DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14803 and MMS22L

DIOPT Version :9

Sequence 1:	NP_569950.1	Gene:	CG14803 / 31142	FlyBaseID:	FBgn0023513	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	XP_011533972.1	Gene:	MMS22L / 253714	HGNCID:	21475	Length:	1261	Species:	Homo sapiens

Alignment Length:	1285	Identity:	262/1285 - (20%)
Similarity:	465/1285 - (36%)	Gaps:	319/1285 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LVDGLHL---------PEFNC-----------SGRDTLKSQLCEGGFLGNGYAQLDP-----PRS 79
            |.|.|.|         |.|:|           ||    :|.||.|. |......|||     ...
Human    11 LTDSLELELGTEWCKPPYFSCAVDNRGGGKHFSG----ESYLCSGA-LKRLILNLDPLPTNFEED 70

  Fly    80 RLDYLCFDFAPAQLAVGAVRN--YLYGEACKNVQKLLTV-----VMGQQHLQATAASMNSGWYRV 137
            .|:.....:......|.:.|.  :|:.:...|::.||..     .:...|.:|.         .:
Human    71 TLEIFGIQWVTETALVNSSRELFHLFRQQLYNLETLLQSSCDFGKVSTLHCKAD---------NI 126

  Fly   138 RQQVTHFYHLMLLL--------RGNELLPSHFLDGFRQLLNDQLDADTWKVLYFAEH-------N 187
            |||...|.|.:.:.        .....:|.|..:.....|...|..:...:|.:..|       |
Human   127 RQQCVLFLHYVKVFIFRYLKVQNAESHVPVHPYEALEAQLPSVLIDELHGLLLYIGHLSELPSVN 191

  Fly   188 KG---NDCQ----APAYHLYHGVLEWRFLDLHILYASG---------------------NDQAFL 224
            .|   |..|    .|::||.|..|:..:|.|.|||..|                     |...|.
Human   192 IGAFVNQNQIKLFPPSWHLLHLHLDIHWLVLEILYMLGEKLKQVVYGHQFMNLASDNLTNISLFE 256

  Fly   225 GQLERTLDDLIVCAGHHYRSKHRSELIHSSPFMCRCNKELWLLLKRLI---PKWLGERELDFW-- 284
            ...|..|.|||..:.:.|.....||.:.|....|.|.||||:||..|:   .||....  .||
Human   257 EHCETLLCDLISLSLNRYDKVRSSESLMSDQCPCLCIKELWVLLIHLLDHRSKWFVSE--SFWNW 319

  Fly   285 ------TLFHKAMQRHK-SLHFQGESNAISLAYHELYSWLRLGLARLDEYNSEGWYQPDHSPLTA 342
                  ||..|:..|.: |:......:.:..::     |:...:|...:::..|  .||......
Human   320 LNKLLKTLLEKSSDRRRSSMPVIQSRDPLGFSW-----WIITHVASFYKFDRHG--VPDEMRKVE 377

  Fly   343 APESFQTASLLKQFLASQPD--EQQRRVYLIQLSPLQLQLGKPDTDVLCQLWEYFHRSLNCNFSV 405
            :..:| ...|||:.::.|..  |:|.|:||.....| ....:|:..::..||||:.::||.:||:
Human   378 SNWNF-VEELLKKSISVQGVILEEQLRMYLHCCLTL-CDFWEPNIAIVTILWEYYSKNLNSSFSI 440

  Fly   406 G------------TELDQLPL--TCSNGSAYVDRYNKLLSKSHIEDLNLSSFTMYAWMLGKTLKL 456
            .            :.|..|.:  ||.     .|:.::.|.||.      ||:|::..:|.|.:|.
Human   441 SWLPFKGLANTMKSPLSMLEMVKTCC-----CDKQDQELYKSS------SSYTIFLCILAKVVKK 494

  Fly   457 LPSQGRSNQRQKLLGRIFSKFSAAKLLALNEPGIHHVIELFLCLLLCHEDLSELAPKLREMLLCL 521
            .......:..:::.|||:|||...::..|.|.|:.:...||| ||....::.::|..:.::
Human   495 AMKSNGPHPWKQVKGRIYSKFHQKRMEELTEVGLQNFFSLFL-LLAAVAEVEDVASHVLDL---- 554

  Fly   522 ALEKLPPV----RRILVAKGHMALLLLHAQHRLSMDDYVSKL-------LNQLATIRNDAEVG-- 573
             |..|.|.    :|.|:.|||||.||::||..|.:.....|.       ..:....:|:..|.
Human   555 -LNFLKPAFVTSQRALIWKGHMAFLLMYAQKNLDIGVLAEKFSCAFREKAKEFLVSKNEEMVQRQ 618

