DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trr and kmt2a

DIOPT Version :9

Sequence 1:NP_726773.2 Gene:trr / 31149 FlyBaseID:FBgn0023518 Length:2431 Species:Drosophila melanogaster
Sequence 2:XP_031762525.1 Gene:kmt2a / 100135006 XenbaseID:XB-GENE-922912 Length:3848 Species:Xenopus tropicalis


Alignment Length:2264 Identity:456/2264 - (20%)
Similarity:763/2264 - (33%) Gaps:666/2264 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   379 PHVHSHAHHNFTKLIKRGPKNSGTIV----SFSGLQIKPANTKIVATKVVSKKMLQLQQHQQQIQ 439
            |.::|...|...:.|...|::..:.|    |..|:       |.:.|..:|              
 Frog  2040 PDINSTVQHEENRTIAHSPQSLHSDVQENQSTDGI-------KCIETLCLS-------------- 2083

  Fly   440 QQQQLQQLQVTSGGGLAPPTGSIVTITTTNPSQTYAMVQDSATVGPAAHSEDDAPAPRKIT---- 500
            ....:....||....:..|:|....|...:|||.          .|.:.....|.:|..:|    
 Frog  2084 SPDSVSAASVTKPWEVGRPSGCRTHIPRYSPSQR----------SPGSRPLPSAGSPSPVTHEIV 2138

  Fly   501 -----AYSENLQKILNKSKSQESTGGPEEFTNINSVVIKPLDKNTLNCPPSFNIFKQQQHSQAAQ 560
                 ..|..|:||.::..|..|. .|::...|.|                       .|.|.  
 Frog  2139 TVGDPLLSSGLRKIGSRRHSSSSL-SPQQHKKIFS-----------------------PHPQT-- 2177

  Fly   561 SQSISAVGSGAGTPVTFTMASGNASDLATTSTVSVSAGTICINSPMMGTRPIISIQNKNISLVLS 625
              .||..|                                   .|:.|. |:.|::|.       
 Frog  2178 --DISRFG-----------------------------------QPLQGI-PVNSLENS------- 2197

  Fly   626 KTTMAQQKPKMITTTTLSSQAALQMHHALIQDSSADKAGSSANSGSATSGASMQLKLTTA----- 685
                ....|..|..:|:||                 |:..|.|:|.    .:::.||..|     
 Frog  2198 ----GNGDPVCIGASTISS-----------------KSSCSPNTGQ----KAIECKLEKAPEARR 2237

  Fly   686 ----NTPTKLSVSLAPDVVKLEEVGSESKAKLLVKQEAVVKDSTGTPTSEERAEEIGTPEKRLNA 746
                .||:|:|..      |.|:|.:.|..         |.|    |:||..:.::.:..:.:.|
 Frog  2238 TGFLETPSKVSTP------KTEKVKTASPR---------VSD----PSSEHPSPKVPSQVQEMTA 2283

  Fly   747 NATMTAINQVQNQSANQIQMATSTSTASNPSTPNPTVNATPMNNQRSAAEDNALLKQLLQNNSSS 811
            :|:......:::.|...:...||::                |.:|:....||.....:.|..:.|
 Frog  2284 DASKNKAGCLKDSSPALLNFKTSSN----------------MQHQKVIRRDNDRQSVVTQGETPS 2332

  Fly   812 --HSLNQISITSAHVGSASASAPLSARKVINVRAPSMGKVRSLEDQLARPVIPPVPTATQAA--- 871
              ...|...:.|.|        .:|..|...|:........|.:...::|     |:..:.|   
 Frog  2333 LEKGKNSQILASNH--------GISVHKDRRVKTKRSMLDNSKDKHSSKP-----PSDNEHAPDN 2384

  Fly   872 --GSSSSSGSVATSTTTT------------TVASGGSSQQVAT-ASATALPVSAVAITTPGVGGE 921
              ....::|:...|.|.:            .::|.|:||...| .||..||.     |..|:.|.
 Frog  2385 RQNEPDTNGNHMLSDTLSFRAHLLKKSIDNGISSPGNSQSEETLVSAGKLPQ-----TKMGIDGG 2444

