Protein Alignment CG14805 and Wdr18

DIOPT Version :9

• Sequence 1: NP_569954.1
• Gene: CG14805 / 31146
• FlyBaseID: FBgn0023514
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_001034116.1
• Gene: Wdr18 / 314617
• RGDID: 1310646
• Length: 431
• Species: Rattus norvegicus
• Alignment Length: 489
• Identity: 143/489 - (29%)
• Similarity: 235/489 - (48%)
• Gaps: 66/489 - (13%)

  Fly     1 MEDAVEALFISTSSEDNTTCSVQDLRTGTDLMRYKGGGCAQHHSLNMIHLNYVMAANSAKPLLHV 65
            |...:|.:..:.|:....:|.|.:|.:|.:|:.|:||. |....|.:::..|::||...|..:..
  Rat     1 MAAPMEVVVCTDSAAPLWSCMVWELHSGANLLTYRGGQ-AGPRGLALLNGEYLLAAQQGKNYICA 64

  Fly    66 WPINKQEQMAGLRFVVPGKVNALALTPDGNFLVAGIQENIYLWHMSSGRMLNTLSKHYQAITCLR 130
            |.:.:::|:. .:.:.||.|..|...|:|.:::|||.|:||||.:|:|.:|..||:|||.::||:
  Rat    65 WELQRKDQLQ-QKIMCPGPVTCLTTAPNGLYVLAGIAESIYLWEVSTGNLLVILSRHYQDVSCLK 128

  Fly   131 FTDNGEHFISGGKDGAVLVWDL--TFSAAPLDTGGGKDSTEPLYSFNDHGLAVTDLYSGIGGIRS 193
            ||.:|.||:|.|||..||.|.|  ...|.|      .....|.:.::.|.|.:|||:.|.||..:
  Rat   129 FTGDGSHFVSAGKDCLVLAWSLCSVLQADP------SRILAPRHVWSQHTLPITDLHCGFGGPMA 187

  Fly   194 YLYTVSLDRCCKVYDLCGGVLLLSVVFPVALHSVIVSKMETRVYVGSSDGKVFVFNMENAPRMKE 258
            .:.|.|||:..|::.:..|.|||||:|.:.:.||.:...|..::.|.|||.:|..::.:.|..:|
  Rat   188 RVATASLDQTMKLWAISSGDLLLSVLFDMGITSVTMDLAEHYIFCGGSDGSIFQVDLCSRPGPRE 252

  Fly   259 YHLEGEEI--QAFVGHTYGKAITCLALNISATTLVSGGEDNQVCVWDVGSRQLIKSLSQKGSVTN 321
            ...:.|:.  :.|.||.  ..:|||:::...:.|:||..|..|.:|||.|:|.::::..||.|||
  Rat   253 QSFQPEQNTGKVFKGHR--NQVTCLSVSTDGSILLSGSHDESVRLWDVKSKQCVRTVPLKGPVTN 315

  Fly   322 LHIRLLSPAIFLPEHKQPQMFADSLKRMISPWDENDCIELFDPDYSGGRKTPELDYTQSHPGTDE 386
            ..|.|..|::..||.:.........|.::.       .|..|....||.:
  Rat   316 AAITLAPPSMLNPEFRPSLPLPHFNKHLLG-------AEHGDEAQGGGLR--------------- 358

  Fly   387 EIILKLIASMSSGKNEDDEGIEAETKATDVEDSEVEEEEPESEPMETASKEAESEKSYAEYQPDS 451
               |:|             |:..:.|    |.|.:|    ..|.::.|.      ..|.|.....
  Rat   359 ---LQL-------------GLHLQGK----EPSYLE----RLEQLQAAL------SGYLEKNMLG 393

  Fly   452 AQTSDERVQELQAENARLKAQSMRLFQIAFKYIT 485
            :|....||.||:.|...|:..:..||..:.:.||
  Rat   394 SQMLPVRVFELEEEVRSLRKINRDLFDFSTRIIT 427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14805	NP_569954.1	WD40	<8..320	CDD:225201	106/315 (34%)
		WD40	82..>322	CDD:295369	91/243 (37%)
		WD40 repeat	86..121	CDD:293791	15/34 (44%)
		WD40 repeat	126..162	CDD:293791	17/37 (46%)
		WD40 repeat	172..219	CDD:293791	18/46 (39%)
		WD40 repeat	224..270	CDD:293791	11/47 (23%)
		WD40 repeat	278..315	CDD:293791	13/36 (36%)
		WD40 repeat	319..363	CDD:293791	10/43 (23%)
Wdr18	NP_001034116.1	WD40	22..297	CDD:421866	97/284 (34%)
		WD 1	36..75		10/40 (25%)
		WD 2	78..116		17/37 (46%)
		WD40 repeat	84..119	CDD:293791	15/34 (44%)
		WD 3	119..158		19/38 (50%)
		WD40 repeat	124..168	CDD:293791	18/49 (37%)
		WD 4	170..211		16/40 (40%)
		WD40 repeat	176..213	CDD:293791	16/36 (44%)
		Periplasmic_Binding_Protein_type1	212..>430	CDD:415822	66/270 (24%)
		WD 5	213..257		11/43 (26%)
		WD40 repeat	218..266	CDD:293791	11/47 (23%)
		WD 6	267..306		15/40 (38%)
		WD40 repeat	272..298	CDD:293791	9/25 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341390
Domainoid	1	1.000	69	1.000	Domainoid score	I9452
eggNOG	1	0.900	-	-		E2759_KOG0646
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32573
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3594
OMA	1	1.010	-	-		QHG52506
OrthoDB	1	1.010	-	-		D336315at33208
OrthoFinder	1	1.000	-	-		FOG0005072
OrthoInspector	1	1.000	-	-		oto98180
orthoMCL	1	0.900	-	-		OOG6_103008
Panther	1	1.100	-	-	LDO	PTHR18763
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5413
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770