DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Coa8 and COA8

DIOPT Version :9

Sequence 1:	NP_001259147.1	Gene:	Coa8 / 31148	FlyBaseID:	FBgn0029594	Length:	176	Species:	Drosophila melanogaster
Sequence 2:	NP_001357524.1	Gene:	COA8 / 84334	HGNCID:	20492	Length:	193	Species:	Homo sapiens

Alignment Length:	177	Identity:	63/177 - (35%)
Similarity:	86/177 - (48%)	Gaps:	17/177 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FSLPRCYAAVQPGCPPPQEKPVVGLPHKPD------PKTVKC-DYIGPPDAQSNLRPYVRHYGDE 73
            |..|.|.|....||....|:........|.      |....| |:|||||..|||||...:..:.
Human    11 FLPPLCRAFACRGCQLAPERGAERRDTAPSGVSRFCPPRKSCHDWIGPPDKYSNLRPVHFYIPEN 75

  Fly    74 ETRLARSLRLKRIEVEAWNTDFWTKHNKRFYEEKEDFIR---------LHKESG-TSEVSADQMS 128
            |:.|.:.||..|.|.:.||..||...|..|.:|||:||.         |..||| .:.::|::|:
Human    76 ESPLEQKLRKLRQETQEWNQQFWANQNLTFSKEKEEFIHSRLKTKGLGLRTESGQKATLNAEEMA 140

  Fly   129 HFYKAFLDKNWRIHIMYNISWYLKNFDILTLAAAVQLQRLLALAKRR 175
            .|||.||.||::.|:.||..||.:||.|......|.|:|:....|::
Human   141 DFYKEFLSKNFQKHMYYNRDWYKRNFAITFFMGKVALERIWNKLKQK 187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Coa8	NP_001259147.1	DUF2315	52..169	CDD:370902	52/126 (41%)
COA8	NP_001357524.1	DUF2315	54..181	CDD:370902	52/126 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151491
Domainoid	1	1.000	98	1.000	Domainoid score	I7221
eggNOG	1	0.900	-	-		E1_KOG4094
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	100	1.000	Inparanoid score	I5008
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1410150at2759
OrthoFinder	1	1.000	-	-		FOG0009713
OrthoInspector	1	1.000	-	-		oto91495
orthoMCL	1	0.900	-	-		OOG6_107150
Panther	1	1.100	-	-	LDO	PTHR31107
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2400
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790