.:|.:.....|..|      
Zfish  3650 ------PFQASP---SHAGSPAGSSVPEAGSPSL-----NKPEPGNMALSSNLSSPSRP------ 3694

  Fly  1115 MHPQLDEKQIQQQAEIPISTSLPTTPTGQGTPDKVQLISAIATYVKKSGVPN-EAQPIQNQSQGQ 1178
                          |..:..|.|.:.||...|      |.:.:...|:..|| ||........|.
Zfish  3695 --------------EGIVGKSSPFSQTGGLIP------SPLRSPTAKTQSPNTEALSAPFPLNGP 3739

  Fly  1179 VQMQAQMQATMQGHLSGQMSGQISGHAA--GQIPAQM-HLQVQHQLHMAVHPQQQQ------QQL 1234
            ....||.||...|.:||       ||.:  .|:|::| .:.:|   ::...|::.|      .:.
Zfish  3740 SSQVAQNQAPNSGQISG-------GHTSQPTQMPSEMCKMTLQ---NIKQEPREVQCDTGNIVET 3794

  Fly  1235 HQNQPQNATIPLPVTGQGAVPIPVPTMESKAGD-----QRKRRKRE-VQKPRRT-NLN-AGQ--A 1289
            |.:..:.......|:|.|.|...|.: .::|||     ||....:: :||..|| ||. |.|  :
Zfish  3795 HSDGIKREISGESVSGSGIVNSAVGS-RNQAGDIGSQIQRTETGQQLLQKLLRTKNLQVAAQRPS 3858

  Fly  1290 GGALKDLTGPLPAG-AMVQLAGMPPGTQYIQGAASGTGHVITSTGQGVTLGGVGASTGASSSPML 1353
            .|...::.|.:... ||::        |.:||.......:.:.|.:...:.....:......|..
Zfish  3859 DGIHNEINGHINNKLAMLE--------QKLQGTPRNMEDLQSLTKRAPIVKAKRTAKAGERGPNS 3915

  Fly  1354 KKRVRKFSKVEEDHDAFTEKLLTHIRQ-MQPLQVLEPHLNRNFHFLIGSNETSGGGSPASMSSAA 1417
            :|:.:|      :....||.::..::| :..|.::||.:.                  ||:...|
Zfish  3916 RKKTKK------EEVGKTEAIMKQLKQGLSLLPLMEPSIT------------------ASLDLFA 3956

  Fly  1418 SAGSSSAGG-GKLKGGSRGWPLSRHLEGLEDCDGTVLGRYGRVNLPGIPSLYDSERFGGSRGLVG 1481
            ..|||.|.. .:|||.                       :|...|..||..|..        |:.
Zfish  3957 PFGSSPANAKTQLKGS-----------------------FGNAILDNIPDYYSQ--------LLT 3990

  Fly  1482 GSARTRSPSPAESPGAEKMLPMSSIQNDFYDQEFSTHME-----RNPRERLVRHIGAVKDCNLET 1541
            .:..:..|:|   |.:....|..|:|:...:.  .|.:|     :...|.....||:|.: .:::
Zfish  3991 KNNLSNPPTP---PSSLPPTPPPSVQHKLLNG--VTQVEELAEGQKETEASEDTIGSVPE-EVKS 4049

  Fly  1542 VDLVESEGVAAWATLPRLTRYPGLILLNGNSRCHGRMSPVALPEDPL---TMRFP---------- 1593
            ||:     :||..|.|........:..:.:|.....:.|.:.||..|   |.|||          
Zfish  4050 VDI-----LAALPTPPHNQNEDIRMESDDDSDASDSIVPASSPESQLGDETTRFPSLLDPKEEEE 4109

  Fly  1594 ---VSPLL----RSCGEELRKTQQMELGMGPLGNNNNNNYQQKNQ--NVILALPASASENIAGVL 1649
               :||::    ||......:|:..|...|.:..:::...:.|:.  :|...|.::|::|:..|:
Zfish  4110 ERAISPVIPIIPRSTIPNFSETKPFESVDGKVVASSSQWDKAKSNEVSVTFMLSSAAAKNLNTVM 4174

  Fly  1650 RDLANLLHLAPALTCKII----EDKIG---NKLED----------------QFMNQDD------- 1684
            ..:|.|||:....:.::.    ..::|   .|:.|                :::.|.|       
Zfish  4175 LAVAQLLHIRMPSSYELAFPQSPGRVGAGPGKVPDSSNPGLKTDASVSNDAEWLKQFDVSLPGCT 4239

  Fly  1685 -EKHVDFKRPLSQVSHGHLRKILNGRRKLCRSCGNVVHATGLRVPRHSVPALEEQLPRLAQLMDM 1748
             .|.||....:.|.|.       ....|..:.| .:.:.:.|.| ||        ||.:...:..
Zfish  4240 LRKQVDILALIKQESQ-------EQEDKPAQHC-YMTNVSDLDV-RH--------LPVIPVEVSP 4287

  Fly  1749 LPRKSVPPPFVYFCDRACFARFKWNGKDGQAEAASLLL---QPAGGSAVKSSNGDSPGSFCASST 1810
            .|..|.|||                .....||..:...   :|...:.|::::..|     ||.:
Zfish  4288 PPSPSPPPP----------------PSSTVAEPENTTQPEPKPESEATVQTTSSPS-----ASPS 4331

  Fly  1811 AP--AEMVVKQ---------EPEDED-----------EKTPSVPGN--PTNIPAQRKCI--VKCF 1849
            ||  .|::|||         |||..:           ::.||.|.:  |.:.|.....:  :|..
Zfish  4332 APVKTEILVKQESHCSPVTVEPESHEPAVLPIAVPPPQEQPSAPASSPPLDSPTIEISLKSIKHR 4396