  Fly   922 AKLE------QKSDQPAAIMQNQ-----SQNQAPPPPPPPQQQQQQQLHQPQQLQPSPHQVKQTV 975
            ..:|      ..::|.|.:..|:     |......|                        |.||.
 Frog  2445 CNIEIAKQTTSSANQSAELADNEKHKCVSDGTGDVP------------------------VSQTN 2485

  Fly   976 QIVSKETSFISG-PVAAKTLVTEATSKPAELLPPPPYEMATAPISNVTISISTKQAAPKELQMKP 1039
            .....|....|. |:...:||.:..||..|                   ..|.|:..|:......
 Frog  2486 SNADSEPQTGSAYPIQESSLVHQDGSKTQE-------------------DGSYKRRYPRRSARAR 2531

  Fly  1040 KAVAMSL-PM----EQGDESLPEQAEPPLHSEQGATAAGVAPHSGGPLVSAQWTNNHLEGGVATT 1099
            ..:...| |:    ..|:|.||..:..|........|.|..  .|...:|....::......:.|
 Frog  2532 SNMFFGLTPLYGVRSYGEEDLPFCSSTPGKKRGKRAAEGQV--DGADDISTSDDDDVYYYNFSRT 2594

  Fly  1100 KIPFKPGEPQ-----------KRKLPMHPQLDEKQIQQQAEIPISTSLPTTPTGQGTPDKVQLIS 1153
            .:  .||:.:           :|.|...||||  .:..:||  .:||:..|.:.|..        
 Frog  2595 VV--TPGDERLGIHTLFRQDDQRDLHKIPQLD--GVDDEAE--CNTSVTVTKSSQAG-------- 2645

  Fly  1154 AIATYVKKSGVPNEAQPIQNQSQGQVQMQAQMQATMQGHLSGQMSGQISGHAAGQIPAQMHLQVQ 1218
                  |:||..|.|..:|               |.:|.|.....|:      ||..::..::..
 Frog  2646 ------KRSGKQNGAGKLQ---------------TPEGQLEKSHVGK------GQKTSEPKIENC 2683

  Fly  1219 HQLHMAVHPQQQQQQLHQNQPQNATIPLPVTGQGAVPIPVPTMESKAGDQRKRRKREVQKPRRTN 1283
            |    ||.....:.||..:.|:.|       ..|:....:.|..|           ::.|....|
 Frog  2684 H----AVKQDTLEAQLALDTPRRA-------HSGSEKNLLDTFNS-----------DLLKSDSDN 2726

  Fly  1284 LNAGQAGGALKDLTGPLPAGAMVQLAGMPPGTQYIQGAASGTGHVITSTGQGVTLG-GVGASTGA 1347
            .|:...|..       ||:..|..:....|..|.:..:..      :|:.:.:||| |:|.....
 Frog  2727 NNSDDCGNI-------LPSDIMDFVLKNTPSMQALGESPE------SSSSELLTLGDGLGLDNNR 2778

  Fly  1348 SSSPMLKKRVRKFSKVEEDHDAFTEKLLTHIRQMQ-PLQV---------LEPHLNRNFHFLIG-- 1400
            .....|.:...:.....|..|......::...|.: ||::         ..|.|....|..:|  
 Frog  2779 GKEMGLFEVFSQQLPTSEPVDGAVPTTISGEEQFELPLELPSDLSVLTTRSPALPSQNHSRLGVI 2843

  Fly  1401 ---SNETSGGGSPASMSSAASA----------------GSSSAGGGKLKGGSRG--WPLSRHLEG 1444
               ...|||..|..::::::..                |.||..|..|...|.|  .| .|.:.|
 Frog  2844 TDSQLSTSGERSLLAITTSSDTVEKRVTVTEKSGTPGDGDSSLLGQNLDRASEGHITP-DRFITG 2907

