DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trr and kmt2c

DIOPT Version :9

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:XP_031760372.1 Gene:kmt2c / 100486829 XenbaseID:XB-GENE-485111 Length:5103 Species:Xenopus tropicalis


Alignment Length:2487 Identity:642/2487 - (25%)
Similarity:952/2487 - (38%) Gaps:720/2487 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   277 TTATGSQTPTTTLL-----NRVNLHPK---------------MKTQLMVNAK------------- 308
            |...|||..:||||     :.|:|..|               :|::|.|.|:             
 Frog  3005 TEQHGSQATSTTLLSVPQASGVSLESKGDLMSSNSSDRPSVEVKSELGVEARTQQHDENSASVPL 3069

  Fly   309 -------KLSEVTQTTAKV-------------SIGNKTISVPLLKPLMSASGAATAGGATIVESK 353
                   |..:....:|.:             |.||...|.|:|..|:|:..:..|.    |||.
 Frog  3070 CSTECSVKREKEAHPSAHISEDAIALPEQDIGSSGNLPESTPVLAGLLSSDKSGNAE----VESL 3130

  Fly   354 QLLQPGGQVTTV------MSAAQQSGGQQVHPHVHSHAHHNF-------TKLIKRGPKNSGTIVS 405
            . ..||..|.|.      :..::|...|.::|.:....:|.|       :..:...|.....:..
 Frog  3131 D-CAPGAVVATEPCIPQDVRTSEQLMEQALNPSMTPRLNHGFPQGSPSKSPFVSALPSGHNFVSG 3194

  Fly   406 FSGLQIKPANTKIVATKVVSKKMLQLQQHQ------------------QQIQQQQQLQQLQVTSG 452
            .:..|..|...:..|..:.|.:.|.|||.:                  |:.|:|||.:|:|....
 Frog  3195 ENPSQTIPLPNQPCAAGLPSAQQLMLQQSRERPLLLEEQPLLLQDLLDQERQEQQQQRQMQAMIR 3259

  Fly   453 GGLAPPTGSIVTITTTNPSQTYAMVQDSATVGPAAHSEDDAPAPRKITAYSENLQKILNKSKSQE 517
            ....|...:|.....|:|.....||                            ..|.:||..:|.
 Frog  3260 QRSEPFFPNIDFDAITDPIMKAKMV----------------------------ALKGINKVMAQN 3296

  Fly   518 STGGPEEFTNINSVVIKPLDKNTLNCPPSFNIFKQQQHS-QAAQSQSISAVGSGAGTPVTFTMAS 581
            :.|.|....|                  .|....||..| ||..||||                 
 Frog  3297 NLGIPPMVIN------------------RFPFMAQQMSSAQAPDSQSI----------------- 3326

  Fly   582 GNASDLATTSTVSVSAGTICINSPMMGTRPIISIQNKNISLVLSKTTMAQQKPKMITTTTLSSQA 646
               ...|.|...|::......|.|..|...:...|.|.....|.:|                 |.
 Frog  3327 ---VQQAITQDGSLAPQMTRPNPPSFGPGFVNDSQKKKYEDWLQET-----------------QQ 3371

  Fly   647 ALQMHHALIQDSSADKAGSSANSGSATSGASMQLKLTTANTPTKLSVSLAPDVVKLEEVGSESKA 711
            .||:....::                                              |::|:..|:
 Frog  3372 LLQIQQKFLE----------------------------------------------EQIGAHRKS 3390

  Fly   712 K--LLVKQEAVVKDSTGTPTSEERAEEIGTPEKRLNANATMT--AINQVQNQSANQIQMATSTST 772
            |  |..||.|..|  ||....||.||::    |::....:|.  .:.|::.|.....::.....|
 Frog  3391 KKALSAKQRAAKK--TGREFPEEDAEQL----KQVTEQQSMVQKQLEQIRKQQKEHTELIEEYRT 3449

  Fly   773 ASNPSTPNPTVNATPM----NNQRSAAEDNALLKQLLQNNSSSHSLN-QISITSAHVGSASAS-- 830
            ..:..     .:.|||    .:|:......|......||...:.:|: |..:.   :|.|:.|  
 Frog  3450 KQHQQ-----FSITPMIPGGQHQQPVMPGGAPTSVNPQNFPLAQTLHPQAPVI---LGQANPSRM 3506