  Fly  1850 SADCFTTDSAP----------SGLELDGTAGAGTGAGPVNNTVWE-TETSGLQLE------DTRQ 1897
            |......:..|          ..|::..|...|......:..|.| .|...:.|:      |.|:
Zfish  4397 SRPLSDEEQRPKVKKWKGLRWKRLQIVITIRKGGSKKESSREVSELMERLRITLKPDKLPRDKRK 4461

  Fly  1898 CVFCNQRGDGQADGPSRLLNFDVDKWVHLNCALWSNGVYETVSGALMNFQTALQAGLSQACSACH 1962
            |.||::.|||..|||:||||.|||.||||||||||..||||..|||:|.:.||:.||...|:.|.
Zfish  4462 CCFCHEEGDGATDGPARLLNIDVDLWVHLNCALWSTEVYETQGGALINVEVALRRGLRTRCAYCQ 4526

  Fly  1963 QPGATIKCFKSRCNSLYHLPCAIREECVFYKNKSVHCSVHGHAHAGITMGAGAGATTGAGLGGSV 2027
            :.|||..|.:.||.::||..||||..|:|:|:|::.|:.|                   .|.|. 
Zfish  4527 KTGATNSCNRLRCPNVYHFACAIRARCMFFKDKTMLCTQH-------------------KLKGP- 4571

  Fly  2028 ADNELSSLVVHRRVFVDRDENRQVATVMHYSELSNLLRVGNMTFLNVGQLLPHQLEAFHTPHYIY 2092
            ::.||||..|.|||:::|||.:|:|:::...:..:|.|||.:.|..||||||.|:..||:|..||
Zfish  4572 SEEELSSFAVFRRVYIERDEVKQIASILQRGDRIHLFRVGGLIFHAVGQLLPSQMAVFHSPSAIY 4636

  Fly  2093 PIGYKVSRYYWCVRRPNRRCRYICSIAEAGCKPEFRIQVQDAGDKEPEREFRGSSPSAVWQQILQ 2157
            |:||:.:|.||..|.|||||||.|.|:|...:|.|.::|.:.|.:  :..||.|:|..:|.:|:.
Zfish  4637 PVGYEATRIYWSTRVPNRRCRYRCRISEQDGRPLFEVRVLEHGYE--DLHFRDSTPDGIWAKIVH 4699

  Fly  2158 PITRLRKVHKWLQLFPQHISGEDLFGLTEPAIVRILESLPGIETLTDYRFKYGRNPLLEFPLAIN 2222
            .:.:||.....|:||.:|:.||:::|||..|::||.|||||:|:..||.|:|||:||:|.||.||
Zfish  4700 QVAKLRDEAAMLKLFTEHVRGEEMYGLTVHAVMRITESLPGVESCQDYTFRYGRHPLMELPLMIN 4764

  Fly  2223 PSGAARTEPKQRQLLVWRKPHTQRTAGSCSTQRMANSAAIAGEVACPYSKQFVHSKSSQYKKMKQ 2287
            |:|.||:|||  .|...::|||..:    ::...|..:...||:..||||||||||||||:::|.
Zfish  4765 PTGCARSEPK--ILTHCKRPHTLNS----TSMSKAYQSTFTGEINTPYSKQFVHSKSSQYRRLKT 4823

  Fly  2288 EWRNNVYLARSKIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQYESKNRGIYMFRLDED 2352
            ||:.|||||||:|||||||||:|:|||||:|||||.:||.||:..|||.||.:||||||||::.:
Zfish  4824 EWKTNVYLARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGIYMFRINNE 4888

  Fly  2353 RVVDATLSGGLARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGEELSYDYKFDIEDESHKI 2417
            .|:||||:||.|||:||||.||||.|:|..|::.:|||.:.|:|.:||||:|||:||.||:.|||
Zfish  4889 HVIDATLTGGPARYVNHSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQFDFEDDQHKI 4953

  Fly  2418 PCACGAPNCRKWMN 2431
            ||.|||.|||||||
Zfish  4954 PCHCGAWNCRKWMN 4967

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513 33/194 (17%)
ePHD2_KMT2C_like 1898..2002 CDD:277136 57/103 (55%)
FYRN 2068..2118 CDD:283589 28/49 (57%)
FYRC 2126..2215 CDD:197781 36/88 (41%)
SET <2266..2431 CDD:225491 111/164 (68%)
SET 2291..2413 CDD:214614 80/121 (66%)
PostSET 2415..2431 CDD:214703 13/15 (87%)
kmt2dXP_009295228.1 PHD_SF 122..205 CDD:304600
PHD1_KMT2C_like 218..263 CDD:276984
PHD_SF 265..310 CDD:304600
PHD 346..391 CDD:214584
PHD_SF 821..871 CDD:304600
PHD5_KMT2C_like 872..918 CDD:276988
PHD5_KMT2D 949..999 CDD:277074
HMG 1473..1528 CDD:197700
Med15 3305..>3717 CDD:255446 112/538 (21%)
PHD_SF 4462..4568 CDD:304600 58/124 (47%)
FYRN 4612..4662 CDD:283589 28/49 (57%)
FYRC 4668..4749 CDD:283590 32/82 (39%)
SET 4828..4949 CDD:214614 80/120 (67%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 155 1.000 Domainoid score I4180
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 638 1.000 Inparanoid score I798
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002860
OrthoInspector 1 1.000 - - otm26107
orthoMCL 1 0.900 - - OOG6_102575
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 1 1.000 - - X2220
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
98.980

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