  Fly  1445 LEDCD-------GTV--LGRYGRVNLPGIPSLYDSERFGGSRGLVGGSARTRS----PSPAESPG 1496
            ..|.:       |.|  .||..|......|:|..|         |..|...::    ||.:||||
 Frog  2908 HIDQEHISSPTCGQVDHTGREERARNSSTPNLQVS---------VSPSVSIQNQKYIPSSSESPG 2963

  Fly  1497 AEKMLPMSSIQNDFYDQEFSTHMERNPRERLVRHIGAVKDCNLETVDLVESEGVAAWATLP---- 1557
            ..: :|.::||:.      ..|: ::|.|:||     |.:.|::.:.:::        |||    
 Frog  2964 TSQ-IPSNTIQST------PQHL-KSPAEKLV-----VVNQNMQPLYVLQ--------TLPNGVT 3007

  Fly  1558 -RLTRYPGLILLNGNSRCHGRMSPVALP-EDPLTMRFPVSPLLRSCGEELRKTQQMELGMGPLGN 1620
             ::...|.  :...:||..|.: ||..| ...||:...::|.|.|......|      |:.|:.:
 Frog  3008 QKIQLAPS--VPTSSSRTEGEV-PVLSPMGGGLTLATALNPTLTSTFPSASK------GILPMSH 3063

  Fly  1621 NNNNNYQQKNQNVILALPASASENIAGVLRDLAN--LLHLAPALTCKIIEDKIGNKLEDQFMNQD 1683
            :.:          :...|..........|.:.::  |:.:.|:....::..:.|.:.:....:..
 Frog  3064 HPH----------LQPFPGGPQTTFLPNLNNQSSGLLIGVQPSSEPSLLVSETGQRSDVGSTSNT 3118

  Fly  1684 DEKHVDFKRPLSQVSHGHLRKILNGRRKLC-------RSCGNVVHATGL--RVPRHSVPALEEQ- 1738
            ....::.||   |::..|.||    .:||.       |...:||....|  ..|.....||... 
 Frog  3119 SAPGMNKKR---QITRLHTRK----NKKLAPSVSPASRHAPDVVSNMTLINFAPSQITGALTSHT 3176

  Fly  1739 -LPRLAQLMDMLPRKSVP-------PPFVYFCDRACFARFKWNGKDGQAEAASLLLQPAGGSA-- 1793
             |..|..:.:..|.:::|       ...:||                  :...||.|..|.|:  
 Frog  3177 GLIDLGTIGNTAPHRNIPSIIKTSKSGVMYF------------------DQTPLLPQNVGTSSSM 3223

  Fly  1794 ------VKSSNGDSPGSFCASST-APAEMVVKQEPEDEDEKTPSVPGNPTNIPAQRKCIVKCFSA 1851
                  :....|..||...:.:| :|...||..:|.   ...|.|.|:.|               
 Frog  3224 GTAPSVIGLDTGHLPGQVTSLATGSPVLNVVSMQPA---SAAPPVSGHVT--------------- 3270

  Fly  1852 DCFTTDSAPSGLELDGTAGAGTGAGPVNNTVWETETSGLQLEDTRQCVFCNQRGDGQADGPSRLL 1916
              .|:....:..||:.          ::|.:.:|...||.::|....:         ..||.   
 Frog  3271 --LTSPGILNPSELNS----------ISNFLIKTSPQGLGIQDNHVTL---------PSGPG--- 3311

  Fly  1917 NFDVDKWVHLNCALWSNGVYETVSGALMNFQTALQAGLSQACS--ACHQPGATIKCFKSRCNSLY 1979
                   :...|:. |..:..|.|..::....::...|||..:  .||.|      .....|.|.
 Frog  3312 -------MFSQCST-SATIATTSSICVVPSSQSVGMTLSQPINDPDCHYP------ISHHMNRLL 3362

  Fly  1980 H-LPCAIREECVFYKNKSVHCSVHGHAHAGITMGAGAGATTGAGLGGS--VADNELSSLVVHRRV 2041
            : .|..:.|.......::....:...:...:|:     .|:..||..:  ....:..|....:..
 Frog  3363 NSRPQILPESSSETNARAPALQMLAESETKLTV-----PTSALGLQRNPVAVPQKTKSKAKRQTA 3422

