DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trr and Kmt2d

DIOPT Version :9

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:XP_017450810.1 Gene:Kmt2d / 100362634 RGDID:2324324 Length:5544 Species:Rattus norvegicus


Alignment Length:2736 Identity:710/2736 - (25%)
Similarity:1062/2736 - (38%) Gaps:768/2736 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 LQKRS--GDDTATPAEDPTRKKAKTELLLGTGTAAPSLPAKASSTAPQQL--------------- 81
            ||||.  ...|..||:...:::.....||.....|.:||....|..||||               
  Rat  3239 LQKRQQLSAQTVLPAQPQQQQQQHQHPLLPVPGPAQALPLPHESGPPQQLALGLGSTRQPGLGQS 3303

  Fly    82 ----------LYQR---------------SGQQA---------KAQVKAASEPQDVETADGVWD- 111
                      |.||               |||||         .:|...|.:|.:...|..... 
  Rat  3304 MMAAQSPAHALQQRLAPSVAMVSNQGHMLSGQQAGQTGLVPQQSSQPVLAQKPMNAMPASMCMKP 3368

  Fly   112 ---ARDQQIIVCNFGSGTEMGAIKAED------------------ADKQSEYRISTPRNSQSNPL 155
               |..||.:..:|...|::....|||                  ...|....::...|.|...|
  Rat  3369 QQLAMQQQQLANSFFPDTDLDKFAAEDIIDPIAKAKMVALKGIKKVMAQGSIGVAPGMNRQQVSL 3433

  Fly   156 LHRNTAFTSFTKKEGASSSASSSSSTASVISIEPSGSGQDHAENSGKSEDLDYVLMPASGADSST 220
            |.:        :..|||.|...:.:.|        ||||:.                        
  Rat  3434 LAQ--------RLSGASGSDLQNHAAA--------GSGQER------------------------ 3458

  Fly   221 SVGNSTGTGTPAGTPIGATTSTIILNANNGTAGVSGAGTTTILTQKSGHTNYN--IFNTTATGSQ 283
               |::....|...|  .|.:..::|                   ::....|.  :|:|... .|
  Rat  3459 ---NASDPSQPRPNP--PTFAQGVIN-------------------EADQRQYEEWLFHTQQL-LQ 3498

  Fly   284 TPTTTLLNRVNLHPKMKTQLM---------------VNAKKLSEVTQTTAKV------------- 320
            .....|..::.:|.|.:..|.               .:|:||..||:..:|:             
  Rat  3499 MQLKVLEEQIGVHRKSRKALCAKQRTAKKAGREFPEADAEKLKLVTEQQSKIQKQLDQVRKQQKE 3563

  Fly   321 ------SIGNK----------------TISV-PLLKP---------LMSASG--------AATAG 345
                  ...||                .::| |...|         |:...|        ...||
  Rat  3564 HTNLMAEYRNKQQQQQQQQQQQQQHSAVLAVSPSQNPRVLTKHPGQLLPGHGLQPPQVPPGGQAG 3628

  Fly   346 GATIVESKQLL--QPGGQVTTVMSAAQQSGGQQVHPHVHSHAHHNFTKLIKRGPKNSGTIVSFSG 408
            |..:.....:|  |.||.......|.||...||..........|:.......||..|        
  Rat  3629 GLRLPPGGMVLPGQSGGPFLNTTLAQQQQQQQQQQQQQQQQQQHSGVAGSLTGPSGS-------- 3685

  Fly   409 LQIKPANTKIVA----TKVVSKKMLQLQQHQ----QQIQQQQQLQQLQVTSGGGLAPPTGSIVTI 465
              ..|.|..:.:    ::::.::.|||||.:    |::|||||.||.|                 
  Rat  3686 --FFPGNLALRSLGPDSRLLQERQLQLQQQRMQLAQKLQQQQQQQQQQ----------------- 3731

  Fly   466 TTTNPSQTYAMVQDSATVGPAAHSEDDAPAPRKITAYSENLQKILNKSKSQESTGGPEEFTNINS 530
               ...|....|......||...::...|.|:.:...| |.|.:|.:..|.:.:.|.:.....:.
  Rat  3732 ---QQQQLLGQVAVQQQQGPVGQNQALGPKPQGLLPPS-NHQGLLVQQLSPQQSQGSQGMLGSSQ 3792

  Fly   531 VVIKPLDKNTLNCPPSFNIFKQQQHSQAAQSQSISAVGSGAGTPVTFTMASGNASDLATTSTVSV 595
            |.:....:.           :|||..|..|.|...|:|                           
  Rat  3793 VAVLQQQQQ-----------QQQQQQQQQQQQHSGALG--------------------------- 3819

