DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14805 and crb3

DIOPT Version :9

Sequence 1:	NP_569954.1	Gene:	CG14805 / 31146	FlyBaseID:	FBgn0023514	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_593710.1	Gene:	crb3 / 2542844	PomBaseID:	SPAC13G7.08c	Length:	446	Species:	Schizosaccharomyces pombe

Alignment Length:	469	Identity:	106/469 - (22%)
Similarity:	198/469 - (42%)	Gaps:	102/469 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DAVEALFISTSSEDNTTCSVQDLRTGTDLMRYKGGGCAQHHSLNMIHLNYVMAANSAKPLLHVWP 67
            :|:|      ....|..|  .:|.|||.:..::....|::.:...  ||::::|...:|.|::..
pombe     9 EAIE------GEPSNVLC--HNLHTGTLVSTFRQSSPAKNATCTT--LNHLLSAQHTRPQLNIHN 63

  Fly    68 INKQEQMAGLRFVVPGKVNALALTPDGNFLVAGIQE-NIYLWHMSSGRMLNTLSKHYQAITCLRF 131
            ..|  ::.....::|..:..:..:|.|::|.||.:: |:|:|.:.||.::.....|||.:|.|:|
pombe    64 FGK--EILDQSIILPEILICVQSSPCGSWLAAGTEKGNLYIWSLKSGALIYFFRAHYQPLTILKF 126

  Fly   132 TDNGEHFISGGKDGAVLVW--------DLTFSAAPLDTGGGKDSTEPLYSFNDHGLAVTDLYSGI 188
            :::|....:...||.|..|        :.||..:       ..|.:.:..|:.|..::..:..|.
pombe   127 SNDGMVLFTASNDGDVFAWLISTLVDQNSTFETS-------NSSVKAISHFSGHKRSIVSMEIGP 184

  Fly   189 GGIRS-YLYTVSLDRCCKVYDLCGGVLLLSVVFPVALHSVIVSKMETRVYVGSSDGKVFV----- 247
            |.|.| .|||.|.|...:::|:..|.||.::..|.....:.|...|..||||:..|.:::
pombe   185 GPIVSGRLYTASEDNTIRIWDVSTGNLLTTIALPSTPSCMTVDPSERVVYVGNEKGIIWIPLYTG 249

  Fly   248 ---FNMENAPRMKEYHLEGEEIQAFVGH-----TYGKA-----------ITCLALNISATTLVSG 293
               |:.....:.:...::...|...:|.     .|..:           ||.|.::..|:.|:||
pombe   250 SSTFSNNVKEKKRVTSVDNTTIPNAIGGMGRVVDYNDSRESSIISCQSPITTLTVSFDASLLISG 314

  Fly   294 GEDNQVCVWDVGSRQLIKSLSQKGSVTNLHIRLLSPAIFLP-EHKQPQMFADS------LKRMIS 351
            .:|..|.|||..|||:::.|          ::..||..||. :..:...:::|      |||||:
pombe   315 DKDGNVLVWDSVSRQVLRRL----------VQYYSPVSFLQCKVDKISFYSNSSLSFPVLKRMIT 369

  Fly   352 ----PWDENDCI------ELFDPDYSGGRKTPELDYTQSHPGTDEEIILKLIASMSSGKNEDDEG 406
                ..|...||      :|..|                      |.|||:.:.:.:..:|....
pombe   370 NEYLNSDVRICIQDDGVEQLMQP----------------------ENILKISSDIVTQGSESSWR 412

  Fly   407 IEAETKATDVEDSE 420
            .:|||....:::::
pombe   413 AKAETSEMQLKEAK 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14805	NP_569954.1	WD40	<8..320	CDD:225201	81/345 (23%)
		WD40	82..>322	CDD:295369	68/273 (25%)
		WD40 repeat	86..121	CDD:293791	10/35 (29%)
		WD40 repeat	126..162	CDD:293791	10/43 (23%)
		WD40 repeat	172..219	CDD:293791	15/47 (32%)
		WD40 repeat	224..270	CDD:293791	9/53 (17%)
		WD40 repeat	278..315	CDD:293791	16/36 (44%)
		WD40 repeat	319..363	CDD:293791	14/60 (23%)
crb3	NP_593710.1	WD40 repeat	44..74	CDD:293791	6/33 (18%)
		CNDH2_C	<45..>71	CDD:293463	6/29 (21%)
		WD40	<67..358	CDD:225201	72/307 (23%)
		WD40	81..355	CDD:295369	71/290 (24%)
		WD40 repeat	81..116	CDD:293791	10/34 (29%)
		WD40 repeat	122..172	CDD:293791	12/56 (21%)
		WD40 repeat	177..216	CDD:293791	13/38 (34%)
		WD40 repeat	224..256	CDD:293791	8/31 (26%)
		WD40 repeat	299..336	CDD:293791	16/46 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0646
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	104	1.000	Inparanoid score	I1624
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005072
OrthoInspector	1	1.000	-	-		oto101824
orthoMCL	1	0.900	-	-		OOG6_103008
Panther	1	1.100	-	-	LDO	PTHR18763
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R615
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.850