  Fly  2042 FVDRDENRQVATV--------MHYSELSNLLRVGNMT-----FLNVGQLLPHQLEAFHTPHYIYP 2093
            ..|:...::..|:        :..||..:.....:.|     .:|..:|:...::  :|.....|
 Frog  3423 PADKTSRKKQKTLHLTPNPPTVQESERHDKPAASDHTGAHEEKVNTSELMVPSMK--NTAEPPLP 3485

  Fly  2094 IGYKVSRYYWCVRRPNRRCRYICSIAEAGCKPEFRIQVQDAGDKEP-------EREFRGS----- 2146
            .|...     .:..|....:.:|.  :.....:.:.:.:|.|...|       ||..:||     
 Frog  3486 AGQLA-----IISDPEPLLKELCQ--QDPKHDDSKQREEDTGFSSPLMRLLQQERNRQGSPTEEK 3543

  Fly  2147 --------------------SPSAVWQQILQPITRLRKVHKWLQLFPQHISGEDLFGLTEPAIVR 2191
                                |....|:.:.:.:...|...:..||....:||..:.|:...|:|.
 Frog  3544 PKTGLLFEISSDDGFQISAGSIEEAWKSLTEKVQEARSNARLKQLSFAGVSGLRMLGIVHDAVVF 3608

  Fly  2192 ILESLPGIETLTDYRFKYGRNPLLEFPLAINPSGAARTEPKQRQLLV---------WRKPHTQRT 2247
            ::|.|.|.....:|:|::.|....|.| .|||.|:||.|..:|:...         .|:|...:.
 Frog  3609 LVEQLYGANRCRNYKFRFHRPEGEEEP-PINPHGSARAEVHRRKSAFDMFNFLASKHRQPPEYKP 3672

  Fly  2248 AGSCSTQRMANSAAIAGEVACPYSKQFVHSKSSQYKKMKQEWRNNVYLARSKIQGLGLYAARDIE 2312
            ......:....||..|..:..|...:|.|.|.:..:.:      .||  ||.|.|.||:..|:|:
 Frog  3673 NDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAV------GVY--RSPIHGRGLFCRRNID 3729

  Fly  2313 KHTMIIEYIGEVIRTEVSEIREKQYESKNRGIYMFRLDEDRVVDATLSGGLARYINHSCNPNCVT 2377
            ...|:|||.|.|||:.:::.|||.|:.|..|.||||:|:..|||||:.|..||:|||||.|||.:
 Frog  3730 AGEMVIEYSGNVIRSILTDKREKYYDGKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYS 3794

  Fly  2378 EIVEVDRDVRIIIFAKRKIYRGEELSYDYKFDIEDESHKIPCACGAPNCRKWMN 2431
            .::.:|....|:|||.|||||||||:|||||.|||.::|:.|.||...|||::|
 Frog  3795 RVIPIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDANNKLACNCGTKKCRKFLN 3848

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trrNP_726773.2 PHA03255 184..>320 CDD:165513
ePHD2_KMT2C_like 1898..2002 CDD:277136 16/106 (15%)
FYRN 2068..2118 CDD:283589 8/54 (15%)
FYRC 2126..2215 CDD:197781 23/120 (19%)
SET <2266..2431 CDD:225491 78/164 (48%)
SET 2291..2413 CDD:214614 66/121 (55%)
PostSET 2415..2431 CDD:214703 7/15 (47%)
kmt2aXP_031762525.1 PHA03247 <648..792 CDD:223021
zf-CXXC 1086..1133 CDD:366873
opacity_OapA <1201..>1319 CDD:411470
PHD1_KMT2A 1378..1424 CDD:277063
PHD2_KMT2A 1426..1490 CDD:277065
PHD3_KMT2A 1528..1584 CDD:277067
Bromo_ALL-1 1607..1737 CDD:99925
ePHD_KMT2A 1830..1942 CDD:277163
FYRN 1983..2030 CDD:399155
FYRC 3548..3631 CDD:197781 16/82 (20%)
SET_KMT2A_2B 3695..3848 CDD:380947 77/160 (48%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D738155at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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