  Fly   596 SAGTICINSPMMGTRPIISIQNKNISLVLSKTTMAQQKPKMITTTTLSSQAALQMHHALIQDSSA 660
                     |....|.::..|::    |||...:|||...::....|::|...|      |....
  Rat  3820 ---------PQGPHRQVLMTQSR----VLSSPQLAQQGHGLMGHRLLTAQQQQQ------QQQQQ 3865

  Fly   661 DKAGSSANSGSATSGASMQLKLTTANTPTKLSV--------------SLAPDVVKLEEVGSESKA 711
            .:.......||.|..:.:|..:.:.....|:||              .|.....:::::..:.:.
  Rat  3866 QQQQQQQQQGSMTGLSQLQQGMMSHGGQPKMSVQALGSLQQQQQQQQQLQQQQQQMQQLQQQQQQ 3930

  Fly   712 KLLVKQEAVVKDSTGTPTSEERAEEIGTPEKRLNANATMTAINQVQ------NQSANQIQMATST 770
            :|..:|:..::.........::.::....:::|:....:....|:|      .|...|:.:....
  Rat  3931 QLQQQQQQQMQQLQQQQQQLQQQQQQQQQQQQLHLQQQLHQQQQLQQQQLQLQQQQQQMSLLNQN 3995

  Fly   771 STASNPS---------TPNPTVNATPMNNQRS-AAEDNALLKQLLQNNSSSHSLNQISIT---SA 822
            .|..:|.         |..|.:...|:.:..| .|...|||....:.|.:..:|.. .:|   ||
  Rat  3996 RTLLSPQQQQQQQQQVTLGPGMPVKPLQHFSSPGALGPALLLTGKEQNIAETALPS-EVTEGPSA 4059

  Fly   823 H------VGSASASAPLSARKVINVRAPSMGKVRSLEDQLARPVIPPVPTATQAAGSSSSSGSVA 881
            |      ||:...|..:...:|    .||:    |.:.||.  ::...||:.|........|...
  Rat  4060 HQGGPPTVGTTPESMSVEPGEV----KPSI----SGDSQLL--LVQSQPTSVQLQPPLRLPGQPQ 4114

  Fly   882 TSTTTTTVASGGSSQQVATASATALPVSAVAITTPGV------GGEAKLEQKSDQPAAI---MQN 937
            ......|...|...||:.:.|::..|.....:..|.|      |..|:....|.||..:   :||
  Rat  4115 QVNLLHTTGGGSHGQQLGSGSSSEAPSGPHLLAQPSVSLGEQPGPMAQNLLGSQQPLGLERPIQN 4179

  Fly   938 QSQNQAPPPPPPPQQ--------------QQQQQLH-----QPQQLQPSPHQVKQTVQIVSKETS 983
            .:.:|.|...|.||.              |.:.||.     .||....||.|.:|          
  Rat  4180 NTGSQPPKSGPAPQSGQGPPGVGVMPTVGQLRAQLQGVLAKTPQLRHLSPQQQQQ---------- 4234

  Fly   984 FISGPVAAKTLVTEATSKPAELLPPPPYEMATAPISNVTISISTKQAAPKE----LQMKPKAVAM 1044
                 :.|..:..:.....|....||..|..|.|             :|.:    .|.:|...:.
  Rat  4235 -----LQALLMQRQLQQSQAVRQMPPGQESGTQP-------------SPLQGLLGCQPQPGVFSA 4281

  Fly  1045 SL--PMEQ-GDESLPEQAEPPLHSEQGATAAGVAPHSGGPLVSAQWTNNHLEGGVATTKIPFKPG 1106
            |.  |::: |..|.| |..|.|...|||.       |.||::          |.|..|..|..|.
  Rat  4282 SQIGPLQELGAGSRP-QGPPRLPVPQGAL-------STGPVL----------GPVHPTPPPSSPQ 4328

  Fly  1107 EPQKRKLPMHPQLDEKQIQQQAEIPISTSLPTTPTGQGTPDKVQLISAIATYVKKSGVPNEAQPI 1171
            ||::                .:::| |.|...|||..|||             |..|..:|..| 
  Rat  4329 EPKR----------------PSQLP-SPSAQLTPTHPGTP-------------KPQGPASELPP- 4362

  Fly  1172 QNQSQGQVQ-MQAQMQATMQG----------HLSGQMSGQISGHAAGQIPAQMHLQVQHQ-LHMA 1224
                 |:|. ..||:.....|          :|......:.|..|||:: .|::.||.|: .|::
  Rat  4363 -----GRVSPAAAQLADAFFGKGLGPWDPSDNLPEAQKPEQSSLAAGRL-EQVNGQVAHEPSHLS 4421

  Fly  1225 VHPQQQQQ------QLHQNQPQNATIPLPVTGQGAVPIPVPTMESKAGD---QRKRRKREVQKPR 1280
            :..:.:::      |..:.:........|.|....:   :....|:||.   |:..|.:.||   
  Rat  4422 IKQEPREEPCALGAQTVKREANGEPAGAPGTSNHLL---LAGSRSEAGHLLLQKLLRAKNVQ--- 4480

