Protein Alignment prage and REXO1

DIOPT Version :9

• Sequence 1: NP_001188528.1
• Gene: prage / 31136
• FlyBaseID: FBgn0283741
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: XP_011526446.1
• Gene: REXO1 / 57455
• HGNCID: 24616
• Length: 1382
• Species: Homo sapiens
• Alignment Length: 649
• Identity: 172/649 - (26%)
• Similarity: 269/649 - (41%)
• Gaps: 130/649 - (20%)

  Fly   255 SSDATSEDIDSSSELP---NKSKGNSCAGSIHASGGSKSRSKRHQKQSGQQTRNPDHNGQRTGAA 316
            |:...:||....:..|   .||:....:|......|.|.|.. |..:.||:...|     |.|.|
Human   623 STSVKTEDRGRLARQPPKEEKSEEKGLSGLTTLFPGQKRRIS-HLSKQGQEVEPP-----RRGPA 681

  Fly   317 TPCTGQKAKQGNAKWRQQQPNPSSNNQQQQMQQQMQQQKRGRNKKPGKWSNNIIDNPNSNHGGSS 381
            .|.......|.....|.||...:|.:..|...:..::........||: ...|...||..
Human   682 VPPARPPTAQEVCYLRAQQAQRASASLLQAPARLAEKSPSVHISAPGE-KRRIAHIPNPR----- 740

  Fly   382 QQKTCDSSSSSALSSPTSSATTSATSSPTNSPTSYPRANGNRKRIEAALEWRREQELGRQNANFL 446
                       ..::||.:..|.|.|...:|  :.|...|.:      |:.|....:..:....:
Human   741 -----------LAAAPTGAKRTLAASGSQSS--NGPEPGGQQ------LKTRTLSGMASKTTTTI 786

  Fly   447 VPPLRQYEQLEFDDKTVVQQLRRHIIDNHLLRVYGFPVDSVVHEGAIEIF--KCMP-----HMSF 504
            :|.       .......:|.|::.||.    :.:|..|.:|:.:..:.:|  :|:.     ..:.
Human   787 IPK-------RIAHSPSLQSLKKPIIP----KEFGGKVPTVIRQRYLNLFIEECLKFCTSNQEAI 840

  Fly   505 AAALAETAQAV-----------TVINYHDGLTNRAEEEVANSTDSGNSSPQSLDSESGGEWSGSE 558
            ..||.|...|.           ..:|....|...|...|...:.:......|.:...||..:...
Human   841 EKALNEEKVAYDRSPSKNIYLNVAVNTLKKLRGLAPSAVPGLSKTSGRRVVSHEVVLGGRLAAKT 905

  Fly   559 CESSNSSSSSAGEAALGLEL----------------------------------------KYCHF 583
            ..|.:..||...|...|..|                                        |.|..
Human   906 SFSLSRPSSPRVEDLKGAALYSRLREYLLTQDQLKENGYPFPHPERPGGAIIFTAEEKRPKDCES 970

  Fly   584 VPVERSLS-KPCARCKRHFLVDELTGQYLTHEECQYHSGKYQRYYDGVSHG---RWTCCNEGEES 644
            :..:...| :.|.||...:||.. :|:.:..|||.||.|:.:|  :.|:.|   ::.||: ....
Human   971 LACDGLASCRTCCRCGTEYLVSS-SGRCIRDEECYYHWGRLRR--NRVAGGWETQYMCCS-AAAG 1031

  Fly   645 SPGCCLGDRHVWSGSVVGVNGPYYDFVRT-EHRGSGEDEPAVYALDCEMSYTGRGLDVTKVSLVA 708
            |.||.:..:||..|....:.|    ||:| |...||:..|.:||||||||||..||::|:|::|.
Human  1032 SVGCQVAKQHVQDGRKERLEG----FVKTFEKELSGDTHPGIYALDCEMSYTTYGLELTRVTVVD 1092

  Fly   709 LNGQLVYEHFVRPVCDIIDYNTQYSGITETDLCSGAKSLAEVQRDLLQLITADTILIGHGLENDL 773
            .:..:||:.||:|..:|:||||::||:||.||...:.:|.:||..||.:.:||||||||.||:||
Human  1093 TDVHVVYDTFVKPDNEIVDYNTRFSGVTEADLADTSVTLRDVQAVLLSMFSADTILIGHSLESDL 1157

  Fly   774 RALRLVHNTLIDTSISFPHCNGFPYRRALRHLTKVHLKRDIQ--------------AGDGTTGH 823
            .||:::|:|::|||:.|||..|.||:|:||:|...:|::.||              ||.|.:.|
Human  1158 LALKVIHSTVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQDNGECRCLPWGRPCAGAGCSPH 1221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
prage	NP_001188528.1	PH-like	<614..650	CDD:302622	14/38 (37%)
		DnaQ	675..>837	CDD:223916	75/163 (46%)
		REX1_like	686..837	CDD:99848	72/152 (47%)
REXO1	XP_011526446.1	EloA-BP1	802..962	CDD:292495	24/163 (15%)
		REX1_like	1070..1203	CDD:99848	68/132 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0847
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103246
Panther	1	1.100	-	-	O	PTHR12801
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2254
SonicParanoid	1	1.000	-	-		X1541
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.840