DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MED18 and MED18

DIOPT Version :9

Sequence 1:	NP_569948.3	Gene:	MED18 / 31140	FlyBaseID:	FBgn0026873	Length:	217	Species:	Drosophila melanogaster
Sequence 2:	NP_001120822.1	Gene:	MED18 / 54797	HGNCID:	25944	Length:	208	Species:	Homo sapiens

Alignment Length:	194	Identity:	105/194 - (54%)
Similarity:	142/194 - (73%)	Gaps:	8/194 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LEYLLQGSILDSAVEHLMHRLKGLCDNVDTSPEPFHDLEVCMSLRQPNANQPLLLRVRRALGR-D 86
            :|||||||:||.::|.|:|||:|||||::  ||.|.|.|:...|:...|: |.:||.||::.| .
Human    19 MEYLLQGSVLDHSLESLIHRLRGLCDNME--PETFLDHEMVFLLKGQQAS-PFVLRARRSMDRAG 80

  Fly    87 APFQMRYLGNPEV-DLRRPTLVRSCMDCACTNGILEFLTEMGFRLEFEYIAKGYMFRKGRMKITV 150
            ||:.:||||.||: |..|..|||:|:|.|.:..:.:||.|||||::.|::|||::||||.|||.|
Human    81 APWHLRYLGQPEMGDKNRHALVRNCVDIATSENLTDFLMEMGFRMDHEFVAKGHLFRKGIMKIMV 145

  Fly   151 SKLIKI-VPGKQQDMANEPISQSYIVELSVVAPTGQENVGEEMRVFAEQLKPLVQLEKIDYKRL 213
            .|:.:| |||...  :.|.:|.||:||||||||.||:.|.::|:.|||||||||.|||||.|||
Human   146 YKIFRILVPGNTD--STEALSLSYLVELSVVAPAGQDMVSDDMKNFAEQLKPLVHLEKIDPKRL 207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED18	NP_569948.3	Med18	24..213	CDD:286687	103/191 (54%)
MED18	NP_001120822.1	Med18	19..207	CDD:401539	102/190 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159171
Domainoid	1	1.000	187	1.000	Domainoid score	I3347
eggNOG	1	0.900	-	-		E1_KOG3264
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9756
Inparanoid	1	1.050	191	1.000	Inparanoid score	I3882
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48991
OrthoDB	1	1.010	-	-		D1140930at2759
OrthoFinder	1	1.000	-	-		FOG0007504
OrthoInspector	1	1.000	-	-		oto91743
orthoMCL	1	0.900	-	-		OOG6_106422
Panther	1	1.100	-	-	LDO	PTHR13321
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6162
SonicParanoid	1	1.000	-	-		X6389
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800