  Fly   831 -------APLSARKVINVRAPSMGKVRSLEDQLARPVIPPVPTATQAAGSSSSSGSVATSTTTTT 888
                   ||.:.|.::...||...:..:.:...:.|..||   ..:...::..|.:.........
 Frog  3507 PSLPGWQAPNAPRALVQPNAPRAQRPTNADVANSNPNAPP---RVEFDDNNPFSETFQERERKER 3568

  Fly   889 VASGGSSQQVATASATALPVSAVAITTPGVGGEAKLEQKSDQPAAIMQ---------------NQ 938
            :......|::                        :|.|:.|:...:.|               |.
 Frog  3569 LREQQERQRI------------------------QLMQEVDRQRVLQQRLEMEQHGMIGPDLNNG 3609

  Fly   939 SQNQAP------PPP----PPPQQQQQQQLH-QPQQLQPSPHQVKQTVQIVSKETSFISGPVAAK 992
            |.:|.|      |..    |.|.||..|..| .|||               :.:...::.|.||.
 Frog  3610 SLSQMPFFSSELPSDFMQLPQPSQQPPQASHTMPQQ---------------NLQQGLVNSPPAAN 3659

  Fly   993 TLVTEATSKPAELLPPPPYEMATAPISNVTIS----ISTKQAAPKELQMKPKAVAMSLPMEQGDE 1053
            .:.| |...|..|   .|:.....|:.:|..|    :||..|.|......|.|   |...:.|..
 Frog  3660 FIQT-AERSPMGL---SPFGQGAQPVQSVQQSPGSILSTGHAKPPFASSVPSA---SPAADNGHS 3717

  Fly  1054 SLPEQAEPPLHSEQGATA----AGVAPHSGGPLVSAQWTNNHLEGGVATTKIPFKPGEPQKRKLP 1114
            |..:.:....|.....:.    :.:.|...|.  ..:......:....:.|.|..|....  ..|
 Frog  3718 SEQDNSNTSSHQAPSQSLIQLYSAIIPEEKGK--KKRQRKKKKDDETESVKSPSTPRSDM--TAP 3778

  Fly  1115 MHPQLDE---------KQIQQQAEIPISTSLPTTPTGQGTPDKVQLISAIATYVKKSGV---PN- 1166
            :.|.|.|         ..:..|||.|......:||...|. ..|:|...:.....|..:   || 
 Frog  3779 LTPSLSEASTPTVTAPNDLAYQAEHPNDFIRSSTPNVTGN-TAVELEDPLVPADVKQRLFQEPNP 3842

  Fly  1167 -----------EAQPIQN---------------QSQGQVQMQAQMQATMQGHLSGQMSGQISGHA 1205
                       ||..|||               |.:|:::   :.:||....||..::.|.:...
 Frog  3843 ERTAAGQHHTTEALKIQNIKLERADEDQAVEAAQEEGKME---ENKATSHNALSMDITSQPASGP 3904

  Fly  1206 AGQIPAQMHLQVQHQLHMAVHPQQQQQQLHQNQPQNATIPLPVTGQGAVPIPVPTMESKAGDQRK 1270
            :|::.:...| ::|.|.....|....|:..::.......||.|        .||.|:   |....
 Frog  3905 SGKLESGNEL-LKHLLKNKKDPFMLHQKSEESLRSEEHCPLNV--------KVPEMQ---GHLNS 3957

  Fly  1271 RRKREVQKPRRTNLNAGQAGGALKDLTGPLPAGAMVQLAGMPPGTQYIQGAASGTGHVITSTGQG 1335
            .:..|.::|...|||......:..::....|....||                      .|.|: 
 Frog  3958 LQMPENKEPGCFNLNQSLFQKSEFEMEKKKPRNKRVQ----------------------RSEGK- 3999

  Fly  1336 VTLGGVGASTGASSSPMLKKRVRKFSKVEEDHDAF--TEKLLTHIR-QMQPLQVLEPHLNRNFHF 1397
                         ::|..|||    .|.||...|.  ..:..|.|: |:..|.::||        
 Frog  4000 -------------ATPRSKKR----KKDEEQKSAIYANAETFTQIKQQLSLLPLIEP-------- 4039

  Fly  1398 LIGSNETSGGGSPASMSSAASAGSSSAGGGKLKGGSRGWPLSRHLEGLEDCDGTVLGRYGRVNLP 1462
            ::|.|          ::.....|:.|...|....|:.|   |..|||:.|....::.:...::.|
 Frog  4040 IVGMN----------IAQFLPYGAGSVCTGSRLHGTFG---SASLEGVSDYYSQLIFKQNNLSNP 4091

