DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14805 and RID3

DIOPT Version :9

Sequence 1:	NP_569954.1	Gene:	CG14805 / 31146	FlyBaseID:	FBgn0023514	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_190487.1	Gene:	RID3 / 824079	AraportID:	AT3G49180	Length:	438	Species:	Arabidopsis thaliana

Alignment Length:	456	Identity:	129/456 - (28%)
Similarity:	214/456 - (46%)	Gaps:	60/456 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VEALFISTSSEDNTTCSVQDLRTGTDLMRYKGGGCAQ-HHSLNMIHLNYV----MAANSAKPLLH 64
            :|...|::||.|....| .||:|||:.:::|  .||. .|.|..:...::    ::|.:....:.
plant     1 MEITVIASSSIDEGIGS-WDLKTGTEQLQFK--PCASPAHGLTAVGEKFLASSQLSARNTSGSIF 62

  Fly    65 VWPINKQEQMAGLRFVVPGKVNALALTPDGNFLV-AGIQENIYLWHMSSGRMLNTLSKHYQAITC 128
            .|...|.:.......|.|  :.|||...:|.:|| .||..:||||.:::|::|.....||:::||
plant    63 YWSWTKPQAEVKSYPVEP--IKALAANNEGTYLVGGGISGDIYLWEVATGKLLKKWHGHYRSVTC 125

  Fly   129 LRFTDNGEHFISGGKDGAVLVWDLTFSAAPLDTGGGKDSTEPLYSFNDHGLAVTDLYSGIGGIRS 193
            |.|:.:....:||.:||::.||.|...........|....|  ::||:|.::|||:....||..:
plant   126 LVFSGDDSLLVSGSQDGSIRVWSLIRLFDDFQRQQGNTLYE--HNFNEHTMSVTDIVIDYGGCNA 188

  Fly   194 YLYTVSLDRCCKVYDLCGGVLLLSVVFPVALHSVIVSKMETRVYVGSSDGKVFVFNMENAPRMKE 258
            .:.:.|.||.|||:.|..|.||.:::||..::::.:.......|.|:.|.|::: ...||  ..|
plant   189 VIISSSEDRTCKVWSLSRGKLLKNIIFPSVINALALDPGGCVFYAGARDSKIYI-GAINA--TSE 250

  Fly   259 YHLEGEEIQAFVGHTYGKAITCLALNISATTLVSGGEDNQVCVWDVGSRQLIKSL-----SQKGS 318
            |   |.::...|... ||||||||.......|:||.||..|||||..|.:.:::|     |:||.
plant   251 Y---GTQVLGSVSEK-GKAITCLAYCADGNLLISGSEDGVVCVWDPKSLRHVRTLIHAKGSRKGP 311

  Fly   319 VTNLHIRLLSPAIFLPEHKQPQMFADSLKRMISPWDENDCIELFDPDYSGGRKTPELD-YTQSHP 382
            |.|:.|            .:..:.|:|.|..:| |...           |....|.|: |.:...
plant   312 VNNIQI------------VRKTIVANSNKTQVS-WKSR-----------GALIPPPLEKYERPVE 352

  Fly   383 GTDEEIILKLIASMSSGKNEDDEGIEAETKATDVEDSEVEEEEPESEPMETASKEAESEKSYAEY 447
            .|.:.|:.......|      |..:.:...:.|:.|.:|:|.:.:.    :|:.|.|.|:...||
plant   353 DTMDGIVTVDPPPFS------DVPVYSSFLSADLIDEQVKELQQQG----SAATEMEMERLKLEY 407

  Fly   448 Q 448
            :
plant   408 K 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14805	NP_569954.1	WD40	<8..320	CDD:225201	102/322 (32%)
		WD40	82..>322	CDD:295369	84/245 (34%)
		WD40 repeat	86..121	CDD:293791	14/35 (40%)
		WD40 repeat	126..162	CDD:293791	11/35 (31%)
		WD40 repeat	172..219	CDD:293791	18/46 (39%)
		WD40 repeat	224..270	CDD:293791	9/45 (20%)
		WD40 repeat	278..315	CDD:293791	17/41 (41%)
		WD40 repeat	319..363	CDD:293791	8/43 (19%)
RID3	NP_190487.1	WD40	<4..298	CDD:225201	98/307 (32%)
		WD40	5..291	CDD:238121	95/299 (32%)
		WD40 repeat	83..118	CDD:293791	14/34 (41%)
		WD40 repeat	124..169	CDD:293791	13/46 (28%)
		WD40 repeat	174..213	CDD:293791	15/38 (39%)
		WD40 repeat	220..257	CDD:293791	9/42 (21%)
		WD40 repeat	266..302	CDD:293791	16/35 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0646
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	151	1.000	Inparanoid score	I1711
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D747023at2759
OrthoFinder	1	1.000	-	-		FOG0005072
OrthoInspector	1	1.000	-	-		oto3599
orthoMCL	1	0.900	-	-		OOG6_103008
Panther	1	1.100	-	-	LDO	PTHR18763
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5413
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.830