  Fly  1281 RTNLNAGQAGGALKDLTGPLPAGAMVQLAGMPPGTQYIQGAASGTGHVITS-TGQGVTLGGVGAS 1344
               |.||:.           |.|...::                .|||.:. :||...|.|..:|
  Rat  4481 ---LGAGRG-----------PEGLRAEI----------------NGHVDSKLSGQEQKLQGTSSS 4515

  Fly  1345 --TGASSSPML--KKRVRKFS--------KV-EEDHDAFTEKLLTHIRQ-MQPLQVLEPHLNRNF 1395
              ..|:..|::  .|||:|.|        |: :||.....|.||..::| :..|.:.||.:..||
  Rat  4516 KEDAAARKPLMAKPKRVQKTSDRLASSRKKLRKEDGVRANEALLKQLKQELSQLPLTEPTITANF 4580

  Fly  1396 HFLIGSNETSGGGSPASMSSAASAGSSSAGGGKLKGGSRGWPLSRHLEGLEDCDGTVLGRYGRVN 1460
            ...                       :..|.|.|.||                ...:.|.:|...
  Rat  4581 SLF-----------------------APFGSGCLVGG----------------QSQLRGAFGSGA 4606

  Fly  1461 LPGIPSLYDSERFGGSRGLVGGSARTRSPSPAESPGAEKMLPMSSIQNDFYD-----QEFSTH-- 1518
            |...|..|..        |:..:..:..|:|   |.:....|..|:|....:     :|...|  
  Rat  4607 LHTGPDYYSQ--------LLTKNNLSNPPTP---PSSLPPTPPPSVQQKMVNGVTPSEELGEHPK 4660

  Fly  1519 --MERNPRERLVRHIGAVK-----------------DCNLETVDLVESEGVAAWATLP------R 1558
              ......||.::....||                 |..:|:.:..:|......|:.|      .
  Rat  4661 DAASAQDSERTLKDAAEVKSLDLLAALPTPPHNQTEDVRMESDEDSDSPDSIVPASSPESILGEE 4725

  Fly  1559 LTRYPGLILLNGNSRCH---GRMSPVALPEDPLTMRFPVSPLLRSCGE-ELR-----KTQQMELG 1614
            ..|:|.|    |:.|..   ..:||| :|..|.| ..||.|..:..|. :|.     .....|.|
  Rat  4726 APRFPQL----GSGRWEQDTRALSPV-IPIIPRT-SIPVFPDTKPYGVLDLEVPGKPPATAWEKG 4784

  Fly  1615 MGPLGNNNNNNYQQKNQNVILALPASASENIAGVLRDLANLLHLAPALTCKIIEDKIGNKLEDQF 1679
            .|            ...:|:|.:.|:|::|:.||:..:|.||.:           ||.|..|..|
  Rat  4785 KG------------SEVSVMLTVSAAAAKNLNGVMVAVAELLSM-----------KIPNSYEVLF 4826

  Fly  1680 MNQDDEKHVDFKRPLSQVSHGHLRKILNGRRKLCRSCGNVVHATGLR-----VPRHSVPALEEQL 1739
            .:......::.|:..::.|.|. .|.|:||       |.......|:     :|.::   |:.||
  Rat  4827 PDGPARAGLEPKKGETEGSGGK-EKGLSGR-------GPDTGPDWLKQFDAVLPGYT---LKSQL 4880

  Fly  1740 PRLAQLMDMLPRKSVPPPFVYFCDRACFARFKWNGKDGQAEAASLLLQPAGGSAVKSSNGDSPGS 1804
            ..|:.|....|   .|.|.:..       .:.:|..:......| ...|...|...|....||.|
  Rat  4881 DILSLLKQESP---APEPSIQH-------SYTYNVSNLDVRQLS-APPPEEPSPPPSPLAPSPAS 4934

  Fly  1805 FCASSTAPAEMVVKQEPEDEDEKTPSVPGNPTNIPAQRKCIVKCFSADCF-----------TTDS 1858
                  .|||.:|:.:.|     .|:.|..|:.:|.       ..|.:..           :.||
  Rat  4935 ------PPAEPMVELQAE-----PPAEPPIPSPLPL-------ASSPEATRPKPRARPPDESEDS 4981

  Fly  1859 AP-----------SGLELDGTAGAGTGAGPVNNTVWE-TETSGLQL------EDTRQCVFCNQRG 1905
            .|           ..|.|..|...|:|.......|.| .|..|..|      .|.|:|.||::.|
  Rat  4982 RPPRLKKWKGVRWKRLRLLLTIQKGSGRQEDEREVAEFMEQLGTALRPSKVPRDNRRCCFCHEEG 5046

