DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14805 and wdr18

DIOPT Version :9

Sequence 1:	NP_569954.1	Gene:	CG14805 / 31146	FlyBaseID:	FBgn0023514	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001032341.1	Gene:	wdr18 / 496904	XenbaseID:	XB-GENE-5818068	Length:	428	Species:	Xenopus tropicalis

Alignment Length:	429	Identity:	138/429 - (32%)
Similarity:	230/429 - (53%)	Gaps:	28/429 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDAVEALFISTSSEDNTTCSVQDLRTGTDLMRYKGGGCAQHHSLNMIHLNYVMAANSAKPLLHV 65
            |...:|.:..:.::.....|:|.:..||:.|:.|:||. ..:..|.::...|::.|...|..::|
Frog     1 MAAPMELVLSADATGQVANCTVWEPVTGSVLLTYRGGN-TSNRGLAVLGGQYLLGAQLGKNYINV 64

  Fly    66 WPINKQEQMAGLRFVVPGKVNALALTPDGNFLVAGIQENIYLWHMSSGRMLNTLSKHYQAITCLR 130
            |.:.:::|:. .:.|.||.||.||.:|:|.:||:||.|:||||.:.:||:|..|:.|||.:|||.
Frog    65 WELQRRDQLQ-QKIVCPGPVNCLATSPNGLYLVSGIAESIYLWEVCTGRLLAILNNHYQDVTCLT 128

  Fly   131 FTDNGEHFISGGKDGAVLVWDLTFSAAPLDTGGGKDSTEPLYSFNDHGLAVTDLYSGIGGIRSYL 195
            |||:..|.|||.||..||||.| :|...::|..|   .||.|.::.|.|.:||:..||||.::.:
Frog   129 FTDDSSHIISGAKDSLVLVWSL-YSVLQVETSRG---PEPRYVWSRHSLPITDVQCGIGGPQARV 189

  Fly   196 YTVSLDRCCKVYDLCGGVLLLSVVFPVALHSVIVSKMETRVYVGSSDGKVFVFNMENAPRMKEYH 260
            .|.|||:..|::::|.|.|||||:|.|.:.||.....|..::.|.|||.::..::...|..:|..
Frog   190 VTSSLDQTVKLWEICSGDLLLSVLFDVRIMSVAFDPAEYHLFCGGSDGVIYQVDLYATPEQRERP 254

  Fly   261 LEGEEIQAFVGHTYGKAITCLALNISATTLVSGGEDNQVCVWDVGSRQLIKSLSQKGSVTNLHIR 325
            ...|:...|.||.  ..:|||::::..:.|:||..|..|||||:.|:|.:::::.:|.|||:.|
Frog   255 FHPEQEMVFKGHR--NQVTCLSVSLDGSMLISGSHDETVCVWDIHSKQCLRTVAHRGPVTNVFI- 316

  Fly   326 LLSPAIFLPEHKQPQMFADSLKRMISPWD-----ENDCIELFDPDYSGGRKTPELDYTQSHPGTD 385
            :.:|...|....:|........:.:...:     |:..:.|......|.|:...|...:.
Frog   317 IPAPGNILRAESKPSFPLPHFSKHLQGAEGCEGPESGGVILRLGKQQGSRENTYLQRAEQ----- 376

  Fly   386 EEIILKLIASMSSGKNEDDEGIEAETKATDVEDSEVEEE 424
                |:.:...|.|||.  .|:..:.::   ..||:|||
Frog   377 ----LQSLLGESEGKNL--SGLVEQLRS---RTSELEEE 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14805	NP_569954.1	WD40	<8..320	CDD:225201	113/311 (36%)
		WD40	82..>322	CDD:295369	99/239 (41%)
		WD40 repeat	86..121	CDD:293791	18/34 (53%)
		WD40 repeat	126..162	CDD:293791	18/35 (51%)
		WD40 repeat	172..219	CDD:293791	20/46 (43%)
		WD40 repeat	224..270	CDD:293791	10/45 (22%)
		WD40 repeat	278..315	CDD:293791	14/36 (39%)
		WD40 repeat	319..363	CDD:293791	9/48 (19%)
wdr18	NP_001032341.1	WD40	62..318	CDD:392136	105/263 (40%)
		WD40 repeat	84..119	CDD:293791	18/34 (53%)
		WD40 repeat	124..160	CDD:293791	19/36 (53%)
		WD40 repeat	168..211	CDD:293791	17/42 (40%)
		WD40 repeat	218..264	CDD:293791	10/45 (22%)
		WD40 repeat	270..296	CDD:293791	11/25 (44%)
		WD40_alt	381..428	CDD:372904	10/31 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9214
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H32573
Inparanoid	1	1.050	231	1.000	Inparanoid score	I3360
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D336315at33208
OrthoFinder	1	1.000	-	-		FOG0005072
OrthoInspector	1	1.000	-	-		oto104865
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R615
SonicParanoid	1	1.000	-	-		X5413
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090