DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pex5 and PEX9

DIOPT Version :9

Sequence 1:	NP_726771.1	Gene:	Pex5 / 31141	FlyBaseID:	FBgn0023516	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_013731.1	Gene:	PEX9 / 855032	SGDID:	S000004620	Length:	514	Species:	Saccharomyces cerevisiae

Alignment Length:	626	Identity:	123/626 - (19%)
Similarity:	215/626 - (34%)	Gaps:	180/626 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 NTVTKPIASITADKQLRSISTSNTMSFRPLVEGDCGGVNPLMQLGGQF----TRDVAHKDEGYVQ 92
            |.||   .|||.|..:..|:....:.:..|               |:|    |.|.|.:|...:.
Yeast     2 NEVT---CSITGDNPIHKINNGLGLKWNNL---------------GKFSDFQTNDSAARDARTID 48

  Fly    93 RHFE-------------RAARPEDQLINEFLGQVTAPPQSFQMDTLLQEMRDINIHGNPQQQMHS 144
            ..|.             |||.|.|:                            :.|....::..|
Yeast    49 YIFTNCQTGSSIGKIDFRAALPADK----------------------------SQHSGVSEKEFS 85

  Fly   145 QQAEQWGQDFA-----RGLAPALPNKMIHMQAQQQDLQHAQEFFDEPLISSQNFRSLPPLRQPLM 204
            :...||.::|:     :......|::..|   :::.......:|.:       :.|....:..:.
Yeast    86 RLENQWSKEFSCFPKNKNADVTKPSRNKH---EKRSANLHNRYFAQ-------YYSTAYQQNRIY 140

  Fly   205 PIAAGQQQDPFFDSAMETIITDHLPQAPQGESLDDWISDYQRSTEQKEQTAANFNEKFWERLQDE 269
            |......:.....:..|.          |.:|:::.:.:..:.....|:....:.
Yeast   141 PCRISYNEHSSVSNGWEF----------QFKSIENQLLNELKIENNVEEKTVGYE---------- 185

  Fly   270 WQKLADENEHPWLSEYNDNMD-------AYKEYEFAEGNPMSDVENPFEKGKEYLSKG-DIPSAV 326
                       :::||.:.:|       ..:.|:|.:.|......:|::.|...:..| ::...|
Yeast   186 -----------YVAEYEETIDFMHMLSSVPQTYQFLKSNIYITERDPYKIGCVLMDNGSNLNEVV 239

  Fly   327 LCFEVAAKKQPERAEVWQLLGTSQTENEMDPQAIAALKRAYDLQPDNQQVLMALAACYTNEGLQN 391
            :.||.|..:.|.....|..||....|||.:.....||:...:|.|:|...|..||..:.|:..::
Yeast   240 MAFEAAISQDPSHINAWLKLGIVNFENESESNGELALRNCLNLDPNNTIALENLAIHHINQQNES 304

  Fly   392 NAVRMLCNWLTVH-------------------PKYQHLVAAHPELQAEGTSLASSLIGPSKLRDL 437
            .::::...|:...                   ||..||  ||                  .|..|
Yeast   305 ESLKLFHKWILSKFSKVFQPSAGENKDSINKIPKKAHL--AH------------------ILESL 349

  Fly   438 QQIYLEAVRQHPSEVDAEVQDALGVLYNLSGEFDKAVDCYQSALQVDPQNAKTWNRLGASLANGS 502
            ..:.:|...|:      ::...|.:||....:..::..|.:..|...|.|...|||.||.|||..
Yeast   350 LNMGIEKKDQY------DIYSVLSILYYSDQKIKQSQKCLEFLLLEKPNNGTIWNRYGAILANTK 408

  Fly   503 RSVEAVEAYQQALQLQPGFIRVRYNVGVCCMN----LKAYKEAVEHLLTALTMQAHTNA------ 557
            ....|:.||.:..||:|.|.|||||:.:..||    :||.|..:|.:|.......|..|
Yeast   409 SYHSAINAYNKCKQLRPNFTRVRYNLAIAYMNKGDYVKASKMLIEVILLRSKGYEHNKAKMQNKF 473

  Fly   558 ARELPNAAMAA-------TFRGQNQMSESIWSTLKMVISLM 591
            .:.|.||.:|:       ...|.:. :||:.||||.:.:.|
Yeast   474 MQNLKNALIASKNFDSLDLINGSHN-TESLISTLKAIYNKM 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex5	NP_726771.1	TPR_11	310..371	CDD:290150	16/61 (26%)
		TPR repeat	310..334	CDD:276809	6/24 (25%)
		TPR repeat	339..369	CDD:276809	8/29 (28%)
		TPR repeat	374..397	CDD:276809	4/22 (18%)
		TPR_11	453..519	CDD:290150	20/65 (31%)
		TPR repeat	454..482	CDD:276809	4/27 (15%)
		TPR_1	460..487	CDD:278916	6/26 (23%)
		TPR repeat	487..517	CDD:276809	12/29 (41%)
		TPR_1	488..521	CDD:278916	14/32 (44%)
		TPR_16	493..549	CDD:290168	25/59 (42%)
		TPR repeat	522..549	CDD:276809	12/30 (40%)
PEX9	NP_013731.1	TPR repeat	222..247	CDD:276809	6/24 (25%)
		PEP_TPR_lipo	234..>455	CDD:274350	64/246 (26%)
		TPR repeat	252..282	CDD:276809	8/29 (28%)
		TPR repeat	287..314	CDD:276809	4/26 (15%)
		TPR repeat	360..388	CDD:276809	4/33 (12%)
		TPR repeat	393..423	CDD:276809	12/29 (41%)
		TPR repeat	428..455	CDD:276809	11/26 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346310
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1125
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001469
OrthoInspector	1	1.000	-	-		otm46634
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10130
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2359
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.830