DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment prage and PAN2

DIOPT Version :9

Sequence 1:	NP_001188528.1	Gene:	prage / 31136	FlyBaseID:	FBgn0283741	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_001120932.2	Gene:	PAN2 / 9924	HGNCID:	20074	Length:	1202	Species:	Homo sapiens

Alignment Length:	607	Identity:	118/607 - (19%)
Similarity:	198/607 - (32%)	Gaps:	200/607 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 QMQQQMQQQKRGRNKKPGKWSNNIIDNPNSNHGGSS----------QQKTCDSSSSSALSSPTSS 400
            |:.|.||:.:              |.......||||          |..:|:..:.|.....:.:
Human   623 QLHQDMQELE--------------IPQAYRGAGGSSFCSSGDSVIGQLFSCEMENCSLCRCGSET 673

  Fly   401 ATTSATSSPTNSPTSYP---RANGNRKRIEAALEWRREQELGRQNANFLVPPLRQYEQLEFDDKT 462
            ...|:|...|   .|||   :::...|..:.|...:|...|. ||.........:|:      .|
Human   674 VRASSTLLFT---LSYPDGSKSDKTGKNYDFAQVLKRSICLD-QNTQAWCDTCEKYQ------PT 728

  Fly   463 VVQQLRRHIIDNHLLRVYGFPVDSVVHEGAIEIFKCMPHMS----FAAALAETAQAVTVINYHDG 523
            :..:..||:.|                   |.:..|..:.|    |....||.|..:.|..:...
Human   729 IQTRNIRHLPD-------------------ILVINCEVNSSKEADFWRMQAEVAFKMAVKKHGGE 774

  Fly   524 LTNRAEEEVANSTDSGNSSPQSL-----DSESGGEWSGSECESSNSSSSSAGEAALGLELKYCHF 583
            ::...|..:|:..:.|  ||:.:     ..|....|.........:.:.       ||::  |::
Human   775 ISKNKEFALADWKELG--SPEGVLVCPSIEELKNVWLPFSIRMKMTKNK-------GLDV--CNW 828

  Fly   584 VPVERSLSKPCARCKR--------------HFLVDELTGQYLTHEEC--QYHSGKYQRYYDGVSH 632
            ...:.....| ||.:.              |.|.....|..:.|.:.  .||..|     :||:|
Human   829 TDGDEMQWGP-ARAEEEHGVYVYDLMATVVHILDSRTGGSLVAHIKVGETYHQRK-----EGVTH 887

  Fly   633 GRWTCCNEG--EESSPGCCLGDRHV-------WS------------------------------- 657
            .:|...|:.  |..       |:|.       |.
Human   888 QQWYLFNDFLIEPI-------DKHEAVQFDMNWKVPAILYYVKRNLNSRYNLNIKNPIEASVLLA 945

  Fly   658 --------------------------GSVVGVNGPYYDFVRTEHRGSGEDEPAVYALDCEMSYTG 696
                                      |.:||::.   :||..     .|:|..:.:...:.:...
Human   946 EASLARKQRKTHTTFIPLMLNEMPQIGDLVGLDA---EFVTL-----NEEEAELRSDGTKSTIKP 1002

  Fly   697 RGLDVTKVSLVALNGQ----LVYEHFVRPVCDIIDYNTQYSGITETDLCS--GAKSLAEVQRDLL 755
            ..:.|.:::.|...|.    ...:.::.....::||.||||||...||.:  .:|.|..::...|
Human  1003 SQMSVARITCVRGQGPNEGIPFIDDYISTQEQVVDYLTQYSGIKPGDLDAKISSKHLTTLKSTYL 1067

  Fly   756 Q---LITADTILIGHGLENDLRALRLV--HNTLIDTSISFPHCNGFPYRR--ALRHLTKVHLKRD 813
            :   ||......:||||:.|.|.:.|:  .:.::||...| |   .|.:|  :||.|....|...
Human  1068 KLRFLIDIGVKFVGHGLQKDFRVINLMVPKDQVLDTVYLF-H---MPRKRMISLRFLAWYFLDLK 1128

  Fly   814 IQAGDGTTGHSSFEDSRACMEL 835
            ||   |.| |.|.||:|..::|
Human  1129 IQ---GET-HDSIEDARTALQL 1146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prage	NP_001188528.1	PH-like	<614..650	CDD:302622	9/39 (23%)
		DnaQ	675..>837	CDD:223916	47/174 (27%)
		REX1_like	686..837	CDD:99848	45/163 (28%)
PAN2	NP_001120932.2	WD 1. /evidence=ECO:0000255\|HAMAP-Rule:MF_03182	153..193
		WD 2. /evidence=ECO:0000255\|HAMAP-Rule:MF_03182	195..231
		WD40	<204..357	CDD:392136
		WD 3. /evidence=ECO:0000255\|HAMAP-Rule:MF_03182	244..280
		WD 4. /evidence=ECO:0000255\|HAMAP-Rule:MF_03182	328..367
		Linker. /evidence=ECO:0000255\|HAMAP-Rule:MF_03182	368..485
		UCH_1	517..898	CDD:372599	62/334 (19%)
		PAN2_exo	975..1148	CDD:99846	51/188 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0847
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810