  Fly  1906 DGQADGPSRLLNFDVDKWVHLNCALWSNGVYETVSGALMNFQTALQAGLSQACSACHQPGATIKC 1970
            ||..|||:||||.|:|.||||||||||..||||..|||||.:.||..||...||.|.:.|||..|
  Rat  5047 DGATDGPARLLNLDLDLWVHLNCALWSTEVYETQGGALMNVEVALHRGLLTKCSLCQRTGATGSC 5111

  Fly  1971 FKSRCNSLYHLPCAIREECVFYKNKSVHCSVHGHAHAGITMGAGAGATTGAGLGGSVADNELSSL 2035
            .:.||.::||..||||.:|:|:|:|::.|.:|                   .:.|. .:.||||.
  Rat  5112 NRMRCPNVYHFACAIRAKCMFFKDKTMLCPMH-------------------KIKGP-CEQELSSF 5156

  Fly  2036 VVHRRVFVDRDENRQVATVMHYSELSNLLRVGNMTFLNVGQLLPHQLEAFHTPHYIYPIGYKVSR 2100
            .|.|||:::|||.:|:|:::...|..::.|||.:.|..:|||||||:..||:...:||:||:.:|
  Rat  5157 AVFRRVYIERDEVKQIASIIQRGERLHMFRVGGLVFHAIGQLLPHQMADFHSATALYPVGYEATR 5221

  Fly  2101 YYWCVRRPNRRCRYICSIAEAGCKPEFRIQVQDAGDKEPEREFRGSSPSAVWQQILQPITRLRKV 2165
            .||.:|..||||.|.|||:|...:|||.|:|.:.|.:  :..|..:||.|||.:|::|:..:||.
  Rat  5222 IYWSLRTNNRRCCYRCSISENNGRPEFVIKVIEQGLE--DLVFTDASPQAVWNRIIEPVAAMRKE 5284

  Fly  2166 HKWLQLFPQHISGEDLFGLTEPAIVRILESLPGIETLTDYRFKYGRNPLLEFPLAINPSGAARTE 2230
            ...|:|||:::.||:|||||..|::||.|||||:|:..:|.|:|||:||:|.||.|||:|.||:|
  Rat  5285 ADMLRLFPEYLKGEELFGLTVHAVLRIAESLPGVESCQNYLFRYGRHPLMELPLMINPTGCARSE 5349

  Fly  2231 PKQRQLLVWRKPHTQRTAGSCSTQRMANSAAIAGEVACPYSKQFVHSKSSQYKKMKQEWRNNVYL 2295
            ||  .|..:::|||..:    ::...|..:...||...||||||||||||||::::.||:|||||
  Rat  5350 PK--ILTHYKRPHTLNS----TSMSKAYQSTFTGETNTPYSKQFVHSKSSQYRRLRTEWKNNVYL 5408

  Fly  2296 ARSKIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQYESKNRGIYMFRLDEDRVVDATLS 2360
            |||:|||||||||:|:|||||:|||||.:||.||:..|||.||.:||||||||::.:.|:||||:
  Rat  5409 ARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGIYMFRINNEHVIDATLT 5473

  Fly  2361 GGLARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRGEELSYDYKFDIEDESHKIPCACGAPN 2425
            ||.||||||||.||||.|:|..|::.:|||.:.|:|.:||||:|||:||.||:.|||||.|||.|
  Rat  5474 GGPARYINHSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQFDFEDDQHKIPCHCGAWN 5538

  Fly  2426 CRKWMN 2431
            ||||||
  Rat  5539 CRKWMN 5544

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513 22/152 (14%)
ePHD2_KMT2C_like 1898..2002 CDD:277136 58/103 (56%)
FYRN 2068..2118 CDD:283589 24/49 (49%)
FYRC 2126..2215 CDD:197781 41/88 (47%)
SET <2266..2431 CDD:225491 112/164 (68%)
SET 2291..2413 CDD:214614 82/121 (68%)
PostSET 2415..2431 CDD:214703 13/15 (87%)
Kmt2dXP_017450810.1 ePHD1_KMT2D 134..217 CDD:277165
PHD1_KMT2C_like 228..273 CDD:276984
PHD_SF 275..320 CDD:304600
PHD3_KMT2D 1335..1385 CDD:277072
PHD5_KMT2C_like 1386..1432 CDD:276988
PHD5_KMT2D 1463..1513 CDD:277074
HMG 1979..2030 CDD:197700
ePHD2_KMT2D 5039..5145 CDD:277168 59/124 (48%)
FYRN 5189..5239 CDD:283589 24/49 (49%)
FYRC 5247..5334 CDD:197781 41/88 (47%)
SET 5404..5526 CDD:214614 82/121 (68%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166351985
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

Return to query results.
Submit another query.