DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment prage and zgc:152968

DIOPT Version :9

Sequence 1:	NP_001188528.1	Gene:	prage / 31136	FlyBaseID:	FBgn0283741	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_001314684.1	Gene:	zgc:152968 / 564848	ZFINID:	ZDB-GENE-061013-448	Length:	1251	Species:	Danio rerio

Alignment Length:	807	Identity:	210/807 - (26%)
Similarity:	317/807 - (39%)	Gaps:	221/807 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 MYYNSSSRPFWRKCRSAAPTNLMTTIPTNNDLCNTAAAATYDKMQSCNKNSSSRITTTNNNVTTT 132
            |..|.|..|.   .:..||..:.|.:.:|.........|...|.:..:|:.:..|......   |
Zfish   629 MEANQSEAPV---VQCDAPDKVGTEMKSNPVALLKKRVAHVAKFEPASKSKAQIIVPLQEG---T 687

  Fly   133 SNISGNSSNKRCPQKYTGNTLAVNSNMLAYQQQATAGGKNSTRKSRHNNNKQNHQQQQQQQQQQF 197
            |:::..|.::.|.::....|.||.    ..|.|..    ||..|..:.:|.  ||..|...|
Zfish   688 SHLNVPSRSQLCQRRAAILTAAVK----GCQSQVI----NSAPKKVYTSNV--HQIHQSAVQ--- 739

  Fly   198 DHIHKRNGTAGGTGSECSPAAPTSNWLQRGYGRQFV--HSSC-----IEDKLLGHHNPGHRNSTS 255
                          :.|....|....||.|....|:  ..:|     :....:....|.|.:...
Zfish   740 --------------NSCVGIIPVGATLQLGTNLHFIVPEGNCALPLTLIPTTMSVQRPPHPSPPV 790

  Fly   256 SDATSEDIDSSSELPNKSKGNSCAGSIHASGGSKSRSKRHQKQSGQQT---RNPDHNGQRTGAAT 317
            ..|.::   ..::..|.:.....|..:.....::.|.|.|:....|.:   ..|:..|.:
Zfish   791 QLAPAQ---HPTQPANYTPAKRQAICLSTQDSTQQRFKYHRPSEAQNSALHSQPNVMGVK----- 847

  Fly   318 PCTGQKAK---QGNAK----WRQQQPN-------PSSNNQQQQMQQQMQQQK----RGRNKKPGK 364
                :|||   :..||    .||:..|       .||...|...::.:.::|    |..||.  |
Zfish   848 ----RKAKVHHEVGAKVPHDVRQRYVNLFVEEFLKSSVTVQDAFEKALAEEKIVYDRSINKL--K 906

  Fly   365 WSNNIIDNPNSNHGGSSQQKTCDSSSSSALSSPTSSATTSATSSPTNSPTSYPRANGNRKRIEAA 429
            :.                     |.:.:||     ....:....|..:|:
Zfish   907 YL---------------------SIAVNAL-----KRLKNQNILPAKAPS--------------- 930

  Fly   430 LEWRREQELGRQNANFLVPPLRQYEQLEFDDKTVVQQLRRHIIDNHLLRVYGFPVDSVVHEGAIE 494
               .|:|.:.|.|.     ||.........|.|:.:||:.||:...||:|..||
Zfish   931 ---ERDQHVSRGNV-----PLNTQALQGPGDLTLFEQLKEHILSEDLLQVNNFP----------- 976

  Fly   495 IFKCMPHMSFAAALAETAQAVTVINYHDGLTNRAEEEVANSTDSGNSSPQSLDSESGGEWSGSEC 559
                ..|..         :|...|.|.|             |..|.|.|
Zfish   977 ----RKHQD---------KADFAIQYGD-------------TKKGISDP---------------- 999

  Fly   560 ESSNSSSSSAGEAALGLELKYCHFVPVERSLSKPCARCKRHFLVDELTGQYLTHEECQYHSGKY- 623
                                          |.:.|.||...|.||. :|::...|||.||.||.
Zfish  1000 ------------------------------LKRICCRCGATFSVDR-SGKHTRREECNYHYGKVI 1033

  Fly   624 -QRYYDGVSHGRWTCCNEGEESSPGCCLGDRHVWSGSVVGVNGPYYDFVRTEHRGS-GEDEPAVY 686
             .|...|| ..|::|| |....||||.:.:.||  ...|.:.|    ||.:.|:.: |:..|.:|
Zfish  1034 ENRVPGGV-ETRYSCC-ENAVGSPGCQVFNLHV--HDAVSLQG----FVSSLHQSAVGKTCPGIY 1090

  Fly   687 ALDCEMSYTGRGLDVTKVSLVALNGQLVYEHFVRPVCDIIDYNTQYSGITETDLCSGAKSLAEVQ 751
            |:|.:..||.:||::.:|::|:.:.|:|::.||:|..|:|||||::|||:|.|:.|.:.||.:||
Zfish  1091 AIDTQTCYTTQGLELARVTVVSSSLQVVFDSFVKPDNDVIDYNTRFSGISEADVKSSSSSLRDVQ 1155

  Fly   752 RDLLQLITADTILIGHGLENDLRALRLVHNTLIDTSISFPHCNGFPYRRALRHLTKVHLKRDIQA 816
            ..||..|.||||||||||||||.||:::|:|::|||:.|||..|.|::|.|..||..:|:|.||
Zfish  1156 AVLLSFINADTILIGHGLENDLAALKIIHSTVVDTSVVFPHRLGLPHKRELNSLTADYLRRIIQ- 1219

  Fly   817 GDGTTGHSSFEDSRACMELMLWRVNRE 843
             :...||.:.||:.||||||||||..:
Zfish  1220 -ESVEGHDTREDATACMELMLWRVKED 1245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prage	NP_001188528.1	PH-like	<614..650	CDD:302622	18/37 (49%)
		DnaQ	675..>837	CDD:223916	79/162 (49%)
		REX1_like	686..837	CDD:99848	76/150 (51%)
zgc:152968	NP_001314684.1	EloA-BP1	855..989	CDD:292495	38/208 (18%)
		REX1_like	1090..1239	CDD:99848	76/150 (51%)
		DnaQ	1091..>1239	CDD:223916	75/149 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589972
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0847
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12801
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1541
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.800