DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pex5 and pex5

DIOPT Version :9

Sequence 1:	NP_726771.1	Gene:	Pex5 / 31141	FlyBaseID:	FBgn0023516	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_595487.1	Gene:	pex5 / 2541112	PomBaseID:	SPBC725.07	Length:	598	Species:	Schizosaccharomyces pombe

Alignment Length:	651	Identity:	159/651 - (24%)
Similarity:	268/651 - (41%)	Gaps:	157/651 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 IRALCNTVTKPIASITADKQLRSISTSNTMSFRPLVEGDCGGVNPLMQLG-GQFTRDVAHKDEGY 90
            :.|.|:|::.|:..:|:...:.: ||.:....:.|.:.......||..|. .|||
pombe     3 VEAGCSTLSNPLKKLTSTAVVNN-STPSAQYRKHLTKSQSRTYAPLQTLSEDQFT---------- 56

  Fly    91 VQRHFERAARPEDQLINEFLGQVTAPPQSFQMDTLLQEMRDINIHGNPQQQMHSQQAEQWGQDFA 155
               .|:..     |..|..||.|...|.|.:...          |.....:..|:  |.|...|:
pombe    57 ---SFKNL-----QGNNSPLGNVVKNPVSLKTGN----------HTGTTTRGGSK--ENWVHSFS 101

  Fly   156 RGLAPALPNKMIHMQAQQQDLQHA--QEFFDEPLISSQN--FRSLPPLRQPLMPIAAGQQQDPFF 216
                          ..|||:.:.|  .||.:..|.||:|  ||:   |.|||        :..||
pombe   102 --------------SLQQQNSKSAWTSEFSEVFLNSSENDRFRN---LNQPL--------KQSFF 141

  Fly   217 DSA------------METIITDHLPQAPQGESLDDWISDYQRSTEQKEQTAANFNEKFWERLQ-- 267
            .||            ..::..|....|.:.|.... ||:  :..::|:.|.:...|:.||..|
pombe   142 GSAGLNLSSNTEIPLQSSLAIDETELAKKFEEASQ-ISN--KLEKEKDATGSKSIEELWEEHQKQ 203

  Fly   268 -----------DEWQKLADE-------NEHPWLSEY----NDNMDAYKEYE---FAEGNPMSDVE 307
                       :|:||..::       ::.|:.|..    |||:...|..:   |...:..:.||
pombe   204 LKNAGLEPASLEEYQKQWEDFLKSNNISDDPYTSSVNSFANDNLAHNKNIDPQIFQHSDTDNVVE 268

  Fly   308 N--------------------------PFEKGKEYLSK-GDIPSAVLCFEVAAKKQPERAEVWQL 345
            |                          ||.:....:.. |.|..|.:..|.:.|:.|:..|.|:.
pombe   269 NSLQTEDVYSQNQDESSEVVKELNGIDPFVEAMNLIKNGGSISKAAVLLEQSVKENPQHFEAWKW 333

  Fly   346 LGTSQTENEMDPQAIAALKRAYDLQPDNQQVLMALAACYTNEGLQNNAVRMLCNWL-TVHPKYQH 409
            ||...|....:.:.:.||..|..|...|..::|.||..|.|:.|...|:..|.:|: ...|:|::
pombe   334 LGRIHTLLGNESRVVEALLEAVKLDSTNLDLMMDLAVSYVNQSLNVQALVCLEDWIVNSFPQYRN 398

  Fly   410 LVAAHPELQAEGTSLASSLIGPSKLRDLQQIYLEAVRQ--HPSEVDAEVQDALGVLYNLSGEFDK 472
            ..|...|...|..| |:.|:      .:|..:|:...:  ...:..::||..||::..:..|:::
pombe   399 RFAKINERFEEKDS-ANDLL------KMQMYFLDVAYELSLAKKRSSKVQAGLGIIMYMLKEYER 456

  Fly   473 AVDCYQSALQVDPQNAKTWNRLGASLANGSRSVEAVEAYQQALQLQPGFIRVRYNVGVCCMNLKA 537
            :.||::.|||.:|.|...||:|||:|.|..::.|||.:|.:|:.|||.::|||.|:.|..:||..
pombe   457 SADCFRQALQDEPSNEILWNKLGAALTNAEKNTEAVSSYNRAVSLQPQYVRVRSNMAVSNINLGY 521

  Fly   538 YKEAVEHLLTALTMQAHTNAARELPNAAMAATFRGQNQMSESIWSTLKMVISLMG--RSDL--QS 598
            :::|.:|||.|:.:..:::.:.|            ..:.:|.:|..|:.|. |:|  .:||  ||
pombe   522 FEDAAKHLLAAIDIIQNSSTSME------------SCESNEELWEMLRKVF-LIGFQSTDLASQS 573

  Fly   599 Y 599
            |
pombe   574 Y 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex5	NP_726771.1	TPR_11	310..371	CDD:290150	16/61 (26%)
		TPR repeat	310..334	CDD:276809	5/24 (21%)
		TPR repeat	339..369	CDD:276809	8/29 (28%)
		TPR repeat	374..397	CDD:276809	7/22 (32%)
		TPR_11	453..519	CDD:290150	25/65 (38%)
		TPR repeat	454..482	CDD:276809	8/27 (30%)
		TPR_1	460..487	CDD:278916	9/26 (35%)
		TPR repeat	487..517	CDD:276809	13/29 (45%)
		TPR_1	488..521	CDD:278916	15/32 (47%)
		TPR_16	493..549	CDD:290168	24/55 (44%)
		TPR repeat	522..549	CDD:276809	11/26 (42%)
pex5	NP_595487.1	DUF3502	<173..226	CDD:288833	11/55 (20%)
		TPR_16	299..361	CDD:290168	15/61 (25%)
		TPR repeat	327..357	CDD:276809	8/29 (28%)
		TPR repeat	362..389	CDD:276809	8/26 (31%)
		TPR_11	471..535	CDD:290150	28/63 (44%)
		TPR repeat	471..501	CDD:276809	13/29 (45%)
		TPR repeat	506..534	CDD:276809	12/27 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1125
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001469
OrthoInspector	1	1.000	-	-		oto100778
orthoMCL	1	0.900	-	-		OOG6_101647
Panther	1	1.100	-	-	LDO	PTHR10130
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2359
SonicParanoid	1	1.000	-	-		X1034
TreeFam	1	0.960	-	-
	10	9.800