DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14803 and mms22l

DIOPT Version :9

Sequence 1:	NP_569950.1	Gene:	CG14803 / 31142	FlyBaseID:	FBgn0023513	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	XP_012818992.3	Gene:	mms22l / 100158637	XenbaseID:	XB-GENE-5932293	Length:	1233	Species:	Xenopus tropicalis

Alignment Length:	1290	Identity:	272/1290 - (21%)
Similarity:	479/1290 - (37%)	Gaps:	334/1290 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PEFNC-------SGRDTLKSQLCEGGFLGNGYAQLDPPRSRLDY-----LCFDFA-PAQLAVGAV 98
            |.|:|       :|.....|.....|.|.....:|||  |..||     ..|||. .|:.|:...
Frog    29 PRFSCAPTSCSGNGNTFSSSSYLSSGSLKRLLLRLDP--SPTDYESDTVEIFDFPWVAETALVES 91

  Fly    99 RNYLYG------EACKNVQKLLTVVMGQQ---HLQATAASMNSGWYRVRQQVTHFYHLMLLLRGN 154
            .:.|:|      :..:|:.:.|::..||.   |::|.         .:|.|...|.|.:.:....
Frog    92 TDLLFGLFRQKLDILENLCQPLSLDPGQLSNIHIEAE---------EIRSQCVQFLHYVKVFIYR 147

  Fly   155 ELLPSHFLDGF----RQLLNDQLDADTWKVLYFAEHNKGNDCQAP-----AYHL-YHGVL---EW 206
            .|.|...:|..    .:.|..||.:...:.|:......|:.|:.|     |..| :||.:   .|
Frog   148 FLDPPQKMDTIPVHPYEELEAQLPSKLIEELHGLRLYLGHLCELPNNIQAALQLQHHGKVLPASW 212

  Fly   207 RFLDLH---------ILYASGNDQAFLGQL------------------------ERTLDDLIVCA 238
            ..|.||         ||...|:...  ||:                        |..|.|||..|
Frog   213 HLLHLHFDVHWSILEILQILGDKMQ--GQIVYAHEYINLIGENLTNVSLIEELCEDLLCDLIYYA 275

  Fly   239 GHHYRSKHRSELIHSSPFMCRCNKELWLLLKRLIP-KWLGERELDFWTLFHKAMQRHKSLHFQGE 302
            .:.|.....||.::...:.|.|.||:|:||.:|:. :..|.....||...:|.:   |||: ||.
Frog   276 ANRYAQVRPSEALNDQIYHCICVKEMWILLLQLLDHRSKGSSSESFWIRVNKLL---KSLN-QGS 336

  Fly   303 SNAISLAYHELYSWLR----LGLARLDEYNSEGWYQPDH-SPLTA------APESFQTAS----- 351
            :   |:..|.:...::    |||:         |:...| |||..      ..|:.|.:|
Frog   337 N---SMESHRISKTVQCKDPLGLS---------WWLIAHLSPLYTFDRNGNREEAVQISSNWKFI 389

  Fly   352 --LLKQFLASQPD--EQQRRVYLIQLSPLQLQLGKPDTDVLCQ-----------LWEYFHRSLNC 401
              |||:...:|..  |.:.|::      ||..|.      ||.           |||||.::||.
Frog   390 EDLLKKSSDAQNGVREDELRMH------LQCCLS------LCDIWESNLTAGTILWEYFSKNLNS 442

  Fly   402 NFSVGTELDQLPLTCSN----------GSAYVDRYNKLLSKSHIEDLNLSSFTMYAWMLGKTLKL 456
            :|:: ..|....|.|.:          .|...|:.:..|.||.      :|:.::..:|.:.:|.
Frog   443 SFTI-RWLGLQTLACVSKSPCSMLEVVRSCCTDKPSLDLYKSD------NSYLIFLRILARLMKK 500

  Fly   457 LPSQGRSNQRQKLLGRIFSKFSAAKLLALNEPGIHHVIELFLCLLLCHEDLSELAPKLREMLLCL 521
            ......::..:::.|||:|||...|:..|.|.|:.|...||| ||....|..::|.::.::|..|
Frog   501 DKESRGAHPWKQIKGRIYSKFHQKKMQELTEVGLQHFFILFL-LLAIVADTEDVASRVIDLLQFL 564

  Fly   522 ALEKLPPVRRILVAKGHMALLLLHAQHRLSMDDYVSKLLNQLATIRND-----AEVG-------- 573
            ....|...:|.|:.:|:.|.||::.:..:.:.....||.:.......:     .:.|
Frog   565 VPGHLSTSQRALLWRGNFAFLLIYVEKNMDISALAEKLSHSFRETAKEFLVTKGDFGQKHTLWTL 629

