DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment prage and REX3

DIOPT Version :9

Sequence 1:	NP_001188528.1	Gene:	prage / 31136	FlyBaseID:	FBgn0283741	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_013208.1	Gene:	REX3 / 850797	SGDID:	S000004097	Length:	404	Species:	Saccharomyces cerevisiae

Alignment Length:	464	Identity:	119/464 - (25%)
Similarity:	202/464 - (43%)	Gaps:	121/464 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   436 QELGRQNANFLVPPLRQYEQLE----------FDDKTVVQQLRRHIIDNHLL-RVYGFPV----- 484
            |.||.|....::..|  ::||:          .|.:.:..:|..|:..|.|. :.|.|.:
Yeast    13 QPLGFQERYKILQKL--FKQLQKAYAHTKGTNIDLERLATRLEVHVAKNSLSGQSYKFNMSILLR 75

  Fly   485 DSVVHEGAIEIFK--------CMPHMSFAAALAETAQAVTVINYHDGLTNRAEEEVANSTDSGNS 541
            |.:.::|.:...|        ..||:|                   .:.|      |||..:.:.
Yeast    76 DVLKYKGDLSKIKINGRPLKGAKPHLS-------------------SIGN------ANSITTKSK 115

  Fly   542 SPQS-----LDS---ESGGEWSGSECESSNSSSSSAGEAALGLELKYCHFVPVERSLSKPCARCK 598
            :.::     |||   |..| :...|.::..:..:|.                   .|..||.||.
Yeast   116 AMEALKALILDSKVLEKNG-YIVKEMQNKTNDDNST-------------------QLYAPCLRCS 160

  Fly   599 RHFLVDELTGQYLTHEECQYHSGK--YQRYYDGVSHGRWTCCNEGEESSP----GCCLGDRHVWS 657
            .:|...::..:.|    |:||..|  |.|  |..:| ::.||.|..:|..    ||.....||:
Yeast   161 SNFKKTDIMEKTL----CRYHPLKRIYNR--DTKNH-QYPCCGETTDSVSFLRLGCKTFFHHVF- 217

  Fly   658 GSVVGVNGPYYDFVRTEHRGSGEDE----PAVYALDCEMSYTGRGLDVTKVSLV-ALNGQLVYEH 717
                  .|..||.:....:.|..|:    ..|.:|||||::|..|.::.::::| ...|:.:::|
Yeast   218 ------RGESYDELCKISKFSSTDDIDGVENVLSLDCEMAFTSLGYEMIRLTIVDFFTGKTLFDH 276

  Fly   718 FVRPVCDIIDYNTQYSGITETDL--CSGAKSLAEVQRDLL--QLITADTILIGHGLENDLRALRL 778
            .::|:.||:|.|:.:||:.|.|.  |...|...:|   .|  .||..::|||||||||||..:||
Yeast   277 VIQPIGDIVDLNSDFSGVHEIDRTNCPTYKEALDV---FLSENLINKNSILIGHGLENDLNVMRL 338

  Fly   779 VHNTLIDTSISFPHCNGFPYRRALRHLTKVHLKRDIQAGDGTTGHSSFEDSRACMELMLWRVNRE 843
            .||.:|||:|.:....   ::.:|::|....|.|.||.|:    |.|.:|:.|.|:::  :|...
Yeast   339 FHNKVIDTAILYSRTK---FKVSLKNLAFEVLSRKIQNGE----HDSSQDAIATMDVV--KVKIG 394

  Fly   844 LDPAWS-WD 851
            :.|:.: |:
Yeast   395 ISPSQNKWE 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prage	NP_001188528.1	PH-like	<614..650	CDD:302622	14/41 (34%)
		DnaQ	675..>837	CDD:223916	59/170 (35%)
		REX1_like	686..837	CDD:99848	56/155 (36%)
REX3	NP_013208.1	REX1_like	244..390	CDD:99848	56/157 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346335
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0847
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103246
Panther	1	1.100	-	-	O	PTHR12801
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2254
SonicParanoid	1	1.000	-	-		X1541
TreeFam	1	0.960	-	-
	9	8.730