DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trr and Setdb2

DIOPT Version :9

Sequence 1:	NP_726773.2	Gene:	trr / 31149	FlyBaseID:	FBgn0023518	Length:	2431	Species:	Drosophila melanogaster
Sequence 2:	XP_038949803.1	Gene:	Setdb2 / 100361710	RGDID:	2319564	Length:	1008	Species:	Rattus norvegicus

Alignment Length:	465	Identity:	91/465 - (19%)
Similarity:	147/465 - (31%)	Gaps:	129/465 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1585 EDPLTMRFP-------VSPLLRSCGEELRKTQQMELGMGPLGNNNNNNYQQKNQNVILALPAS-- 1640
            |.|.|...|       ..|::......:.:||:..:...|....:..:|.:||...:.:..|:
  Rat   431 ESPKTEGCPPKFSSDLEEPVVEMNNRNISRTQRHSVIRRPKSKTDVFHYNEKNMGFVCSYSAAPE 495

  Fly  1641 -------ASENIAGVLR----DLANLLHLAPALTCKIIEDKIGNKLEDQFMNQDDEKHVDFKRPL 1694
                   |.|::....|    ||::              .::|.. ||:.:.:.|.......|..
  Rat   496 EKNGFKPAQEHLDSKARRAHEDLSS--------------SQVGYS-EDKQLTESDVIDTTTSRED 545

  Fly  1695 SQVSHG--HLRKILNGR--RKLCRSCGNVVHATGLRVPRHSVPALEEQLPRLAQLMDM------- 1748
            :..::|  | ..|||.:  :|:            |.||   |...:|:.|..:|...:
  Rat   546 TSPAYGCKH-AAILNSKNTKKV------------LEVP---VKTSQEEEPAASQSQQVSCGEELA 594

  Fly  1749 LPRKSVPPPFVYFCDRACFARFKWNGKDGQAEAASLLLQPAGGSAVKSSNGDSPGSFCASSTAPA 1813
            ..|..:|...:.                 |....||.|       :.:|...:.|.|...|..|.
  Rat   595 SERTKIPSASLV-----------------QLSKESLFL-------LDASKEGNVGRFLNHSCYPN 635

  Fly  1814 EMVVKQEPEDEDEKTPSVPGNPTNIPAQRKCIVKCFSADCFTTDSAPSGLELDGTAGAGTGAGPV 1878
            ..|.....|..|...|                    .|..||.....:..||....|...|..|.
  Rat   636 LWVQNVFVETHDRNFP--------------------LAAFFTNRYVKARTELTWDYGYEAGTMPE 680

  Fly  1879 NNTVWETETSGLQLEDTRQCVFCNQRGDGQADGPSRLLNFDVDKWVHLNCALWSNGVYETVS--- 1940
            ...:.:......:..:.|.||.|.:..|......|...|..    .|.||.|:|:|:.|..:
  Rat   681 KEILCQCFCQVTEKMEKRTCVLCPEGHDWSVIYFSPSANIA----AHENCLLYSSGLVECEAHDP 741

  Fly  1941 -GALMNFQTA-----LQAGLSQACSACHQPGATIKCFKSRCNSLYHLPCAIREECVF-------Y 1992
             ....||..:     :..|.:..||.|:..||.:.|.::.|...|||.||..:..:.       |
  Rat   742 FNIAKNFDVSSVLEKIWNGSTSKCSFCNNEGAIMGCDETSCAKNYHLLCAKEDRAILQVGVKRTY 806

  Fly  1993 KNKSVHCSVH 2002
            |   :.|..|
  Rat   807 K---IFCPEH 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trr	NP_726773.2	PHA03255	184..>320	CDD:165513
		ePHD2_KMT2C_like	1898..2002	CDD:277136	31/119 (26%)
		FYRN	2068..2118	CDD:283589
		FYRC	2126..2215	CDD:197781
		SET	<2266..2431	CDD:225491
		SET	2291..2413	CDD:214614
		PostSET	2415..2431	CDD:214703
Setdb2	XP_038949803.1	HMT_MBD	152..212	CDD:238689
		SET	210..687	CDD:394802	58/330 (18%)
		SET	365..>425	CDD:395687
		PHD_SF	700..813	CDD:419867	31/119 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351976
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930