Protein Alignment Pex5 and prx-5

DIOPT Version :10

• Sequence 1: NP_726771.1
• Gene: Pex5 / 31141
• FlyBaseID: FBgn0023516
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_001022019.1
• Gene: prx-5 / 174392
• WormBaseID: WBGene00004194
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 571
• Identity: 163/571 - (28%)
• Similarity: 259/571 - (45%)
• Gaps: 100/571 - (17%)

  Fly    61 LVEGDCGGVNPLMQLGGQFTRDVAHKDEGYVQRHFERAARPEDQLINEFLGQV--TAPPQSFQMD 123
            :|||.||..|.|:.|...|..................::...:|:.||||.|.  |..|.||.|.
 Worm     4 VVEGQCGQQNALVGLANTFGTSNQRVAPSNAAASLLPSSSMGEQMANEFLRQQARTMAPTSFSMK 68

  Fly   124 TLLQEMRDINIHGNPQQQMHSQQAEQWGQDFARGLAPALPNKMIHMQAQQQDLQHAQEFFDEPLI 188
            ::...:        ||....|..|..|.::|               |.:|..|  |.::
 Worm    69 SMQNNL--------PQASASSSLAANWTKEF---------------QPRQNQL--ASQW------ 102

  Fly   189 SSQNFRSLPPLRQPLMPIAAGQQQDPFFDSAMETIITDHLPQAPQGESLDDWISDYQRSTE---Q 250
             ||.:.|    ..|.|..|..|.|.|...|.     :.|.|....|.    |.|:|..:.:   .
 Worm   103 -SQQYTS----SAPSMESAWRQVQAPSMTST-----SSHQPITDAGM----WSSEYLDTVDTSLT 153

  Fly   251 KEQTAANFNEKFWER-----LQDEWQKLADENEHPWLS-----EYNDNMDAYKEYEFAEGNPMSD 305
            |.....|:.:.|.|:     :::.| |.|...|..|..     |.::::.:.:.|.:.|.||.:.
 Worm   154 KSSGTQNWADDFMEQQDNYGMENTW-KDAQAFEQRWEEIKRDMEKDESLQSPENYVYQEANPFTT 217

  Fly   306 VENPFEKGKEYLSKGDIPSAVLCFEVAAKKQPERAEVWQLLGTSQTENEMDPQAIAALKRAYDLQ 370
            :.:|..:|...:..|||.:|:|.:|.|.:|.|:.|..|..||.:..|||.|..|:.|.::...:.
 Worm   218 MSDPLMEGDNLMRNGDIGNAMLAYEAAVQKDPQDARAWCKLGLAHAENEKDQLAMQAFQKCLQID 282

  Fly   371 PDNQQVLMALAACYTNEGLQNNAVRMLCNWLTVHPKYQHLVAAHPELQAEGTS------LASSLI 429
            ..|::.|:.|:....|||::|.|:..|..|::.:            |.:..|.      |.||.:
 Worm   283 AGNKEALLGLSVSQANEGMENEALHQLDKWMSSY------------LGSNSTQVTTTPPLYSSFL 335

  Fly   430 GPSKLRDLQQIYLEAVRQHPSEVDAEVQDALGVLYNLSGEFDKAVDCYQSALQVDPQNAKTWNRL 494
            .......::..:|:|.||..:..|.::|:||||||||:..|.:|||..:.|:..:|.:|:.||||
 Worm   336 DSDTFNRVEARFLDAARQQGATPDPDLQNALGVLYNLNRNFARAVDSLKLAISKNPTDARLWNRL 400

  Fly   495 GASLANGSRSVEAVEAYQQALQLQPGFIRVRYNVGVCCMNLKAYKEAVEHLLTALTMQAHTNAAR 559
            ||:||||..:.||:.||::||:|.|.::|.|||:|:.||.|.:|.||::|.|:||.:|
 Worm   401 GATLANGDHTAEAISAYREALKLYPTYVRARYNLGISCMQLSSYDEALKHFLSALELQ------- 458

  Fly   560 ELPNAAMAATFRGQNQMSESIWSTLKMVISLMGR--SDLQSYVSDRNLAAL 608
                       :|.|..| .||:|::........  .:|...|..|:|||:
 Worm   459 -----------KGGNDAS-GIWTTMRSAAIRTSNVPDNLLRAVERRDLAAV 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pex5	NP_726771.1	LapB	310..561	CDD:442196	90/256 (35%)
		TPR repeat	310..334	CDD:276809	8/23 (35%)
		TPR repeat	339..369	CDD:276809	10/29 (34%)
		TPR repeat	374..397	CDD:276809	7/22 (32%)
		TPR repeat	454..482	CDD:276809	14/27 (52%)
		TPR repeat	487..517	CDD:276809	17/29 (59%)
		TPR repeat	522..549	CDD:276809	13/26 (50%)
prx-5	NP_001022019.1	LapB	222..>458	CDD:442196	89/247 (36%)
		TPR repeat	222..246	CDD:276809	8/23 (35%)
		TPR repeat	251..281	CDD:276809	10/29 (34%)
		TPR repeat	286..314	CDD:276809	9/27 (33%)
		TPR repeat	360..388	CDD:276809	14/27 (52%)
		TPR repeat	393..423	CDD:276809	17/29 (59%)
		TPR repeat	428..456	CDD:276809	14/27 (52%)