  Fly   574 -AIYVGSLQAIFNLADDFNRGEQQLLGPWLAHYVEKCGQASQDRVWQTLHNLILRLS--ERRAVA 635
             :.||..:|.:|..:.:....|::||....:..:..|.::....|...|...:.||.  ..|::.
Frog   630 LSTYVDGVQEVFETSHNLQLSEEKLLNDGFSMMLPACRESELCSVLNFLQTAVARLRNIHSRSIQ 694

  Fly   636 G---NAS-------------GIKEALQQHIMPLVRTQYVS-SHSSWLPKLAANF----IALENNG 679
            |   |:|             .:...|.::..|.::...:| :..|.|...||.:    :|:.|:.
Frog   695 GPGNNSSHAQTLLVVKEHHLAVANGLWRNFFPFLKNLRLSQTPPSQLADTAAGYTLLALAMPNSA 759

  Fly   680 DKLLLGFLQGPEP-------------INMAASAQLLLQVLEDG-------GRPASS---TILQVW 721
            ...|     .|:|             |.....::.|..||.:|       |...||   ..::.|
Frog   760 PPEL-----QPQPFVSMFQLFGWDDMITPQLVSRYLNHVLPNGEFMDAFSGIGYSSFQALSVRTW 819

  Fly   722 VKSLVLL---------NAQHESVLALMPHVTQLEEFRLLAID---------PTSL-EGGREPLCA 767
            ::.::.:         :.|..|::..:..:|:| .|||..::         |.|. :..|..|..
Frog   820 IRCVLQIYIDQPGGTDSEQKSSIMEQLGELTRL-VFRLPEVENLLSKGQVLPLSYKQDPRSALLQ 883

  Fly   768 FFGALGRRAQQEEAAAHVRMQLSHKLHAYVNHFELWL---------------PPDRSRSELGSRF 817
            |..|.|        ..:.|:|...:..|.|:..:.:|               ||:    .|...:
Frog   884 FIKAAG--------VMYGRLQTLAEKSAMVSKCQEYLGDVLKYIKPYLTKKGPPE----GLQITY 936

  Fly   818 YSFLAIVIYNCSTLAYVRSKPSCFFHLAMVRFLLTTQL----QAGVPPEGRLPQVVHKIFPVLLQ 878
            .:...:|.|....||..:::...|   .::.|||....    ...:||  .:...:.:..|..||
Frog   937 RTIGCLVRYWALMLATSKAQQLLF---RIIDFLLLPHALFHQDKNLPP--AMLSNIRESLPQFLQ 996

  Fly   879 G---IGRLPYRTDAYVAKTLEQLVQHWTPHF--------SFSSNAKLVARPYATLLQADVDGELA 932
            |   |.|......|||.:.|..:||.:...|        :..::..|:|  .:..|::.....|.
Frog   997 GLSIISRQSQAQGAYVKQQLRTIVQQYFGRFLPSVPSAGAGGNHPMLLA--LSDTLESQHSVHLR 1059

  Fly   933 QFVLQLLVTQFLVVQRRRAGQHAGLVITIMQQLIESTGKEQE------EQLLTVLRGVHIPLLEH 991
            :.::|:|...:|   :.|.......:.:::..:.::..|.:.      |.||.       .:|:.
Frog  1060 RIIMQVLSENYL---QFRGNAPPPRLASVLSFIFDALNKSKNIDTFDAEALLP-------SVLKC 1114

  Fly   992 VMFVDEVDLSRNQVFGLYKVLISHDAYKRSQAVRDMCSNH--------LRSLAEKHLAHCTYFYF 1048
            ::.|:|..:.:...    :||         |.:.:.|.:.        |.|:..|.:...:..|.
Frog  1115 LILVNEPQVRKLSA----EVL---------QCIIENCQSDQTGETATTLASVLRKFIQENSLLYD 1166

  Fly  1049 QMLINLAE----LAPDLVAPILSFIREQAEQVELKRGAGEDVGIRKCLQRLQKVL 1099
            |.:..:.|    |...||..::..|.:.....|.|||.|.:...|...:||..:|
Frog  1167 QHIFGILETISVLDQPLVISLIPTITQSLMDSEHKRGLGRNASSRAAYRRLLSLL 1221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14803	NP_569950.1	MMS22L_N	<195..559	CDD:291571	110/447 (25%)
CG14803	NP_569950.1	MMS22L_C	733..1099	CDD:291572	81/423 (19%)
mms22l	XP_012818992.3	MMS22L_N	29..734	CDD:405580	170/753 (23%)
mms22l	XP_012818992.3	MMS22L_C	844..1221	CDD:405581	80/419 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47780
OrthoDB	1	1.010	-	-		D242609at33208
OrthoFinder	1	1.000	-	-		FOG0008254
OrthoInspector	1	1.000	-	-		oto102489
Panther	1	1.100	-	-	LDO	PTHR28547
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4663
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.060