  Fly  1463 GIP------------------SLYDSERFGGSRGLVGG-----------------------SART 1486
            ..|                  ....:|...|...::||                       .|.|
 Frog  4092 PTPPASLPPTPPPVSCQKLVNGFATTEELAGKAAILGGHVTKALGPKQFQLPFRTQDDLIARAMT 4156

  Fly  1487 RSPSPAESPGAEKMLPMSSIQNDFYDQEFSTHME-RNPRERLVRHIGAVKDCNLETVDLVESEGV 1550
            :.|...:.| |....|..:.|.:...|:   |.: |:..:..      |...:.|:|..:|    
 Frog  4157 QGPKSVDVP-ASLPTPPHNNQEELRAQD---HCDSRDSPDSF------VPSSSPESVVGIE---- 4207

  Fly  1551 AAWATLPRLTRYPGLILLNGNSRCHGRMSPVALPEDPLTMRFPVSPLLRSC---GEELR----KT 1608
                    :.|||.|.|:...            |.||  .:.|:.|:|.|.   |..||    ||
 Frog  4208 --------IRRYPDLSLVKEE------------PPDP--AQSPIIPILPSSMGKGSVLRDCAFKT 4250

  Fly  1609 QQM--ELGMGPLGNNNNNNYQQKNQNVILALPASASENIAGVLRDLANLLHLAPALTCKIIEDK- 1670
            :..  .:..||......:..:....:|.:.|..:|:|||:||:...|:||.:....:.::...: 
 Frog  4251 EPPPGTMFFGPQFVQAPSGPKTGLISVAITLHPTAAENISGVVAAFADLLQVQIPTSYEVSNARE 4315

  Fly  1671 -------IGNKLEDQ----------------------------------FMNQDDEKHVDFKRPL 1694
                   .|::|...                                  |::.|:    .|:...
 Frog  4316 PGSVILMNGHRLNPNMDYRQQFFRQRPRPGPLPPGRLIGPYGLRPQNLPFLSSDN----GFRHNN 4376

  Fly  1695 SQVSHGHLRKILNGRRKLCRSCGNVVHATGLRVPRHSVPALEEQLPRLAQLMDMLPRKSVPPPFV 1759
            |.:....:.|     ...|..|..||...|:|.....:...:::..|....||         ..:
 Frog  4377 SNIESSPVLK-----PSWCCHCKVVVLGCGVRKSMKDLSFFKQECLRSPGRMD---------GNL 4427

  Fly  1760 YFCDRACFARF-------------------------------KWNGKDGQAEAASL-LLQPAGGS 1792
            .||...||..:                               ::|......:...| |||.    
 Frog  4428 VFCSNNCFLLYSAAQSKHLEAKRPDPSFLPPSVKEAQPKSCHQYNTNTSTLDVHCLPLLQE---- 4488

  Fly  1793 AVKSSNGDSPG-SFCASSTAPAEMVVKQEPEDEDEKTPSVPGNPTNI--------PAQRK----- 1843
              |||...||. ||..::...|::..|   .||.:.|..:...|..:        ||.:|     
 Frog  4489 --KSSPPTSPPISFPPAAFQTAKVEAK---PDELKVTVKLKPRPRAVHGGYDDCRPASKKWRGMK 4548

  Fly  1844 --------CIVKC-FSADCFTTDSAPSGLELDGTAGAGTGAGPVNNTVWETETSGLQLEDTRQCV 1899
                    .|.|. |...| ..:.|    |:....|......|:             .:|.|:|.
 Frog  4549 WKKWSVQIVIPKMPFKPQC-ENELA----EMFRRLGTSLKPHPL-------------CKDYRKCC 4595

  Fly  1900 FCNQRGDGQADGPSRLLNFDVDKWVHLNCALWSNGVYETVSGALMNFQTALQAGLSQACSACHQP 1964
            ||::.|||..||.:||||.|:|.||||||||||..||||.:|||:|.:.||:.||...|..||:.
 Frog  4596 FCHEEGDGLTDGSARLLNLDLDLWVHLNCALWSTEVYETQAGALINVELALRRGLQMKCGFCHKT 4660

  Fly  1965 GATIKCFKSRCNSLYHLPCAIREECVFYKNKSVHCSVHGHAHAGITMGAGAGATTGAGLGGSVAD 2029
            |||..|.:.||.::||..|||:.:|:|:|:|::.|::|                ...||    .:
 Frog  4661 GATSSCHRLRCTNIYHFTCAIKAQCMFFKDKTMLCTMH----------------KPKGL----HE 4705

