DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment prage and rexo1

DIOPT Version :9

Sequence 1:	NP_001188528.1	Gene:	prage / 31136	FlyBaseID:	FBgn0283741	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_001119888.1	Gene:	rexo1 / 564551	ZFINID:	ZDB-GENE-030131-1650	Length:	1207	Species:	Danio rerio

Alignment Length:	1020	Identity:	240/1020 - (23%)
Similarity:	396/1020 - (38%)	Gaps:	255/1020 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GQQENMLP--------------PPYVAAIKRKID--------PEQQQQRKQHRSNILGCNKSSSI 49
            |:.|..:|              |.|.|:.....:        |....:.|.:|.|| |..|||::
Zfish   255 GEAEEYVPTVKKPKSSFTKADVPKYTASFSESDEESSGTEYRPVNVSRLKHNRINI-GLPKSSAM 318

  Fly    50 N---------------CSSINGDNRHLQRQQGKMYYNSSSRPFWRKCRSAAPTNLMTTIPTNNDL 99
            .               |.|.:.:::.:.|...|.....|:        |...||....:...|..
Zfish   319 GQQKKQISKTDAYFSPCESDDTESQDVNRTNKKTDKKVSA--------SQTKTNKTDKVKKENKD 375

  Fly   100 CNTAAAATYDKMQSCNKNSSSRITTTNNNVTTTSNISGNSSNKRCPQKYTGNTLAV---NSNMLA 161
            .|..:........|.:|.|.|.....|:.   :.||.|:|.:|....|....:.:.   :..::.
Zfish   376 SNKKSQKEQQDSSSVDKTSKSSSKKDNSQ---SKNIEGSSKSKEKSHKDKSASKSAEEKDKKVVK 437

  Fly   162 YQQQATAGGKNST---------------------------------------RKSRHNNNKQ--- 184
            .:.:::...||.:                                       :||..:|.|.
Zfish   438 IKTESSHKEKNKSSDGIKKPKMDKPVKTDKVLSKIKDQKNGKLESGSKEKDKKKSSSSNTKDKSK 502

  Fly   185 ------NHQQQQQQQQQQFDHIHKRNGTAGGTGSECSPAAPTSNWLQRGYGRQFVHSSCIEDKLL 243
                  :|::.::.:|:...|:......:.....|              ...:.|..|....|..
Zfish   503 KSISVLDHKEAKKTKQRNLSHVDLFGADSAEEEDE--------------EDERIVRKSASAFKRG 553

  Fly   244 GHHNPGHRNSTSSDATSE--------DIDSSSELPNKSKGNS-----CAGSIHASGGSKSRSK-R 294
            |..|...::|:||:..||        |.:..|.|.:..:.:|     |....:.|...|...| |
Zfish   554 GLVNNKRKSSSSSEDDSEVDEDDGGVDTEDFSCLQDVMEYDSDPMEECLRIFNESKEVKMEDKGR 618

  Fly   295 HQKQSGQQTRNPDHNGQRTGAATPCTGQKAKQGNAKWRQQQPNPSSNNQQQQMQQQMQQQKRGRN 359
            ..||..::|...|...:.| ..|...|||.:..:.|.:.:.....::...||.:...|:....|.
Zfish   619 QAKQPSRETEEEDEETEST-LTTLFPGQKKRVSHFKAQGKSETTMNSVPMQQRRMTAQEICYQRM 682

  Fly   360 KKPGKWSNNIIDNPNSNHGGSSQQKTCDSSSSSALSSPTSSATTSATSSPTNSPTSYPRANGNRK 424
            :|                   :||:      ::.|:....:|:.||:|:|...      .:|.::
Zfish   683 QK-------------------AQQQ------AAQLAEAVKTASASASSNPVLG------ISGEKR 716

