DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14805 and wdr18

DIOPT Version :9

Sequence 1:	NP_569954.1	Gene:	CG14805 / 31146	FlyBaseID:	FBgn0023514	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001005206.1	Gene:	wdr18 / 445819	ZFINID:	ZDB-GENE-040905-4	Length:	431	Species:	Danio rerio

Alignment Length:	426	Identity:	139/426 - (32%)
Similarity:	232/426 - (54%)	Gaps:	20/426 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDAVEALFISTSSEDNTTCSVQDLRTGTDLMRYKGGGCAQHHSLNMIHLNYVMAANSAKPLLHV 65
            |...||.:..:.|:.....|:|.|..||::.:.|:||..:. .||.:::..|::.|...|..::|
Zfish     1 MSAPVEVVLSADSAGQLFNCAVYDPHTGSEFLSYRGGNTSS-RSLTILNGEYILGAQLGKNYINV 64

  Fly    66 WPINKQEQMAGLRFVVPGKVNALALTPDGNFLVAGIQENIYLWHMSSGRMLNTLSKHYQAITCLR 130
            |.|.:::|:. .:.|.||.|..|..:|||.:::|||.|.||||.:|:|.:|..||:|:|.::|::
Zfish    65 WEIQRKDQLQ-QKIVCPGIVTCLCASPDGLYVLAGIAEAIYLWEVSTGNLLAILSRHFQDLSCIK 128

  Fly   131 FTDNGEHFISGGKDGAVLVWDLTFSAAPLDTGGGKDSTEPLYSFNDHGLAVTDLYSGIGGIRSYL 195
            |||:..||:|||||....:|:|: |...||:   ..:.||.:..:.|.|.:||::.|:.|.::.:
Zfish   129 FTDDSSHFVSGGKDNLAFIWNLS-SVVQLDS---SRTPEPRHILSRHSLPITDIHCGLMGPQARV 189

  Fly   196 YTVSLDRCCKVYDLCGGVLLLSVVFPVALHSVIVSKMETRVYVGSSDGKVFVFNM--ENAPRMKE 258
            .|.|||:..||:::..|.:||||:|.|.:.||.....|..::.|.|||.:|..::  .:..|.|.
Zfish   190 ATASLDQTVKVWEISSGEMLLSVLFDVGIMSVTFDPCEYFLFCGGSDGNIFQVSLCSTSLSRDKT 254

  Fly   259 YHLEGEEIQAFVGHTYGKAITCLALNISATTLVSGGEDNQVCVWDVGSRQLIKSLSQKGSVTNLH 323
            :..:.|..|.|.||.  ..:|||::::..|.|:||..|..|.:|||.|:|.|.:::.:|.|||..
Zfish   255 FQSDSEGNQVFKGHR--NLVTCLSVSMDGTVLLSGSNDETVRMWDVQSKQCIWTINHRGPVTNAA 317

  Fly   324 IRLLSPAIFLPEHKQPQMFADSLKRMISPWDENDCIELFDPDYSGGRKTPELDYTQSHPGTDEEI 388
            | :.:||........|.:......|.::|.::.      |...:||........||...||..|.
Zfish   318 I-IPAPANMFLSDSHPAVPLPRFSRHLNPSEQG------DGTGTGGMSLRLGANTQEPEGTYLEK 375

  Fly   389 ILKLIASMSSGKNEDDEGIEAETKATDVEDSEVEEE 424
            ..:|.:.|.:   ..|:.:..:.:.|.|..||:|||
Zfish   376 AEELYSLMCA---VTDKSVFGDGENTKVRVSELEEE 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14805	NP_569954.1	WD40	<8..320	CDD:225201	109/313 (35%)
		WD40	82..>322	CDD:295369	92/241 (38%)
		WD40 repeat	86..121	CDD:293791	16/34 (47%)
		WD40 repeat	126..162	CDD:293791	16/35 (46%)
		WD40 repeat	172..219	CDD:293791	16/46 (35%)
		WD40 repeat	224..270	CDD:293791	12/47 (26%)
		WD40 repeat	278..315	CDD:293791	15/36 (42%)
		WD40 repeat	319..363	CDD:293791	9/43 (21%)
wdr18	NP_001005206.1	WD40	6..320	CDD:225201	114/322 (35%)
		WD 1	78..118		19/39 (49%)
		WD40	80..>320	CDD:295369	94/246 (38%)
		WD40 repeat	84..119	CDD:293791	16/34 (47%)
		WD 2	119..158		17/39 (44%)
		WD40 repeat	124..169	CDD:293791	18/48 (38%)
		WD 3	170..211		14/40 (35%)
		WD40 repeat	176..214	CDD:293791	15/37 (41%)
		WD 4	213..252		10/38 (26%)
		WD40 repeat	218..256	CDD:293791	10/37 (27%)
		WD 5	267..306		17/40 (43%)
		WD40 repeat	272..298	CDD:293791	10/25 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..363		4/26 (15%)
		WD40_alt	383..430	CDD:290784	9/29 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581376
Domainoid	1	1.000	75	1.000	Domainoid score	I9054
eggNOG	1	0.900	-	-		E2759_KOG0646
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32573
Inparanoid	1	1.050	228	1.000	Inparanoid score	I3449
OMA	1	1.010	-	-		QHG52506
OrthoDB	1	1.010	-	-		D336315at33208
OrthoFinder	1	1.000	-	-		FOG0005072
OrthoInspector	1	1.000	-	-		oto40086
orthoMCL	1	0.900	-	-		OOG6_103008
Panther	1	1.100	-	-	LDO	PTHR18763
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R615
SonicParanoid	1	1.000	-	-		X5413
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800