  Fly   574 ------AIYVGSLQAIFNLADDFNRGEQQLLGPWLAHYVEKCGQASQDRVWQTLHNLILRL---- 628
                  :||:..:|.:|..:.......::||....:..:..|.::....|...|..::.|:
Human   619 TIWTLLSIYIDGVQEVFETSYCLYPSHEKLLNDGFSMLLRACRESELRTVLSFLQAVLARIRSMH 683

  Fly   629 -----------------SERRAVAGNASGIKEALQQHIMPLVRTQYVSS--HSSWLPKLAANFIA 674
                             |...|...:.:.:..||.:|....:::|.:|.  ..|.|...||:|..
Human   684 QQLCQELQRDNVDLFVQSSLSAKERHLAAVASALWRHFFSFLKSQRMSQVVPFSQLADAAADFTL 748

  Fly   675 LENNGDKLLLGFLQGPEPI----------------------NMAASAQLLLQVLEDGG------- 710
            |..:.........| |:|:                      :.......|.:.|...|
Human   749 LAMDMPSTAPSDFQ-PQPVISIIQLFGWDDIICPQVVARYLSHVLQNSTLCEALSHSGYVSFQAL 812

  Fly   711 --RPASSTILQVWVKSL-----VLLNAQHESVL------------ALMPHVTQLE--------EF 748
              |.....:||:::|:|     :|::...|..:            .|:.::::::        |:
Human   813 TVRSWIRCVLQMYIKNLSGPDDLLIDKNLEEAVEKEYMKQLVKLTRLLFNLSEVKSIFSKAQVEY 877

  Fly   749 RLLAIDPTSLEGGREPLCAFFGALGRRAQQEEAAAHVRMQLSHKLHAYVNHFELWLPPDRSRSEL 813
            ..::.||      ::.|..||.|:|......:..:.....::..|. |:.....::.|     .|
Human   878 LSISEDP------KKALVRFFEAVGVTYGNVQTLSDKSAMVTKSLE-YLGEVLKYIKP-----YL 930

  Fly   814 GSRF--------YSFLAIVIYNCSTLAYVRSKPSCFFHLAMVRFLLTTQLQAGVPPEGRLP---- 866
            |.:.        |..:.|::.:.:.:..........|.:.....|....||    .|..||
Human   931 GKKVFSAGLQLTYGMMGILVKSWAQIFATSKAQKLLFRIIDCLLLPHAVLQ----QEKELPAPML 991

  Fly   867 QVVHKIFPVLLQGI------GRLPYRTDAYVAKTLEQLVQHWTPHFSFSSNAKLVARPYATLLQA 925
            ..:.|..|:.|||:      .:.|   :||:.:.|..:::.:...|       |.|.||.:
Human   992 SAIQKSLPLYLQGMCIVCCQSQNP---NAYLNQLLGNVIEQYIGRF-------LPASPYVS---- 1042

  Fly   926 DVDGELAQFVLQLLVTQFLVVQRRRAGQHAGLVITIMQQLIESTGKEQEEQLLTVLRGVHIPLLE 990
                :|.|..:.|.:.....:....:.:.. :|..|.:..:|..|.....:|.::|..:.....|
Human  1043 ----DLGQHPVLLALRNTATIPPISSLKKC-IVQVIRKSYLEYKGSSPPPRLASILAFILQLFKE 1102

  Fly   991 HVMFVDEVDLSRNQVFGLYK--VLISHDAYKR-----SQAVRDMC--------SNHLRSLAEKHL 1040
            ....:.||:|   .:.|:.|  ||:|....||     .|.:...|        |:.|.|:..:.:
Human  1103 TNTDIYEVEL---LLPGILKCLVLVSEPQVKRLATENLQYMVKACQVGSEEEPSSQLTSVFRQFI 1164

  Fly  1041 AH--CTYFY--FQMLINLAELAPDLVAPILSFIREQAEQVELKRGAGEDV 1086
            ..  ..|:|  :.:|..:|.|...:|..::|.:.:..:..|.|.|.|.::
Human  1165 QDYGMRYYYQVYSILETVATLDQQVVIHLISTLTQSLKDSEQKWGLGRNI 1214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14803	NP_569950.1	MMS22L_N	<195..559	CDD:291571	109/416 (26%)
CG14803	NP_569950.1	MMS22L_C	733..1099	CDD:291572	74/411 (18%)
MMS22L	XP_011533972.1	MMS22L_N	26..731	CDD:291571	165/746 (22%)
MMS22L	XP_011533972.1	MMS22L_C	852..1224	CDD:291572	73/401 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149991
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28I22
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47780
OrthoDB	1	1.010	-	-		D242609at33208
OrthoFinder	1	1.000	-	-		FOG0008254
OrthoInspector	1	1.000	-	-		oto88612
orthoMCL	1	0.900	-	-		OOG6_107741
Panther	1	1.100	-	-	LDO	PTHR28547
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4663
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.750