  Fly   425 RI----EAALEWRREQELGRQNANFLVPPLRQYEQLEFD--------DKTVVQQLRRHIIDNHLL 477
            |:    .|:|...:..:   .::..|.|.....:||...        .||:...:::.:.....|
Zfish   717 RVAHRPNASLPSSKPAD---ASSRVLSPTRVVTDQLSVKAQTSAGILSKTISTTVQKRVAHTPTL 778

  Fly   478 R-----------VYGFPVDSVVHEGAIEIF--KCMPHMS-----FAAALAETA------------ 512
            :           .:|..|.::|.:..:.||  :|:...|     |..||.|..
Zfish   779 KSSTMKRPVIPTEFGAKVPTIVRQRYLNIFIDECLKFCSSEQDAFQLALEEEKVVYDRSSSKNIY 843

  Fly   513 --QAVTVINYHDGLTNRAEEEVANSTDSGNSSPQSLDSESGGEWSGSECESSNSSSSSAGEAALG 575
              .||..:......:..|.....:...|.|...||.:...||..:.:...:.|.|.........|
Zfish   844 LNVAVNTVKKLRSRSTPASPVTKSPAVSVNKKAQSHEEVLGGRLAATTSFTINRSGKQHDVNPKG 908

  Fly   576 LEL-----KYC------------------------HFVPVERS---LSKPCARCKRHFLVDELTG 608
            ..|     ||.                        |.:|.:::   .||.|.||...:.|:. .|
Zfish   909 AILYKKLRKYAMTEEQLQEHGYPLPHPEISGHAVVHNLPEKKNNDPFSKICCRCGAEYKVNS-NG 972

  Fly   609 QYLTHEECQYHSGKYQRYYDGVSHGRW----TCCNEGEESSPGCCLGDRHVWSGSVVGVNGPYYD 669
            ..:..|||.:|.|:.:|   ....|.|    .||: |...||||.:..:||..|....::|
Zfish   973 SCVRKEECSHHWGRLRR---NRVPGGWETLYNCCS-GAVGSPGCEVCKQHVQDGRKESLDG---- 1029

  Fly   670 FVRTEHRGSGEDEPA-VYALDCEMSYTGRGLDVTKVSLVALNGQLVYEHFVRPVCDIIDYNTQYS 733
            ||:|..:....|..| ||||||||.||.:||::|:|:::....::||:.||:|...::||||::|
Zfish  1030 FVKTFSKPLPVDGNAGVYALDCEMCYTKQGLELTRVTVINSELKVVYDTFVKPGSRVVDYNTRFS 1094

  Fly   734 GITETDLCSGAKSLAEVQRDLLQLITADTILIGHGLENDLRALRLVHNTLIDTSISFPHCNGFPY 798
            |:|..||.:...||.:||..||.:.:||:|||||.||:||.||:|:|:.::||:|.|||..|.||
Zfish  1095 GVTADDLENTTISLRDVQAVLLSMFSADSILIGHSLESDLFALKLIHSMVVDTAIVFPHRLGLPY 1159

  Fly   799 RRALRHLTKVHLKRDIQAGDGTTGHSSFEDSRACMELMLWRVNRE 843
            :||||:|...:|||.||  |...||.|.||:|||||||:|::..:
Zfish  1160 KRALRNLMADYLKRIIQ--DNVGGHDSSEDARACMELMIWKIKED 1202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prage	NP_001188528.1	PH-like	<614..650	CDD:302622	15/39 (38%)
		DnaQ	675..>837	CDD:223916	82/162 (51%)
		REX1_like	686..837	CDD:99848	79/150 (53%)
rexo1	NP_001119888.1	EloA-BP1	785..948	CDD:292495	27/162 (17%)
		REX1_like	1047..1195	CDD:99848	78/149 (52%)
		DnaQ	1060..>1196	CDD:223916	69/137 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589970
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0847
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103246
Panther	1	1.100	-	-	O	PTHR12801
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2254
SonicParanoid	1	1.000	-	-		X1541
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.770