  Fly  2030 NELSSLVVHRRVFVDRDENRQVATVMHYSELSNLLRVGNMTFLNVGQLLPHQLEAFHTPHYIYPI 2094
            .||:...|.|||:|.|||.||:|:::...|..:..|||::.|..:|||||.|::.||:...::|:
 Frog  4706 QELTYFAVFRRVYVQRDEVRQIASIVQRGERDHTFRVGSLIFHAIGQLLPQQMQNFHSATALFPV 4770

  Fly  2095 GYKVSRYYWCVRRPNRRCRYICSIAEAGCKPEFRIQVQDAGDKEPEREFRGSSPSAVWQQILQPI 2159
            |::.||.||.:|..||||||:|||.|....|.|.::|.:.|.:  |.....||...||.:||:|:
 Frog  4771 GFEASRLYWSMRYANRRCRYLCSIEENDGLPLFVVRVIEPGHE--ELVLMDSSLKGVWDKILEPV 4833

  Fly  2160 TRLRKVHKWLQLFPQHISGEDLFGLTEPAIVRILESLPGIETLTDYRFKYGRNPLLEFPLAINPS 2224
            ...||..:.|:|||..:.||||:|||..|:.||.|||||:|...:|.|:||||||:|.|||||||
 Frog  4834 ANCRKGSEILRLFPVFLKGEDLYGLTASAVTRIAESLPGVEACENYTFRYGRNPLMELPLAINPS 4898

  Fly  2225 GAARTEPK-----QRQLLVWRKPHTQRTAGSCSTQRMANSAAIAGEVACPYSKQFVHSKSSQYKK 2284
            |:||:|||     :|.:|   :||   |..|.||.:...| .:.||:..||||||||||||||:|
 Frog  4899 GSARSEPKMNSHVKRFVL---RPH---TLNSTSTSKSFQS-TVTGELNAPYSKQFVHSKSSQYRK 4956

  Fly  2285 MKQEWRNNVYLARSKIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQYESKNRGIYMFRL 2349
            ||.||::|||||||:|||||||||||||||||:|||||.:||.||:..:||.|||:|||:||||:
 Frog  4957 MKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGVYMFRI 5021

  Fly  2350 DEDRVVDATLSGGLARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGEELSYDYKFDIEDES 2414
            |.:.|:||||:||.||||||||.||||.|:|..::..||||.:.|:|.:|||||||||||.||:.
 Frog  5022 DNEHVIDATLTGGPARYINHSCAPNCVAEVVTFEKGHRIIISSNRRIQKGEELSYDYKFDFEDDQ 5086

  Fly  2415 HKIPCACGAPNCRKWMN 2431
            |||||.|||.|||||||
 Frog  5087 HKIPCHCGAVNCRKWMN 5103

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513 17/82 (21%)
ePHD2_KMT2C_like 1898..2002 CDD:277136 55/103 (53%)
FYRN 2068..2118 CDD:283589 23/49 (47%)
FYRC 2126..2215 CDD:197781 40/88 (45%)
SET <2266..2431 CDD:225491 118/164 (72%)
SET 2291..2413 CDD:214614 85/121 (70%)
PostSET 2415..2431 CDD:214703 13/15 (87%)
kmt2cXP_031760372.1 PHD_SF 244..327 CDD:419867
PHD1_KMT2C_like 340..385 CDD:276984
PHD2_KMT2C 387..432 CDD:277069
PHD3_KMT2C 464..515 CDD:276986
PHD4_KMT2C 919..975 CDD:277071
PHD5_KMT2C_like 976..1022 CDD:276988
PHD_SF 1053..1103 CDD:419867
HMG 1645..1698 CDD:197700
PHA03247 <2019..2550 CDD:223021
Myosin_tail_1 <3363..>3450 CDD:396244 24/155 (15%)
PHD_SF 4594..4698 CDD:419867 55/103 (53%)
FYRN 4743..4794 CDD:399155 24/50 (48%)
FYRC 4801..4884 CDD:399156 36/84 (43%)
SET_KMT2C_2D 4950..5102 CDD:380948 108/151 (72%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 156 1.000 Domainoid score I4130
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002860
OrthoInspector 1 1.000 - - otm47942
Panther 1 1.100 - - O PTHR45888
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2220
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
55.100

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