DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pex5 and pex5la

DIOPT Version :9

Sequence 1:	NP_726771.1	Gene:	Pex5 / 31141	FlyBaseID:	FBgn0023516	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	XP_021327449.1	Gene:	pex5la / 557009	ZFINID:	ZDB-GENE-070705-298	Length:	666	Species:	Danio rerio

Alignment Length:	389	Identity:	152/389 - (39%)
Similarity:	234/389 - (60%)	Gaps:	31/389 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 QGESLDDWISDYQRSTEQKEQTAANFNEKFWERLQDEWQKLADENEHPWLSEYN-----DNMDAY 292
            :.:||::   :::|:     :.|...:.:||:::|.||::||..|   ||:|..     .|:..|
Zfish   296 RNQSLEE---EFERA-----KAAVESDTEFWDKMQAEWEELARRN---WLTENEQPQIPSNVSPY 349

  Fly   293 -KEYEFAEGNPMSDVENPFEKGKEYLSKGDIPSAVLCFEVAAKKQPERAEVWQLLGTSQTENEMD 356
             |.|.|...||..|..|.||:|.....:|::|:|||..|.|..:.|:.:|.|.:|||:|.|||.:
Zfish   350 EKGYYFHTDNPFKDWPNAFEEGLRKSREGELPNAVLLLEAAVLQDPQDSEAWLVLGTTQAENENE 414

  Fly   357 PQAIAALKRAYDLQPDNQQVLMALAACYTNEGLQNNAVRMLCNWLTVHPKYQHLVAAHPELQAEG 421
            ..||.:|:|..:|.|:|.|.|||||...||.|::..|...|..|:..:|||:||:.:...||...
Zfish   415 QAAIVSLQRCLELHPNNLQALMALAVSLTNTGMRQEACEALLGWIRHNPKYKHLLKSRTHLQGSP 479

  Fly   422 TSLASSLIGPSK---LRDLQQIYLEAVRQHPSEVDAEVQDALGVLYNLSGEFDKAVDCYQSALQV 483
            .|...|...|..   |.:::.:|||:.:|:...:|.::|..||||||||.||:||||.:.:||.|
Zfish   480 GSRRPSYPCPVSCPLLPEVKDLYLESAQQNVDTIDPDLQTGLGVLYNLSSEFNKAVDAFNAALSV 544

  Fly   484 DPQNAKTWNRLGASLANGSRSVEAVEAYQQALQLQPGFIRVRYNVGVCCMNLKAYKEAVEHLLTA 548
            .|::...||||||:||||.||.||||||.:||:|||||||.|||:|:.|:|:.|::||..:.|||
Zfish   545 RPEDYLLWNRLGATLANGDRSEEAVEAYTKALELQPGFIRSRYNLGISCINMGAHREAASNFLTA 609

  Fly   549 LTMQAHTNAARELPNAAMAATFRGQNQMSESIWSTLKMVISLMGRSDLQSYVSDRNLAALNEAF 612
            |.:| ..:.:|:|.:..          ||.:||:.|::.:|::.:.:|....:..:|..|.:||
Zfish   610 LGLQ-RKSRSRQLSHQV----------MSGNIWAALRIALSMLDQPELFQAANIGDLDLLMKAF 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex5	NP_726771.1	TPR_11	310..371	CDD:290150	25/60 (42%)
		TPR repeat	310..334	CDD:276809	10/23 (43%)
		TPR repeat	339..369	CDD:276809	13/29 (45%)
		TPR repeat	374..397	CDD:276809	10/22 (45%)
		TPR_11	453..519	CDD:290150	41/65 (63%)
		TPR repeat	454..482	CDD:276809	16/27 (59%)
		TPR_1	460..487	CDD:278916	18/26 (69%)
		TPR repeat	487..517	CDD:276809	20/29 (69%)
		TPR_1	488..521	CDD:278916	23/32 (72%)
		TPR_16	493..549	CDD:290168	36/55 (65%)
		TPR repeat	522..549	CDD:276809	13/26 (50%)
pex5la	XP_021327449.1	TPR	304..580	CDD:223533	117/283 (41%)
		TPR repeat	368..392	CDD:276809	10/23 (43%)
		TPR repeat	397..427	CDD:276809	13/29 (45%)
		TPR repeat	432..455	CDD:276809	10/22 (45%)
		TPR repeat	515..543	CDD:276809	16/27 (59%)
		TPR repeat	548..578	CDD:276809	20/29 (69%)
		TPR_12	551..615	CDD:315987	41/64 (64%)
		TPR repeat	583..610	CDD:276809	13/26 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593628
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1125
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	324	1.000	Inparanoid score	I2473
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D284122at33208
OrthoFinder	1	1.000	-	-		FOG0001469
OrthoInspector	1	1.000	-	-		otm25115
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10130
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1034
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.860