Protein Alignment Pex5 and Pex5l

DIOPT Version :10

• Sequence 1: NP_726771.1
• Gene: Pex5 / 31141
• FlyBaseID: FBgn0023516
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: XP_011247990.1
• Gene: Pex5l / 58869
• MGIID: 1916672
• Length: 673
• Species: Mus musculus
• Alignment Length: 608
• Identity: 195/608 - (32%)
• Similarity: 308/608 - (50%)
• Gaps: 95/608 - (15%)

  Fly    30 LCNT----VTKPIASITADKQLRSISTSNTMSFRPLVEGDCGGVNPLMQLGGQFTRDVAHKDEGY 90
            ||.|    :.||:.|.||      :.|:. :....|.|       |:.|     |:..|.|.|..
Mouse   132 LCETKSEAIAKPVTSNTA------VLTTG-LDLLDLSE-------PVSQ-----TQTKAKKSEPS 177

  Fly    91 VQRHFERAARPEDQLIN---EFLGQVTAPPQSFQMD-----TLLQEMRDINIHGNPQQQMHSQQA 147
            .:....:.......||:   |...|....|::..:|     |.|::..|:..||:...:.| ..|
Mouse   178 SKSSSLKKKADGSDLISADAEQRAQALRGPETSSLDLVDIQTQLEKWDDVKFHGDRTSKGH-LMA 241

  Fly   148 EQWGQDFARGLAPALPNKMIHMQAQQQDLQHAQEFFDEPLI----SSQNFRSLPPLRQPLMPIAA 208
            |:               |....:...::|..:.|...:|.:    |:.|..|...| :.:.|..|
Mouse   242 ER---------------KSCSSRTGSKELLWSAEHRSQPELSTGKSALNSESASEL-ELVAPAQA 290

  Fly   209 GQQQDPFFDSAMETIITDHLPQAPQGESLDDWISDYQRSTEQKEQTAANFNEKFWERLQDEWQKL 273
            ...::..:.||:          ..:..||::   :::|:     :.|...:.:||:::|.||:::
Mouse   291 RLTKEHRWGSAL----------LSRNHSLEE---EFERA-----KAAVESDTEFWDKMQAEWEEM 337

  Fly   274 ADENEHPWLSEYNDNMDAY---------KEYEFAEGNPMSDVENPFEKGKEYLSKGDIPSAVLCF 329
            |..|   |:||   |.:|.         |.|.|...||..|....||:|.:.|.:||:|..:|..
Mouse   338 ARRN---WISE---NQEAQNQVTVSASEKGYYFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFM 396

  Fly   330 EVAAKKQPERAEVWQLLGTSQTENEMDPQAIAALKRAYDLQPDNQQVLMALAACYTNEGLQNNAV 394
            |.|..:.|..||.||.||.:|.|||.:..||.||:|..:|||:|.:.|||||..|||...|.:|.
Mouse   397 EAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTSHQQDAC 461

  Fly   395 RMLCNWLTVHPKYQHLVAAHPELQAEGTSLASSLIGPSKLRDLQQIYLEAVRQHPSEVDAEVQDA 459
            ..|.||:..:|||::||............::.|.:..|.|..::::||||..|:...:|.::|..
Mouse   462 EALKNWIKQNPKYKYLVKNKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTG 526

  Fly   460 LGVLYNLSGEFDKAVDCYQSALQVDPQNAKTWNRLGASLANGSRSVEAVEAYQQALQLQPGFIRV 524
            ||||::|||||::|:|.:.:||.|.|::...||||||:||||.||.||||||.:||::||||||.
Mouse   527 LGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRS 591

  Fly   525 RYNVGVCCMNLKAYKEAVEHLLTALTMQAHTNAARELPNAAMAATFRGQNQMSESIWSTLKMVIS 589
            |||:|:.|:||.||:|||.:.||||::|..:...:::|:.|          :|.:||:.|::.:|
Mouse   592 RYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPA----------ISGNIWAALRIALS 646

  Fly   590 LMGRSDLQSYVSDRNLAALNEAF 612
            ||.:.:|....:..:|..|..||
Mouse   647 LMDQPELFQAANLGDLDVLLRAF 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pex5	NP_726771.1	LapB	310..561	CDD:442196	116/250 (46%)
		TPR repeat	310..334	CDD:276809	10/23 (43%)
		TPR repeat	339..369	CDD:276809	15/29 (52%)
		TPR repeat	374..397	CDD:276809	10/22 (45%)
		TPR repeat	454..482	CDD:276809	13/27 (48%)
		TPR repeat	487..517	CDD:276809	20/29 (69%)
		TPR repeat	522..549	CDD:276809	16/26 (62%)
Pex5l	XP_011247990.1	Spy	279..>474	CDD:443119	71/219 (32%)
		TPR repeat	377..401	CDD:276809	10/23 (43%)
		TPR	403..672	CDD:440225	120/277 (43%)
		TPR repeat	406..436	CDD:276809	15/29 (52%)
		TPR repeat	441..469	CDD:276809	13/27 (48%)
		TPR repeat	521..549	CDD:276809	13/27 (48%)
		TPR repeat	554..584	CDD:276809	20/29 (69%)
		TPR repeat	589..617	CDD:276809	17/27 (63%)